NO178500C - Spikamycinderivater, mellomprodukt samt antitumormiddel - Google Patents

Spikamycinderivater, mellomprodukt samt antitumormiddel

Info

Publication number: NO178500C
Authority: NO; Norway
Prior art keywords: chem; denotes; integer; carbon atoms; given number
Prior art date: 1991-07-12

Application number

NO922674A

Other languages

English (en)

Norwegian (no)

Other versions

NO178500B (no

NO922674D0 (no

NO922674L (no

Inventor

Noboru Otake

Hiroyuki Kawai

Tomiko Kawasaki

Atsuo Odagawa

Masaru Kamishohara

Teruyuki Sakai

Original Assignee

Kirin Brewery

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-12

Filing date

1992-07-08

Publication date

1996-04-10

1992-07-08 Application filed by Kirin Brewery filed Critical Kirin Brewery

1992-07-08 Publication of NO922674D0 publication Critical patent/NO922674D0/no

1993-01-13 Publication of NO922674L publication Critical patent/NO922674L/no

1996-01-02 Publication of NO178500B publication Critical patent/NO178500B/no

1996-04-10 Publication of NO178500C publication Critical patent/NO178500C/no

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
YBZRLMLGUBIIDN-NZSGCTDASA-N spicamycin Chemical class O1[C@@H](C(O)CO)[C@H](NC(=O)CNC(=O)CCCCCCCCCCCCC(C)C)[C@@H](O)[C@@H](O)[C@H]1NC1=NC=NC2=C1N=CN2 YBZRLMLGUBIIDN-NZSGCTDASA-N 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 3
DCERHCFNWRGHLK-UHFFFAOYSA-N C[Si](C)C Chemical compound C[Si](C)C DCERHCFNWRGHLK-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001188 haloalkyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
231100001274 therapeutic index Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO922674A 1991-07-12 1992-07-08 Spikamycinderivater, mellomprodukt samt antitumormiddel NO178500C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP19890391		1991-07-12
JP32684591		1991-11-15
JP4110665A JP2783722B2 (ja)	1991-07-12	1992-04-03	スピカマイシン誘導体およびそれを含む抗腫瘍剤

Publications (4)

Publication Number	Publication Date
NO922674D0 NO922674D0 (no)	1992-07-08
NO922674L NO922674L (no)	1993-01-13
NO178500B NO178500B (no)	1996-01-02
NO178500C true NO178500C (no)	1996-04-10

Family

ID=27311786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO922674A NO178500C (no)	1991-07-12	1992-07-08	Spikamycinderivater, mellomprodukt samt antitumormiddel

Country Status (15)

