NO180541C - Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-purinylfosfonsyrederivater og mellomprodukt for fremstilling derav - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-purinylfosfonsyrederivater og mellomprodukt for fremstilling derav

Info

Publication number: NO180541C
Authority: NO; Norway
Prior art keywords: preparation; acid derivatives; phosphonic acid; therapeutically active; analogous process
Prior art date: 1990-07-04

Application number

NO912606A

Other languages

English (en)

Norwegian (no)

Other versions

NO180541B (no

NO912606L (no

NO912606D0 (no

Inventor

Serge Halazy

Charles Danzin

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-04

Filing date

1991-07-03

Publication date

1997-05-07

1991-07-03 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1991-07-03 Publication of NO912606D0 publication Critical patent/NO912606D0/no

1992-01-06 Publication of NO912606L publication Critical patent/NO912606L/no

1997-01-27 Publication of NO180541B publication Critical patent/NO180541B/no

1997-05-07 Publication of NO180541C publication Critical patent/NO180541C/no

Links

238000000034 method Methods 0.000 title abstract 2
KVRVLSICJKOUET-UHFFFAOYSA-N purin-9-ylphosphonic acid Chemical class N1=CN=C2N(P(O)(=O)O)C=NC2=C1 KVRVLSICJKOUET-UHFFFAOYSA-N 0.000 title 1
230000000719 anti-leukaemic effect Effects 0.000 abstract 1
230000000690 anti-lymphoma Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
239000000063 antileukemic agent Substances 0.000 abstract 1
-1 antilymphoma Substances 0.000 abstract 1
239000003904 antiprotozoal agent Substances 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229960003444 immunosuppressant agent Drugs 0.000 abstract 1
239000003018 immunosuppressive agent Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000784 purine nucleoside phosphorylase inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Oncology (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Transplantation (AREA)
Obesity (AREA)
Diabetes (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO912606A 1990-07-04 1991-07-03 Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-purinylfosfonsyrederivater og mellomprodukt for fremstilling derav NO180541C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP90401940		1990-07-04

Publications (4)

Publication Number	Publication Date
NO912606D0 NO912606D0 (no)	1991-07-03
NO912606L NO912606L (no)	1992-01-06
NO180541B NO180541B (no)	1997-01-27
NO180541C true NO180541C (no)	1997-05-07

Family

ID=8205733

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO912606A NO180541C (no)	1990-07-04	1991-07-03	Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-purinylfosfonsyrederivater og mellomprodukt for fremstilling derav

Country Status (22)

