NO178260C - Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat - Google Patents

Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat

Info

Publication number
NO178260C
NO178260C NO921141A NO921141A NO178260C NO 178260 C NO178260 C NO 178260C NO 921141 A NO921141 A NO 921141A NO 921141 A NO921141 A NO 921141A NO 178260 C NO178260 C NO 178260C
Authority
NO
Norway
Prior art keywords
alkyl
alkylamino
phenyl
benzyl
optionally substituted
Prior art date
Application number
NO921141A
Other languages
English (en)
Norwegian (no)
Other versions
NO921141D0 (no
NO921141L (no
NO178260B (no
Inventor
Didier Festal
Denis Descours
Robert Bellemin
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of NO921141D0 publication Critical patent/NO921141D0/no
Publication of NO921141L publication Critical patent/NO921141L/no
Publication of NO178260B publication Critical patent/NO178260B/no
Publication of NO178260C publication Critical patent/NO178260C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO921141A 1991-03-26 1992-03-24 Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat NO178260C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9103618A FR2674522B1 (fr) 1991-03-26 1991-03-26 Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Publications (4)

Publication Number Publication Date
NO921141D0 NO921141D0 (no) 1992-03-24
NO921141L NO921141L (no) 1992-09-28
NO178260B NO178260B (no) 1995-11-13
NO178260C true NO178260C (no) 1996-02-21

Family

ID=9411107

Family Applications (1)

Application Number Title Priority Date Filing Date
NO921141A NO178260C (no) 1991-03-26 1992-03-24 Indolderivater, mellomproduktforbindelser for deres fremstilling, anvendelse derav samt farmasöytisk preparat

Country Status (25)

Country Link
US (1) US5219859A (de)
EP (1) EP0506532B1 (de)
JP (1) JPH0597802A (de)
KR (1) KR950007753B1 (de)
AT (1) ATE111078T1 (de)
AU (1) AU658609B2 (de)
CA (1) CA2063170A1 (de)
CS (1) CS89592A3 (de)
DE (1) DE69200378T2 (de)
DK (1) DK0506532T3 (de)
ES (1) ES2064149T3 (de)
FR (1) FR2674522B1 (de)
HU (1) HUT65489A (de)
IE (1) IE65366B1 (de)
IL (1) IL101248A (de)
MA (1) MA22474A1 (de)
MX (1) MX9201365A (de)
NO (1) NO178260C (de)
NZ (1) NZ242078A (de)
OA (1) OA09573A (de)
RU (1) RU2074179C1 (de)
SI (1) SI9210305A (de)
TN (1) TNSN92022A1 (de)
YU (1) YU30592A (de)
ZA (1) ZA922163B (de)

Families Citing this family (34)

