NO178105C - Tramadol-N-oksydmateriale, enantiomerer og preparater derav - Google Patents

Tramadol-N-oksydmateriale, enantiomerer og preparater derav

Info

Publication number: NO178105C
Authority: NO; Norway
Prior art keywords: tramadol; oxide material; enantiomers; compositions; preparations
Prior art date: 1991-09-13

Application number

NO923530A

Other languages

English (en)

Norwegian (no)

Other versions

NO923530D0 (no

NO923530L (no

NO178105B (no

Inventor

Cynthia A Maryanoff

Robert B Raffa

Frank J Villani

Original Assignee

Mcneilab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-13

Filing date

1992-09-11

Publication date

1996-01-24

1992-09-11 Application filed by Mcneilab Inc filed Critical Mcneilab Inc

1992-09-11 Publication of NO923530D0 publication Critical patent/NO923530D0/no

1993-03-15 Publication of NO923530L publication Critical patent/NO923530L/no

1995-10-16 Publication of NO178105B publication Critical patent/NO178105B/no

1996-01-24 Publication of NO178105C publication Critical patent/NO178105C/no

Links

HBXKSXMNNGHBEA-ZBFHGGJFSA-N 1-[(1r,2r)-2-hydroxy-2-(3-methoxyphenyl)cyclohexyl]-n,n-dimethylmethanamine oxide Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)C[N+](C)(C)[O-])=C1 HBXKSXMNNGHBEA-ZBFHGGJFSA-N 0.000 title abstract 5
239000000463 material Substances 0.000 title abstract 4
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 3
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 abstract 1
206010010774 Constipation Diseases 0.000 abstract 1
206010012735 Diarrhoea Diseases 0.000 abstract 1
208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
206010038678 Respiratory depression Diseases 0.000 abstract 1
230000036592 analgesia Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229940127240 opiate Drugs 0.000 abstract 1
230000036407 pain Effects 0.000 abstract 1
229960004380 tramadol Drugs 0.000 abstract 1
TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 abstract 1
230000000294 tussive effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Cosmetics (AREA)
Catching Or Destruction (AREA)

NO923530A 1991-09-13 1992-09-11 Tramadol-N-oksydmateriale, enantiomerer og preparater derav NO178105C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/759,259 US5223541A (en)	1991-09-13	1991-09-13	Tramadol n-oxide material, enantiomers and compositions thereof, and their use

Publications (4)

Publication Number	Publication Date
NO923530D0 NO923530D0 (no)	1992-09-11
NO923530L NO923530L (no)	1993-03-15
NO178105B NO178105B (no)	1995-10-16
NO178105C true NO178105C (no)	1996-01-24

Family

ID=25054992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO923530A NO178105C (no)	1991-09-13	1992-09-11	Tramadol-N-oksydmateriale, enantiomerer og preparater derav

Country Status (23)

