DK0448191T3 - 1,4,7,10-tetraazacyklododecan-butyltrioler, fremgangsmåde til deres fremstilling og farmaceutiske midler indeholdende disse - Google Patents

1,4,7,10-tetraazacyklododecan-butyltrioler, fremgangsmåde til deres fremstilling og farmaceutiske midler indeholdende disse

Info

Publication number
DK0448191T3
DK0448191T3 DK91250081.6T DK91250081T DK0448191T3 DK 0448191 T3 DK0448191 T3 DK 0448191T3 DK 91250081 T DK91250081 T DK 91250081T DK 0448191 T3 DK0448191 T3 DK 0448191T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical agents
tetraazacyclododecan
triols
butyl
processes
Prior art date
Application number
DK91250081.6T
Other languages
English (en)
Inventor
Heinz Dr Gries
Gabriele D Schuhmann-Giampieri
Hanns-Joachim Dr Weinmann
Wolf-Ruediger Press
Johannes Dr Platzek
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0448191T3 publication Critical patent/DK0448191T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91250081.6T 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododecan-butyltrioler, fremgangsmåde til deres fremstilling og farmaceutiske midler indeholdende disse DK0448191T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009119A DE4009119A1 (de) 1990-03-19 1990-03-19 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
DK0448191T3 true DK0448191T3 (da) 1995-11-20

Family

ID=6402765

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91250081.6T DK0448191T3 (da) 1990-03-19 1991-03-18 1,4,7,10-tetraazacyklododecan-butyltrioler, fremgangsmåde til deres fremstilling og farmaceutiske midler indeholdende disse

Country Status (17)

Country Link
US (4) US5980864A (da)
EP (1) EP0448191B1 (da)
JP (1) JP2968367B2 (da)
AT (1) ATE124405T1 (da)
AU (1) AU647091B2 (da)
CA (1) CA2038493C (da)
DE (3) DE4009119A1 (da)
DK (1) DK0448191T3 (da)
ES (1) ES2074219T3 (da)
FI (1) FI109695B (da)
HK (1) HK1002811A1 (da)
HU (1) HU215964B (da)
IE (1) IE67643B1 (da)
IL (1) IL97592A (da)
NO (2) NO179610C (da)
NZ (1) NZ237461A (da)
PT (1) PT97065B (da)

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DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
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DE19525924A1 (de) * 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19646762B4 (de) * 1996-11-04 2004-05-13 Schering Ag Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren
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EP1088559A3 (de) * 1999-09-29 2002-10-02 INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN Galenische Formulierungen
DE10064467C2 (de) * 2000-12-15 2002-10-31 Schering Ag Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
US7011816B2 (en) * 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
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US20050192195A1 (en) * 2002-08-27 2005-09-01 Busch Daryle H. Catalysts and methods for catalytic oxidation
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WO2006002873A2 (en) * 2004-07-02 2006-01-12 Bracco Imaging Spa 1 , 4 -bis (carboxymethyl) -6- ' bis ( carboxymethyl) amino ! -6 -methyl- perhydro-1 , 4 diazepine (aazta) derivatives as ligands in high relaxivity contrast agents for use in magnetic resonance imaging (mri )
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
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DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
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US11007283B2 (en) * 2016-04-13 2021-05-18 Bracco Imaging S.P.A. Contrast agents
HRP20200922T1 (hr) 2016-09-27 2020-09-18 Bayer Pharma Aktiengesellschaft Postupak za proizvodnju kristalnog oblika modifikacije a kalkobutrola
WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
EP3551614B1 (en) 2016-12-12 2021-08-25 Bracco Imaging SpA Dimeric contrast agents
EP3392254A1 (en) * 2017-04-20 2018-10-24 Koninklijke Philips N.V. Compounds for use in the diagnosis of a disease
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
US12227527B2 (en) 2018-07-10 2025-02-18 Biophore India Pharmaceuticals Pvt. Ltd Process for the preparation of 2,2′,2″-(10-((2R,3S)-1,3,4-trihydroxy butan-2-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid and its complexes
KR102167614B1 (ko) 2018-08-23 2020-10-19 에스티팜 주식회사 가도부트롤의 제조방법
CN114573521B (zh) * 2020-12-01 2023-10-27 威智医药股份有限公司 一种钆布醇及其中间体的制备方法
CN117440959A (zh) * 2021-07-27 2024-01-23 伯拉考成像股份公司 用于制造钆络合物溶液的方法
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Also Published As

Publication number Publication date
ATE124405T1 (de) 1995-07-15
CA2038493C (en) 2002-07-02
US20020176823A1 (en) 2002-11-28
DE4009119A1 (de) 1991-09-26
JP2968367B2 (ja) 1999-10-25
FI911330L (fi) 1991-09-20
JPH05320146A (ja) 1993-12-03
DE59105815D1 (de) 1995-08-03
US20060078503A1 (en) 2006-04-13
US5980864A (en) 1999-11-09
NO2001003I1 (no) 2001-03-05
IL97592A (en) 1995-10-31
CA2038493A1 (en) 1991-09-20
AU7361091A (en) 1991-09-19
US6951639B2 (en) 2005-10-04
US6399043B1 (en) 2002-06-04
ES2074219T3 (es) 1995-09-01
IE67643B1 (en) 1996-04-17
FI109695B (fi) 2002-09-30
NZ237461A (en) 1993-12-23
FI911330A0 (fi) 1991-03-19
NO179610B (no) 1996-08-05
HUT60478A (en) 1992-09-28
PT97065B (pt) 1998-07-31
EP0448191A1 (de) 1991-09-25
HU215964B (hu) 1999-03-29
IL97592A0 (en) 1992-06-21
HK1002811A1 (en) 1998-09-18
PT97065A (pt) 1991-10-31
IE910902A1 (en) 1991-09-25
NO179610C (no) 1996-11-13
EP0448191B1 (de) 1995-06-28
AU647091B2 (en) 1994-03-17
NO911063L (no) 1991-09-20
DE10075007I2 (de) 2003-06-12
HU910874D0 (en) 1991-09-30
NO911063D0 (no) 1991-03-18

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