NO179610C - 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler - Google Patents

1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler

Info

Publication number
NO179610C
NO179610C NO911063A NO911063A NO179610C NO 179610 C NO179610 C NO 179610C NO 911063 A NO911063 A NO 911063A NO 911063 A NO911063 A NO 911063A NO 179610 C NO179610 C NO 179610C
Authority
NO
Norway
Prior art keywords
tetraazacyclododecan
triols
butyl
compounds
preparation
Prior art date
Application number
NO911063A
Other languages
English (en)
Other versions
NO911063D0 (no
NO179610B (no
NO911063L (no
Inventor
Johannes Platzek
Heinz Gries
Hanns-Joachim Weinmann
Gabriele Schuhmann-Giampieri
Wolf-Rudiger Press
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO911063D0 publication Critical patent/NO911063D0/no
Publication of NO911063L publication Critical patent/NO911063L/no
Publication of NO179610B publication Critical patent/NO179610B/no
Publication of NO179610C publication Critical patent/NO179610C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO911063A 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler NO179610C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (4)

Publication Number Publication Date
NO911063D0 NO911063D0 (no) 1991-03-18
NO911063L NO911063L (no) 1991-09-20
NO179610B NO179610B (no) 1996-08-05
NO179610C true NO179610C (no) 1996-11-13

Family

ID=6402765

Family Applications (2)

Application Number Title Priority Date Filing Date
NO911063A NO179610C (no) 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododekanbutyltrioler, gadoliniumkompleks og diagnostisk middel som inneholder slike forbindelser, samt anvendelse derav for fremstilling av diagnostiske midler
NO2001003C NO2001003I1 (no) 1990-03-19 2001-02-14 Gadovist

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2001003C NO2001003I1 (no) 1990-03-19 2001-02-14 Gadovist

Country Status (16)

Country Link
US (4) US5980864A (no)
EP (1) EP0448191B1 (no)
JP (1) JP2968367B2 (no)
AT (1) ATE124405T1 (no)
AU (1) AU647091B2 (no)
CA (1) CA2038493C (no)
DE (3) DE4009119A1 (no)
DK (1) DK0448191T3 (no)
ES (1) ES2074219T3 (no)
FI (1) FI109695B (no)
HU (1) HU215964B (no)
IE (1) IE67643B1 (no)
IL (1) IL97592A (no)
NO (2) NO179610C (no)
NZ (1) NZ237461A (no)
PT (1) PT97065B (no)

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DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
EP0955044B1 (en) * 1995-06-26 2005-11-16 Chelator LLC Method of inhibiting bacterial or fungal growth using a complexing agent
DE19525924A1 (de) * 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
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US20080125344A1 (en) * 2006-11-28 2008-05-29 Daryle Hadley Busch Bleach compositions
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US20050187126A1 (en) * 2002-08-27 2005-08-25 Busch Daryle H. Catalysts and methods for catalytic oxidation
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DE10064467C2 (de) 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
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WO2004006934A2 (de) * 2002-07-10 2004-01-22 Hans Robert Kalbitzer 1,4,7,10-tetraazacyclododecane als modulatoren des guanin-nukleotid bindenden roteins zur behandlung von tumoren
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WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
AU2017375728B2 (en) 2016-12-12 2021-05-27 Bracco Imaging Spa Dimeric contrast agents
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP4083026A1 (en) 2018-07-10 2022-11-02 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of 2,2',2''-(10-((2r,3s)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR102167614B1 (ko) * 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
CN114573521B (zh) * 2020-12-01 2023-10-27 威智医药股份有限公司 一种钆布醇及其中间体的制备方法
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Also Published As

Publication number Publication date
HU910874D0 (en) 1991-09-30
FI911330L (fi) 1991-09-20
DK0448191T3 (da) 1995-11-20
NO911063D0 (no) 1991-03-18
HU215964B (hu) 1999-03-29
US5980864A (en) 1999-11-09
CA2038493C (en) 2002-07-02
IE67643B1 (en) 1996-04-17
ATE124405T1 (de) 1995-07-15
PT97065A (pt) 1991-10-31
JP2968367B2 (ja) 1999-10-25
DE4009119A1 (de) 1991-09-26
US20060078503A1 (en) 2006-04-13
AU647091B2 (en) 1994-03-17
HK1002811A1 (en) 1998-09-18
DE59105815D1 (de) 1995-08-03
US6951639B2 (en) 2005-10-04
NZ237461A (en) 1993-12-23
NO2001003I1 (no) 2001-03-05
HUT60478A (en) 1992-09-28
AU7361091A (en) 1991-09-19
PT97065B (pt) 1998-07-31
IL97592A (en) 1995-10-31
JPH05320146A (ja) 1993-12-03
DE10075007I2 (de) 2003-06-12
FI911330A0 (fi) 1991-03-19
ES2074219T3 (es) 1995-09-01
FI109695B (fi) 2002-09-30
NO179610B (no) 1996-08-05
EP0448191A1 (de) 1991-09-25
CA2038493A1 (en) 1991-09-20
IL97592A0 (en) 1992-06-21
US6399043B1 (en) 2002-06-04
US20020176823A1 (en) 2002-11-28
EP0448191B1 (de) 1995-06-28
IE910902A1 (en) 1991-09-25
NO911063L (no) 1991-09-20

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SPCG Granted supplementary protection certificate

Spc suppl protection certif: SPC/NO 2001 003

Filing date: 20010214

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