LU90488I2 - Eptifibatide - Google Patents

Eptifibatide

Info

Publication number: LU90488I2
Authority: LU; Luxembourg
Prior art keywords: alkyl; pais; independently; assay; benzyl
Prior art date: 1989-06-16

Application number

LU90488C

Other languages

English (en)

Original Assignee

Cor Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-16

Filing date

1999-12-15

Publication date

2000-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90488(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-12-15 Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc

2000-02-15 Publication of LU90488I2 publication Critical patent/LU90488I2/fr

Links

108010056764 Eptifibatide Proteins 0.000 title 1
GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 title 1
229960004468 eptifibatide Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229940127218 antiplatelet drug Drugs 0.000 abstract 4
239000000106 platelet aggregation inhibitor Substances 0.000 abstract 4
239000003998 snake venom Substances 0.000 abstract 3
IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 abstract 2
238000003556 assay Methods 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
108010049003 Fibrinogen Proteins 0.000 abstract 1
102000008946 Fibrinogen Human genes 0.000 abstract 1
108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 abstract 1
238000012512 characterization method Methods 0.000 abstract 1
229940012952 fibrinogen Drugs 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000001288 lysyl group Chemical group 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
108010047303 von Willebrand Factor Proteins 0.000 abstract 1
102100036537 von Willebrand factor Human genes 0.000 abstract 1
229960001134 von willebrand factor Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Immunology (AREA)
Hematology (AREA)
Marine Sciences & Fisheries (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Control And Other Processes For Unpacking Of Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)

LU90488C 1989-06-16 1999-12-15 Eptifibatide LU90488I2 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US36750989A	1989-06-16	1989-06-16
US41802889A	1989-10-06	1989-10-06
US07/483,229 US5318899A (en)	1989-06-16	1990-02-20	Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (fr)	1989-06-16	1990-06-15	Inhibiteurs de l'agregation des plaquettes

Publications (1)

Publication Number	Publication Date
LU90488I2 true LU90488I2 (fr)	2000-02-15

Family

ID=27408820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU90488C LU90488I2 (fr)	1989-06-16	1999-12-15	Eptifibatide

Country Status (16)

