NO178578C - Fremgangsmåte for ekstraksjon av tromboplastiner samt anvendelse av det ekstraherte tromboplastin - Google Patents

Fremgangsmåte for ekstraksjon av tromboplastiner samt anvendelse av det ekstraherte tromboplastin

Info

Publication number: NO178578C
Authority: NO; Norway
Prior art keywords: thromboplastin; thromboplastins; extraction; sensitivity; extracting
Prior art date: 1988-11-23

Application number

NO903261A

Other languages

English (en)

Norwegian (no)

Other versions

NO178578B (no

NO903261D0 (no

NO903261L (no

Inventor

Pamela L H Hawkins

James R Maynard

Original Assignee

Baxter Diagnostics Inc

Baxter Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-23

Filing date

1990-07-20

Publication date

1996-04-24

1990-07-20 Application filed by Baxter Diagnostics Inc, Baxter Int filed Critical Baxter Diagnostics Inc

1990-07-20 Publication of NO903261D0 publication Critical patent/NO903261D0/no

1990-07-20 Publication of NO903261L publication Critical patent/NO903261L/no

1996-01-15 Publication of NO178578B publication Critical patent/NO178578B/no

1996-04-24 Publication of NO178578C publication Critical patent/NO178578C/no

Links

PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 4
108010000499 Thromboplastin Proteins 0.000 title abstract 4
102000002262 Thromboplastin Human genes 0.000 title abstract 4
108010094028 Prothrombin Proteins 0.000 abstract 2
102100027378 Prothrombin Human genes 0.000 abstract 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
239000003153 chemical reaction reagent Substances 0.000 abstract 2
238000000605 extraction Methods 0.000 abstract 2
229940039716 prothrombin Drugs 0.000 abstract 2
230000035945 sensitivity Effects 0.000 abstract 2
239000003146 anticoagulant agent Substances 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
230000003196 chaotropic effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000015271 coagulation Effects 0.000 abstract 1
238000005345 coagulation Methods 0.000 abstract 1
208000014763 coagulation protein disease Diseases 0.000 abstract 1
229940072645 coumadin Drugs 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
230000006624 extrinsic pathway Effects 0.000 abstract 1
238000012544 monitoring process Methods 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Peptides Or Proteins (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Compounds Of Unknown Constitution (AREA)

NO903261A 1988-11-23 1990-07-20 Fremgangsmåte for ekstraksjon av tromboplastiner samt anvendelse av det ekstraherte tromboplastin NO178578C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US27608388A	1988-11-23	1988-11-23
PCT/US1989/004867 WO1990005740A1 (fr)	1988-11-23	1989-11-03	Procedes ameliores d'extraction pour la preparation de reactifs thromboplastines

Publications (4)

Publication Number	Publication Date
NO903261D0 NO903261D0 (no)	1990-07-20
NO903261L NO903261L (no)	1990-07-20
NO178578B NO178578B (no)	1996-01-15
NO178578C true NO178578C (no)	1996-04-24

Family

ID=23055093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO903261A NO178578C (no)	1988-11-23	1990-07-20	Fremgangsmåte for ekstraksjon av tromboplastiner samt anvendelse av det ekstraherte tromboplastin

Country Status (9)

Country	Link
US (1)	US5426031A (fr)
EP (1)	EP0396733B1 (fr)
JP (1)	JP3348228B2 (fr)
AT (1)	ATE99697T1 (fr)
CA (1)	CA2002208C (fr)
DE (1)	DE68912115T2 (fr)
DK (1)	DK173090A (fr)
NO (1)	NO178578C (fr)
WO (1)	WO1990005740A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5281528A (en) *	1989-12-18	1994-01-25	Warner-Lambert Company	Process for purified thromboplastin for ultra-pure thrombin preparation
US5254350A (en) *	1991-07-22	1993-10-19	Helena Laboratories Corporation	Method of preparing a thromboplastin extract
US5358853A (en) *	1992-08-03	1994-10-25	Akzo Av	Liquid thromboplastin reagent
DE4407386B4 (de) *	1994-03-05	2009-01-15	Dade Behring Marburg Gmbh	Verfahren zur Reaktivierung von gereinigten Membranproteinen durch Einfrieren
JPH08512139A (ja) *	1994-04-28	1996-12-17	デイド、インターナショナル、インコーポレイテッド	プロトロンビン時間（ｐｔ）アッセイ用のキャリブレーター
US6379975B1 (en)	1996-11-27	2002-04-30	T.A.C. Thrombosis And Coagulation Aktiebolag	Methods and reagents for determining protein S
DE69832628T2 (de) *	1997-04-23	2006-09-07	Instrumentation Laboratory S.P.A.	Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
CA2342606A1 (fr)	1998-10-07	2000-04-13	Sigma-Aldrich Co.	Reactifs de thromboplastine, procedes de preparation et d'utilisation correspondants
US6855509B2 (en)	2000-12-19	2005-02-15	Instrumentation Laboratory Company	Protein S functional assay and kit therefor
US7148067B2 (en) *	2004-08-31	2006-12-12	The Board Of Trustees Of The University Of Illinois	Thromboplastin reagents
US20080260858A1 (en) *	2005-02-16	2008-10-23	The Board Of Trustees Of The University Of Illnois	Universal Procoagulant
DE602006021290D1 (de) *	2005-03-04	2011-05-26	Univ Illinois	Modulator von coagulationskaskaden und fibrinolytischen kaskaden
US8821861B2 (en) *	2007-10-05	2014-09-02	The Board Of Trustees Of The University Of Illinois	Fibrin sealant
WO2009061697A1 (fr)	2007-11-09	2009-05-14	The Board Of Trustees Of The University Of Illinois	Antagoniste d'anticoagulant et procoagulant anti-hémophilique
CN112481355B (zh) *	2020-11-16	2023-05-30	武汉市长立生物技术有限责任公司	液体型凝血酶原时间测定试剂盒及其制备方法
CN115166268B (zh) *	2022-08-02	2025-07-04	南京颐兰贝生物科技有限责任公司	一种凝血酶原时间检测试剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3522148A (en) *	1965-08-13	1970-07-28	Dade Reagents Inc	Stabilized thromboplastin preparation
JPS6366556A (ja) *	1986-09-09	1988-03-25	Fujitsu Ltd	フオトマスクの修正方法
US5017556A (en) *	1986-11-04	1991-05-21	Genentech, Inc.	Treatment of bleeding disorders using lipid-free tissue factor protein

