LU90488I2 - Eptifibatide - Google Patents

Eptifibatide

Info

Publication number: LU90488I2
Authority: LU; Luxembourg
Prior art keywords: alkyl; pais; independently; assay; benzyl
Prior art date: 1989-06-16

Application number

LU90488C

Other languages

English (en)

Original Assignee

Cor Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-16

Filing date

1999-12-15

Publication date

2000-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27408820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90488(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-12-15 Application filed by Cor Therapeutics Inc filed Critical Cor Therapeutics Inc

2000-02-15 Publication of LU90488I2 publication Critical patent/LU90488I2/fr

Links

108010056764 Eptifibatide Proteins 0.000 title 1
GLGOPUHVAZCPRB-LROMGURASA-N eptifibatide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCNC(=N)N)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]1CC1=CN=C2[C]1C=CC=C2 GLGOPUHVAZCPRB-LROMGURASA-N 0.000 title 1
229960004468 eptifibatide Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
229940127218 antiplatelet drug Drugs 0.000 abstract 4
239000000106 platelet aggregation inhibitor Substances 0.000 abstract 4
239000003998 snake venom Substances 0.000 abstract 3
IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 abstract 2
238000003556 assay Methods 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
108010049003 Fibrinogen Proteins 0.000 abstract 1
102000008946 Fibrinogen Human genes 0.000 abstract 1
108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 abstract 1
238000012512 characterization method Methods 0.000 abstract 1
229940012952 fibrinogen Drugs 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000001288 lysyl group Chemical group 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
108010047303 von Willebrand Factor Proteins 0.000 abstract 1
102100036537 von Willebrand factor Human genes 0.000 abstract 1
229960001134 von willebrand factor Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Hematology (AREA)
Marine Sciences & Fisheries (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Control And Other Processes For Unpacking Of Materials (AREA)
Materials For Medical Uses (AREA)
External Artificial Organs (AREA)

LU90488C 1989-06-16 1999-12-15 Eptifibatide LU90488I2 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US36750989A	1989-06-16	1989-06-16
US41802889A	1989-10-06	1989-10-06
US07/483,229 US5318899A (en)	1989-06-16	1990-02-20	Platelet aggregation inhibitors
PCT/US1990/003417 WO1990015620A1 (fr)	1989-06-16	1990-06-15	Inhibiteurs de l'agregation des plaquettes

Publications (1)

Publication Number	Publication Date
LU90488I2 true LU90488I2 (fr)	2000-02-15

Family

ID=27408820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LU90488C LU90488I2 (fr)	1989-06-16	1999-12-15	Eptifibatide

Country Status (16)

Country	Link
US (4)	US5318899A (fr)
EP (2)	EP0751219A1 (fr)
JP (1)	JP3281370B2 (fr)
KR (1)	KR0180918B1 (fr)
AT (1)	ATE146969T1 (fr)
CA (2)	CA2059124C (fr)
DE (2)	DE19975072I2 (fr)
DK (1)	DK0477295T4 (fr)
ES (1)	ES2097150T5 (fr)
FI (1)	FI104364B (fr)
HU (1)	HU216318B (fr)
LU (1)	LU90488I2 (fr)
NL (1)	NL990043I2 (fr)
NO (3)	NO304267B1 (fr)
RU (1)	RU2156468C2 (fr)
WO (1)	WO1990015620A1 (fr)

Families Citing this family (70)