Country	Link
US (1)	US5223541A (fr)
EP (1)	EP0532348B1 (fr)
JP (1)	JP3115119B2 (fr)
KR (1)	KR100241859B1 (fr)
CN (1)	CN1032533C (fr)
AT (1)	ATE132852T1 (fr)
AU (1)	AU651000B2 (fr)
CA (1)	CA2078028C (fr)
DE (1)	DE69207526T2 (fr)
DK (1)	DK0532348T3 (fr)
ES (1)	ES2086079T3 (fr)
FI (1)	FI111717B (fr)
GR (1)	GR3019345T3 (fr)
HU (1)	HU214321B (fr)
IL (1)	IL103154A (fr)
MX (1)	MX9205219A (fr)
MY (1)	MY121910A (fr)
NO (1)	NO178105C (fr)
NZ (1)	NZ244309A (fr)
SG (1)	SG63550A1 (fr)
TW (1)	TW221968B (fr)
ZA (1)	ZA926968B (fr)
ZW (1)	ZW14592A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU219332B (hu)	1991-09-06	2001-03-28	Mcneilab Inc	Transz-(+)-2-[(dimetil-amino)-metil]-1-(3-metoxi-fenil)-ciklohexanolt és acetaminofent tartalmazó szinergetikus gyógyszerkészítmények
US5478577A (en) *	1993-11-23	1995-12-26	Euroceltique, S.A.	Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5968551A (en) *	1991-12-24	1999-10-19	Purdue Pharma L.P.	Orally administrable opioid formulations having extended duration of effect
US5958459A (en) *	1991-12-24	1999-09-28	Purdue Pharma L.P.	Opioid formulations having extended controlled released
IL110014A (en)	1993-07-01	1999-11-30	Euro Celtique Sa	Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en)	1993-07-01	2010-06-22	Purdue Pharma Lp	Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) *	1993-07-27	1999-03-09	Euro-Celtique S.A.	Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US6017963A (en)	1995-11-14	2000-01-25	Euro-Celtique, S.A.	Formulation for intranasal administration
WO1999003820A1 (fr)	1997-07-15	1999-01-28	Russinsky Limited	Tramadol, sels de ramadol, et procedes d'elaboration
US6156342A (en) *	1998-05-26	2000-12-05	Andex Pharmaceuticals, Inc.	Controlled release oral dosage form
US6806294B2 (en)	1998-10-15	2004-10-19	Euro-Celtique S.A.	Opioid analgesic
US10179130B2 (en)	1999-10-29	2019-01-15	Purdue Pharma L.P.	Controlled release hydrocodone formulations
ATE526950T1 (de)	1999-10-29	2011-10-15	Euro Celtique Sa	Hydrocodon-formulierungen mit gesteuerter freisetzung
DE10000312A1 (de) *	2000-01-05	2001-07-12	Gruenenthal Gmbh	Substituierte Aminomethyl-Phenyl-Cyclohexanderivate
EP2283829A1 (fr)	2000-10-30	2011-02-16	Euro-Celtique S.A.	Formulations d'hydrocodone à liberation lente
CN1289071C (zh)	2001-03-16	2006-12-13	Dmi生物科学公司	曲马朵物质在制备用于延缓男性射精的药物中的用途
UA81224C2 (uk)	2001-05-02	2007-12-25	Euro Celtic S A	Дозована форма оксикодону та її застосування
US20110104214A1 (en)	2004-04-15	2011-05-05	Purdue Pharma L.P.	Once-a-day oxycodone formulations
US6649783B2 (en)	2001-10-03	2003-11-18	Euro-Celtique, S.A.	Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
WO2003048113A1 (fr)	2001-11-30	2003-06-12	Sepracor Inc.	Analogues de tramadole et leurs utilisations
US9092841B2 (en)	2004-06-09	2015-07-28	Cognex Technology And Investment Llc	Method and apparatus for visual detection and inspection of objects
US7940687B2 (en)	2005-11-16	2011-05-10	Qualcomm Incorporated	Efficient partitioning of control and data fields
DK2114147T3 (da)	2007-02-12	2012-06-25	Dmi Biosciences Inc	Reduktion af bivirkninger af tramadol
NZ579169A (en) *	2007-02-12	2012-05-25	Dmi Biosciences Inc	Treatment of comorbid premature ejaculation and erectile dysfunction using tramadol and a phosphodiesterase (pde) inhibitor
KR20100040881A (ko) *	2007-06-26	2010-04-21	솔베이 파마슈티칼스 비. 브이	전구약물로서 벤라팍신 및 ｏ－데스메틸벤라팍신의 ｎ－옥사이드
US20100003322A1 (en) *	2008-07-03	2010-01-07	Lai Felix S	Enteric coated hydrophobic matrix formulation
US10475492B1 (en)	2018-07-27	2019-11-12	Macronix International Co., Ltd.	Circuit and method for read latency control

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3652589A (en) *	1967-07-27	1972-03-28	Gruenenthal Chemie	1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
US4017637A (en) *	1973-03-26	1977-04-12	American Home Products Corporation	Benzylamine analgesics
DE3515349A1 (de) *	1985-04-27	1986-10-30	Messerschmitt-Bölkow-Blohm GmbH, 8012 Ottobrunn	Elektrischer geber zur messung mechanischer groessen

