NO20002962L - FremgangsmÕte for fremstilling av fludarabinfosfatlium-, - natrium-, -kalium-, -kalsium- og -magnesiumsalter, fremgangsmÕte for rensing av fludarabinfosfat, og fludarabinfosfat som er minst 99,5% rent - Google Patents

FremgangsmÕte for fremstilling av fludarabinfosfatlium-, - natrium-, -kalium-, -kalsium- og -magnesiumsalter, fremgangsmÕte for rensing av fludarabinfosfat, og fludarabinfosfat som er minst 99,5% rent

Info

Publication number: NO20002962L
Authority: NO; Norway
Prior art keywords: fludarabine; fludarabine phosphate; phosphatlium; purification; potassium
Prior art date: 1997-12-11

Application number

NO20002962A

Other languages

English (en)

Other versions

NO315324B1 (no

NO20002962D0 (no

Inventor

Ulf Tilstam

Thomas Schmitz

Klaus Nickisch

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-11

Filing date

2000-06-09

Publication date

2000-06-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7852365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20002962(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-06-09 Application filed by Schering Ag filed Critical Schering Ag

2000-06-09 Publication of NO20002962L publication Critical patent/NO20002962L/no

2000-06-09 Publication of NO20002962D0 publication Critical patent/NO20002962D0/no

2003-08-18 Publication of NO315324B1 publication Critical patent/NO315324B1/no

Links

GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 title 3
229960005304 fludarabine phosphate Drugs 0.000 title 2
238000000034 method Methods 0.000 title 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 title 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title 1
239000011575 calcium Substances 0.000 title 1
229910052791 calcium Inorganic materials 0.000 title 1
229960000390 fludarabine Drugs 0.000 title 1
159000000003 magnesium salts Chemical class 0.000 title 1
239000011591 potassium Substances 0.000 title 1
229910052700 potassium Inorganic materials 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1
239000011734 sodium Substances 0.000 title 1
229910052708 sodium Inorganic materials 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/19—Purine radicals with arabinosyl as the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20002962A 1997-12-11 2000-06-09 Fremgangsmate for fremstilling av fludarabinfosfatlitium-, - natrium-, -kalium-, -kalsium- og -magnesiumsalter, fremgangsmate for rensing avfludarabinfosfat, og fludarabinfosfat som er minst 99,5% rent NO315324B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19756289		1997-12-11
PCT/EP1998/007651 WO1999029710A2 (de)	1997-12-11	1998-11-30	Reinigungsverfahren zur herstellung von fludarabin-phosphat

Publications (3)

Publication Number	Publication Date
NO20002962L true NO20002962L (no)	2000-06-09
NO20002962D0 NO20002962D0 (no)	2000-06-09
NO315324B1 NO315324B1 (no)	2003-08-18

Family

ID=7852365

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20002962A NO315324B1 (no)	1997-12-11	2000-06-09	Fremgangsmate for fremstilling av fludarabinfosfatlitium-, - natrium-, -kalium-, -kalsium- og -magnesiumsalter, fremgangsmate for rensing avfludarabinfosfat, og fludarabinfosfat som er minst 99,5% rent

Country Status (20)

