ZA908069B - Inclusion complexes with silybinin,their preparation and their pharmaceutical compositions containing them - Google Patents

Inclusion complexes with silybinin,their preparation and their pharmaceutical compositions containing them

Info

Publication number: ZA908069B
Authority: ZA; South Africa
Prior art keywords: silybinin; inclusion complexes; preparation; pharmaceutical compositions; compositions containing
Prior art date: 1989-10-09

Application number

ZA908069A

Other languages

English (en)

Inventor

Umberto Valcavi

Valcavi Umberto

Vincenzo Monterosso

Monterosso Vincenzo

Roberto Caponi

Caponi Roberto

Enrico Bosone

Bosone Enrico

Wilfried Wachter

Wachter Wilfried

Jozsef Szetil

Szetil Jozsef

Original Assignee

Madaus A G Istituto Biochimico

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-09

Filing date

1990-10-09

Publication date

1991-08-28

1990-10-09 Application filed by Madaus A G Istituto Biochimico filed Critical Madaus A G Istituto Biochimico

1991-08-28 Publication of ZA908069B publication Critical patent/ZA908069B/xx

Links

SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 title abstract 4
239000008194 pharmaceutical composition Substances 0.000 title 1
229920000858 Cyclodextrin Polymers 0.000 abstract 3
229920001450 Alpha-Cyclodextrin Polymers 0.000 abstract 1
HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 abstract 1
229940043377 alpha-cyclodextrin Drugs 0.000 abstract 1
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
229960004853 betadex Drugs 0.000 abstract 1
GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 abstract 1
229940080345 gamma-cyclodextrin Drugs 0.000 abstract 1
231100000334 hepatotoxic Toxicity 0.000 abstract 1
230000003082 hepatotoxic effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
- C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Steroid Compounds (AREA)

ZA908069A 1989-10-09 1990-10-09 Inclusion complexes with silybinin,their preparation and their pharmaceutical compositions containing them ZA908069B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT21962A IT1241673B (it)	1989-10-09	1989-10-09	Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number	Publication Date
ZA908069B true ZA908069B (en)	1991-08-28

Family

ID=11189460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA908069A ZA908069B (en)	1989-10-09	1990-10-09	Inclusion complexes with silybinin,their preparation and their pharmaceutical compositions containing them

Country Status (12)

Country	Link
US (1)	US5198430A (ja)
EP (1)	EP0422497B1 (ja)
JP (1)	JPH0786105B2 (ja)
AT (1)	ATE135017T1 (ja)
CA (1)	CA2027133C (ja)
DE (1)	DE69025691T2 (ja)
DK (1)	DK0422497T3 (ja)
ES (1)	ES2088780T3 (ja)
GR (1)	GR3020146T3 (ja)
IT (1)	IT1241673B (ja)
NO (1)	NO178547C (ja)
ZA (1)	ZA908069B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4401902C2 (de) *	1994-01-24	2000-02-03	Madaus Ag	Verwendung von Flavolignanen als Adjuvans in der Tumortherapie
CZ292832B6 (cs) *	2001-08-30	2003-12-17	Ivax Pharmaceuticals S.R.O.	Způsob přípravy silymarinu se zvýšenou rozpustností
JP4648669B2 (ja) *	2004-09-24	2011-03-09	株式会社ファンケル	シリマリン含有化粧料
WO2006052921A2 (en) *	2004-11-08	2006-05-18	Eastman Chemical Company	Cyclodextrin solubilizers for liquid and semi-solid formulations
DE102004060914A1 (de) *	2004-12-17	2006-07-06	Bioghurt Biogarde Gmbh & Co. Kg	Verwendung von Liponsäure-haltigen Cyclodextrin-Komplexen
JP5351414B2 (ja) *	2006-12-25	2013-11-27	株式会社ファンケル	シリビン含有化粧料組成物
ES2374117T3 (es)	2007-11-15	2012-02-13	Madaus Gmbh	Componente de silibinina para el tratamiento de la hepatitis.
DE102008039271A1 (de)	2007-12-23	2009-06-25	Euromed Sa	Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
CZ2008407A3 (cs) *	2008-06-26	2009-08-26	Agra Group, A. S.	Vodorozpustný prípravek na bázi flavanonol lignanu a zpusob jeho prípravy
JP5841048B2 (ja) *	2009-05-14	2016-01-06	エウロメッド・エセ・ア	ウイルス性肝炎の治療のための非晶質シリビニン
CN105816422B (zh) *	2015-01-05	2020-08-14	天士力医药集团股份有限公司	一种水飞蓟宾注射剂及其制备方法
CA2980170A1 (en) *	2015-03-19	2016-09-22	Cydex Pharmaceuticals, Inc.	Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same
GR1008865B (el) *	2015-06-23	2016-10-06	Δημητριος Μιχαηλ Ρεκκας	Μεθοδος για την αυξηση της υδατοδιαλυτοτητας της σιλιμπινινης ως συστατικου της σιλυμαρινης
ES2834732B2 (es)	2019-12-17	2022-03-24	Univ Valladolid	Solucion acuosa que comprende un complejo de inclusion, metodo de obtencion y su uso para aplicacion en cultivos y la mejora de su rendimiento
CN118845567B (zh) *	2024-07-02	2025-09-09	珀莱雅化妆品股份有限公司	一种高渗透性的水飞蓟素超分子制剂及其制备方法和应用
CN119097622A (zh) *	2024-08-16	2024-12-10	内蒙古昶辉生物科技股份有限公司	一种水飞蓟宾复合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU194858B (en) *	1982-12-03	1988-03-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them
DE3344171A1 (de) *	1983-12-07	1985-06-20	Chinoin Gyógyszer és Vegyészeti Termékek Gyára RT., Budapest	Dibenzo(bd)pyran-derivate und deren cyclodextrin-einschlusskomplexe, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittelpraeparate
US4727064A (en) *	1984-04-25	1988-02-23	The United States Of America As Represented By The Department Of Health And Human Services	Pharmaceutical preparations containing cyclodextrin derivatives
IT1215291B (it) *	1985-07-17	1990-01-31	Inverni Della Beffa Spa	Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
HU199444B (en) *	1985-09-10	1990-02-28	Chinoin Gyogyszer Es Vegyeszet	Process for producing 7-isopropoxy-isoflavone-cyclodextrene inclusion complex and pharmaceutical compositions therefrom
GB8613688D0 (en) *	1986-06-05	1986-07-09	Euro Celtique Sa	Pharmaceutical composition
JPH0819004B2 (ja) *	1986-12-26	1996-02-28	日清製粉株式会社	徐放性医薬製剤