Country	Link
US (4)	US5318899A (fr)
EP (2)	EP0751219A1 (fr)
JP (1)	JP3281370B2 (fr)
KR (1)	KR0180918B1 (fr)
AT (1)	ATE146969T1 (fr)
CA (2)	CA2388770A1 (fr)
DE (2)	DE69029579T3 (fr)
DK (1)	DK0477295T4 (fr)
ES (1)	ES2097150T5 (fr)
FI (1)	FI104364B (fr)
HU (1)	HU216318B (fr)
LU (1)	LU90488I2 (fr)
NL (1)	NL990043I2 (fr)
NO (3)	NO304267B1 (fr)
RU (1)	RU2156468C2 (fr)
WO (1)	WO1990015620A1 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
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US5827821A (en)	1987-12-10	1998-10-27	The Burnham Institute	Conformationally stabilized cell adhesion peptides
US5770198A (en) *	1988-05-18	1998-06-23	The Research Foundation Of The State Of New York	Platelet-specific chimeric 7E3 immunoglobulin
US5780595A (en) *	1989-06-16	1998-07-14	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
CA2027936C (fr)	1989-10-23	2001-07-24	Smithkline Beecham Corporation	Peptides cycliques anti-agregants
US5643872A (en) *	1989-10-23	1997-07-01	Smithkline Beecham Corporation	Cyclic anti-aggregatory peptides
US5612311A (en) *	1990-04-06	1997-03-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US6521594B1 (en)	1990-04-06	2003-02-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
ATE155482T1 (de) *	1990-04-06	1997-08-15	Jolla Cancer Res Found	Verfahren und verbindung zur behandlung von thrombose
US5648330A (en) *	1990-04-06	1997-07-15	La Jolla Cancer Research Foundation	Method and composition for treating vascular graft occlusion
US5780303A (en) *	1990-04-06	1998-07-14	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5192746A (en) *	1990-07-09	1993-03-09	Tanabe Seiyaku Co., Ltd.	Cyclic cell adhesion modulation compounds
EP0555328A1 (fr) *	1990-11-02	1993-08-18	Genentech, Inc.	Inhibiteurs d'agregation de plaquettes
US5342830A (en) *	1990-11-16	1994-08-30	Cor Therapeutics, Inc.	Antithrombosis agents
US5610148A (en) *	1991-01-18	1997-03-11	University College London	Macroscopically oriented cell adhesion protein for wound treatment
US5629287A (en) *	1991-01-18	1997-05-13	University College London	Depot formulations
DK0578728T3 (da) *	1991-04-05	1999-04-12	Genentech Inc	Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5565449A (en) *	1991-10-18	1996-10-15	Genentech, Inc.	Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5227490A (en) *	1992-02-21	1993-07-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
DE4212304A1 (de) *	1992-04-13	1993-10-14	Cassella Ag	Asparaginsäurederivate, ihre Herstellung und Verwendung
ES2124308T3 (es)	1992-04-30	1999-02-01	Cor Therapeutics Inc	Composicion estable de polipeptidos.
US5747447A (en) *	1992-04-30	1998-05-05	Cor Therapeutics	Stable polypeptide composition
ES2121088T3 (es) *	1992-06-04	1998-11-16	Merrell Pharma Inc	Analogos de peptidos limitados conformacionalmente como agentes antiplaquetarios.
IL106197A (en) *	1992-07-30	1999-11-30	Cor Therapeutics Inc	Agagonists for the rhombin receptors and pharmaceutical preparations containing them
EP0690847A1 (fr) *	1993-03-29	1996-01-10	Zeneca Limited	Composes heterocycliques en tant qu'inhibiteurs de l'agregation plaquettaire
US5753659A (en) *	1993-03-29	1998-05-19	Zeneca Limited	Heterocyclic compouds
US5652242A (en) *	1993-03-29	1997-07-29	Zeneca Limited	Heterocyclic derivatives
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
DK0691959T3 (da) *	1993-03-29	1999-04-26	Zeneca Ltd	Heterocykliske derivater som blodpladeaggregations-inhibitorer
AU7112794A (en) *	1993-06-18	1995-01-17	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5770575A (en) *	1994-03-16	1998-06-23	Ortho Pharmaceutical Corporation	Nipecotic acid derivatives as antithrombotic compounds
WO1996040250A2 (fr) *	1995-06-07	1996-12-19	Centocor, Inc.	Immunoglobuline chimerique specifique des plaquettes et procedes d'utilisation
US5877224A (en)	1995-07-28	1999-03-02	Rutgers, The State University Of New Jersey	Polymeric drug formulations
EP0877620A4 (fr) *	1996-01-16	1999-04-14	Rensselaer Polytech Inst	Peptides utilises pour la modification d'une adhesion osteoblastique
CA2265827A1 (fr) *	1996-09-18	1998-03-26	Merck & Co., Inc.	Traitement combine destine a reduire les risques de maladies cardio-vasculaires
EP0939900A4 (fr) *	1996-11-21	2003-01-08	Merck & Co Inc	DETECTION D'ANTICORPS DE RECEPTEUR GPIIb/IIIa DEPENDANT D'ANTAGONISTES
FR2764389B1 (fr) *	1997-06-06	1999-08-06	Stago Diagnostica	Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) *	1997-08-12	2001-01-23	Mcintyre John A.	Antigens embedded in thermoplastic
WO1999013898A1 (fr) *	1997-08-15	1999-03-25	Stefan Niewiarowski	Ec-3 en tant qu'inhibiteur des integrines alpha4 beta1 et alpha4 beta7
US6818617B1 (en)	1997-08-15	2004-11-16	Temple University- Of The Commonwealth System Of Higher Education	EC-3, an inhibitor of α4β1 and α4β7 integrins
US6210904B1 (en)	1997-10-14	2001-04-03	Merck & Co., Inc.	Anticoagulant test
US6063584A (en) *	1997-11-21	2000-05-16	Merck & Co., Inc.	Anticoagulant test
US6087332A (en) *	1997-12-23	2000-07-11	Galler; Lawrence Isaac	Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
WO1999047128A1 (fr)	1998-03-19	1999-09-23	Bristol-Myers Squibb Company	Systeme d'apport a liberation lente biphasique destine a des medicaments a solubilite elevee et procede associe
WO2002022571A2 (fr) *	2000-09-11	2002-03-21	Temple University-Of The Commonwealth System Of Higher Education	Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1
ATE441115T1 (de) *	2001-11-05	2009-09-15	Irm Llc	Markierungsreagens und anwendungsverfahren
DE60309019T2 (de) *	2002-05-03	2007-05-16	Avecia Ltd., Blackley	Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase
RU2524129C2 (ru) *	2003-01-10	2014-07-27	Аблинкс Н.В.	Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
WO2005044978A2 (fr) *	2003-07-15	2005-05-19	Washington University	Methodes de traitement, prevention et inhibition des metastases cancereuses et de la formation de tumeurs
US7723474B2 (en) *	2003-10-21	2010-05-25	The Regents Of The University Of California	Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US20050221414A1 (en) *	2004-03-31	2005-10-06	Katalin Varadi	Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
ME01063B (fr) *	2004-04-08	2012-10-20	Millennium Pharm Inc	Procedes de preparation de l'eptifibatide
CA2560007A1 (fr) *	2004-06-14	2005-12-22	Usv Limited	Processus de preparation de peptides
AU2005282380A1 (en) *	2004-09-07	2006-03-16	Archemix Corp.	Aptamer medicinal chemistry
US7566701B2 (en) *	2004-09-07	2009-07-28	Archemix Corp.	Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
JP2008512098A (ja) *	2004-09-07	2008-04-24	アーケミックスコーポレイション	フォン・ビルブラント因子に対するアプタマー、および血栓性疾患の処置剤としてのその使用
EP1717588A1 (fr) *	2005-04-29	2006-11-02	Synapse B.V.	Mesure de l'activité thrombique dans le sang total
KR20080031383A (ko)	2005-07-05	2008-04-08	베이커 메디컬 리서치 인스티튜트	항응고제 및 그의 용도
WO2008020743A2 (fr) *	2006-08-16	2008-02-21	Wisdom Asset Company	Procédé permettant d'extraire un inhibiteur de l'agrégation plaquettaire du venin d'agkistrodon blomhoffii ussuriensis
WO2008150495A2 (fr) *	2007-06-01	2008-12-11	Archemix Corp.	Formulations d'aptamère vwf et procédés d'utilisation
GB2460915B (en) *	2008-06-16	2011-05-25	Biovascular Inc	Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
RU2596787C2 (ru)	2010-07-09	2016-09-10	БиЭйчВи ФАРМА, ИНК.	Комбинированная система доставки с немедленным/замедленным высвобождением для лекарственных средств с коротким периодом полувыведения, в том числе для ремоглифлозина
RU2444731C1 (ru) *	2010-10-06	2012-03-10	Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России)	Способ выравнивания хроматограмм пептидных смесей
ES2800027T3 (es)	2012-08-09	2020-12-23	Swimc Llc	Estabilizador y composiciones de recubrimiento del mismo
CN104540874B (zh)	2012-08-09	2018-05-01	威士伯采购公司	聚碳酸酯
DE102014108210A1 (de)	2014-06-11	2015-12-17	Dietrich Gulba	Rodentizid
EP3333177B1 (fr)	2015-08-05	2021-07-14	Shaanxi Micot Technology Limited Company	Composé multicible présentant une activité d'anticoagulation et antiplaquettaire, son procédé de préparation et son utilisation
US11202854B2 (en) *	2017-08-09	2021-12-21	National Taiwan University	Disintegrin variants and uses thereof

