NO2000008I2 - Analogifremgangsmaate for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor - Google Patents

Analogifremgangsmaate for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor

Info

Publication number
NO2000008I2
NO2000008I2 NO2000008C NO2000008C NO2000008I2 NO 2000008 I2 NO2000008 I2 NO 2000008I2 NO 2000008 C NO2000008 C NO 2000008C NO 2000008 C NO2000008 C NO 2000008C NO 2000008 I2 NO2000008 I2 NO 2000008I2
Authority
NO
Norway
Prior art keywords
alkyl
pais
independently
platelet aggregation
preparing
Prior art date
Application number
NO2000008C
Other languages
English (en)
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2000008(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of NO2000008I2 publication Critical patent/NO2000008I2/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
NO2000008C 1989-06-16 2000-09-06 Analogifremgangsmaate for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor NO2000008I2 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US41802889A 1989-10-06 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (en) 1989-06-16 1990-06-15 Platelet aggregation inhibitors

Publications (1)

Publication Number Publication Date
NO2000008I2 true NO2000008I2 (no) 2006-01-16

Family

ID=27408820

Family Applications (3)

Application Number Title Priority Date Filing Date
NO914962A NO304267B1 (no) 1989-06-16 1991-12-16 AnalogifremgangsmÕte for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor (PAI) peptid
NO19982249A NO312965B1 (no) 1989-06-16 1998-05-15 Blodplate-aggregasjonsinhibitorer
NO2000008C NO2000008I2 (no) 1989-06-16 2000-09-06 Analogifremgangsmaate for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO914962A NO304267B1 (no) 1989-06-16 1991-12-16 AnalogifremgangsmÕte for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor (PAI) peptid
NO19982249A NO312965B1 (no) 1989-06-16 1998-05-15 Blodplate-aggregasjonsinhibitorer

Country Status (16)

