NO178401C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav

Info

Publication number
NO178401C
NO178401C NO912051A NO912051A NO178401C NO 178401 C NO178401 C NO 178401C NO 912051 A NO912051 A NO 912051A NO 912051 A NO912051 A NO 912051A NO 178401 C NO178401 C NO 178401C
Authority
NO
Norway
Prior art keywords
triazines
preparation
triazolo
pyrazolo
heteroaryl
Prior art date
Application number
NO912051A
Other languages
English (en)
Norwegian (no)
Other versions
NO178401B (no
NO912051L (no
NO912051D0 (no
Inventor
Peter William Rodney Caulkett
Geraint Jones
Michael George Collis
Simon Martin Poucher
Original Assignee
Zeneca Ltd
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909011914A external-priority patent/GB9011914D0/en
Priority claimed from GB909011913A external-priority patent/GB9011913D0/en
Priority claimed from GB919101380A external-priority patent/GB9101380D0/en
Priority claimed from GB919101379A external-priority patent/GB9101379D0/en
Priority claimed from GB919104125A external-priority patent/GB9104125D0/en
Application filed by Zeneca Ltd, Ici Plc filed Critical Zeneca Ltd
Publication of NO912051D0 publication Critical patent/NO912051D0/no
Publication of NO912051L publication Critical patent/NO912051L/no
Publication of NO178401B publication Critical patent/NO178401B/no
Publication of NO178401C publication Critical patent/NO178401C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO912051A 1990-05-29 1991-05-28 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav NO178401C (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909011914A GB9011914D0 (en) 1990-05-29 1990-05-29 Heterocyclic compounds
GB909011913A GB9011913D0 (en) 1990-05-29 1990-05-29 Azole derivatives
GB919101380A GB9101380D0 (en) 1991-01-22 1991-01-22 Azole derivatives
GB919101379A GB9101379D0 (en) 1991-01-22 1991-01-22 Heterocyclic compounds
GB919104125A GB9104125D0 (en) 1991-02-27 1991-02-27 Azole derivatives

Publications (4)

Publication Number Publication Date
NO912051D0 NO912051D0 (no) 1991-05-28
NO912051L NO912051L (no) 1991-12-02
NO178401B NO178401B (no) 1995-12-11
NO178401C true NO178401C (no) 1996-03-20

Family

ID=27516979

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912051A NO178401C (no) 1990-05-29 1991-05-28 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav

Country Status (20)

