NO178547C - Fremgangsmåte for fremstilling av inklusjonskomplekser - Google Patents

Fremgangsmåte for fremstilling av inklusjonskomplekser

Info

Publication number: NO178547C
Authority: NO; Norway
Prior art keywords: inclusion complexes; preparation; silybinin; procedure; cyclodextrin
Prior art date: 1989-10-09

Application number

NO913887A

Other languages

English (en)

Norwegian (no)

Other versions

NO913887D0 (no

NO913887L (no

NO178547B (no

Inventor

Wilfried Wachter

Jozsef Szejtli

Original Assignee

Madaus Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-09

Filing date

1991-10-03

Publication date

1996-04-17

1991-10-03 Application filed by Madaus Ag filed Critical Madaus Ag

1991-10-03 Publication of NO913887D0 publication Critical patent/NO913887D0/no

1992-04-06 Publication of NO913887L publication Critical patent/NO913887L/no

1996-01-08 Publication of NO178547B publication Critical patent/NO178547B/no

1996-04-17 Publication of NO178547C publication Critical patent/NO178547C/no

Links

238000000034 method Methods 0.000 title abstract 2
229920000858 Cyclodextrin Polymers 0.000 abstract 3
SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 abstract 3
229920001450 Alpha-Cyclodextrin Polymers 0.000 abstract 1
HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 abstract 1
229940043377 alpha-cyclodextrin Drugs 0.000 abstract 1
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
229960004853 betadex Drugs 0.000 abstract 1
GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
231100000334 hepatotoxic Toxicity 0.000 abstract 1
230000003082 hepatotoxic effect Effects 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Steroid Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Plural Heterocyclic Compounds (AREA)

NO913887A 1989-10-09 1991-10-03 Fremgangsmåte for fremstilling av inklusjonskomplekser NO178547C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT21962A IT1241673B (it)	1989-10-09	1989-10-09	Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
EP90118964A EP0422497B1 (en)	1989-10-09	1990-10-04	Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them

Publications (4)

Publication Number	Publication Date
NO913887D0 NO913887D0 (no)	1991-10-03
NO913887L NO913887L (no)	1992-04-06
NO178547B NO178547B (no)	1996-01-08
NO178547C true NO178547C (no)	1996-04-17

Family

ID=11189460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO913887A NO178547C (no)	1989-10-09	1991-10-03	Fremgangsmåte for fremstilling av inklusjonskomplekser

Country Status (12)

