NO178401C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav

Info

Publication number
NO178401C
NO178401C NO912051A NO912051A NO178401C NO 178401 C NO178401 C NO 178401C NO 912051 A NO912051 A NO 912051A NO 912051 A NO912051 A NO 912051A NO 178401 C NO178401 C NO 178401C
Authority
NO
Norway
Prior art keywords
triazines
preparation
triazolo
pyrazolo
heteroaryl
Prior art date
Application number
NO912051A
Other languages
English (en)
Norwegian (no)
Other versions
NO912051L (no
NO178401B (no
NO912051D0 (no
Inventor
Peter William Rodney Caulkett
Geraint Jones
Michael George Collis
Simon Martin Poucher
Original Assignee
Zeneca Ltd
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909011913A external-priority patent/GB9011913D0/en
Priority claimed from GB909011914A external-priority patent/GB9011914D0/en
Priority claimed from GB919101380A external-priority patent/GB9101380D0/en
Priority claimed from GB919101379A external-priority patent/GB9101379D0/en
Priority claimed from GB919104125A external-priority patent/GB9104125D0/en
Application filed by Zeneca Ltd, Ici Plc filed Critical Zeneca Ltd
Publication of NO912051D0 publication Critical patent/NO912051D0/no
Publication of NO912051L publication Critical patent/NO912051L/no
Publication of NO178401B publication Critical patent/NO178401B/no
Publication of NO178401C publication Critical patent/NO178401C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO912051A 1990-05-29 1991-05-28 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav NO178401C (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB909011913A GB9011913D0 (en) 1990-05-29 1990-05-29 Azole derivatives
GB909011914A GB9011914D0 (en) 1990-05-29 1990-05-29 Heterocyclic compounds
GB919101380A GB9101380D0 (en) 1991-01-22 1991-01-22 Azole derivatives
GB919101379A GB9101379D0 (en) 1991-01-22 1991-01-22 Heterocyclic compounds
GB919104125A GB9104125D0 (en) 1991-02-27 1991-02-27 Azole derivatives

Publications (4)

Publication Number Publication Date
NO912051D0 NO912051D0 (no) 1991-05-28
NO912051L NO912051L (no) 1991-12-02
NO178401B NO178401B (no) 1995-12-11
NO178401C true NO178401C (no) 1996-03-20

Family

ID=27516979

Family Applications (1)

Application Number Title Priority Date Filing Date
NO912051A NO178401C (no) 1990-05-29 1991-05-28 Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-heteroaryl-triazolo-[1,5-aÅ[1,3,5Åtriaziner og -pyrazolo[2,3-aÅ[1,3,5Åtriaziner og nye mellomprodukter for fremstilling derav

Country Status (20)

Country Link
US (1) US5270311A (cs)
EP (1) EP0459702A1 (cs)
JP (1) JP2504879B2 (cs)
KR (1) KR910020012A (cs)
CN (1) CN1056879A (cs)
AP (1) AP248A (cs)
AU (1) AU642494B2 (cs)
CA (1) CA2043424A1 (cs)
CS (1) CS159591A3 (cs)
FI (1) FI912563A7 (cs)
GB (1) GB2244487B (cs)
HU (1) HUT61311A (cs)
IE (1) IE911818A1 (cs)
IL (1) IL98316A (cs)
NO (1) NO178401C (cs)
NZ (1) NZ238288A (cs)
OA (1) OA09358A (cs)
PT (1) PT97776A (cs)
RO (1) RO109542B1 (cs)
YU (1) YU47812B (cs)