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US4652639A (en) *	1982-05-06	1987-03-24	Amgen	Manufacture and expression of structural genes
US4792525A (en) *	1982-08-04	1988-12-20	La Jolla Cancer Research Foundation	Tetrapeptide
US4517686A (en) *	1982-08-04	1985-05-21	La Jolla Cancer Research Foundation	Polypeptide
US4578079A (en) *	1982-08-04	1986-03-25	La Jolla Cancer Research Foundation	Tetrapeptide
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US4661111A (en) *	1982-08-04	1987-04-28	La Jolla Cancer Research Foundation	Polypeptide
US4589881A (en) *	1982-08-04	1986-05-20	La Jolla Cancer Research Foundation	Polypeptide
SU1269024A1 (ru) *	1984-01-13	1986-11-07	Белорусский государственный институт усовершенствования врачей	Способ определени активности антитромбина 111
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US5352664A (en) *	1986-10-31	1994-10-04	Board Of Regents, The University Of Texas System	Thrombin derived polypeptides; compositions and methods for use
SU1522102A1 (ru) *	1987-01-07	1989-11-15	Московский медицинский стоматологический институт им.Н.А.Семашко	Способ определени активности антитромбина ш в плазме крови
DE3716513A1 (de) *	1987-05-16	1988-11-24	Basf Ag	Proteine mit tnf-wirkung
FR2617170B1 (fr) *	1987-06-25	1989-12-22	Inst Nat Sante Rech Med	Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) *	1987-08-04	1990-09-05	Ellem Ind Farmaceutica	Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) *	1987-10-30	1990-12-21	Inst Vaisseaux Sang	Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
EP0317053B1 (fr) *	1987-11-18	1993-12-08	Temple University of the Commonwealth System of Higher Education	Trigramine, un polypeptide inhibant l'aggrégation des plaquettes
US4857508A (en) *	1987-12-03	1989-08-15	Monsanto Company	Novel platelet-aggregation inhibitor peptide derivatives
AU3040589A (en) *	1988-02-22	1989-09-06	Upjohn Company, The	Homoarginine-based peptides as platelet aggregation inhibitors
ZW6189A1 (en) *	1988-05-09	1990-05-09	Smithkline Beckman Corp	Anti-aggregatory peptides
US5182260A (en) *	1989-01-27	1993-01-26	Biogen, Inc.	Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (fr) *	1989-02-07	1991-05-29	Merck & Co. Inc.	Polypeptides issus du venin de vipère et leurs variantes
WO1990015072A1 (fr) *	1989-06-07	1990-12-13	Genentech, Inc.	Inhibiteurs d'agregation de thrombocytes et molecules associees
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors

