ATE243711T1 - Aggregate von menschlichen insulinderivaten - Google Patents

Aggregate von menschlichen insulinderivaten

Info

Publication number: ATE243711T1
Authority: AT; Austria
Prior art keywords: human insulin; derivatives; insulin derivative; soluble; aggregates
Prior art date: 1997-10-24

Application number

AT98949960T

Other languages

English (en)

Inventor

Svend Havelund

Per Balschmidt

Ib Jonassen

Thomas Hoeg-Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-24

Filing date

1998-10-23

Publication date

2003-07-15

1998-10-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2003-07-15 Application granted granted Critical

2003-07-15 Publication of ATE243711T1 publication Critical patent/ATE243711T1/de

Links

PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title abstract 2
102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 abstract 1
108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 abstract 1
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Obesity (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98949960T 1997-10-24 1998-10-23 Aggregate von menschlichen insulinderivaten ATE243711T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK121897		1997-10-24
US6417097P	1997-11-04	1997-11-04
PCT/DK1998/000461 WO1999021888A1 (en)	1997-10-24	1998-10-23	Aggregates of human insulin derivatives

Publications (1)

Publication Number	Publication Date
ATE243711T1 true ATE243711T1 (de)	2003-07-15

Family

ID=26065414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98949960T ATE243711T1 (de)	1997-10-24	1998-10-23	Aggregate von menschlichen insulinderivaten

Country Status (20)

Country	Link
EP (1)	EP1025125B1 (de)
JP (1)	JP2003525846A (de)
KR (1)	KR100539193B1 (de)
CN (1)	CN1240718C (de)
AT (1)	ATE243711T1 (de)
AU (1)	AU757933B2 (de)
BR (1)	BR9813128A (de)
CA (1)	CA2308705A1 (de)
DE (1)	DE69815877T2 (de)
DK (1)	DK1025125T3 (de)
ES (1)	ES2202899T3 (de)
HU (1)	HUP0004096A3 (de)
IL (2)	IL135400A0 (de)
NO (1)	NO20002050L (de)
PL (1)	PL195845B1 (de)
PT (1)	PT1025125E (de)
RU (1)	RU2218349C2 (de)
UA (1)	UA69393C2 (de)
WO (1)	WO1999021888A1 (de)
ZA (1)	ZA989722B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7316999B2 (en)	2000-06-02	2008-01-08	Novo Nordisk A/S	Glucose dependent release of insulin from glucose sensing insulin derivatives
MY137181A (en)	2001-05-21	2009-01-30	Nektar Therapeutics	Pulmonary administration of chemically modified insulin
US7317000B2 (en)	2001-12-02	2008-01-08	Novo Nordisk A/S	Glucose-dependent insulins
JP4463814B2 (ja) *	2003-08-05	2010-05-19	ノボノルディスクアクティーゼルスカブ	新規のインスリン誘導体
EP2287184A3 (de) *	2003-08-05	2011-08-10	Novo Nordisk A/S	Neue Insulinderivate
CA2910494C (en) *	2004-07-19	2018-10-23	Biocon Limited	Insulin-oligomer conjugates, formulations and uses thereof
WO2006125765A2 (en) *	2005-05-26	2006-11-30	Novo Nordisk A/S	Acylated insulin with high purity
EP1969004B1 (de)	2005-12-28	2011-08-10	Novo Nordisk A/S	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
ATE482977T1 (de) *	2006-02-27	2010-10-15	Novo Nordisk As	Insulinderivate
WO2007140619A1 (en) *	2006-06-08	2007-12-13	Diabecore Medical Inc.	Derivatized insulin oligomers
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
WO2008034881A1 (en)	2006-09-22	2008-03-27	Novo Nordisk A/S	Protease resistant insulin analogues
CN101674812B (zh)	2007-04-30	2013-12-11	诺沃-诺迪斯克有限公司	干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
US9034818B2 (en)	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
PT2910570T (pt)	2008-03-18	2017-01-24	Novo Nordisk As	Análogos de insulina acilados, estabilizados contra proteases
ES2607003T3 (es)	2008-10-30	2017-03-28	Novo Nordisk A/S	Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
CN103191416A (zh) *	2012-01-05	2013-07-10	四川大学	一种猪胰岛素超分子聚集体及其制备方法
CA2870313A1 (en)	2012-04-11	2013-10-17	Novo Nordisk A/S	Insulin formulations
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
CN105636979B (zh)	2013-10-07	2020-01-10	诺和诺德股份有限公司	胰岛素类似物的新衍生物
AR099569A1 (es)	2014-02-28	2016-08-03	Novo Nordisk As	Derivados de insulina y los usos médicos de estos
DK3554534T3 (da)	2016-12-16	2021-08-23	Novo Nordisk As	Farmaceutisk sammensætning omfattende insulin
CA3082033A1 (en)	2017-08-24	2019-02-28	Novo Nordisk A\S	Glp-1 compositions and uses thereof
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
JP7518149B2 (ja)	2019-07-12	2024-07-17	ノヴォノルディスクアー／エス	高濃度インスリン製剤
US11318191B2 (en)	2020-02-18	2022-05-03	Novo Nordisk A/S	GLP-1 compositions and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0792290T3 (da) *	1993-09-17	2001-10-01	Novo Nordisk As	Acyleret insulin
US5559094A (en) *	1994-08-02	1996-09-24	Eli Lilly And Company	AspB1 insulin analogs
US6451970B1 (en) *	1996-02-21	2002-09-17	Novo Nordisk A/S	Peptide derivatives

