NO914962L - Blodplate-aggregasjonsinhibitorer - Google Patents

Blodplate-aggregasjonsinhibitorer

Info

Publication number
NO914962L
NO914962L NO91914962A NO914962A NO914962L NO 914962 L NO914962 L NO 914962L NO 91914962 A NO91914962 A NO 91914962A NO 914962 A NO914962 A NO 914962A NO 914962 L NO914962 L NO 914962L
Authority
NO
Norway
Prior art keywords
alkyl
pais
independently
assay
benzyl
Prior art date
Application number
NO91914962A
Other languages
English (en)
Other versions
NO914962D0 (no
NO304267B1 (no
Inventor
Robert M Scarborough
David Lawrence Wolf
Israel F Charo
Original Assignee
Cor Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO914962(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc
Publication of NO914962D0 publication Critical patent/NO914962D0/no
Publication of NO914962L publication Critical patent/NO914962L/no
Publication of NO304267B1 publication Critical patent/NO304267B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Materials For Medical Uses (AREA)
NO914962A 1989-06-16 1991-12-16 AnalogifremgangsmÕte for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor (PAI) peptid NO304267B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36750989A 1989-06-16 1989-06-16
US41802889A 1989-10-06 1989-10-06
US07/483,229 US5318899A (en) 1989-06-16 1990-02-20 Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (en) 1989-06-16 1990-06-15 Platelet aggregation inhibitors

Publications (3)

Publication Number Publication Date
NO914962D0 NO914962D0 (no) 1991-12-16
NO914962L true NO914962L (no) 1992-01-31
NO304267B1 NO304267B1 (no) 1998-11-23

Family

ID=27408820

Family Applications (3)

Application Number Title Priority Date Filing Date
NO914962A NO304267B1 (no) 1989-06-16 1991-12-16 AnalogifremgangsmÕte for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor (PAI) peptid
NO19982249A NO312965B1 (no) 1989-06-16 1998-05-15 Blodplate-aggregasjonsinhibitorer
NO2000008C NO2000008I2 (no) 1989-06-16 2000-09-06 Analogifremgangsmaate for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO19982249A NO312965B1 (no) 1989-06-16 1998-05-15 Blodplate-aggregasjonsinhibitorer
NO2000008C NO2000008I2 (no) 1989-06-16 2000-09-06 Analogifremgangsmaate for fremstilling av en terapeutisk aktiv spesifikk blodplateaggregasjonsinhibitor

Country Status (16)