Country	Link
US (2)	US5461036A (de)
EP (1)	EP0525479B1 (de)
JP (1)	JP2783722B2 (de)
KR (1)	KR100253050B1 (de)
AT (1)	ATE159948T1 (de)
AU (1)	AU657551B2 (de)
CA (1)	CA2073567C (de)
DE (1)	DE69222992T2 (de)
DK (1)	DK0525479T3 (de)
ES (1)	ES2111019T3 (de)
FI (1)	FI105815B (de)
GR (1)	GR3025293T3 (de)
HU (1)	HU221808B1 (de)
NO (1)	NO178500C (de)
SG (1)	SG52704A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7017208B2 (en) *	1995-08-04	2006-03-28	Hill-Rom Services, Inc.	Hospital bed
US5905069A (en) *	1998-01-26	1999-05-18	The General Hospital Corporation	Methods of decreasing or preventing pain using spicamycin or derivatives thereof
WO2000043366A1 (en) *	1999-01-22	2000-07-27	Kirin Beer Kabushiki Kaisha	Quinoline derivatives and quinazoline derivatives
ES2365473T3 (es)	2000-09-20	2011-10-06	The General Hospital Corporation	Procedimientos para reducir o prevenir el dolor usando derivados de espicamicina.
US20060074014A1 (en) *	2002-11-18	2006-04-06	Vicuron Pharmaceuticals Inc.	Dalbavancin compositions for treatment of bacterial infections
US20050090433A1 (en) *	2002-11-18	2005-04-28	Vicuron Pharmaceuticals, Inc	Dalbavancin compositions for treatment of bacterial infections
CN1878748B (zh) *	2003-09-11	2010-04-21	因维斯塔技术有限公司	氢氰化不饱和羧酸衍生物的方法
JP4608651B2 (ja) *	2004-06-24	2011-01-12	財団法人ヒューマンサイエンス振興財団	抗ガン作用を有する化合物、その製造方法及び抗ガン剤
US8119829B2 (en) *	2004-09-08	2012-02-21	Invista North America S.A.R.L.	Process of hydrocyanation of unsaturated carboxylic acid derivatives
US9248098B2 (en) *	2008-10-10	2016-02-02	Dara Biosciences, Inc.	Treating or preventing pain using spicamycin derivatives
EP2597082A1 (de)	2011-11-24	2013-05-29	Symrise AG	Verbindungen zur Maskierung eines unangenehmen Geschmacks
JP2015524482A (ja) *	2012-08-09	2015-08-24	ダラ・バイオサイエンシズ，インコーポレイテッド	スピカマイシン誘導体を含む組成物およびその使用方法
WO2015061481A1 (en)	2013-10-23	2015-04-30	Dara Biosciences, Inc.	Methods of treating liquid tumors using compositions comprising spicamycin derivatives
CN110386874B (zh) *	2018-04-16	2022-10-04	湖北金鹤化工有限公司	一种12-酮基硬脂酸酯及其制备方法
WO2025090774A1 (en) *	2023-10-24	2025-05-01	Seagen Inc.	Chemotherapeutic compounds and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3264195A (en) *	1963-07-24	1966-08-02	Squibb & Sons Inc	Process for the preparation of septacidin and derivatives
US3155647A (en)	1963-07-24	1964-11-03	Olin Mathieson	Septaciding and derivatives thereof
US4086416A (en) *	1977-05-17	1978-04-25	Stanford Research Institute	Septacidin analogs
JPS59161389A (ja) *	1983-03-07	1984-09-12	Eisai Co Ltd	７−カルボキシメトキシフエニルアセトアミドセフエム誘導体，その製造法およびそれからなる抗菌剤
JPS59161396A (ja) *	1983-03-04	1984-09-12	Kirin Brewery Co Ltd	新規抗生物質スピカマイシン
US4975434A (en) *	1986-05-27	1990-12-04	The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services	Antiviral and anticancer cyclopentenyl cytosine
WO1990015811A1 (fr)	1989-06-16	1990-12-27	Kirin Beer Kabushiki Kaisha	Spicamycine x et son utilisation

1992
- 1992-04-03 JP JP4110665A patent/JP2783722B2/ja not_active Expired - Lifetime
- 1992-07-08 US US07/910,640 patent/US5461036A/en not_active Expired - Lifetime
- 1992-07-08 NO NO922674A patent/NO178500C/no not_active IP Right Cessation
- 1992-07-09 FI FI923170A patent/FI105815B/fi active
- 1992-07-10 DK DK92111782.6T patent/DK0525479T3/da active
- 1992-07-10 AU AU19600/92A patent/AU657551B2/en not_active Ceased
- 1992-07-10 HU HU9202285A patent/HU221808B1/hu not_active IP Right Cessation
- 1992-07-10 ES ES92111782T patent/ES2111019T3/es not_active Expired - Lifetime
- 1992-07-10 CA CA002073567A patent/CA2073567C/en not_active Expired - Lifetime
- 1992-07-10 EP EP92111782A patent/EP0525479B1/de not_active Expired - Lifetime
- 1992-07-10 SG SG1996008096A patent/SG52704A1/en unknown
- 1992-07-10 AT AT92111782T patent/ATE159948T1/de active
- 1992-07-10 DE DE69222992T patent/DE69222992T2/de not_active Expired - Lifetime
- 1992-07-11 KR KR1019920012373A patent/KR100253050B1/ko not_active Expired - Fee Related
1995
- 1995-04-26 US US08/429,303 patent/US5631238A/en not_active Expired - Lifetime
1997
- 1997-11-06 GR GR970401503T patent/GR3025293T3/el unknown