1989
- 1989-11-03 DE DE68912115T patent/DE68912115T2/de not_active Expired - Fee Related
- 1989-11-03 EP EP90900532A patent/EP0396733B1/fr not_active Expired - Lifetime
- 1989-11-03 WO PCT/US1989/004867 patent/WO1990005740A1/fr not_active Ceased
- 1989-11-03 JP JP50074490A patent/JP3348228B2/ja not_active Expired - Fee Related
- 1989-11-03 CA CA002002208A patent/CA2002208C/fr not_active Expired - Lifetime
- 1989-11-03 AT AT90900532T patent/ATE99697T1/de not_active IP Right Cessation
1990
- 1990-07-19 DK DK173090A patent/DK173090A/da not_active IP Right Cessation
- 1990-07-20 NO NO903261A patent/NO178578C/no not_active IP Right Cessation
1993
- 1993-05-25 US US08/070,875 patent/US5426031A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE68912115T2 (de)	1994-08-11
CA2002208A1 (fr)	1990-05-23
EP0396733B1 (fr)	1994-01-05
NO178578B (no)	1996-01-15
ATE99697T1 (de)	1994-01-15
JP3348228B2 (ja)	2002-11-20
JPH03503534A (ja)	1991-08-08
DK173090D0 (da)	1990-07-19
DE68912115D1 (de)	1994-02-17
US5426031A (en)	1995-06-20
EP0396733A1 (fr)	1990-11-14
DK173090A (da)	1990-07-19
NO903261D0 (no)	1990-07-20
WO1990005740A1 (fr)	1990-05-31
NO903261L (no)	1990-07-20
CA2002208C (fr)	1998-02-24

Legal Events

Date	Code	Title	Description
2001-07-09	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN MAY 2001

Publication	Publication Date	Title
NO178578C (no)	1996-04-24	Fremgangsmåte for ekstraksjon av tromboplastiner samt anvendelse av det ekstraherte tromboplastin
ATE203567T1 (de)	2001-08-15	Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern
DE3685937D1 (de)	1992-08-13	Testverfahren mit oberflaechengebundenem fibrinogen und loesliches markiertes fibrinogen.
ES2088992T3 (es)	1996-10-01	Metodo para determinar los niveles de factores de coagulacion intrinsecos y extrinsecos y proteina c.
AU751525B2 (en)	2002-08-22	Method for determining the anticoagulatory potential of a sample
ATE376187T1 (de)	2007-11-15	Nachweis von erkrankungen der nieren und behandlung
ES2072243T3 (es)	2000-03-16	Prueba de coagulacion cuantitativa para medir la concentracion de factor vii activo.
WO1991002812A1 (fr)	1991-03-07	PROCEDE ET ANALYSE A INACTIVATION PAR LA PROTEINE C DES FACTEURS Va et VIIIa
ES547898A0 (es)	1987-04-01	Un metodo para determinar la presencia de un componente de coagulacion
JP2003517610A (ja)	2003-05-27	血液学的アッセイ及び試薬
JPH11225796A5 (fr)	2005-12-08
DK492185A (da)	1986-04-27	Screeningtest for omvendt-transkriptaseholdig virus
Stokol et al.	2000	Effect of citrate concentration on coagulation test results in dogs
DK0690991T4 (da)	2004-02-16	Ny antikoagulant-cofaktor-aktivitet
Moore et al.	2008	Further evidence of false negative screening for lupus anticoagulants
WO1998032389A1 (fr)	1998-07-30	Procede et appareil permettant de mesurer les proprietes de coagulation du sang au moyen de materiaux absorbants
ES2090106T3 (es)	1996-10-16	Metodo de asociacion quimica directa de dimero d procedente de una muestra biologica y que permite el diagnostico y el seguimiento de estados de trombolisis y de hipercoagulabilidad.
ATE191278T1 (de)	2000-04-15	Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen
Middleton et al.	1978	Thrombogenic potential of factor IX concentrates: comparison of tests
Hawkins et al.	1996	Extraction methods for preparing thromboplastin reagents
DE69520725D1 (de)	2001-05-23	Verfahren zur Diagnose von Blutgerinnungsstörungen
Dejanov et al.	1990	A method of heparin therapy control with Vipera venom and diluted tissue thromboplastin preparations
Wagner et al.	1990	CTS-Neothromtin®-aPTT determination by a new chromogenic two step-assay
Elsing et al.	1990	A comparison of different fibrinolytic agents by a fluorescence measurement method
Nomura et al.	2004	Determination of plasma prothrombin levels by a novel Ca2+-dependent prothrombin activator (CA-1) in patients with chronic liver diseases