Country Link
US (4) US5318899A (no)
EP (2) EP0477295B2 (no)
JP (1) JP3281370B2 (no)
KR (1) KR0180918B1 (no)
AT (1) ATE146969T1 (no)
CA (2) CA2388770A1 (no)
DE (2) DE69029579T3 (no)
DK (1) DK0477295T4 (no)
ES (1) ES2097150T5 (no)
FI (1) FI104364B (no)
HU (1) HU216318B (no)
LU (1) LU90488I2 (no)
NL (1) NL990043I2 (no)
NO (3) NO304267B1 (no)
RU (1) RU2156468C2 (no)
WO (1) WO1990015620A1 (no)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
AU639409B2 (en) * 1987-12-10 1993-07-29 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
US5770198A (en) * 1988-05-18 1998-06-23 The Research Foundation Of The State Of New York Platelet-specific chimeric 7E3 immunoglobulin
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5643872A (en) * 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2027936C (en) 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
WO1991015515A1 (en) * 1990-04-06 1991-10-17 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5612311A (en) * 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
CA2092315A1 (en) * 1990-11-02 1992-05-03 John P. Burnier Platelet aggregation inhibitors
US5342830A (en) * 1990-11-16 1994-08-30 Cor Therapeutics, Inc. Antithrombosis agents
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
CA2106314A1 (en) * 1991-04-05 1992-10-06 John P. Burnier Platelet aggregation inhibitors having high specification for gpiibiiia
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5674863A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
AU679913B2 (en) 1992-04-30 1997-07-17 Millennium Pharmaceuticals, Inc. Stable polypeptide composition
US5747447A (en) * 1992-04-30 1998-05-05 Cor Therapeutics Stable polypeptide composition
DE69319733T2 (de) * 1992-06-04 1999-01-14 Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them
EP0691959B1 (en) * 1993-03-29 1998-07-22 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
AU7112794A (en) * 1993-06-18 1995-01-17 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5770575A (en) * 1994-03-16 1998-06-23 Ortho Pharmaceutical Corporation Nipecotic acid derivatives as antithrombotic compounds
JPH11511120A (ja) * 1995-06-07 1999-09-28 セントコー，インコーポレイテッド 血小板特異的キメラ免疫グロブリン及びその使用方法
US5877224A (en) * 1995-07-28 1999-03-02 Rutgers, The State University Of New Jersey Polymeric drug formulations
AU1749497A (en) * 1996-01-16 1997-08-11 Rensselaer Polytechnic Institute Peptides for altering osteoblast adhesion
WO1998011896A1 (en) * 1996-09-18 1998-03-26 Merck & Co., Inc. Combination therapy for reducing the risks associated with cardiovascular disease
WO1998022821A1 (en) * 1996-11-21 1998-05-28 Merck & Co., Inc. DETECTION OF ANTAGONIST-DEPENDENT GPIIb/IIIa RECEPTOR ANTIBODIES
FR2764389B1 (fr) 1997-06-06 1999-08-06 Stago Diagnostica Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6818617B1 (en) 1997-08-15 2004-11-16 Temple University- Of The Commonwealth System Of Higher Education EC-3, an inhibitor of α4β1 and α4β7 integrins
WO1999013898A1 (en) * 1997-08-15 1999-03-25 Stefan Niewiarowski EC-3, AN INHIBITOR OF α4β1 AND α4β7 INTEGRINS
US6210904B1 (en) 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
US6063584A (en) * 1997-11-21 2000-05-16 Merck & Co., Inc. Anticoagulant test
US6087332A (en) * 1997-12-23 2000-07-11 Galler; Lawrence Isaac Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
EP1063973B1 (en) 1998-03-19 2016-11-16 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
CA2421786A1 (en) * 2000-09-11 2002-03-21 Temple University - Of The Commonwealth System Of Higher Education Compounds and methods for inhibiting alpha-1 beta-1 integrins
ATE441115T1 (de) * 2001-11-05 2009-09-15 Irm Llc Markierungsreagens und anwendungsverfahren
EP1504022B1 (en) * 2002-05-03 2006-10-11 Avecia Limited Process for the synthesis of peptide amides by side-chain attachment to a solid phase
RU2524129C2 (ru) * 2003-01-10 2014-07-27 Аблинкс Н.В. Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
WO2005044978A2 (en) * 2003-07-15 2005-05-19 Washington University Methods of treating, preventing and inhibiting cancer metastasis and tumor formation
US7723474B2 (en) * 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
WO2005100381A2 (en) * 2004-04-08 2005-10-27 Millennium Pharmaceuticals, Inc. Processes for preparing eptifibatide and pertinent intermediate compounds
CN1968961A (zh) * 2004-06-14 2007-05-23 Usv有限公司 制备肽的方法
US7566701B2 (en) * 2004-09-07 2009-07-28 Archemix Corp. Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101227A (ko) * 2004-09-07 2007-10-16 아케믹스 코포레이션 폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
JP2008512097A (ja) * 2004-09-07 2008-04-24 アーケミックス コーポレイション アプタマー医薬品化学
EP1717588A1 (en) * 2005-04-29 2006-11-02 Synapse B.V. Measuring thrombin activity in whole blood
CA2613691A1 (en) 2005-07-05 2007-01-11 Baker Medical Research Institute Anticoagulation agent and uses thereof
WO2008020743A2 (en) * 2006-08-16 2008-02-21 Wisdom Asset Company Method for extracting a platelet aggregation inhibitor from agkistrodon blomhoffii ussuriensis venom
US20090203766A1 (en) * 2007-06-01 2009-08-13 Archemix Corp. vWF aptamer formulations and methods for use
GB2460915B (en) * 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
CN103153288B (zh) 2010-07-09 2017-02-15 詹姆斯·特林卡·格林 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统
RU2444731C1 (ru) * 2010-10-06 2012-03-10 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Способ выравнивания хроматограмм пептидных смесей
CN104540874B (zh) 2012-08-09 2018-05-01 威士伯采购公司 聚碳酸酯
CN104583347B (zh) 2012-08-09 2016-11-16 威士伯采购公司 稳定剂和其涂料组合物
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
WO2017020282A1 (zh) 2015-08-05 2017-02-09 陕西麦科奥特科技有限公司 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
JP7016945B2 (ja) * 2017-08-09 2022-02-07 国立台湾大学 ディスインテグリン変異体及びその使用法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4517686A (en) * 1982-08-04 1985-05-21 La Jolla Cancer Research Foundation Polypeptide
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4589881A (en) * 1982-08-04 1986-05-20 La Jolla Cancer Research Foundation Polypeptide
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
SU1269024A1 (ru) * 1984-01-13 1986-11-07 Белорусский государственный институт усовершенствования врачей Способ определени активности антитромбина 111
US4661471A (en) * 1984-04-10 1987-04-28 New England Deaconess Hospital Method of inhibiting and inducing human platelet aggregation
US5352664A (en) * 1986-10-31 1994-10-04 Board Of Regents, The University Of Texas System Thrombin derived polypeptides; compositions and methods for use
SU1522102A1 (ru) * 1987-01-07 1989-11-15 Московский медицинский стоматологический институт им.Н.А.Семашко Способ определени активности антитромбина ш в плазме крови
DE3716513A1 (de) * 1987-05-16 1988-11-24 Basf Ag Proteine mit tnf-wirkung
FR2617170B1 (fr) * 1987-06-25 1989-12-22 Inst Nat Sante Rech Med Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) * 1987-10-30 1990-12-21 Inst Vaisseaux Sang Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
ES2060654T3 (es) * 1987-11-18 1994-12-01 Univ Temple Trigramina - un polipeptido inhibidor de la agregacion plaquetaria.
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
WO1989007609A1 (en) * 1988-02-22 1989-08-24 The Upjohn Company Homoarginine-based peptides as platelet aggregation inhibitors
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) * 1989-02-07 1991-05-29 Merck & Co. Inc. Viper venom polypeptides and variants
AU5939890A (en) * 1989-06-07 1991-01-07 Genentech Inc. Platelet aggregation inhibitors and related molecules
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
DE69029579T2 (de) 1997-07-24
KR0180918B1 (ko) 1999-04-01
EP0751219A1 (en) 1997-01-02
NO982249L (no) 1992-01-31
CA2059124A1 (en) 1990-12-17
EP0477295B1 (en) 1997-01-02
EP0477295B2 (en) 2005-11-16
NO914962D0 (no) 1991-12-16
ES2097150T3 (es) 1997-04-01
JP3281370B2 (ja) 2002-05-13
LU90488I2 (fr) 2000-02-15
DE19975072I2 (de) 2011-01-20
HU216318B (hu) 1999-06-28
JPH05500750A (ja) 1993-02-18
KR920702627A (ko) 1992-10-06
DE19975072I1 (de) 2000-03-09
AU636159B2 (en) 1993-04-22
NO982249D0 (no) 1998-05-15
DK0477295T4 (da) 2005-12-12
US5958732A (en) 1999-09-28
AU6036990A (en) 1991-01-08
NO312965B1 (no) 2002-07-22
ATE146969T1 (de) 1997-01-15
RU2156468C2 (ru) 2000-09-20
FI915919A0 (fi) 1991-12-16
DE69029579D1 (de) 1997-02-13
NO2000008I2 (no) 2006-01-16
DE69029579T3 (de) 2006-06-22
WO1990015620A1 (en) 1990-12-27
US5318899A (en) 1994-06-07
HU905490D0 (en) 1992-03-30
US5736339A (en) 1998-04-07
NL990043I1 (nl) 2000-02-01
CA2388770A1 (en) 1990-12-27
NO304267B1 (no) 1998-11-23
DK0477295T3 (da) 1997-07-07
US5496724A (en) 1996-03-05
NL990043I2 (nl) 2000-04-03
CA2059124C (en) 2002-08-20
EP0477295A1 (en) 1992-04-01
ES2097150T5 (es) 2006-06-16
EP0477295A4 (en) 1992-10-07
FI104364B (fi) 2000-01-14
HUT59835A (en) 1992-07-28

