NO20002050L - Aggregater av humaninsulinderivater - Google Patents

Aggregater av humaninsulinderivater

Info

Publication number: NO20002050L
Authority: NO; Norway
Prior art keywords: aggregates; derivatives; human insulin; soluble; insulin derivatives
Prior art date: 1997-10-24

Application number

NO20002050A

Other languages

English (en)

Other versions

NO20002050D0 (no

Inventor

Svend Havelund

Per Balschmidt

Ib Jonassen

Thomas Hoeg-Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

2000-04-18

Publication date

2000-06-23

2000-04-18 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2000-04-18 Publication of NO20002050D0 publication Critical patent/NO20002050D0/no

2000-06-23 Publication of NO20002050L publication Critical patent/NO20002050L/no

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Immunology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO20002050A 1997-10-24 2000-04-18 Aggregater av humaninsulinderivater NO20002050L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives

Publications (2)

Publication Number	Publication Date
NO20002050D0 NO20002050D0 (no)	2000-04-18
NO20002050L true NO20002050L (no)	2000-06-23

Family

ID=26065414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002050A NO20002050L (no)	1997-10-24	2000-04-18	Aggregater av humaninsulinderivater

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (no)
JP (1)	JP2003525846A (no)
KR (1)	KR100539193B1 (no)
CN (1)	CN1240718C (no)
AT (1)	ATE243711T1 (no)
AU (1)	AU757933B2 (no)
BR (1)	BR9813128A (no)
CA (1)	CA2308705A1 (no)
DE (1)	DE69815877T2 (no)
DK (1)	DK1025125T3 (no)
ES (1)	ES2202899T3 (no)
HU (1)	HUP0004096A3 (no)
IL (2)	IL135400A0 (no)
NO (1)	NO20002050L (no)
PL (1)	PL195845B1 (no)
PT (1)	PT1025125E (no)
RU (1)	RU2218349C2 (no)
UA (1)	UA69393C2 (no)
WO (1)	WO1999021888A1 (no)
ZA (1)	ZA989722B (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
CZ20033182A3 (cs)	2001-05-21	2004-09-15	Nektar Therapeutics	Inzulínový prostředek a způsob podávání inzulínu
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
CA2531988C (en) *	2003-08-05	2016-06-28	Novo Nordisk A/S	Novel insulin derivatives
DK2275439T3 (da) *	2003-08-05	2014-05-12	Novo Nordisk As	Hidtil ukendte insulinderivater
RU2527893C2 (ru) *	2004-07-19	2014-09-10	Биокон Лимитед	Инсулин-олигомерные конъюгаты, их препараты и применения
WO2006125765A2 (en) *	2005-05-26	2006-11-30	Novo Nordisk A/S	Acylated insulin with high purity
ES2371361T3 (es)	2005-12-28	2011-12-30	Novo Nordisk A/S	Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
DE602007009496D1 (de)	2006-02-27	2010-11-11	Novo Nordisk As	Insulinderivate
US20090099064A1 (en) *	2006-06-08	2009-04-16	Diabecore Medical Inc.,	Derivatized insulin oligomers
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
RU2524150C2 (ru)	2006-09-22	2014-07-27	Ново Нордиск А/С	Аналоги инсулина, устойчивые к протеазам
JP5496082B2 (ja)	2007-04-30	2014-05-21	ノボ・ノルデイスク・エー／エス	タンパク質組成物を乾燥させる方法、乾燥タンパク質組成物、及び乾燥タンパク質を含有する薬学的組成物
JP5552046B2 (ja)	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
HUE032284T2 (en)	2008-03-18	2017-09-28	Novo Nordisk As	Protease-stabilized, acylated insulin analogues
JP4959005B2 (ja)	2008-10-30	2012-06-20	ノボ・ノルデイスク・エー／エス	毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
CN104364260B (zh)	2012-04-11	2017-02-22	诺和诺德股份有限公司	胰岛素制剂
EP2991672A1 (en)	2013-04-30	2016-03-09	Novo Nordisk A/S	Novel administration regime
JP6499184B2 (ja)	2013-10-07	2019-04-10	ノヴォノルディスクアー／エス	インスリン類似体の新規な誘導体
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
PE20210857A1 (es)	2016-12-16	2021-05-18	Novo Nordisk As	Composiciones farmaceuticas que contienen insulina
KR102665710B1 (ko)	2017-08-24	2024-05-14	노보 노르디스크 에이/에스	Glp-1 조성물 및 그 용도
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation
JP7761567B2 (ja)	2020-02-18	2025-10-28	ノヴォノルディスクアー／エス	医薬製剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1132404A3 (en) *	1993-09-17	2002-03-27	Novo Nordisk A/S	Acylated insulin
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-23 EP EP98949960A patent/EP1025125B1/en not_active Expired - Lifetime
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en not_active Ceased
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
KR20010031247A (ko)	2001-04-16
RU2218349C2 (ru)	2003-12-10
WO1999021888A1 (en)	1999-05-06
BR9813128A (pt)	2000-08-15
JP2003525846A (ja)	2003-09-02
CN1240718C (zh)	2006-02-08
DK1025125T3 (da)	2003-10-06
ES2202899T3 (es)	2004-04-01
DE69815877T2 (de)	2004-05-19
EP1025125A1 (en)	2000-08-09
CA2308705A1 (en)	1999-05-06
AU9622198A (en)	1999-05-17
NO20002050D0 (no)	2000-04-18
CN1281466A (zh)	2001-01-24
AU757933B2 (en)	2003-03-13
DE69815877D1 (de)	2003-07-31
PL195845B1 (pl)	2007-10-31
IL135400A (en)	2007-08-19
ZA989722B (en)	1999-04-26
HUP0004096A3 (en)	2001-12-28
EP1025125B1 (en)	2003-06-25
PL340032A1 (en)	2001-01-15
UA69393C2 (uk)	2004-09-15
KR100539193B1 (ko)	2005-12-27
IL135400A0 (en)	2001-05-20
HUP0004096A2 (hu)	2001-05-28
ATE243711T1 (de)	2003-07-15
PT1025125E (pt)	2003-11-28

