NO180047C - Indolinderivater med en amidgruppe og farmasöytiske blandinger som inneholder dem - Google Patents

Indolinderivater med en amidgruppe og farmasöytiske blandinger som inneholder dem

Info

Publication number: NO180047C
Authority: NO; Norway
Prior art keywords: alkyl; mono; substd; halogen; opt
Prior art date: 1991-08-02

Application number

NO931262A

Other languages

English (en)

Norwegian (no)

Other versions

NO931262D0 (no

NO180047B (no

NO931262L (no

Inventor

Jean Wagnon

Claude Plouzane

Claudine Serradeil-Legal

Dino Nisato

Bernard Tonnerre

Original Assignee

Sanofi Elf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-02

Filing date

1993-04-01

Publication date

1997-02-05

1993-04-01 Application filed by Sanofi Elf filed Critical Sanofi Elf

1993-04-01 Publication of NO931262D0 publication Critical patent/NO931262D0/no

1993-05-26 Publication of NO931262L publication Critical patent/NO931262L/no

1996-10-28 Publication of NO180047B publication Critical patent/NO180047B/no

1997-02-05 Publication of NO180047C publication Critical patent/NO180047C/no

Links

125000003368 amide group Chemical group 0.000 title 1
125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 18
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 6
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 6
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
150000002367 halogens Chemical class 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
-1 benzylcarbonyl Chemical group 0.000 abstract 3
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 3
125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 3
125000003302 alkenyloxy group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000006501 nitrophenyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
FUYYQWDRKFFOTN-UHFFFAOYSA-N OC1CN(C2=CC=CC=C12)S(=O)(=O)N1CC(C2=CC=CC=C12)O Chemical class OC1CN(C2=CC=CC=C12)S(=O)(=O)N1CC(C2=CC=CC=C12)O FUYYQWDRKFFOTN-UHFFFAOYSA-N 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
125000005505 thiomorpholino group Chemical group 0.000 abstract 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)

NO931262A 1991-08-02 1993-04-01 Indolinderivater med en amidgruppe og farmasöytiske blandinger som inneholder dem NO180047C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9109908A FR2679903B1 (fr)	1991-08-02	1991-08-02	Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant.
PCT/FR1992/000758 WO1993003013A1 (fr)	1991-08-02	1992-07-31	Derives d'indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant

Publications (4)

Publication Number	Publication Date
NO931262D0 NO931262D0 (no)	1993-04-01
NO931262L NO931262L (no)	1993-05-26
NO180047B NO180047B (no)	1996-10-28
NO180047C true NO180047C (no)	1997-02-05

Family

ID=9415909

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO931262A NO180047C (no)	1991-08-02	1993-04-01	Indolinderivater med en amidgruppe og farmasöytiske blandinger som inneholder dem

Country Status (28)