1991
- 1991-09-13 US US07/759,259 patent/US5223541A/en not_active Expired - Lifetime
1992
- 1992-09-11 EP EP92308298A patent/EP0532348B1/fr not_active Expired - Lifetime
- 1992-09-11 AU AU23557/92A patent/AU651000B2/en not_active Expired
- 1992-09-11 NZ NZ244309A patent/NZ244309A/en not_active IP Right Cessation
- 1992-09-11 HU HU9202918A patent/HU214321B/hu unknown
- 1992-09-11 CA CA002078028A patent/CA2078028C/fr not_active Expired - Lifetime
- 1992-09-11 AT AT92308298T patent/ATE132852T1/de active
- 1992-09-11 DK DK92308298.6T patent/DK0532348T3/da active
- 1992-09-11 DE DE69207526T patent/DE69207526T2/de not_active Expired - Lifetime
- 1992-09-11 SG SG1996001523A patent/SG63550A1/en unknown
- 1992-09-11 ES ES92308298T patent/ES2086079T3/es not_active Expired - Lifetime
- 1992-09-11 ZA ZA926968A patent/ZA926968B/xx unknown
- 1992-09-11 MX MX9205219A patent/MX9205219A/es unknown
- 1992-09-11 CN CN92111582A patent/CN1032533C/zh not_active Expired - Lifetime
- 1992-09-11 NO NO923530A patent/NO178105C/no not_active IP Right Cessation
- 1992-09-11 FI FI924084A patent/FI111717B/fi not_active IP Right Cessation
- 1992-09-12 MY MYPI92001635A patent/MY121910A/en unknown
- 1992-09-13 IL IL10315492A patent/IL103154A/en not_active IP Right Cessation
- 1992-09-14 KR KR1019920016819A patent/KR100241859B1/ko not_active Expired - Lifetime
- 1992-09-14 JP JP04269183A patent/JP3115119B2/ja not_active Expired - Lifetime
- 1992-09-14 ZW ZW14592A patent/ZW14592A1/xx unknown
- 1992-11-10 TW TW081108968A patent/TW221968B/zh not_active IP Right Cessation
1996
- 1996-03-19 GR GR960400740T patent/GR3019345T3/el unknown

Also Published As

Publication number	Publication date
HU9202918D0 (en)	1992-11-30
AU2355792A (en)	1993-03-18
EP0532348A3 (en)	1993-05-26
ZW14592A1 (en)	1994-05-11
ZA926968B (en)	1994-03-11
JPH06122668A (ja)	1994-05-06
NO923530D0 (no)	1992-09-11
EP0532348A2 (fr)	1993-03-17
CA2078028C (fr)	2003-04-29
IL103154A (en)	1996-09-12
CN1032533C (zh)	1996-08-14
DE69207526D1 (de)	1996-02-22
NO923530L (no)	1993-03-15
HU214321B (hu)	1998-03-02
FI111717B (fi)	2003-09-15
GR3019345T3 (en)	1996-06-30
CN1071913A (zh)	1993-05-12
EP0532348B1 (fr)	1996-01-10
KR100241859B1 (ko)	2000-02-01
NO178105B (no)	1995-10-16
AU651000B2 (en)	1994-07-07
FI924084A0 (fi)	1992-09-11
MY121910A (en)	2006-03-31
ES2086079T3 (es)	1996-06-16
TW221968B (fr)	1994-04-01
HUT65476A (en)	1994-06-28
IL103154A0 (en)	1993-02-21
JP3115119B2 (ja)	2000-12-04
NZ244309A (en)	1994-10-26
FI924084L (fi)	1993-03-14
SG63550A1 (en)	1999-03-30
KR930005969A (ko)	1993-04-20
DE69207526T2 (de)	1996-07-04
CA2078028A1 (fr)	1993-03-14
DK0532348T3 (da)	1996-02-05
ATE132852T1 (de)	1996-01-15
US5223541A (en)	1993-06-29
MX9205219A (es)	1994-02-28

Legal Events

Date	Code	Title	Description
2012-10-08	MK1K	Patent expired

Publication	Publication Date	Title
DK0532348T3 (da)	1996-02-05	Tramadol-N-oxidmateriale, enantiomerer og præparater deraf og deres anvendelse
ATE169498T1 (de)	1998-08-15	Zusammensetzung, die eine tramadol-verbindung und acetaminophen enthält, und ihre verwendung
IL103594A0 (en)	1993-03-15	Compositions comprising a tramadol material and a nonsteroidal anti-inflammatory drug
ATE145330T1 (de)	1996-12-15	Zusammensetzungen, die tramadol und irgendein kodein, oxykoden oder hydrokoden enthalten, und deren verwendung
IL126795A (en)	2003-05-29	Pharmaceutical compositions for the treatment of substance abuse disorders comprising pyridyl- and pyrimidyl-piperazines
MY114755A (en)	2003-01-31	Composition comprising a tramadol material and acetaminophen and its use.
ZA894098B (en)	1990-06-27	Alpha-adrenergic receptor antagonists