Country Link
US (1) US5270311A (cs)
EP (1) EP0459702A1 (cs)
JP (1) JP2504879B2 (cs)
KR (1) KR910020012A (cs)
CN (1) CN1056879A (cs)
AP (1) AP248A (cs)
AU (1) AU642494B2 (cs)
CA (1) CA2043424A1 (cs)
CS (1) CS159591A3 (cs)
FI (1) FI912563A7 (cs)
GB (1) GB2244487B (cs)
HU (1) HUT61311A (cs)
IE (1) IE911818A1 (cs)
IL (1) IL98316A (cs)
NO (1) NO178401C (cs)
NZ (1) NZ238288A (cs)
OA (1) OA09358A (cs)
PT (1) PT97776A (cs)
RO (1) RO109542B1 (cs)
YU (1) YU47812B (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2244487B (en) * 1990-05-29 1994-02-02 Ici Plc Azole derivatives
GB9226735D0 (en) * 1992-12-22 1993-02-17 Ici Plc Azole derivatives
US5356894A (en) * 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9125001D0 (en) * 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
GB9124968D0 (en) * 1991-11-25 1992-01-22 Ici Plc Chemical process
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
ES2165393T3 (es) * 1993-07-27 2002-03-16 Kyowa Hakko Kogyo Kk Remedio contra la enfermedad de parkinson.
AU7546794A (en) * 1993-09-06 1995-03-27 Kyowa Hakko Kogyo Co. Ltd. Depression remedy
CA2284737C (en) 1997-03-24 2007-03-13 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]triazolo[1,5-c]pyrimidine derivatives
US6060481A (en) * 1998-05-28 2000-05-09 The Penn State Research Foundation Method for improving insulin sensitivity using an adenosine receptor antagonist
AU756144B2 (en) 1998-09-22 2003-01-02 Kyowa Hakko Kogyo Co. Ltd. (1,2,4)triazolo(1,5-c)pyrimidine derivatives
AU2003272886A1 (en) * 2002-09-24 2004-04-19 Kyowa Hakko Kogyo Co., Ltd. (1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2004092170A2 (en) * 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
US20070010522A1 (en) * 2003-04-09 2007-01-11 Chi Vu Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
US7674791B2 (en) 2003-04-09 2010-03-09 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
DE602004018637D1 (de) 2003-04-09 2009-02-05 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
WO2006076706A1 (en) 2005-01-14 2006-07-20 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
BR112015013195A2 (pt) 2012-12-06 2017-08-29 Siemens Ag Disposição e método para introduzir calor em uma formação geológica por meio de indução eletromagnética
CN106916073A (zh) * 2017-01-20 2017-07-04 上海巧坤化工科技有限公司 一种大麦芽碱盐酸盐的合成方法
CA3089159A1 (en) * 2018-02-06 2019-08-15 Jiangsu Hengrui Medicine Co., Ltd. Pyrazolo[1,5-a][1,3,5]triazine-2-amine derivative, preparation method therefor and medical use thereof
WO2020002969A1 (en) * 2018-06-26 2020-01-02 Zhejiang Vimgreen Pharmaceuticals, Ltd Triazolotriazine derivatives as a2a receptor antagonists
KR102633145B1 (ko) * 2018-06-26 2024-02-05 쩌지앙 빔그린 파머슈티컬스, 엘티디 A2a 수용체 길항제로서의 트리아졸로 트리아진 유도체
BE1026602B1 (fr) 2018-09-27 2020-06-18 Iteos Therapeutics S A Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers
WO2020103939A1 (zh) * 2018-11-22 2020-05-28 上海科技大学 三唑并环类化合物、其制备方法、中间体和应用
CN112608316B (zh) * 2019-07-30 2022-10-21 厦门宝太生物科技股份有限公司 一种吡唑并三嗪类腺苷受体拮抗剂
WO2021105916A1 (en) * 2019-11-26 2021-06-03 Aurigene Discovery Technologies Limited Sulfonamide compounds targeting cd73 and adenosine receptors
CN114901665B (zh) * 2019-12-26 2025-02-18 浙江春禾医药科技有限公司 三唑并三嗪衍生物在治疗疾病中的用途
US20240217978A1 (en) * 2021-04-23 2024-07-04 Chong Kun Dang Pharmaceutical Corp. COMPOUND AS ADENOSINE A2a RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846423A (en) * 1972-06-08 1974-11-05 Icn Pharmaceuticals Pyrazolo (1,5a) 1,3,5-triazines
BE815405A (en) * 1973-05-22 1974-11-22 Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
GB1579932A (en) * 1976-05-12 1980-11-26 Ici Ltd Herbicidal triazolotriazines
GB2016002B (en) * 1978-01-09 1982-05-06 Aron Sa Amino derivatives of pyrazolo(1,5-a)s triazine
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
CA1267143A (en) * 1985-06-06 1990-03-27 Sun H. Kim Anti-arthritic 7-phenylpyrazole[1,5-a]-1,3,5- triazine derivatives
DE3677445D1 (de) * 1985-09-30 1991-03-14 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DE3781080T2 (de) * 1986-09-30 1992-12-24 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,2,4)triazolo-(1,5-c)pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
US4734413A (en) * 1987-03-02 1988-03-29 Riker Laboratories, Inc. Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
DE3885357T2 (de) * 1987-06-29 1994-03-24 Duphar Int Res Anellierte Indolderivate.
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
US4970142A (en) * 1989-02-16 1990-11-13 Konica Corporation Silver halide photographic light-sensitive material containing cyan coupler
GB2244487B (en) * 1990-05-29 1994-02-02 Ici Plc Azole derivatives