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EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives
GB9226735D0 (en) * 1992-12-22 1993-02-17 Ici Plc Azole derivatives
US5356894A (en) * 1990-05-29 1994-10-18 Rodney Peter W Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
GB9125001D0 (en) * 1991-11-25 1992-01-22 Ici Plc Heterocyclic compounds
GB9125002D0 (en) * 1991-11-25 1992-01-22 Ici Plc Azole derivatives
GB9124968D0 (en) * 1991-11-25 1992-01-22 Ici Plc Chemical process
WO1995003806A1 (en) * 1993-07-27 1995-02-09 Kyowa Hakko Kogyo Co., Ltd. Remedy for parkinson's disease
CA2148502A1 (en) * 1993-09-06 1995-03-16 Fumio Suzuki Antidepressants
DE69820866T2 (de) 1997-03-24 2004-12-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
US6060481A (en) * 1998-05-28 2000-05-09 The Penn State Research Foundation Method for improving insulin sensitivity using an adenosine receptor antagonist
WO2000017201A1 (en) * 1998-09-22 2000-03-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
WO2004029056A1 (ja) * 2002-09-24 2004-04-08 Kyowa Hakko Kogyo Co., Ltd. [１，２，４]トリアゾロ[１，５−ｃ]ピリミジン誘導体
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
WO2004092170A2 (en) * 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
WO2004092177A1 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
WO2004092172A2 (en) * 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
AU2006204724A1 (en) 2005-01-14 2006-07-20 Millennium Pharmaceuticals, Inc. Cinnamide and hydrocinnamide derivatives with raf-kinase inhibitory activity
RU2015126797A (ru) 2012-12-06 2017-01-12 Сименс Акциенгезелльшафт Система и способ введения тепла в геологическую формацию при помощи электромагнитной индукции
CN106916073A (zh) * 2017-01-20 2017-07-04 上海巧坤化工科技有限公司 一种大麦芽碱盐酸盐的合成方法
WO2019154294A1 (zh) * 2018-02-06 2019-08-15 江苏恒瑞医药股份有限公司 吡唑并[1,5-a][1,3,5]三嗪-2-胺类衍生物、其制备方法及其在医药上的应用
JP7197206B2 (ja) * 2018-06-26 2022-12-27 チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド Ａ２ａ受容体拮抗薬として用いられるトリアゾロトリアジン誘導体
KR102633145B1 (ko) * 2018-06-26 2024-02-05 쩌지앙 빔그린 파머슈티컬스, 엘티디 A2a 수용체 길항제로서의 트리아졸로 트리아진 유도체
BE1026602B1 (fr) 2018-09-27 2020-06-18 Iteos Therapeutics S A Inhibiteurs d’a2a ne penetrant pas dans le cerveau et methodes d’utilisation dans le traitement de cancers
WO2020103939A1 (zh) * 2018-11-22 2020-05-28 上海科技大学 三唑并环类化合物、其制备方法、中间体和应用
CN112028891B (zh) * 2019-07-30 2022-07-05 厦门宝太生物科技股份有限公司 腺苷受体拮抗剂
WO2021105916A1 (en) * 2019-11-26 2021-06-03 Aurigene Discovery Technologies Limited Sulfonamide compounds targeting cd73 and adenosine receptors
JP2023508182A (ja) * 2019-12-26 2023-03-01 チェジン ヴィムグリーン ファーマシューティカルズ リミテッド トリアゾロトリアジン誘導体の疾患治療への応用
MX2023012338A (es) * 2021-04-23 2023-10-30 Chong Kun Dang Pharmaceutical Corp Compuesto como antagonista del receptor de adenosina a2a y composicion farmaceutica que comprende al mismo.

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US3846423A (en) * 1972-06-08 1974-11-05 Icn Pharmaceuticals Pyrazolo (1,5a) 1,3,5-triazines
ZA743316B (en) * 1973-05-22 1976-01-28 Sandoz Ltd Improvements in or relating to organic compounds
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
GB1579932A (en) * 1976-05-12 1980-11-26 Ici Ltd Herbicidal triazolotriazines
GB2016002B (en) * 1978-01-09 1982-05-06 Aron Sa Amino derivatives of pyrazolo(1,5-a)s triazine
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
CA1267143A (en) * 1985-06-06 1990-03-27 Sun H. Kim Anti-arthritic 7-phenylpyrazole[1,5-a]-1,3,5- triazine derivatives
DE3677445D1 (de) * 1985-09-30 1991-03-14 Ciba Geigy Ag 2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
ES2051772T3 (es) * 1986-09-30 1994-07-01 Ciba Geigy Ag 2-sustituido-e-fusionado-(1,2,4)-triazol(1,5-c)pirimidinas, composiciones farmaceuticas y sus usos.
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
US4734413A (en) * 1987-03-02 1988-03-29 Riker Laboratories, Inc. Substituted 1,2,4-triazolo[1,5-A]triazines as bronchodilators
DE3885357T2 (de) * 1987-06-29 1994-03-24 Duphar Int Res Anellierte Indolderivate.
DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
US4970142A (en) * 1989-02-16 1990-11-13 Konica Corporation Silver halide photographic light-sensitive material containing cyan coupler
EP0459702A1 (en) * 1990-05-29 1991-12-04 Zeneca Limited Azole Derivatives

Also Published As

Publication number Publication date
EP0459702A1 (en) 1991-12-04
AU642494B2 (en) 1993-10-21
PT97776A (pt) 1992-03-31
GB9111132D0 (en) 1991-07-17
RO109542B1 (ro) 1995-03-30
KR910020012A (ko) 1991-12-19
JP2504879B2 (ja) 1996-06-05
FI912563A7 (fi) 1991-11-30
US5270311A (en) 1993-12-14
YU94791A (sh) 1994-06-24
AP9100266A0 (en) 1991-07-31
AU7734891A (en) 1991-12-05
CS159591A3 (en) 1992-01-15
FI912563A0 (fi) 1991-05-28
NO912051L (no) 1991-12-02
CN1056879A (zh) 1991-12-11
NO178401B (no) 1995-12-11
OA09358A (fr) 1992-09-15
AP248A (en) 1993-03-16
NO912051D0 (no) 1991-05-28
JPH0597855A (ja) 1993-04-20
HU911789D0 (en) 1991-12-30
IL98316A (en) 1995-05-26
CA2043424A1 (en) 1991-11-30
IE911818A1 (en) 1991-12-04
IL98316A0 (en) 1992-06-21
HUT61311A (en) 1992-12-28
GB2244487A (en) 1991-12-04
GB2244487B (en) 1994-02-02
YU47812B (sr) 1996-01-09
NZ238288A (en) 1993-07-27

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