Country	Link
US (2)	US5538978A (fr)
EP (1)	EP0465297B1 (fr)
JP (1)	JP3006919B2 (fr)
KR (1)	KR100217807B1 (fr)
CN (1)	CN1031713C (fr)
AT (1)	ATE133678T1 (fr)
AU (1)	AU643533B2 (fr)
CA (1)	CA2045783C (fr)
DE (1)	DE69116750T2 (fr)
DK (1)	DK0465297T3 (fr)
ES (1)	ES2085446T3 (fr)
FI (1)	FI101793B (fr)
GR (1)	GR3019793T3 (fr)
HU (1)	HU208832B (fr)
IE (1)	IE72096B1 (fr)
IL (1)	IL98702A (fr)
MX (1)	MX9203682A (fr)
NO (1)	NO180541C (fr)
NZ (1)	NZ238774A (fr)
PT (1)	PT98198B (fr)
TW (1)	TW199896B (fr)
ZA (1)	ZA914978B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0465297B1 (fr) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	Dérivés d'acides 9-purinyl phosphoniques
EP0531597A1 (fr) *	1991-09-12	1993-03-17	Merrell Dow Pharmaceuticals Inc.	Dérivés acycliques insaturés d'acides phosphoniques puriniques ou pyrimidimiques
US5817672A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
CA2084222C (fr) *	1991-12-06	2004-04-06	David R. Borcherding	Nouveaux analogues de trans-cyclopentanypurine utiles comme immunosuppresseurs
US5723466A (en) *	1991-12-06	1998-03-03	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817660A (en) *	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
US5817661A (en)	1991-12-06	1998-10-06	Hoechst Marion Roussel, Inc.	Trans cyclopentanyl purine analogs useful as immunosuppressants
EP0719274A1 (fr) *	1993-09-17	1996-07-03	Gilead Sciences, Inc.	Procede de dosage de composes therapeutiques
US5656745A (en) *	1993-09-17	1997-08-12	Gilead Sciences, Inc.	Nucleotide analogs
US5798340A (en) *	1993-09-17	1998-08-25	Gilead Sciences, Inc.	Nucleotide analogs
US5703058A (en) *	1995-01-27	1997-12-30	Emory University	Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
MY141789A (en) *	2001-01-19	2010-06-30	Lg Chem Investment Ltd	Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
US7241890B2 (en)	2001-10-30	2007-07-10	Conforma Therapeutics Corporation	Purine analogs having HSP90-inhibiting activity
AU2003231765B9 (en)	2002-04-26	2010-01-28	Gilead Sciences, Inc.	Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
US7273716B2 (en)	2003-04-25	2007-09-25	Gilead Sciences, Inc.	Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase
EP2359833A1 (fr)	2003-04-25	2011-08-24	Gilead Sciences, Inc.	Analogues antiviraux du phosphonate
US7432261B2 (en)	2003-04-25	2008-10-07	Gilead Sciences, Inc.	Anti-inflammatory phosphonate compounds
US7470724B2 (en)	2003-04-25	2008-12-30	Gilead Sciences, Inc.	Phosphonate compounds having immuno-modulatory activity
US7407965B2 (en)	2003-04-25	2008-08-05	Gilead Sciences, Inc.	Phosphonate analogs for treating metabolic diseases
WO2005002626A2 (fr)	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Composes de phosphonate therapeutiques
US7300924B2 (en)	2003-04-25	2007-11-27	Gilead Sciences, Inc.	Anti-infective phosphonate analogs
US7452901B2 (en)	2003-04-25	2008-11-18	Gilead Sciences, Inc.	Anti-cancer phosphonate analogs
WO2004096287A2 (fr)	2003-04-25	2004-11-11	Gilead Sciences, Inc.	Composes de phosphonate inhibiteurs de l'inosine monophosphate deshydrogenase
MXPA05011296A (es)	2003-04-25	2006-01-24	Gilead Sciences Inc	Conjugados de fosfonato inhibidores de la cinasa.
KR20060070572A (ko)	2003-09-18	2006-06-23	콘포마 세러퓨틱스 코포레이션	Ｈｓｐ90-저해제로서의 신규 헤테로시클릭 화합물
US7427624B2 (en)	2003-10-24	2008-09-23	Gilead Sciences, Inc.	Purine nucleoside phosphorylase inhibitory phosphonate compounds
WO2005044308A1 (fr)	2003-10-24	2005-05-19	Gilead Sciences, Inc.	Analogues phosphonates d'antimetabolites
WO2005063751A1 (fr)	2003-12-22	2005-07-14	Gilead Sciences, Inc.	Derives de carbovir et d'abacavir 4'-substitues et composes associes dotes d'une activite antivirale dirigee contre le vih et le vhc
ME03423B (fr)	2004-07-27	2020-01-20	Gilead Sciences Inc	Analogues phosphonates de composés inhibiteurs du VIH
CA2602257A1 (fr) *	2005-03-30	2006-10-05	Conforma Therapeutics Corporation	Alkynyle pyrrolopyrimidines et analogues associes en tant qu'inhibiteurs de hsp90
US8158108B2 (en) *	2006-06-28	2012-04-17	S.C. Johnson & Son, Inc.	VOC-free compressed gas aerosol compositions
US8178078B2 (en) *	2008-06-13	2012-05-15	S.C. Johnson & Son, Inc.	Compositions containing a solvated active agent suitable for dispensing as a compressed gas aerosol
UA103329C2 (ru)	2008-07-08	2013-10-10	Гилиад Сайенсиз, Инк.	Соли соединений-ингибиторов вич
KR101692133B1 (ko)	2015-01-13	2017-01-02	연세대학교 원주산학협력단	폴리이미드 수용액을 이용한 폴리이미드 성형방법
CN105061504A (zh) *	2015-09-16	2015-11-18	湖南大学	P-炔基磷酸酯类化合物的制备方法
SI3661937T1 (sl)	2017-08-01	2021-11-30	Gilead Sciences, Inc.	Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1288098C (fr) *	1984-08-24	1991-08-27	Richard L. Tolman	Les 4-(guanin-9-yl)butanals et leurs derives 3-oxa, 3-thia et 2-ene, a activite antivirale et antitumorale
US4988702A (en) *	1986-08-26	1991-01-29	Warner-Lambert Company	Novel 9-deazaguanines
EP0328834A1 (fr) *	1988-02-16	1989-08-23	Merrell Dow Pharmaceuticals Inc.	Inhibiteurs d'aspartate transcarbamylase
EP0335770B1 (fr) *	1988-04-01	1997-01-15	Merrell Pharmaceuticals Inc.	Dérivés de nucléotides de fluorophosphonates
US4927830A (en) *	1988-04-08	1990-05-22	The Regents Of The University Of Michigan	Acyclic pyrrolo[2,3-D]pyrimidine analogs as antiviral agents
ATE98249T1 (de) *	1988-04-19	1993-12-15	Merrell Dow Pharma	Phosphonoalkylpurin-derivate.
EP0338168A1 (fr) *	1988-04-19	1989-10-25	Merrell Dow Pharmaceuticals Inc.	Dérivés de la phosphonoalkyl purine
JPH02124898A (ja) *	1988-04-28	1990-05-14	Nippon Kayaku Co Ltd	プリン塩基を有する新規化合物、その用途及び中間体
JPH02124897A (ja) *	1988-07-28	1990-05-14	Nippon Kayaku Co Ltd	エリスロフラノシルヌクレオシド誘導体の製造法及び新規誘導体
GB8827339D0 (en) *	1988-11-23	1988-12-29	Wellcome Found	Antiviral compounds
DE58902899D1 (de) *	1988-12-14	1993-01-14	Ciba Geigy Ag	2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor kombinationstherapie und zusammensetzungen dafuer.
EP0465297B1 (fr) *	1990-07-04	1996-01-31	Merrell Dow Pharmaceuticals Inc.	Dérivés d'acides 9-purinyl phosphoniques
EP0468119A1 (fr) *	1990-07-24	1992-01-29	Merrell Dow Pharmaceuticals Inc.	Nouveaux analogues carbocycliques de certains nucléosides
EP0477454A1 (fr) *	1990-09-28	1992-04-01	Merrell Dow Pharmaceuticals Inc.	Dérivés phosphonates de certains nucléosides