Also Published As

Publication number Publication date
JPH0597855A (ja) 1993-04-20
HU911789D0 (en) 1991-12-30
CS159591A3 (en) 1992-01-15
EP0459702A1 (en) 1991-12-04
OA09358A (fr) 1992-09-15
HUT61311A (en) 1992-12-28
YU94791A (sh) 1994-06-24
FI912563A0 (fi) 1991-05-28
AU7734891A (en) 1991-12-05
GB9111132D0 (en) 1991-07-17
KR910020012A (ko) 1991-12-19
AU642494B2 (en) 1993-10-21
CA2043424A1 (en) 1991-11-30
IL98316A (en) 1995-05-26
GB2244487A (en) 1991-12-04
NO178401B (no) 1995-12-11
NZ238288A (en) 1993-07-27
IE911818A1 (en) 1991-12-04
AP248A (en) 1993-03-16
JP2504879B2 (ja) 1996-06-05
NO912051L (no) 1991-12-02
NO912051D0 (no) 1991-05-28
AP9100266A0 (en) 1991-07-31
US5270311A (en) 1993-12-14
FI912563A7 (fi) 1991-11-30
GB2244487B (en) 1994-02-02
YU47812B (sr) 1996-01-09
PT97776A (pt) 1992-03-31
CN1056879A (zh) 1991-12-11
IL98316A0 (en) 1992-06-21
RO109542B1 (ro) 1995-03-30

Similar Documents

Publication Publication Date Title
NO178401C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav
FI913477L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten imidatsoli-fenyyli-imidatso/1,2-a/pyridiini- ja imidatsoli-fenyyli-imidatso/1,2-a/pyrimidiinijohdannaisten valmistamiseksi
NO179584C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-acylaminotiazoler
FI914905L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
FI925737A7 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten indol-3-yylialkyylipiperatsiinijohdannaisten valmistamiseksi
NO175873C (no) Mikrobiell fremgangsmåte for fremstilling av immunhemmende antibiotika
FI880815A7 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 5-okso-4,5-dihydro-imidatso/1,5-a/kinatsoliinijohdannaisten valmistamiseksi
NO177057C (no) Fremgangsmåte for fremstilling av pyrrolopyrimidiner og mellomprodukter derav
FI891952A7 (fi) Menetelmä ja välituotteita uusien, terapeuttisesti käyttökelpoisten karbonyyliamino(tetrahydropyrrolo tai heksahydropyrido)/3,2,1-jk//1,4/bentsodiatsepinonijohdannaisten valmistamiseksi
NO176275C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive pyridazinonderivater
FI900897A0 (fi) Analogiamenetelmä terapeuttisesti käyttökelpoisten 4,5,6,7-tetrahydroimidatso/4,5,1-jk//1,4/bentsodiatsepiini-2(1H)-tionijohdannaisten valmistamiseksi
FI885518A7 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4,5-dihydro-4-okso-5-isopropyyli-imidatso/1,5-a/kinoksaliinijohdannaisten valmistamiseksi
FI880467A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 3,4-dihydro-2H-bentsopyraanien valmistamiseksi
FI881892A7 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,5,6-tetrahydropyridiinijohdannaisten valmistamiseksi
FI892908L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso/1,5-a/kinoksaliinijohdannaisten valmistamiseksi
NO175976C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 4-(1,6-dihydro-6-okso-pyridazinyl-3-oksy)-3-kromanolderivater
FI891004A7 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4-substituoitujen pyratsolo/3,4-d/pyrimidiinijohdannaisten valmistamiseksi
FI892684L (fi) Menetelmä terapeuttisesti aktiivisten 4-okso-imidatso/1,5-a/kinoksaliinijohdannaisten valmistamiseksi
NO174203C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive
FI92205C (fi) Menetelmä terapeuttisesti käyttökelpoisten N-pyrrolo- ja pyrido /3,2,1,-j k/ /1,4/ bentsodiatsepinyyli-N'-aryyliurea ja tioureajohdannaisten valmistamiseksi
NO177712C (no) Analogifremgangsmåte for fremstilling av nye terapeutisk virksomme alkylfosfonoseriner
FI892946A7 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 2,3,4,5-tetrahydro-1H-3-bentsoatsepiinijohdannaisten valmistamiseksi
AU7291891A (en) Process for the isolation and expression of the human ciliary neuronotrophic factor by recombinant dna technology
EG19767A (en) Process for preparing of substituted 1,2,4- triazinediones intermediates therefor and their use
FI893682L (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,5-ditiatsosiinijohdannaisten valmistamiseksi