Country	Link
EP (1)	EP0526348B1 (de)
JP (1)	JP2633085B2 (de)
KR (1)	KR100241583B1 (de)
AT (1)	ATE163289T1 (de)
AU (2)	AU658664B2 (de)
BR (1)	BR9205336A (de)
CA (2)	CA2206776C (de)
CZ (1)	CZ288173B6 (de)
DE (1)	DE69224450T2 (de)
DK (1)	DK0526348T3 (de)
ES (1)	ES2117038T3 (de)
FI (2)	FI104069B (de)
FR (1)	FR2679903B1 (de)
HU (2)	HUT68927A (de)
IL (3)	IL117592A (de)
LT (1)	LT3064B (de)
LV (1)	LV10091B (de)
MX (1)	MX9204487A (de)
MY (1)	MY110517A (de)
NO (1)	NO180047C (de)
NZ (1)	NZ243795A (de)
PH (1)	PH30661A (de)
RU (1)	RU2104268C1 (de)
SG (1)	SG47501A1 (de)
SK (1)	SK283463B6 (de)
UA (1)	UA27238C2 (de)
WO (1)	WO1993003013A1 (de)
ZA (1)	ZA925781B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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FR2665441B1 (fr) *	1990-07-31	1992-12-04	Sanofi Sa	Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
FR2708608B1 (fr) *	1993-07-30	1995-10-27	Sanofi Sa	Dérivés de N-sulfonylbenzimidazolone, leur préparation, les compositions pharmaceutiques en contenant.
FR2756736B1 (fr) *	1996-12-05	1999-03-05	Sanofi Sa	Compositions pharmaceutiques contenant des derives de n-sulfonyl indoline
AU8678698A (en) *	1997-07-31	1999-02-22	American Home Products Corporation	Compounds which inhibit leukocyte adhesion mediated by vla-4
US6423688B1 (en)	1997-07-31	2002-07-23	Athena Neurosciences, Inc.	Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en)	1997-07-31	2006-04-18	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en)	1997-07-31	2002-03-26	Athena Neurosciences, Inc.	Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en)	1997-07-31	2003-05-06	Athena Neurosciences, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en)	1997-07-31	2003-06-24	Eugene D. Thorsett	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6291453B1 (en)	1997-07-31	2001-09-18	Athena Neurosciences, Inc.	4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6939855B2 (en)	1997-07-31	2005-09-06	Elan Pharmaceuticals, Inc.	Anti-inflammatory compositions and method
PL338457A1 (en) *	1997-07-31	2000-11-06	Elan Pharm Inc	Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4
US6492421B1 (en)	1997-07-31	2002-12-10	Athena Neurosciences, Inc.	Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en)	1997-07-31	2002-12-03	Eugene D. Thorsett	Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
IL133639A0 (en) *	1997-07-31	2001-04-30	Elan Pharm Inc	Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4
FR2775598A1 (fr)	1998-03-06	1999-09-10	Sanofi Sa	Compositions pharmaceutiques contenant en association un antagoniste selectif des recepteurs v1a de l'arginine-vasopressine et un antagoniste selectif des recepteur v2 de l'arginine-vasopressine
FR2778103A1 (fr) *	1998-04-29	1999-11-05	Sanofi Sa	Compositions pharmaceutiques contenant en association un antagoniste v1a de l'arginine-vasopressine et un antagoniste des recepteurs at1 de l'angiotensine ii
FR2786486B3 (fr) *	1998-11-16	2000-12-08	Sanofi Sa	Procede de preparation du (2s)-1-[(2r,3s)-5-chloro-3-(2- chlorophenyl)-1-(3,4-dimethoxy benzenesulfonyl)-3-hydroxy- 2,3-dihydro-1h-indole-2-carbonyl]pyrrolidine-2-carboxamide, de ses solvats et/ou hydrates
HK1043794A1 (zh)	1999-01-22	2002-09-27	依兰制药公司	抑制vla-4介导的白细胞粘附的稠合环杂芳基和杂环化合物
ATE455106T1 (de)	1999-01-22	2010-01-15	Elan Pharm Inc	Acyl derivate zur behandlung von krankheiten die in zusammenhang mit vla-4 stehen