1989
- 1989-10-09 IT IT21962A patent/IT1241673B/it active IP Right Grant
1990
- 1990-10-04 EP EP90118964A patent/EP0422497B1/en not_active Expired - Lifetime
- 1990-10-04 DK DK90118964.7T patent/DK0422497T3/da active
- 1990-10-04 DE DE69025691T patent/DE69025691T2/de not_active Expired - Fee Related
- 1990-10-04 AT AT90118964T patent/ATE135017T1/de not_active IP Right Cessation
- 1990-10-04 ES ES90118964T patent/ES2088780T3/es not_active Expired - Lifetime
- 1990-10-09 ZA ZA908069A patent/ZA908069B/xx unknown
- 1990-10-09 JP JP2269689A patent/JPH0786105B2/ja not_active Expired - Lifetime
- 1990-10-09 CA CA002027133A patent/CA2027133C/en not_active Expired - Fee Related
- 1990-10-09 US US07/593,933 patent/US5198430A/en not_active Expired - Lifetime
1991
- 1991-10-03 NO NO913887A patent/NO178547C/no not_active IP Right Cessation
1996
- 1996-06-04 GR GR960401440T patent/GR3020146T3/el unknown

Also Published As

Publication number	Publication date
CA2027133A1 (en)	1991-04-10
EP0422497A2 (en)	1991-04-17
CA2027133C (en)	1997-07-01
NO178547C (no)	1996-04-17
NO178547B (no)	1996-01-08
EP0422497A3 (en)	1991-08-14
DK0422497T3 (da)	1996-07-15
GR3020146T3 (en)	1996-09-30
ES2088780T3 (es)	1996-09-16
DE69025691D1 (de)	1996-04-11
NO913887D0 (no)	1991-10-03
EP0422497B1 (en)	1996-03-06
JPH0786105B2 (ja)	1995-09-20
IT8921962A1 (it)	1991-04-09
IT1241673B (it)	1994-01-27
DE69025691T2 (de)	1996-08-14
JPH03206090A (ja)	1991-09-09
US5198430A (en)	1993-03-30
IT8921962A0 (it)	1989-10-09
NO913887L (no)	1992-04-06
ATE135017T1 (de)	1996-03-15

Publication	Publication Date	Title
GR3020146T3 (en)	1996-09-30	Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them
EP0214647A3 (en)	1987-09-30	Inclusion complexes of 7-isopropoxy-isoflavone and cyclodextrins, process for their preparation and pharmaceutical preparations containing these complexes
IL97019A0 (en)	1992-03-29	Pharmaceutical compositions containing erythropoietin and cyclodextrin
HUT60784A (en)	1992-10-28	Process for producing n,o-sulfated heparosanes and pharmaceutical compositions comprising such compounds
AU8033594A (en)	1995-06-22	Aqueous solution inclusion complexes of benzothiophene compounds with water soluble cyclodextrins, and pharmaceutical formulations and methods thereof
AU661591B2 (en)	1995-07-27	5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compounds
IL96326A0 (en)	1991-08-16	Polymyxin conjugates,their preparation and pharmaceutical compositions containing them
HUT65418A (en)	1994-06-28	Process for producing inclusion compounds of nimesulide with cyclodextrins and pharmaceutical preparatives containing them
NZ225393A (en)	1990-06-26	Cyclodextrin/bis-biguanido hexane complexes and pharmaceutical compositions containing them
AU8452891A (en)	1992-03-26	Calcium uptake inhibitors
IT8922199A0 (it)	1989-10-31	Complessi con le ciclodestrine indicati per il trattamento di tutte leforme anemiche da carenza di folati, loro preparazione e relative composizioni farmaceutiche
MD679F1 (en)	1997-02-28	Inclusion complex of N-ethoxycarbonyl-3-morpholinsydnonimine or salts thereof with cyclodextrin or its derivatives, preparation thereof and pharmaceutical compositions containing them, method of preparation thereof and treatment method
FR2701952B1 (fr)	1995-03-31	Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AU1523388A (en)	1988-10-27	Novel derivative of d.25, process for its preparation, its use as an immunostimulant, and pharmaceutical compositions containing the derivative
IT1264495B1 (it)	1996-09-24	Complessi solubili in acqua di glicosaminoglicani, loro procedimento di preparazione e composizioni farmaceutiche che li contengono
CA2027773A1 (en)	1991-04-19	Treatment of shock by cyclodextrins and their derivatives
EG21377A (en)	2001-09-30	Process for preparing piroxicam / cyclodextrin complexes the products obtained and their pharmaceutical compositions
ES2094080A1 (es)	1997-01-01	Procedimiento de preparacion de complejos de inclusion de tenoxicam con ciclodextrinas.
ATE97553T1 (de)	1993-12-15	Verfahren zur herstellung von kaugummigrundmasse fuer kaugummi und produkt hergestellt nach dem verfahren.