Country	Link
US (1)	US5198430A (ja)
EP (1)	EP0422497B1 (ja)
JP (1)	JPH0786105B2 (ja)
AT (1)	ATE135017T1 (ja)
CA (1)	CA2027133C (ja)
DE (1)	DE69025691T2 (ja)
DK (1)	DK0422497T3 (ja)
ES (1)	ES2088780T3 (ja)
GR (1)	GR3020146T3 (ja)
IT (1)	IT1241673B (ja)
NO (1)	NO178547C (ja)
ZA (1)	ZA908069B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4401902C2 (de) *	1994-01-24	2000-02-03	Madaus Ag	Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
CZ292832B6 (cs) *	2001-08-30	2003-12-17	Ivax Pharmaceuticals S.R.O.	Způsob přípravy silymarinu se zvýšenou rozpustností
JP4648669B2 (ja) *	2004-09-24	2011-03-09	株式会社ファンケル	シリマリン含有化粧料
US20060105045A1 (en) *	2004-11-08	2006-05-18	Buchanan Charles M	Cyclodextrin solubilizers for liquid and semi-solid formulations
DE102004060914A1 (de) *	2004-12-17	2006-07-06	Bioghurt Biogarde Gmbh & Co. Kg	Verwendung von Liponsäure-haltigen Cyclodextrin-Komplexen
JP5351414B2 (ja) *	2006-12-25	2013-11-27	株式会社ファンケル	シリビン含有化粧料組成物
PT2219642E (pt)	2007-11-15	2011-10-18	Madaus Gmbh	Componente de silibinina para o tratamento de hepatite
DE102008039271A1 (de)	2007-12-23	2009-06-25	Euromed Sa	Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
CZ300846B6 (cs) *	2008-06-26	2009-08-26	Agra Group, A. S.	Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
JP5841048B2 (ja)	2009-05-14	2016-01-06	エウロメッド・エセ・ア	ウイルス性肝炎の治療のための非晶質シリビニン
CN105816422B (zh) *	2015-01-05	2020-08-14	天士力医药集团股份有限公司	一种水飞蓟宾注射剂及其制备方法
CN108348560A (zh) *	2015-03-19	2018-07-31	锡德克斯药物公司	包含水飞蓟素和磺烃基醚环糊精的组合物及其使用方法
GR1008865B (el) *	2015-06-23	2016-10-06	Δημητριος Μιχαηλ Ρεκκας	Μεθοδος για την αυξηση της υδατοδιαλυτοτητας της σιλιμπινινης ως συστατικου της σιλυμαρινης
ES2834732B2 (es)	2019-12-17	2022-03-24	Univ Valladolid	Solucion acuosa que comprende un complejo de inclusion, metodo de obtencion y su uso para aplicacion en cultivos y la mejora de su rendimiento
CN118845567B (zh) *	2024-07-02	2025-09-09	珀莱雅化妆品股份有限公司	一种高渗透性的水飞蓟素超分子制剂及其制备方法和应用
CN119097622A (zh) *	2024-08-16	2024-12-10	内蒙古昶辉生物科技股份有限公司	一种水飞蓟宾复合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU194858B (en) *	1982-12-03	1988-03-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
DE3344171A1 (de) *	1983-12-07	1985-06-20	Chinoin Gyógyszer és Vegyészeti Termékek Gyára RT., Budapest	Dibenzo(bd)pyran-derivate und deren cyclodextrin-einschlusskomplexe, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittelpraeparate
US4727064A (en) *	1984-04-25	1988-02-23	The United States Of America As Represented By The Department Of Health And Human Services	Pharmaceutical preparations containing cyclodextrin derivatives
IT1215291B (it) *	1985-07-17	1990-01-31	Inverni Della Beffa Spa	Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
HU199444B (en) *	1985-09-10	1990-02-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing 7-isopropoxy-isoflavone-cyclodextrene inclusion complex and pharmaceutical compositions therefrom
GB8613688D0 (en) *	1986-06-05	1986-07-09	Euro Celtique Sa	Pharmaceutical composition
JPH0819004B2 (ja) *	1986-12-26	1996-02-28	日清製粉株式会社	徐放性医薬製剤

1989
- 1989-10-09 IT IT21962A patent/IT1241673B/it active IP Right Grant
1990
- 1990-10-04 DK DK90118964.7T patent/DK0422497T3/da active
- 1990-10-04 EP EP90118964A patent/EP0422497B1/en not_active Expired - Lifetime
- 1990-10-04 ES ES90118964T patent/ES2088780T3/es not_active Expired - Lifetime
- 1990-10-04 AT AT90118964T patent/ATE135017T1/de not_active IP Right Cessation
- 1990-10-04 DE DE69025691T patent/DE69025691T2/de not_active Expired - Fee Related
- 1990-10-09 JP JP2269689A patent/JPH0786105B2/ja not_active Expired - Lifetime
- 1990-10-09 US US07/593,933 patent/US5198430A/en not_active Expired - Lifetime
- 1990-10-09 ZA ZA908069A patent/ZA908069B/xx unknown
- 1990-10-09 CA CA002027133A patent/CA2027133C/en not_active Expired - Fee Related
1991
- 1991-10-03 NO NO913887A patent/NO178547C/no not_active IP Right Cessation
1996
- 1996-06-04 GR GR960401440T patent/GR3020146T3/el unknown