Country Link
US (4) US5318899A (no)
EP (2) EP0751219A1 (no)
JP (1) JP3281370B2 (no)
KR (1) KR0180918B1 (no)
AT (1) ATE146969T1 (no)
CA (2) CA2388770A1 (no)
DE (2) DE69029579T3 (no)
DK (1) DK0477295T4 (no)
ES (1) ES2097150T5 (no)
FI (1) FI104364B (no)
HU (1) HU216318B (no)
LU (1) LU90488I2 (no)
NL (1) NL990043I2 (no)
NO (3) NO304267B1 (no)
RU (1) RU2156468C2 (no)
WO (1) WO1990015620A1 (no)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5827821A (en) 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5780595A (en) * 1989-06-16 1998-07-14 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
ATE155482T1 (de) * 1990-04-06 1997-08-15 Jolla Cancer Res Found Verfahren und verbindung zur behandlung von thrombose
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
EP0555328A1 (en) * 1990-11-02 1993-08-18 Genentech, Inc. Platelet aggregation inhibitors
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
DK0578728T3 (da) * 1991-04-05 1999-04-12 Genentech Inc Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5565449A (en) * 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
ES2124308T3 (es) 1992-04-30 1999-02-01 Cor Therapeutics Inc Composicion estable de polipeptidos.
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
ES2121088T3 (es) * 1992-06-04 1998-11-16 Merrell Pharma Inc Analogos de peptidos limitados conformacionalmente como agentes antiplaquetarios.
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
DK0691959T3 (da) * 1993-03-29 1999-04-26 Zeneca Ltd Heterocykliske derivater som blodpladeaggregations-inhibitorer
AU7112794A (en) * 1993-06-18 1995-01-17 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
WO1996040250A2 (en) * 1995-06-07 1996-12-19 Centocor, Inc. Platelet-specific chimeric immunoglobulin and methods of use therefor
US5877224A (en) 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
EP0877620A4 (en) * 1996-01-16 1999-04-14 Rensselaer Polytech Inst PEPTIDES USED FOR MODIFYING OSTEOBLASTIC ADHESION
CA2265827A1 (en) * 1996-09-18 1998-03-26 Merck & Co., Inc. Combination therapy for reducing the risks associated with cardiovascular disease
EP0939900A4 (en) * 1996-11-21 2003-01-08 Merck & Co Inc DETECTION OF ANTAGONIST-DEPENDENT GPIIb / IIIa RECEPTOR ANTIBODIES
FR2764389B1 (fr) * 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
WO1999013898A1 (en) * 1997-08-15 1999-03-25 Stefan Niewiarowski EC-3, AN INHIBITOR OF α4β1 AND α4β7 INTEGRINS
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
WO1999047128A1 (en) 1998-03-19 1999-09-23 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
WO2002022571A2 (en) * 2000-09-11 2002-03-21 Temple University-Of The Commonwealth System Of Higher Education Compounds and methods for inhibiting alpha-1 beta-1 integrins
ATE441115T1 (de) * 2001-11-05 2009-09-15 Irm Llc Markierungsreagens und anwendungsverfahren
DE60309019T2 (de) * 2002-05-03 2007-05-16 Avecia Ltd., Blackley Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
WO2005044978A2 (en) * 2003-07-15 2005-05-19 Washington University Methods of treating, preventing and inhibiting cancer metastasis and tumor formation
US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
ME01063B (me) * 2004-04-08 2012-10-20 Millennium Pharm Inc Postupak za dobijanje eptifibatida i odgovarajućih intermedijernih jedinjenja
CA2560007A1 (en) * 2004-06-14 2005-12-22 Usv Limited Process for the preparation of peptides
AU2005282380A1 (en) * 2004-09-07 2006-03-16 Archemix Corp. Aptamer medicinal chemistry
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
JP2008512098A (ja) * 2004-09-07 2008-04-24 アーケミックス コーポレイション フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
EP1717588A1 (en) * 2005-04-29 2006-11-02 Synapse B.V. Measuring thrombin activity in whole blood
KR20080031383A (ko) 2005-07-05 2008-04-08 베이커 메디컬 리서치 인스티튜트 항응고제 및 그의 용도
WO2008020743A2 (en) * 2006-08-16 2008-02-21 Wisdom Asset Company Method for extracting a platelet aggregation inhibitor from agkistrodon blomhoffii ussuriensis venom
WO2008150495A2 (en) * 2007-06-01 2008-12-11 Archemix Corp. Vwf aptamer formulations and methods for use
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
RU2596787C2 (ru) 2010-07-09 2016-09-10 БиЭйчВи ФАРМА, ИНК. Комбинированная система доставки с немедленным/замедленным высвобождением для лекарственных средств с коротким периодом полувыведения, в том числе для ремоглифлозина
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
ES2800027T3 (es) 2012-08-09 2020-12-23 Swimc Llc Estabilizador y composiciones de recubrimiento del mismo
CN104540874B (zh) 2012-08-09 2018-05-01 威士伯采购公司 聚碳酸酯
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
EP3333177B1 (en) 2015-08-05 2021-07-14 Shaanxi Micot Technology Limited Company Multi-target compound with anticoagulation and antiplatelet activity, preparation method therefor, and use thereof
US11202854B2 (en) * 2017-08-09 2021-12-21 National Taiwan University Disintegrin variants and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
SU1269024A1 (ru) * 1984-01-13 1986-11-07 Белорусский государственный институт усовершенствования врачей Способ определени активности антитромбина 111
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
SU1522102A1 (ru) * 1987-01-07 1989-11-15 Московский медицинский стоматологический институт им.Н.А.Семашко Способ определени активности антитромбина ш в плазме крови
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
FR2617170B1 (fr) * 1987-06-25 1989-12-22 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) * 1987-10-30 1990-12-21 Inst Vaisseaux Sang Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
EP0317053B1 (en) * 1987-11-18 1993-12-08 Temple University of the Commonwealth System of Higher Education Trigramin- a platelet aggregation inhibiting polypeptide
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
AU3040589A (en) * 1988-02-22 1989-09-06 Upjohn Company, The Homoarginine-based peptides as platelet aggregation inhibitors
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
WO1990015072A1 (en) * 1989-06-07 1990-12-13 Genentech, Inc. Platelet aggregation inhibitors and related molecules
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
DE19975072I1 (de) 2000-03-09
EP0477295A4 (en) 1992-10-07
DE69029579T3 (de) 2006-06-22
CA2059124C (en) 2002-08-20
NO914962D0 (no) 1991-12-16
HU216318B (hu) 1999-06-28
DE19975072I2 (de) 2011-01-20
JP3281370B2 (ja) 2002-05-13
DE69029579D1 (de) 1997-02-13
AU6036990A (en) 1991-01-08
RU2156468C2 (ru) 2000-09-20
AU636159B2 (en) 1993-04-22
US5318899A (en) 1994-06-07
NO312965B1 (no) 2002-07-22
DE69029579T2 (de) 1997-07-24
ES2097150T5 (es) 2006-06-16
EP0477295A1 (en) 1992-04-01
KR0180918B1 (ko) 1999-04-01
EP0751219A1 (en) 1997-01-02
NO982249L (no) 1992-01-31
LU90488I2 (fr) 2000-02-15
KR920702627A (ko) 1992-10-06
WO1990015620A1 (en) 1990-12-27
HU905490D0 (en) 1992-03-30
NO982249D0 (no) 1998-05-15
FI915919A0 (fi) 1991-12-16
US5496724A (en) 1996-03-05
JPH05500750A (ja) 1993-02-18
US5736339A (en) 1998-04-07
NL990043I1 (nl) 2000-02-01
NO304267B1 (no) 1998-11-23
CA2388770A1 (en) 1990-12-27
US5958732A (en) 1999-09-28
DK0477295T3 (da) 1997-07-07
ES2097150T3 (es) 1997-04-01
NO914962L (no) 1992-01-31
DK0477295T4 (da) 2005-12-12
EP0477295B2 (en) 2005-11-16
HUT59835A (en) 1992-07-28
EP0477295B1 (en) 1997-01-02
CA2059124A1 (en) 1990-12-17
ATE146969T1 (de) 1997-01-15
FI104364B (fi) 2000-01-14
NL990043I2 (nl) 2000-04-03

Similar Documents

Publication Publication Date Title
DK0477295T3 (da) Blodpladeaggregationsinhibitorer
FI906438A0 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
CA2158268A1 (en) N-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
NO178969C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte kinazolinoner
ATE126509T1 (de) Disäuren von diarylstyrylchinolin.
AU1634288A (en) Cyclic anticoagulant peptides
AU1634388A (en) Cyclic anticoagulant peptides
MX9101270A (es) Compuesto,preparacion y uso
AU7826891A (en) Heterocyclyl substituted 6-halopenem compounds
FI904663A0 (fi) Nya substituerade alkylpiperidiner och deras anvaendning som inhibitorer i kolesterolsyntes.
ATE73795T1 (de) Thioformamid-derivate.
SE8700366D0 (sv) Medel vid lungfibros

Legal Events

Date Code Title Description
MK1K Patent expired