Similar Documents

Publication Publication Date Title
DE19975072I2 (de) Blutplättchen-Aggregationsinhibitoren
CA2158268A1 (en) N-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
BR9803109A (pt) N,n',n"'- tris({2,4-bis[(1-hidroxicarbilóxi-2,2,6,6-tetrametilpipe ridin-4-il)alquilamino]-s-triazin-6-il}3,3'-etilenodiimin odipropilaminas, seus usÈmeros e derivados ligados por ponte e composições de polìmero estabilizadas com as mesmas.
AU581000B2 (en) Preparation of 6-oxygenated-1,3,4,5-tetrahydrobenz``cd`` indol-4-amines and indole-4-one intermediates therefor
AU1634288A (en) Cyclic anticoagulant peptides
AU1634388A (en) Cyclic anticoagulant peptides
MX9101270A (es) Compuesto,preparacion y uso
ES2016408B3 (es) Agentes antiarritmicos.
FI870176A0 (fi) Nya foereningar och deras framstaellningsfoerfaranden.
SE8700366D0 (sv) Medel vid lungfibros
RO85395B1 (ro) Derivati de 2-izobutilidenciclohexilamina

Legal Events

Date Code Title Description
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: EPTIFIBATID; NAT. REG. NO/DATE: NO , 98/5634, NO , 98/5635 20000306; FIRST REG. NO/DATE: EP , EU/1/99/10 19990701

Spc suppl protection certif: 2000008

Filing date: 20000906

Extension date: 20120227

MK1K Patent expired
SPCX Expiry of an spc

Free format text: PRODUCT NAME: EPTIFIBATID; NAT. REG. NO/DATE: NO , 98/5634, NO , 98/5635 20000306; FIRST REG. NO/DATE: EP , EU/1/99/10 19990701

Spc suppl protection certif: 2000008

Filing date: 20000906

Effective date: 20120227