1990
- 1990-02-20 US US07/483,229 patent/US5318899A/en not_active Expired - Lifetime
- 1990-06-15 DE DE69029579T patent/DE69029579T3/de not_active Expired - Lifetime
- 1990-06-15 EP EP96105955A patent/EP0751219A1/fr not_active Withdrawn
- 1990-06-15 DE DE19975072C patent/DE19975072I2/de active Active
- 1990-06-15 DK DK90911002T patent/DK0477295T4/da active
- 1990-06-15 HU HU905490A patent/HU216318B/hu unknown
- 1990-06-15 WO PCT/US1990/003417 patent/WO1990015620A1/fr not_active Ceased
- 1990-06-15 AT AT90911002T patent/ATE146969T1/de active
- 1990-06-15 ES ES90911002T patent/ES2097150T5/es not_active Expired - Lifetime
- 1990-06-15 EP EP90911002A patent/EP0477295B2/fr not_active Expired - Lifetime
- 1990-06-15 RU SU5010733/14A patent/RU2156468C2/ru active
- 1990-06-15 KR KR1019910701881A patent/KR0180918B1/ko not_active Expired - Lifetime
- 1990-06-15 JP JP51036990A patent/JP3281370B2/ja not_active Expired - Lifetime
- 1990-06-15 CA CA002388770A patent/CA2388770A1/fr not_active Abandoned
- 1990-06-15 CA CA002059124A patent/CA2059124C/fr not_active Expired - Lifetime
1991
- 1991-12-16 FI FI915919A patent/FI104364B/fi active Protection Beyond IP Right Term
- 1991-12-16 NO NO914962A patent/NO304267B1/no not_active IP Right Cessation
1993
- 1993-05-24 US US08/067,139 patent/US5496724A/en not_active Expired - Lifetime
1995
- 1995-06-05 US US08/463,986 patent/US5736339A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,249 patent/US5958732A/en not_active Expired - Lifetime
1998
- 1998-05-15 NO NO19982249A patent/NO312965B1/no not_active IP Right Cessation
1999
- 1999-12-15 LU LU90488C patent/LU90488I2/fr unknown
- 1999-12-17 NL NL990043C patent/NL990043I2/nl unknown
2000
- 2000-09-06 NO NO2000008C patent/NO2000008I2/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE19975072I1 (de)	2000-03-09
EP0477295A4 (en)	1992-10-07
DE69029579T3 (de)	2006-06-22
CA2059124C (fr)	2002-08-20
NO914962D0 (no)	1991-12-16
HU216318B (hu)	1999-06-28
DE19975072I2 (de)	2011-01-20
JP3281370B2 (ja)	2002-05-13
DE69029579D1 (de)	1997-02-13
AU6036990A (en)	1991-01-08
RU2156468C2 (ru)	2000-09-20
AU636159B2 (en)	1993-04-22
US5318899A (en)	1994-06-07
NO312965B1 (no)	2002-07-22
DE69029579T2 (de)	1997-07-24
ES2097150T5 (es)	2006-06-16
EP0477295A1 (fr)	1992-04-01
KR0180918B1 (ko)	1999-04-01
EP0751219A1 (fr)	1997-01-02
NO982249L (no)	1992-01-31
KR920702627A (ko)	1992-10-06
WO1990015620A1 (fr)	1990-12-27
HU905490D0 (en)	1992-03-30
NO982249D0 (no)	1998-05-15
FI915919A0 (fi)	1991-12-16
US5496724A (en)	1996-03-05
JPH05500750A (ja)	1993-02-18
US5736339A (en)	1998-04-07
NL990043I1 (nl)	2000-02-01
NO304267B1 (no)	1998-11-23
CA2388770A1 (fr)	1990-12-27
NO2000008I2 (no)	2006-01-16
US5958732A (en)	1999-09-28
DK0477295T3 (da)	1997-07-07
ES2097150T3 (es)	1997-04-01
NO914962L (no)	1992-01-31
DK0477295T4 (da)	2005-12-12
EP0477295B2 (fr)	2005-11-16
HUT59835A (en)	1992-07-28
EP0477295B1 (fr)	1997-01-02
CA2059124A1 (fr)	1990-12-17
ATE146969T1 (de)	1997-01-15
FI104364B (fi)	2000-01-14
NL990043I2 (nl)	2000-04-03