1991
- 1991-06-24 EP EP91401700A patent/EP0465297B1/fr not_active Expired - Lifetime
- 1991-06-24 ES ES91401700T patent/ES2085446T3/es not_active Expired - Lifetime
- 1991-06-24 DK DK91401700.9T patent/DK0465297T3/da active
- 1991-06-24 DE DE69116750T patent/DE69116750T2/de not_active Expired - Lifetime
- 1991-06-24 AT AT91401700T patent/ATE133678T1/de not_active IP Right Cessation
- 1991-06-27 CA CA002045783A patent/CA2045783C/fr not_active Expired - Lifetime
- 1991-06-27 AU AU79414/91A patent/AU643533B2/en not_active Ceased
- 1991-06-27 ZA ZA914978A patent/ZA914978B/xx unknown
- 1991-06-28 NZ NZ238774A patent/NZ238774A/en unknown
- 1991-06-28 TW TW080105043A patent/TW199896B/zh active
- 1991-07-01 IL IL9870291A patent/IL98702A/xx not_active IP Right Cessation
- 1991-07-03 HU HU912253A patent/HU208832B/hu not_active IP Right Cessation
- 1991-07-03 IE IE232991A patent/IE72096B1/en not_active IP Right Cessation
- 1991-07-03 NO NO912606A patent/NO180541C/no unknown
- 1991-07-03 CN CN91104477A patent/CN1031713C/zh not_active Expired - Fee Related
- 1991-07-03 PT PT98198A patent/PT98198B/pt not_active IP Right Cessation
- 1991-07-03 FI FI913236A patent/FI101793B/fi active
- 1991-07-04 JP JP3189498A patent/JP3006919B2/ja not_active Expired - Lifetime
- 1991-07-04 KR KR1019910011290A patent/KR100217807B1/ko not_active Expired - Fee Related
1992
- 1992-06-29 MX MX9203682A patent/MX9203682A/es unknown
1994
- 1994-11-08 US US08/336,703 patent/US5538978A/en not_active Expired - Lifetime
1995
- 1995-06-06 US US08/469,097 patent/US5527803A/en not_active Expired - Fee Related
1996
- 1996-04-29 GR GR960401173T patent/GR3019793T3/el unknown