Also Published As

Publication number	Publication date
CA2073567A1 (en)	1993-01-13
AU657551B2 (en)	1995-03-16
FI105815B (fi)	2000-10-13
CA2073567C (en)	1998-05-05
HU9202285D0 (en)	1992-10-28
GR3025293T3 (en)	1998-02-27
NO178500B (no)	1996-01-02
JP2783722B2 (ja)	1998-08-06
EP0525479B1 (de)	1997-11-05
FI923170A0 (fi)	1992-07-09
HK1001729A1 (en)	1998-07-03
HU221808B1 (hu)	2003-01-28
KR930002370A (ko)	1993-02-23
SG52704A1 (en)	1998-09-28
ATE159948T1 (de)	1997-11-15
DK0525479T3 (da)	1998-04-20
NO922674D0 (no)	1992-07-08
DE69222992T2 (de)	1998-03-05
NO922674L (no)	1993-01-13
HUT61773A (en)	1993-03-01
AU1960092A (en)	1993-01-14
KR100253050B1 (ko)	2000-04-15
US5631238A (en)	1997-05-20
DE69222992D1 (de)	1997-12-11
FI923170A7 (fi)	1993-01-13
US5461036A (en)	1995-10-24
JPH05186494A (ja)	1993-07-27
EP0525479A1 (de)	1993-02-03
ES2111019T3 (es)	1998-03-01

Legal Events

Date	Code	Title	Description
2012-07-16	MK1K	Patent expired

Publication	Publication Date	Title
NO178500C (no)	1996-04-10	Spikamycinderivater, mellomprodukt samt antitumormiddel
ATE176237T1 (de)	1999-02-15	Sphingoglycolipid und verwendung davon
KR950702431A (ko)	1995-07-29	신규한 의약 조성물(novel pharmaceutical compositions)
EP0421634A3 (en)	1992-03-04	Bis(3,4-dialkylbenzylidene) sorbitol acetals and compositions containing same
DE69022675D1 (de)	1995-11-02	Flüssigkristallzusammensetzung.
MX9204029A (es)	1993-01-01	Procedimiento de preparacion de un derivado de la bacatina iii y de la 10-desacetil bacatina iii
AU4216993A (en)	1994-02-03	Novel arylglycinamide derivatives and preparative processes therefor
DK0568147T3 (da)	1996-09-02	Polysiloxanstabilisatorer indeholdende sterisk hindrede phenolgrupper og oxamidgrupper
DE3875346D1 (de)	1992-11-19	Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.
GR3034023T3 (en)	2000-11-30	Phenyl carboxamide-isoxazole-derivatives and salts, process for their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
ATE113030T1 (de)	1994-11-15	Hydroxyalkancarbonsäure-derivate und deren verwendung.
AU641686B2 (en)	1993-09-30	Benzanilides
DK0502304T3 (da)	1993-11-29	Middel til permanentbølgning af menneskehår indeholdende alkylpolyglycosider
DK606286D0 (da)	1986-12-16	Anthracyclin-derivater og laegemidler indeholdende disse forbindelser
ATE110763T1 (de)	1994-09-15	Ferroelektrische chirale smektische flüssigkristallzusammensetzung und dieselbe verwendende vorrichtung.
DE69018552D1 (de)	1995-05-18	Mesomorphe Verbindung, dieselbe enthaltende flüssigkristalline Zusammensetzung und dieselbe benutzende flüssigkristalline Vorrichtung.
ES2023760A6 (es)	1992-02-01	Procedimiento para la preparacion de derivados benzotiazinicos.
ATE86629T1 (de)	1993-03-15	4-piperidincarboxamid-derivate.
ATE24887T1 (de)	1987-01-15	Cycloaliphatische alkohole.