JP2002539080A (ja) *	1999-01-25	2002-11-19	エランファーマシューティカルズ，インコーポレイテッド	Ｖｌａ−４によって媒介される白血球接着を阻害する化合物
US6436904B1 (en)	1999-01-25	2002-08-20	Elan Pharmaceuticals, Inc.	Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6407066B1 (en)	1999-01-26	2002-06-18	Elan Pharmaceuticals, Inc.	Pyroglutamic acid derivatives and related compounds which inhibit leukocyte adhesion mediated by VLA-4
GB9902461D0 (en) *	1999-02-05	1999-03-24	Zeneca Ltd	Chemical compounds
FR2792834A1 (fr) *	1999-04-29	2000-11-03	Sanofi Sa	Utilisation du sr 49059, de ses solvats et/ou hydrates pharmaceutiquement acceptables, pour la preparation de medicaments utiles dans le traitement ou la prevention du phenomene de raynaud
FR2805536B1 (fr) *	2000-02-25	2002-08-23	Sanofi Synthelabo	Nouveaux derives de 1,3-dihydro-2h-indol-2-one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
FR2805992A1 (fr) *	2000-03-08	2001-09-14	Sanofi Synthelabo	Compositions pharmaceutiques orales contenant des derives de n-sulfonylindoline
AU1401902A (en)	2000-10-17	2002-04-29	Applied Research Systems	Pharmaceutically active sulfanilide derivatives
US7056910B2 (en)	2000-11-28	2006-06-06	Astellas Pharma Inc.	1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
JP4044740B2 (ja) *	2001-05-31	2008-02-06	信越化学工業株式会社	レジスト材料及びパターン形成方法
ES2249636T3 (es)	2001-12-20	2006-04-01	Applied Research Systems Ars Holding N.V.	Triazoles como antagonistas de la oxitocina.
NZ566263A (en)	2002-05-24	2009-09-25	Millennium Pharm Inc	CCR9 inhibitors and methods of use thereof
TW200307671A (en)	2002-05-24	2003-12-16	Elan Pharm Inc	Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TWI281470B (en)	2002-05-24	2007-05-21	Elan Pharm Inc	Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
DK1587788T3 (da) *	2002-09-17	2007-09-24	Hoffmann La Roche	2,7-substituerede indoler og anvendelsen deraf som 5-HT6-modulatorer
EP1542973B1 (de) *	2002-09-17	2008-07-30	F. Hoffmann-La Roche Ag	2,4-substituierte indole und deren verwendung als 5-ht6 modulatoren
RU2334735C2 (ru) *	2002-10-11	2008-09-27	Актелион Фармасьютиклз Лтд.	Производные сульфониламиноуксусной кислоты и их применение в качестве антагонистов рецепторов орексина
KR100874292B1 (ko)	2002-11-18	2008-12-18	케모센트릭스	아릴 술폰아마이드
US7420055B2 (en)	2002-11-18	2008-09-02	Chemocentryx, Inc.	Aryl sulfonamides
US7741519B2 (en)	2007-04-23	2010-06-22	Chemocentryx, Inc.	Bis-aryl sulfonamides
US7227035B2 (en)	2002-11-18	2007-06-05	Chemocentryx	Bis-aryl sulfonamides
ES2362788T3 (es) *	2004-10-27	2011-07-13	Kissei Pharmaceutical Co., Ltd.	Compuesto de indolina y proceso para la producción del mismo.
CA2624524C (en)	2005-09-29	2014-07-08	Elan Pharmaceuticals, Inc.	Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4
BRPI0616687A2 (pt)	2005-09-29	2011-06-28	Elan Pharm Inc	compostos de pirimidinil amida que inibem a adesão leucocitária mediada por vla-4
CA2643838A1 (en)	2006-02-27	2007-09-07	Elan Pharmaceuticals, Inc.	Pyrimidinyl sulfonamide compounds which inhibit leukocyte adhesion mediated by vla-4
WO2010126914A1 (en)	2009-04-27	2010-11-04	Elan Pharmaceuticals, Inc.	Pyridinone antagonists of alpha-4 integrins
HU231206B1 (hu)	2017-12-15	2021-10-28	Richter Gedeon Nyrt.	Triazolobenzazepinek
TW201938171A (zh)	2017-12-15	2019-10-01	匈牙利商羅特格登公司	作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
TW202542165A (zh)	2023-12-19	2025-11-01	瑞士商愛杜西亞製藥有限公司	大環食慾素激動劑