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US5827821A (en)	1987-12-10	1998-10-27	The Burnham Institute	Conformationally stabilized cell adhesion peptides
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US5770198A (en) *	1988-05-18	1998-06-23	The Research Foundation Of The State Of New York	Platelet-specific chimeric 7E3 immunoglobulin
US5795868A (en) *	1989-06-16	1998-08-18	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors
AU6470590A (en)	1989-10-23	1991-04-26	Smithkline Beecham Corporation	Cyclic anti-aggregatory peptides
US5643872A (en) *	1989-10-23	1997-07-01	Smithkline Beecham Corporation	Cyclic anti-aggregatory peptides
US6521594B1 (en)	1990-04-06	2003-02-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5648330A (en) *	1990-04-06	1997-07-15	La Jolla Cancer Research Foundation	Method and composition for treating vascular graft occlusion
US5780303A (en) *	1990-04-06	1998-07-14	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
ATE155482T1 (de) *	1990-04-06	1997-08-15	Jolla Cancer Res Found	Verfahren und verbindung zur behandlung von thrombose
US5612311A (en)	1990-04-06	1997-03-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5192746A (en) *	1990-07-09	1993-03-09	Tanabe Seiyaku Co., Ltd.	Cyclic cell adhesion modulation compounds
CA2092315A1 (fr) *	1990-11-02	1992-05-03	John P. Burnier	Inhibiteurs de l'agregation plaquettaire
US5342830A (en) *	1990-11-16	1994-08-30	Cor Therapeutics, Inc.	Antithrombosis agents
US5629287A (en) *	1991-01-18	1997-05-13	University College London	Depot formulations
US5610148A (en) *	1991-01-18	1997-03-11	University College London	Macroscopically oriented cell adhesion protein for wound treatment
DK0578728T3 (da) *	1991-04-05	1999-04-12	Genentech Inc	Inhibitorer for aggregering af blodplader, hvilke inhibitorer har høj specificitet for GP IIbIIIa
US5250679A (en) *	1991-10-18	1993-10-05	Genentech, Inc.	Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5663166A (en) *	1991-10-18	1997-09-02	Genentech, Inc.	Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5227490A (en) *	1992-02-21	1993-07-13	Merck & Co., Inc.	Fibrinogen receptor antagonists
DE4212304A1 (de) *	1992-04-13	1993-10-14	Cassella Ag	Asparaginsäurederivate, ihre Herstellung und Verwendung
US5747447A (en) *	1992-04-30	1998-05-05	Cor Therapeutics	Stable polypeptide composition
DK0639202T3 (da)	1992-04-30	1999-08-09	Cor Therapeutics Inc	Stabil polypeptidsammensætning
DE69319733T2 (de) *	1992-06-04	1999-01-14	Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio	In der konformation beschränkte peptid analoge als wirkstoff gegen plättchenaggregation
IL106197A (en) *	1992-07-30	1999-11-30	Cor Therapeutics Inc	Agagonists for the rhombin receptors and pharmaceutical preparations containing them
US5652242A (en) *	1993-03-29	1997-07-29	Zeneca Limited	Heterocyclic derivatives
ATE202345T1 (de) *	1993-03-29	2001-07-15	Astrazeneca Ab	Heterozyklische derivate als plätchenaggregationsinhibitoren
CA2155307A1 (fr) *	1993-03-29	1994-10-13	Michael Garth Wayne	Composes heterocycliques, inhibiteurs de l'agregation des plaquettes
US5753659A (en) *	1993-03-29	1998-05-19	Zeneca Limited	Heterocyclic compouds
US5750754A (en) *	1993-03-29	1998-05-12	Zeneca Limited	Heterocyclic compounds
CA2165332A1 (fr) *	1993-06-18	1995-01-05	Michael D. Pierschbacher	Methode et composition pour traiter la thrombose
US5770575A (en) *	1994-03-16	1998-06-23	Ortho Pharmaceutical Corporation	Nipecotic acid derivatives as antithrombotic compounds
NZ513882A (en) *	1995-06-07	2001-09-28	Centocor Inc	Platelet-specific chimeric immunogloulin and method of use thereof
US5877224A (en)	1995-07-28	1999-03-02	Rutgers, The State University Of New Jersey	Polymeric drug formulations
CA2242911A1 (fr) *	1996-01-16	1997-07-24	Kay C. Dee	Peptides utilises pour la modification d'une adhesion osteoblastique
WO1998011896A1 (fr) *	1996-09-18	1998-03-26	Merck & Co., Inc.	Traitement combine destine a reduire les risques de maladies cardio-vasculaires
CA2271684A1 (fr) *	1996-11-21	1998-05-28	Merck & Co., Inc.	Detection d'anticorps de recepteur gpiia/iiib dependant d'antagonistes
FR2764389B1 (fr) *	1997-06-06	1999-08-06	Stago Diagnostica	Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee
US6177282B1 (en) *	1997-08-12	2001-01-23	Mcintyre John A.	Antigens embedded in thermoplastic
WO1999013898A1 (fr) *	1997-08-15	1999-03-25	Stefan Niewiarowski	Ec-3 en tant qu'inhibiteur des integrines alpha4 beta1 et alpha4 beta7
US6818617B1 (en)	1997-08-15	2004-11-16	Temple University- Of The Commonwealth System Of Higher Education	EC-3, an inhibitor of α4β1 and α4β7 integrins
US6210904B1 (en)	1997-10-14	2001-04-03	Merck & Co., Inc.	Anticoagulant test
US6063584A (en) *	1997-11-21	2000-05-16	Merck & Co., Inc.	Anticoagulant test
US6087332A (en) *	1997-12-23	2000-07-11	Galler; Lawrence Isaac	Streptokinase derivatives with high affinity for activated platelets and methods of their production and use in thrombolytic therapy
AP1224A (en)	1998-03-19	2003-11-14	Bristol Myers Squibb Co	Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
WO2002022571A2 (fr) *	2000-09-11	2002-03-21	Temple University-Of The Commonwealth System Of Higher Education	Composes et procedes pour l'inhibition d'integrines alpha-1 beta-1
ATE441115T1 (de) *	2001-11-05	2009-09-15	Irm Llc	Markierungsreagens und anwendungsverfahren
CA2484594C (fr) *	2002-05-03	2012-06-26	Avecia Limited	Procede de synthese de peptides
RU2524129C2 (ru) *	2003-01-10	2014-07-27	Аблинкс Н.В.	Терапевтические полипептиды, их гомологи, их фрагменты и их применение для модуляции агрегации, опосредованной тромбоцитами
WO2005044978A2 (fr) *	2003-07-15	2005-05-19	Washington University	Methodes de traitement, prevention et inhibition des metastases cancereuses et de la formation de tumeurs
US7723474B2 (en) *	2003-10-21	2010-05-25	The Regents Of The University Of California	Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US20050221414A1 (en) *	2004-03-31	2005-10-06	Katalin Varadi	Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
RS51182B (sr) *	2004-04-08	2010-10-31	Millennium Pharmaceuticals Inc.	Postupak za dobijanje eptifibatida i odgovarajućih intermedijernih jedinjenja
ATE451384T1 (de) *	2004-06-14	2009-12-15	Usv Ltd	Verfahren zur herstellung von peptiden
US7566701B2 (en) *	2004-09-07	2009-07-28	Archemix Corp.	Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
KR20070101227A (ko) *	2004-09-07	2007-10-16	아케믹스 코포레이션	폰 빌레브란트 인자에 대한 앱타머 및 이의 혈전증치료제로서의 용도
CA2578046A1 (fr) *	2004-09-07	2006-03-16	Archemix Corp.	Chimie medicale utilisant des aptameres
EP1717588A1 (fr) *	2005-04-29	2006-11-02	Synapse B.V.	Mesure de l'activité thrombique dans le sang total
KR20080031383A (ko)	2005-07-05	2008-04-08	베이커 메디컬 리서치 인스티튜트	항응고제 및 그의 용도
WO2008020743A2 (fr) *	2006-08-16	2008-02-21	Wisdom Asset Company	Procédé permettant d'extraire un inhibiteur de l'agrégation plaquettaire du venin d'agkistrodon blomhoffii ussuriensis
US20090203766A1 (en) *	2007-06-01	2009-08-13	Archemix Corp.	vWF aptamer formulations and methods for use
GB2462022B (en)	2008-06-16	2011-05-25	Biovascular Inc	Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
CN103153288B (zh)	2010-07-09	2017-02-15	詹姆斯·特林卡·格林	用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统
RU2444731C1 (ru) *	2010-10-06	2012-03-10	Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России)	Способ выравнивания хроматограмм пептидных смесей
EP2882792A4 (fr)	2012-08-09	2016-04-13	Valspar Sourcing Inc	Polycarbonates
CN104583347B (zh)	2012-08-09	2016-11-16	威士伯采购公司	稳定剂和其涂料组合物
DE102014108210A1 (de)	2014-06-11	2015-12-17	Dietrich Gulba	Rodentizid
CN113773369B (zh)	2015-08-05	2022-11-08	陕西麦科奥特科技有限公司	有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CA3072163C (fr) *	2017-08-09	2022-09-20	National Cheng Kung University	Variants de desintegrine et utilisations de ceux-ci