Legal Events

Date	Code	Title	Description
2008-11-24	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20002050D0 (no)	2000-04-18	Aggregater av humaninsulinderivater
CA2209060A1 (en)	1997-12-28	Water-soluble or water-swellable polymers
TR199600322A2 (tr)	1996-11-21	Arilsülfonil hidroksamik asit türevleri.
CA2119154A1 (en)	1994-02-03	Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof
BR9809025B1 (pt)	2010-05-18	polìmero anfótero, e, veìculo cosmeticamente aceitável.
AU2002343557A1 (en)	2003-06-10	Substituted aryl 1,4-pyrazine derivatives
AU6636598A (en)	1998-10-20	Novel 3,4-dialkoxyphenyl derivatives and the use thereof
AU612172B2 (en)	1991-07-04	5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
HK1006974B (en)	1999-03-26	Aqueous wax and silicone dispersions, their production and use
PT1140835E (pt)	2004-07-30	Derivados da 3,3-biarilpiperidina e 2,2-biarilmorfolina
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
TR200002248T2 (tr)	2000-12-21	Yeni dihidroksiheksanoik asit türevleri
NO980303D0 (no)	1998-01-23	Vandige dispersjoner på basis av vannopplöselige polymerer
AU7624598A (en)	1998-06-29	1,4-diazabicyclo (2.2.2) Oct-2-ylmethyl derivatives, their preparation and the rapeutic application
FI965064L (fi)	1997-06-20	Veteenliukeneva suurimolekyylinen yhdiste, joka sisältää silikonia ja sen tuotanto ja käyttö
DK0861120T3 (da)	2003-12-15	Oliefri, vandopløselig, flydende hydroxyethylcellulosepolymerdispersion
DE69628458D1 (de)	2003-07-03	25-hydroxy-16-ene-26,27-bishome-cholecalceriferol derivate
ATE230592T1 (de)	2003-01-15	Dekorative kosmetische zubereitungen
CA2314716A1 (en)	1999-06-17	Modified polysaccharides exhibiting altered biological recognition
TR199501104A2 (tr)	1996-06-21	Imidik asit türevleri.
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate
AU4506499A (en)	2000-01-05	Novel 2,4-diaminophenol derivatives and the use thereof
ATE202922T1 (de)	2001-07-15	Ophthalmische cromolyn-gelzubereitung
FI905116A0 (fi)	1990-10-17	Membraner av haerdat gummi, vilka formats pao anvaendningsplatsen.