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3838167A (en) *	1972-08-01	1974-09-24	Lilly Co Eli	Process for preparing indoles
US4479963A (en) *	1981-02-17	1984-10-30	Ciba-Geigy Corporation	1-Carboxyalkanoylindoline-2-carboxylic acids
DE3705934A1 (de) *	1987-02-25	1988-09-08	Nattermann A & Cie	Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
FR2665441B1 (fr) *	1990-07-31	1992-12-04	Sanofi Sa	Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.

1991
- 1991-08-02 FR FR9109908A patent/FR2679903B1/fr not_active Expired - Fee Related
1992
- 1992-07-31 ZA ZA925781A patent/ZA925781B/xx unknown
- 1992-07-31 LV LVP-92-87A patent/LV10091B/lv unknown
- 1992-07-31 PH PH44760A patent/PH30661A/en unknown
- 1992-07-31 IL IL11759292A patent/IL117592A/xx not_active IP Right Cessation
- 1992-07-31 CA CA002206776A patent/CA2206776C/en not_active Expired - Fee Related
- 1992-07-31 NZ NZ243795A patent/NZ243795A/en unknown
- 1992-07-31 RU RU93005168A patent/RU2104268C1/ru not_active IP Right Cessation
- 1992-07-31 KR KR1019930701034A patent/KR100241583B1/ko not_active Expired - Fee Related
- 1992-07-31 CA CA002093221A patent/CA2093221C/en not_active Expired - Fee Related
- 1992-07-31 SK SK426-93A patent/SK283463B6/sk unknown
- 1992-07-31 HU HU9300951A patent/HUT68927A/hu unknown
- 1992-07-31 MX MX9204487A patent/MX9204487A/es not_active IP Right Cessation
- 1992-07-31 AU AU24758/92A patent/AU658664B2/en not_active Ceased
- 1992-07-31 CZ CZ1993682A patent/CZ288173B6/cs not_active IP Right Cessation
- 1992-07-31 LT LTIP114A patent/LT3064B/lt not_active IP Right Cessation
- 1992-07-31 WO PCT/FR1992/000758 patent/WO1993003013A1/fr not_active Ceased
- 1992-07-31 IL IL102703A patent/IL102703A/xx not_active IP Right Cessation
- 1992-07-31 BR BR9205336A patent/BR9205336A/pt not_active Application Discontinuation
- 1992-07-31 MY MYPI92001379A patent/MY110517A/en unknown
- 1992-07-31 UA UA93002340A patent/UA27238C2/uk unknown
- 1992-07-31 JP JP5503337A patent/JP2633085B2/ja not_active Expired - Fee Related
- 1992-08-03 AT AT92402213T patent/ATE163289T1/de not_active IP Right Cessation
- 1992-08-03 EP EP92402213A patent/EP0526348B1/de not_active Expired - Lifetime
- 1992-08-03 SG SG1996002367A patent/SG47501A1/en unknown
- 1992-08-03 ES ES92402213T patent/ES2117038T3/es not_active Expired - Lifetime
- 1992-08-03 DK DK92402213T patent/DK0526348T3/da active
- 1992-08-03 DE DE69224450T patent/DE69224450T2/de not_active Expired - Fee Related
1993
- 1993-04-01 NO NO931262A patent/NO180047C/no not_active IP Right Cessation
- 1993-04-01 FI FI931476A patent/FI104069B/fi not_active IP Right Cessation
1995
- 1995-02-03 AU AU11541/95A patent/AU691223B2/en not_active Ceased
- 1995-06-28 HU HU95P/P00474P patent/HU211884A9/hu unknown
1996
- 1996-03-21 IL IL11759296A patent/IL117592A0/xx unknown
1998
- 1998-01-27 FI FI980175A patent/FI107048B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
UA27238C2 (uk)	2000-08-15
DK0526348T3 (da)	1998-11-23
NO931262D0 (no)	1993-04-01
LV10091B (en)	1995-04-20
HU9300951D0 (en)	1993-06-28
ATE163289T1 (de)	1998-03-15
CA2093221C (en)	1998-09-22
ZA925781B (en)	1993-03-02
FI107048B (fi)	2001-05-31
NO180047B (no)	1996-10-28
RU2104268C1 (ru)	1998-02-10
CA2206776C (en)	2002-02-26
IL102703A0 (en)	1993-01-14
NO931262L (no)	1993-05-26
IL117592A0 (en)	1996-07-23
IL117592A (en)	1999-04-11
EP0526348A1 (de)	1993-02-03
WO1993003013A1 (fr)	1993-02-18
ES2117038T3 (es)	1998-08-01
FI931476A0 (fi)	1993-04-01
FR2679903B1 (fr)	1993-12-03
HK1008741A1 (en)	1999-05-14
MY110517A (en)	1998-07-31
AU658664B2 (en)	1995-04-27
DE69224450T2 (de)	1998-07-30
FI980175A0 (fi)	1998-01-27
CA2093221A1 (en)	1993-02-03
FR2679903A1 (fr)	1993-02-05
EP0526348B1 (de)	1998-02-18
AU2475892A (en)	1993-03-02
CA2206776A1 (en)	1993-02-03
FI980175L (fi)	1998-01-27
PH30661A (en)	1997-09-16
JPH06501960A (ja)	1994-03-03
AU1154195A (en)	1995-05-04
KR100241583B1 (ko)	2000-03-02
HU211884A9 (en)	1995-12-28
JP2633085B2 (ja)	1997-07-23
BR9205336A (pt)	1993-11-16
MX9204487A (es)	1993-02-01
NZ243795A (en)	1995-04-27
SK283463B6 (sk)	2003-08-05
SG47501A1 (en)	1998-04-17
FI104069B1 (fi)	1999-11-15
CZ288173B6 (en)	2001-05-16
DE69224450D1 (de)	1998-03-26
LV10091A (lv)	1994-05-10
HUT68927A (en)	1995-08-28
IL102703A (en)	1997-03-18
CZ68293A3 (en)	1994-01-19
AU691223B2 (en)	1998-05-14
LT3064B (en)	1994-10-25
FI931476A7 (fi)	1993-04-01
SK42693A3 (en)	1993-10-06
LTIP114A (en)	1994-06-15
FI104069B (fi)	1999-11-15