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US4589881A (en) *	1982-08-04	1986-05-20	La Jolla Cancer Research Foundation	Polypeptide
US4578079A (en) *	1982-08-04	1986-03-25	La Jolla Cancer Research Foundation	Tetrapeptide
US4517686A (en) *	1982-08-04	1985-05-21	La Jolla Cancer Research Foundation	Polypeptide
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US4792525A (en) *	1982-08-04	1988-12-20	La Jolla Cancer Research Foundation	Tetrapeptide
US4614517A (en) *	1982-08-04	1986-09-30	La Jolla Cancer Research Foundation	Tetrapeptide
SU1269024A1 (ru) *	1984-01-13	1986-11-07	Белорусский государственный институт усовершенствования врачей	Способ определени активности антитромбина 111
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US5352664A (en) *	1986-10-31	1994-10-04	Board Of Regents, The University Of Texas System	Thrombin derived polypeptides; compositions and methods for use
SU1522102A1 (ru) *	1987-01-07	1989-11-15	Московский медицинский стоматологический институт им.Н.А.Семашко	Способ определени активности антитромбина ш в плазме крови
DE3716513A1 (de) *	1987-05-16	1988-11-24	Basf Ag	Proteine mit tnf-wirkung
FR2617170B1 (fr) *	1987-06-25	1989-12-22	Inst Nat Sante Rech Med	Nouveaux derives peptidiques et leur application notamment en therapeutique
IT1222437B (it) *	1987-08-04	1990-09-05	Ellem Ind Farmaceutica	Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
FR2622587B1 (fr) *	1987-10-30	1990-12-21	Inst Vaisseaux Sang	Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
DE3886175T2 (de) *	1987-11-18	1994-04-07	Univ Temple	Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.
US4857508A (en) *	1987-12-03	1989-08-15	Monsanto Company	Novel platelet-aggregation inhibitor peptide derivatives
WO1989007609A1 (fr) *	1988-02-22	1989-08-24	The Upjohn Company	Peptides a base d'homoarginine utilises comme inhibiteurs de l'agglomeration de plaquettes
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US5182260A (en) *	1989-01-27	1993-01-26	Biogen, Inc.	Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (fr) *	1989-02-07	1991-05-29	Merck & Co. Inc.	Polypeptides issus du venin de vipère et leurs variantes
AU5939890A (en) *	1989-06-07	1991-01-07	Genentech Inc.	Platelet aggregation inhibitors and related molecules
US5318899A (en) *	1989-06-16	1994-06-07	Cor Therapeutics, Inc.	Platelet aggregation inhibitors