Also Published As

Publication number	Publication date
NZ238774A (en)	1993-08-26
US5538978A (en)	1996-07-23
IE72096B1 (en)	1997-03-12
ZA914978B (en)	1992-04-29
CA2045783A1 (fr)	1992-01-05
MX9203682A (es)	1992-08-01
ATE133678T1 (de)	1996-02-15
CN1058021A (zh)	1992-01-22
HUT59151A (en)	1992-04-28
HU912253D0 (en)	1991-12-30
HU208832B (en)	1994-01-28
KR920002622A (ko)	1992-02-28
TW199896B (fr)	1993-02-11
DE69116750T2 (de)	1996-11-14
ES2085446T3 (es)	1996-06-01
FI913236L (fi)	1992-01-05
KR100217807B1 (ko)	1999-10-01
DK0465297T3 (da)	1996-02-19
IE912329A1 (en)	1992-01-15
AU643533B2 (en)	1993-11-18
EP0465297B1 (fr)	1996-01-31
IL98702A0 (en)	1992-07-15
IL98702A (en)	1997-02-18
US5527803A (en)	1996-06-18
NO180541B (no)	1997-01-27
EP0465297A1 (fr)	1992-01-08
FI913236A0 (fi)	1991-07-03
JPH04253989A (ja)	1992-09-09
FI101793B1 (fi)	1998-08-31
NO912606L (no)	1992-01-06
CN1031713C (zh)	1996-05-01
AU7941491A (en)	1992-01-09
PT98198A (pt)	1992-04-30
PT98198B (pt)	1998-12-31
DE69116750D1 (de)	1996-03-14
JP3006919B2 (ja)	2000-02-07
NO912606D0 (no)	1991-07-03
GR3019793T3 (en)	1996-07-31
CA2045783C (fr)	2001-09-18
FI101793B (fi)	1998-08-31

Publication	Publication Date	Title
NO180541C (no)	1997-05-07	Analogifremgangsmåte for fremstilling av terapeutisk aktive 9-purinylfosfonsyrederivater og mellomprodukt for fremstilling derav
DK224286D0 (da)	1986-05-14	2',3'-dideoxy-nucleosider
IL101931A0 (en)	1992-12-30	Processes for the diastereoselective synthesis of nucleosides,and hydrofuran derivatives for use therein
MY102693A (en)	1992-09-30	Antiviral nucleosides
KR950700298A (ko)	1995-01-16	뉴클레오시드 치료제(Therapeutic Nucleosides)
YU29099A (sh)	2002-06-19	Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola
AP2000002016A0 (en)	2000-12-31	2-(Purin-9-yl) Tetrahydrofuran-3,4-diol derivatives.
SE8900192L (sv)	1989-07-21	Dideoxididehydrokarbocykliska nukleosider
UA41296C2 (uk)	2001-09-17	Складні ефіри нуклеозиду та його похідні, фармацевтична композиція на їх основі
DK468288A (da)	1989-02-23	Antivirale forbindelser
DE3875769D1 (de)	1992-12-17	Therapeutische nukleoside.
ATE57703T1 (de)	1990-11-15	Verfahren zur herstellung von 2,6-substituierten 9-(1,3-dihydroxy-2-propoxymethyl)-purinen und einige derivate.
FI91763C (fi)	1994-08-10	Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi
DE3485419D1 (de)	1992-02-13	Glyzerinderivate.
ZA892284B (en)	1990-02-28	Novel fluorophosphonate nucleotide derivatives
ES467943A1 (es)	1978-11-01	Un metodo de preparacion de una purina sustituida.
NO974512L (no)	1997-09-29	Fremgangsmåte for syntese av nukleosid-analoger
MY103900A (en)	1993-10-30	6-substituted 2'', 3''-dideoxynucleosides and pharmaceutical compositions
MX9707400A (es)	1997-11-29	Preparacion de derivados de 2-ciclopentanol cis-4-protegidos.
FI863729L (fi)	1987-03-18	Menetelmä terapeuttisesti käyttökelpoisten 3'-atsido nukleosidien valmistamiseksi