1998
- 1998-10-23 EP EP98949960A patent/EP1025125B1/de not_active Expired - Lifetime
- 1998-10-23 WO PCT/DK1998/000461 patent/WO1999021888A1/en not_active Ceased
- 1998-10-23 PL PL98340032A patent/PL195845B1/pl unknown
- 1998-10-23 ES ES98949960T patent/ES2202899T3/es not_active Expired - Lifetime
- 1998-10-23 DE DE69815877T patent/DE69815877T2/de not_active Expired - Fee Related
- 1998-10-23 DK DK98949960T patent/DK1025125T3/da active
- 1998-10-23 BR BR9813128-1A patent/BR9813128A/pt not_active IP Right Cessation
- 1998-10-23 IL IL13540098A patent/IL135400A0/xx not_active IP Right Cessation
- 1998-10-23 HU HU0004096A patent/HUP0004096A3/hu unknown
- 1998-10-23 RU RU2000112882/04A patent/RU2218349C2/ru not_active IP Right Cessation
- 1998-10-23 AU AU96221/98A patent/AU757933B2/en not_active Ceased
- 1998-10-23 CN CNB988104458A patent/CN1240718C/zh not_active Expired - Fee Related
- 1998-10-23 KR KR10-2000-7004229A patent/KR100539193B1/ko not_active Expired - Fee Related
- 1998-10-23 CA CA002308705A patent/CA2308705A1/en not_active Abandoned
- 1998-10-23 UA UA2000042275A patent/UA69393C2/uk unknown
- 1998-10-23 PT PT98949960T patent/PT1025125E/pt unknown
- 1998-10-23 JP JP2000517995A patent/JP2003525846A/ja not_active Withdrawn
- 1998-10-23 AT AT98949960T patent/ATE243711T1/de not_active IP Right Cessation
- 1998-10-26 ZA ZA989722A patent/ZA989722B/xx unknown
2000
- 2000-03-31 IL IL135400A patent/IL135400A/en unknown
- 2000-04-18 NO NO20002050A patent/NO20002050L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
UA69393C2 (uk)	2004-09-15
EP1025125A1 (de)	2000-08-09
RU2218349C2 (ru)	2003-12-10
AU757933B2 (en)	2003-03-13
HUP0004096A2 (hu)	2001-05-28
KR20010031247A (ko)	2001-04-16
PT1025125E (pt)	2003-11-28
PL340032A1 (en)	2001-01-15
DK1025125T3 (da)	2003-10-06
WO1999021888A1 (en)	1999-05-06
BR9813128A (pt)	2000-08-15
PL195845B1 (pl)	2007-10-31
IL135400A (en)	2007-08-19
DE69815877T2 (de)	2004-05-19
JP2003525846A (ja)	2003-09-02
ZA989722B (en)	1999-04-26
DE69815877D1 (de)	2003-07-31
CN1240718C (zh)	2006-02-08
ES2202899T3 (es)	2004-04-01
KR100539193B1 (ko)	2005-12-27
CN1281466A (zh)	2001-01-24
NO20002050D0 (no)	2000-04-18
NO20002050L (no)	2000-06-23
AU9622198A (en)	1999-05-17
IL135400A0 (en)	2001-05-20
EP1025125B1 (de)	2003-06-25
HUP0004096A3 (en)	2001-12-28
CA2308705A1 (en)	1999-05-06

Legal Events

Date

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Title

Description

2004-02-15

UEP

Publication of translation of european patent specification

Ref document number: 1025125

Country of ref document: EP

2009-07-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE243711T1 (de)	2003-07-15	Aggregate von menschlichen insulinderivaten
PT977741E (pt)	2004-01-30	Derivados de fenilo substituido, sua preparacao e utilizacao
AU2002343557A1 (en)	2003-06-10	Substituted aryl 1,4-pyrazine derivatives
IS4963A (is)	1999-01-29	Setnar 6,5-heteró-bísýklískar afleiður
DE3880465D1 (de)	1993-05-27	Wasserloesliche polymerdispersion.
CA2119154A1 (en)	1994-02-03	Derivatives of Cyclodextrins Exhibiting Enhanced Aqueous Solubility and the Use Thereof
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AU612172B2 (en)	1991-07-04	5-amino or substituted amino 1,2,3-triazoles useful as antiproliferative agents
MX9803728A (es)	1998-09-30	Agentes floculantes de polimero de alto rendimiento.
AU3657100A (en)	2000-10-04	Use of water-soluble beta-(1,3) glucans as agents for producing therapeutic skintreatment agents
TR200002248T2 (tr)	2000-12-21	Yeni dihidroksiheksanoik asit türevleri
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TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
IT1302243B1 (it)	2000-09-05	Sintesi dell'1,1,1,3,3-pentafluoropropano.
NO980303D0 (no)	1998-01-23	Vandige dispersjoner på basis av vannopplöselige polymerer
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ATE230592T1 (de)	2003-01-15	Dekorative kosmetische zubereitungen
AU6832498A (en)	1998-11-13	Substituted benzyl oximino compounds
ATE220674T1 (de)	2002-08-15	12h-dibenzo(d,g)(1,3)dioxocin derivate
FR2787329B1 (fr)	2001-02-09	Nouvelle application therapeutique des heparines de bas poids moleculaire
PT896004E (pt)	2005-01-31	Processo de preparacao de amido modificado e sua utilizacao