Also Published As

Publication number	Publication date
NO913887D0 (no)	1991-10-03
JPH03206090A (ja)	1991-09-09
CA2027133C (en)	1997-07-01
EP0422497A2 (en)	1991-04-17
CA2027133A1 (en)	1991-04-10
GR3020146T3 (en)	1996-09-30
US5198430A (en)	1993-03-30
EP0422497A3 (en)	1991-08-14
DE69025691D1 (de)	1996-04-11
DE69025691T2 (de)	1996-08-14
ZA908069B (en)	1991-08-28
IT1241673B (it)	1994-01-27
IT8921962A1 (it)	1991-04-09
DK0422497T3 (da)	1996-07-15
JPH0786105B2 (ja)	1995-09-20
EP0422497B1 (en)	1996-03-06
ATE135017T1 (de)	1996-03-15
IT8921962A0 (it)	1989-10-09
NO913887L (no)	1992-04-06
ES2088780T3 (es)	1996-09-16
NO178547B (no)	1996-01-08

Legal Events

Date	Code	Title	Description
2002-06-10	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN APRIL 2002

Publication	Publication Date	Title
NO178547C (no)	1996-04-17	Fremgangsmåte for fremstilling av inklusjonskomplekser
GB2314840B (en)	2000-09-06	Oxidized oligosaccharides and pharmaceutical compositions
EP0214647A3 (en)	1987-09-30	Inclusion complexes of 7-isopropoxy-isoflavone and cyclodextrins, process for their preparation and pharmaceutical preparations containing these complexes
HUT62198A (en)	1993-04-28	Erythropoietin compositions comprising cyclodextrin
DE69322478D1 (de)	1999-01-21	Verfahren zur Herstellung von hypokalorischem, löslichen Polymerisat von Glukose
DE69023765D1 (de)	1996-01-04	Verfahren zur Herstellung von Bauelementen mit übereinander angeordneten Feldeffekttransistoren mit Wolfram-Gitter und sich daraus ergebende Struktur.
BR9206741A (pt)	1995-10-31	Composição fluoroquímica artigo e processo de preparação da composição fluoroquímica
DK0579996T3 (da)	1995-07-10	5,10-Methylentetrahydrofolsyrecyclodextrin-inklusionsforbindelser
HUT65418A (en)	1994-06-28	Process for producing inclusion compounds of nimesulide with cyclodextrins and pharmaceutical preparatives containing them
DK0865738T3 (da)	2007-07-30	Oplöseligt natamycin-proteinkompleks
FI943007A0 (fi)	1994-06-22	Syklodekstriiniglykosyylitransferaasit gamma-syklodekstriinin valmistamiseksi
DE3867718D1 (de)	1992-02-27	Einschlusskomplexe von dipyridamol und cyclodextrinen.
EP0712864A3 (en)	1996-10-16	Non-absorbable synthetic sulfated polysaccharides
DE69010307D1 (de)	1994-08-04	Fetthydrolyseverfahren.
GR900100458A (en)	1991-11-15	Novel cyclodextrin inclusion complexes
PT99146A (pt)	1992-10-30	Processo para a preparacao de complexos de inclusao com silibinina e de composicoes farmaceuticas que os contem
EP0427402A3 (en)	1991-06-12	Treatment of shock by cyclodextrins and their derivatives
DE69004804D1 (de)	1994-01-05	Verfahren zur Herstellung von Kaugummigrundmasse für Kaugummi und Produkt hergestellt nach dem Verfahren.
ATE97553T1 (de)	1993-12-15	Verfahren zur herstellung von kaugummigrundmasse fuer kaugummi und produkt hergestellt nach dem verfahren.
IT1264495B1 (it)	1996-09-24	Complessi solubili in acqua di glicosaminoglicani, loro procedimento di preparazione e composizioni farmaceutiche che li contengono
ES2094080A1 (es)	1997-01-01	Procedimiento de preparacion de complejos de inclusion de tenoxicam con ciclodextrinas.