1990
- 1990-02-20 US US07/483,229 patent/US5318899A/en not_active Expired - Lifetime
- 1990-06-15 HU HU905490A patent/HU216318B/hu unknown
- 1990-06-15 JP JP51036990A patent/JP3281370B2/ja not_active Expired - Lifetime
- 1990-06-15 CA CA002059124A patent/CA2059124C/fr not_active Expired - Lifetime
- 1990-06-15 KR KR1019910701881A patent/KR0180918B1/ko not_active Expired - Lifetime
- 1990-06-15 DK DK90911002T patent/DK0477295T4/da active
- 1990-06-15 WO PCT/US1990/003417 patent/WO1990015620A1/fr not_active Ceased
- 1990-06-15 EP EP96105955A patent/EP0751219A1/fr not_active Withdrawn
- 1990-06-15 DE DE19975072C patent/DE19975072I2/de active Active
- 1990-06-15 EP EP90911002A patent/EP0477295B2/fr not_active Expired - Lifetime
- 1990-06-15 ES ES90911002T patent/ES2097150T5/es not_active Expired - Lifetime
- 1990-06-15 RU SU5010733/14A patent/RU2156468C2/ru active
- 1990-06-15 AT AT90911002T patent/ATE146969T1/de active
- 1990-06-15 CA CA002388770A patent/CA2388770A1/fr not_active Abandoned
- 1990-06-15 DE DE69029579T patent/DE69029579T3/de not_active Expired - Lifetime
1991
- 1991-12-16 FI FI915919A patent/FI104364B/fi active Protection Beyond IP Right Term
- 1991-12-16 NO NO914962A patent/NO304267B1/no not_active IP Right Cessation
1993
- 1993-05-24 US US08/067,139 patent/US5496724A/en not_active Expired - Lifetime
1995
- 1995-06-05 US US08/463,986 patent/US5736339A/en not_active Expired - Lifetime
- 1995-06-07 US US08/474,249 patent/US5958732A/en not_active Expired - Lifetime
1998
- 1998-05-15 NO NO19982249A patent/NO312965B1/no not_active IP Right Cessation
1999
- 1999-12-15 LU LU90488C patent/LU90488I2/fr unknown
- 1999-12-17 NL NL990043C patent/NL990043I2/nl unknown
2000
- 2000-09-06 NO NO2000008C patent/NO2000008I2/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0477295A4 (en)	1992-10-07
FI104364B (fi)	2000-01-14
NO312965B1 (no)	2002-07-22
DK0477295T4 (da)	2005-12-12
ES2097150T5 (es)	2006-06-16
DE19975072I1 (de)	2000-03-09
JPH05500750A (ja)	1993-02-18
US5958732A (en)	1999-09-28
CA2388770A1 (fr)	1990-12-27
EP0477295B2 (fr)	2005-11-16
AU6036990A (en)	1991-01-08
NO914962D0 (no)	1991-12-16
NO982249D0 (no)	1998-05-15
DE69029579D1 (de)	1997-02-13
US5736339A (en)	1998-04-07
EP0477295A1 (fr)	1992-04-01
CA2059124A1 (fr)	1990-12-17
NO2000008I2 (no)	2006-01-16
CA2059124C (fr)	2002-08-20
HUT59835A (en)	1992-07-28
FI915919A0 (fi)	1991-12-16
DE69029579T2 (de)	1997-07-24
RU2156468C2 (ru)	2000-09-20
NO982249L (no)	1992-01-31
US5496724A (en)	1996-03-05
HU216318B (hu)	1999-06-28
HU905490D0 (en)	1992-03-30
JP3281370B2 (ja)	2002-05-13
ATE146969T1 (de)	1997-01-15
NL990043I1 (nl)	2000-02-01
DK0477295T3 (da)	1997-07-07
EP0477295B1 (fr)	1997-01-02
ES2097150T3 (es)	1997-04-01
NL990043I2 (nl)	2000-04-03
DE19975072I2 (de)	2011-01-20
EP0751219A1 (fr)	1997-01-02
DE69029579T3 (de)	2006-06-22
NO304267B1 (no)	1998-11-23
AU636159B2 (en)	1993-04-22
WO1990015620A1 (fr)	1990-12-27
KR0180918B1 (ko)	1999-04-01
NO914962L (no)	1992-01-31
KR920702627A (ko)	1992-10-06
US5318899A (en)	1994-06-07