Publication	Publication Date	Title
DK0477295T3 (da)	1997-07-07	Blodpladeaggregationsinhibitorer
CA2158268A1 (fr)	1994-11-24	Esters (ou thioesters) d'acide sulfamique n-acyliques, sulfonamides n-acyliques et esters (ou thioesters) d'acide carbamique n-sulfonylique, agents hypercholesterolemiques
AU581000B2 (en)	1989-02-09	Preparation of 6-oxygenated-1,3,4,5-tetrahydrobenz``cd`` indol-4-amines and indole-4-one intermediates therefor
AU1634288A (en)	1988-11-24	Cyclic anticoagulant peptides
AU1634388A (en)	1988-11-24	Cyclic anticoagulant peptides
ES2038668T3 (es)	1993-08-01	Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica.
ES2097733T3 (es)	1997-04-16	Derivados de la manobiosa.
MX9101270A (es)	1992-07-08	Compuesto,preparacion y uso
ATE53996T1 (de)	1990-07-15	Antiarrhythmische mittel.
FI870176A0 (fi)	1987-01-16	Nya foereningar och deras framstaellningsfoerfaranden.
SE8700366D0 (sv)	1987-01-30	Medel vid lungfibros
RO96101B (ro)	1989-01-31	Compozitie erbicida lichida