Legal Events

Date	Code	Title	Description
2005-05-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO180047C (no)	1997-02-05	Indolinderivater med en amidgruppe og farmasöytiske blandinger som inneholder dem
IT1271495B (it)	1997-05-30	Composizione farmaceutica contenente 3-2 (dimetilammino) etil-n-metil-1h-indol-5-metansolfonammide, relativo procedimento di preparazione e impiego della stessa nel trattamento di mammiferi
SG49053A1 (en)	1998-05-18	Arylalkylamines process for preparing them and pharmaceutical compositions containing them
NO951044D0 (no)	1995-03-17	Selektive antagonist-forbindelser for menneske -NK3-reseptor og deres anvendelse som medikamenter og diagnostiske midler
HUP9901630A2 (hu)	1999-08-30	Új indol-2,3-dion-3-oxim-származékok
ES8601206A1 (es)	1985-11-01	Procedimiento para preparar amidinas ciclicas sustituidas aromaticas.
HUP0002330A2 (hu)	2001-06-28	Azetidinilpropilpiperidin-származékok, ezek intermedierjei és tachikinin antagonistaként történő alkalmazásuk
SE9603283D0 (sv)	1996-09-10	New compounds
NZ333926A (en)	2000-05-26	Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use
ES459865A1 (es)	1978-04-01	Procedimiento para preparar nuevos derivados de indol.
DE3783657D1 (de)	1993-03-04	Peptide mit einfluss auf die diurese und natriurese, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung.
IE36710L (en)	1972-11-11	Hydrazinopyridazine derivatives
RU96114993A (ru)	1998-10-20	Производные n-замещенного 3-азабицикло[3.2.0]гептана
TW197420B (de)	1993-01-01
ES8607910A1 (es)	1986-06-01	Un procedimiento para la preparacion de nuevos derivados de feniletanamina
ES8101045A1 (es)	1980-12-01	Procedimiento para la preparacion de derivados de acidos pi-rrolidinilsulfamoilbenzoicos sustituidos
HUP9902606A2 (hu)	1999-12-28	Mátrix metalloproteináz inhibitorok
IL107915A (en)	1997-04-15	N-substituted azabicycloheptane derivatives and their use as medicaments
IL99819A0 (en)	1992-08-18	Imidazole-2-yl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them