Publication	Publication Date	Title
LU90488I2 (fr)	2000-02-15	Eptifibatide
CA2158268A1 (fr)	1994-11-24	Esters (ou thioesters) d'acide sulfamique n-acyliques, sulfonamides n-acyliques et esters (ou thioesters) d'acide carbamique n-sulfonylique, agents hypercholesterolemiques
BR9803109A (pt)	2000-03-14	N,n',n"'- tris({2,4-bis[(1-hidroxicarbilóxi-2,2,6,6-tetrametilpipe ridin-4-il)alquilamino]-s-triazin-6-il}3,3'-etilenodiimin odipropilaminas, seus usÈmeros e derivados ligados por ponte e composições de polìmero estabilizadas com as mesmas.
AU581000B2 (en)	1989-02-09	Preparation of 6-oxygenated-1,3,4,5-tetrahydrobenz``cd`` indol-4-amines and indole-4-one intermediates therefor
AU1634288A (en)	1988-11-24	Cyclic anticoagulant peptides
AU1634388A (en)	1988-11-24	Cyclic anticoagulant peptides
ES2038668T3 (es)	1993-08-01	Vasodilatadores de benzotiazepina dotados de sustitucion aralquilica.
MX9101270A (es)	1992-07-08	Compuesto,preparacion y uso
SE9704272D0 (sv)	1997-11-21	Novel Compounds
ATE53996T1 (de)	1990-07-15	Antiarrhythmische mittel.
FI870176A0 (fi)	1987-01-16	Nya foereningar och deras framstaellningsfoerfaranden.
ATE38675T1 (de)	1988-12-15	Phosphatesterderivate und ihre verwendung als anti-krebsmittel.
SE8700366L (sv)	1987-08-06	Medel vid lungfibros
TH3947A (th)	1987-03-02	เบนซามีดชนิดใหม่
RO96101B (ro)	1989-01-31	Compozitie erbicida lichida