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FR2687402B1 (fr) * 1992-02-14 1995-06-30 Lipha Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
EP0642498A1 (de) * 1992-05-28 1995-03-15 Pfizer Inc. N-aryl und n-heteroaryl derivate als acat-hemmstoffe
NZ250916A (en) * 1993-02-27 1995-08-28 Nihon Nohyaku Co Ltd N-heteroaryl-n'-phenylureas, their use as acat inhibitors
IL109568A0 (en) * 1993-05-19 1994-08-26 Fujisawa Pharmaceutical Co Urea derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
US5952354A (en) * 1993-07-21 1999-09-14 American Home Products Corporation Tris carbamic acid esters: inhibitors of cholesterol absorption
DE4401893A1 (de) * 1994-01-24 1995-07-27 Bayer Ag Substituierte Arylharnstoffe
JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
FI974437A0 (fi) 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogeenifosforylaasi-inhibiittoreina
KR100241643B1 (ko) * 1995-06-06 2000-03-02 디. 제이. 우드 당뇨병치료제인 치환된 N-(인돌-2-카르보닐)-β-알라님아미드 및 그의 유도체
JP3314938B2 (ja) * 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたn−(インドール−2−カルボニル)−グリシンアミド類および誘導体
NZ299242A (en) * 1995-09-11 1997-12-19 Nihon Nohyaku Co Ltd N-phenyl-n'-(phenyl substituted imidazol-5-yl, -oxazol-4-yl, and -thiazol-4-yl)urea derivatives
CZ292632B6 (cs) * 1995-10-05 2003-11-12 Kyoto Pharmaceutical Industries, Ltd. Indolinový, indolový nebo tetrahydrochinolinový derivát a farmaceutický přípravek s jeho obsahem
EP0773218A1 (de) * 1995-11-13 1997-05-14 Mitsubishi Chemical Corporation N-(Piperazinylalkoxyphenyl)-N'-phenylalkylharnstoffderivate als ACAT-Hemmer zur Atherosklerosebehandlung
DE122010000020I1 (de) * 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
FR2763334A1 (fr) * 1997-05-13 1998-11-20 Lipha Derives anthraniliques
WO1999031075A1 (en) * 1997-12-16 1999-06-24 Warner-Lambert Company 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
KR20010033153A (ko) * 1997-12-16 2001-04-25 로즈 암스트롱, 크리스틴 에이. 트러트웨인 4(3)-치환-4(3)-아미노메틸-(티오)피란 또는 -피페리딘유도체(=가바펜틴 동족체), 그의 제법 및 신경 질환 치료용도
ES2216338T3 (es) * 1997-12-16 2004-10-16 Warner-Lambert Company Llc Aminas novedosas como agentes farmaceuticos.
SK282727B6 (sk) 1997-12-19 2002-11-06 Slovakofarma, A. S. 1,3-Disubstituované močoviny - inhibítory ACAT a spôsob ich prípravy
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
EP1349858B1 (de) 2000-11-02 2008-08-27 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Wirkstoffe für die verminderung von amyloid precursor protein und die behandlung von schwachsinn, und deren verfahren der verwendung
JP2005538047A (ja) * 2002-05-03 2005-12-15 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ボンベシンアンタゴニスト
EP1541553B1 (de) * 2002-07-17 2010-06-02 Kyoto Pharmaceutical Industries, Ltd. Indolinverbindung und deren medizinische verwendung
US7595403B2 (en) 2003-04-01 2009-09-29 Eli Lilly And Company Benzisothiazol-3-one-carboxylic acid amides as phospholipase inhibitors
NZ544803A (en) * 2003-08-29 2009-11-27 Kowa Co Method of stabilizing lipid-rich plaque and method of preventing rupture thereof
AU2006319231A1 (en) 2005-11-30 2007-06-07 F. Hoffmann-La Roche Ag 3-amino-1-arylpropyl indoles and aza-substituted indoles
JP2009517432A (ja) 2005-11-30 2009-04-30 エフ.ホフマン−ラ ロシュ アーゲー 3−アミノ−2−アリールプロピルアザインドールおよびその使用
RU2361581C2 (ru) * 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
SK287385B6 (sk) 2007-11-27 2010-08-09 Hameln-Rds, A. S. 1,3-Disubstituované močoviny, spôsob ich prípravy a použitia
CN104628621A (zh) * 2015-01-22 2015-05-20 湖南华腾制药有限公司 一种氟取代吲哚衍生物的制备方法
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
CU20190106A7 (es) 2017-06-26 2020-11-30 Lunella Biotech Inc Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas
JP7770673B2 (ja) 2019-02-27 2025-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 脳障害を治療するためのアゼピノ-インドール及び他の複素環化合物
AU2022416279A1 (en) 2021-12-15 2024-07-25 Delix Therapeutics, Inc. Phenoxy and benzyloxy substituted psychoplastogens and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55151505A (en) * 1979-05-14 1980-11-26 Kuraray Co Ltd Indole agricultural and horticultural fungicide
CA1299174C (en) * 1987-02-02 1992-04-21 Michael Edward Flaugh Alkylmelatonins
EP0375133A1 (de) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indol-3-essigsäure, verwendbar als antidiabetische, antifettleibige und antiarteriosklerotische Agenten
IL95584A (en) * 1989-09-07 1995-03-15 Abbott Lab Indole-, benzoporene- and benzothiophene compounds including lipoxygenase-inhibiting compounds and pharmaceutical compounds containing them
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
EP0471296B1 (de) * 1990-08-13 1995-11-08 Hoechst-Roussel Pharmaceuticals Incorporated 1-(Pyridinylalkyl)-1H-indole, -indoline und Analoge
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
WO1993005020A1 (en) * 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles as inhibitors of hiv reverse transcriptase

Also Published As

Publication number Publication date
DE69200378T2 (de) 1995-03-09
DK0506532T3 (da) 1995-02-20
FR2674522B1 (fr) 1993-07-16
JPH0597802A (ja) 1993-04-20
AU1309492A (en) 1992-10-01
OA09573A (fr) 1993-01-31
ATE111078T1 (de) 1994-09-15
HUT65489A (en) 1994-06-28
KR920018022A (ko) 1992-10-21
IE65366B1 (en) 1995-10-18
IL101248A (en) 1996-12-05
EP0506532B1 (de) 1994-09-07
MX9201365A (es) 1992-10-01
MA22474A1 (fr) 1992-10-01
ZA922163B (en) 1993-09-27
TNSN92022A1 (fr) 1993-06-08
NO921141D0 (no) 1992-03-24
HU9200997D0 (en) 1992-05-28
IL101248A0 (en) 1992-11-15
AU658609B2 (en) 1995-04-27
EP0506532A1 (de) 1992-09-30
SI9210305A (en) 1996-02-29
IE920937A1 (en) 1992-10-07
NO921141L (no) 1992-09-28
NZ242078A (en) 1994-10-26
YU30592A (sh) 1994-12-28
CA2063170A1 (en) 1992-09-27
RU2074179C1 (ru) 1997-02-27
KR950007753B1 (ko) 1995-07-14
ES2064149T3 (es) 1995-01-16
FR2674522A1 (fr) 1992-10-02
DE69200378D1 (de) 1994-10-13
CS89592A3 (en) 1992-10-14
NO178260B (no) 1995-11-13
US5219859A (en) 1993-06-15

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