Country	Link
US (2)	US6046322A (no)
EP (1)	EP1047704B2 (no)
JP (2)	JP4261051B2 (no)
KR (2)	KR100532898B1 (no)
AT (2)	ATE231880T1 (no)
AU (1)	AU739574B2 (no)
CA (1)	CA2313486A1 (no)
CZ (1)	CZ296366B6 (no)
DE (2)	DE29825173U1 (no)
DK (1)	DK1047704T4 (no)
ES (1)	ES2190136T5 (no)
HU (1)	HU226997B1 (no)
IL (1)	IL136283A (no)
NO (1)	NO315324B1 (no)
PL (1)	PL195712B1 (no)
SI (1)	SI1047704T2 (no)
SK (1)	SK283475B6 (no)
TW (1)	TW424093B (no)
WO (1)	WO1999029710A2 (no)
ZA (1)	ZA9811338B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4261051B2 (ja)	1997-12-11	2009-04-30	バイエル・シエーリング・ファーマアクチエンゲゼルシャフト	リン酸フルダラビンのリチウム、ナトリウム、カリウム、カルシウム及びマグネシウム塩の製造方法、リン酸フルダラビンを製造するための精製方法及び少なくとも９９．５％の純度を有するリン酸フルダラビン
KR100381930B1 (ko) *	2000-03-16	2003-04-26	(주)바이오니아	유전자 변형 농산물 검출방법 및 검출용 프라이머
CA2469623C (en)	2001-12-12	2012-05-29	F H Faulding & Co Limited	Composition for the preservation of viruses
DE10164510A1 (de) *	2001-12-20	2003-07-10	Schering Ag	Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
CA2487070A1 (en) *	2002-05-24	2003-12-04	Sicor Inc.	Aqueous fludarabine phosphate composition
EP1464708A1 (en) *	2003-04-03	2004-10-06	Pro. Bio. Sint. S.p.A.	A process for the preparation of fludarabine phosphate from 2-fluoroadenine
US7698201B2 (en) *	2006-09-14	2010-04-13	The Prudential Insurance Company Of America	Financial instrument utilizing an optional benefit election
CN103040855B (zh) *	2012-12-28	2014-05-14	海南锦瑞制药股份有限公司	一种磷酸氟达拉滨的药物组合物及其制备方法
US10669302B2 (en) *	2015-08-28	2020-06-02	Zhejianf Hisun Pharmaceutical Co., Ltd.	Crystal form of fludarabine phosphate, preparation method therefor, and application thereof
CN109265505A (zh) *	2018-09-12	2019-01-25	连云港杰瑞药业有限公司	一种磷酸氟达拉滨异构体杂质的合成方法
WO2025038371A1 (en) *	2023-08-11	2025-02-20	Purdue Research Foundation	Salt-loaded solid lipid nanoparticles loaded with an active agent

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE756704A (fr)	1969-09-26	1971-03-01	Parke Davis & Co	Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
US4188378A (en) *	1978-01-04	1980-02-12	The United States Of America As Represented By The Department Of Health, Education And Welfare	Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4210745A (en) *	1978-01-04	1980-07-01	The United States Of America As Represented By The Department Of Health, Education And Welfare	Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) *	1981-02-24	1982-11-02	The United States Of America As Represented By The Department Of Health And Human Services	Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
DE3323621A1 (de)	1982-07-08	1984-03-01	Yamasa Shoyu K.K., Choshi, Chiba	Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier
US5110919A (en) *	1989-12-04	1992-05-05	Ash Stevens, Inc.	Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
DE69129971T2 (de) *	1990-06-27	1998-12-24	Ash Stevens Inc., Detroit, Mich.	Verfahren zur herstellung von 9-beta-d-arabinofuranosyl-2-fluoroadenin 5'-phosphaten
US5602246A (en)	1992-11-25	1997-02-11	Schering Aktiengesellschaft	Process for the preparation of fludarabine or fludarabine phosphate from guanosine
FR2701027B1 (fr) *	1993-02-01	1997-07-18	Warner Lambert Co	Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
DE19543052A1 (de) *	1995-11-06	1997-05-07	Schering Ag	Verfahren zur Herstellung und Reinigung von Fludarabin-Phosphat und die Verwendung von sauren Ionenaustauschern im Verfahren
IT1276126B1 (it)	1995-11-14	1997-10-27	Archimica Spa	Procedimento per la preparazine di 9-((2-idrossietossi)metil) guanina
JP4261051B2 (ja)	1997-12-11	2009-04-30	バイエル・シエーリング・ファーマアクチエンゲゼルシャフト	リン酸フルダラビンのリチウム、ナトリウム、カリウム、カルシウム及びマグネシウム塩の製造方法、リン酸フルダラビンを製造するための精製方法及び少なくとも９９．５％の純度を有するリン酸フルダラビン
US6174873B1 (en)	1998-11-04	2001-01-16	Supergen, Inc.	Oral administration of adenosine analogs

1998
- 1998-11-30 JP JP2000524302A patent/JP4261051B2/ja not_active Expired - Fee Related
- 1998-11-30 EP EP98965703A patent/EP1047704B2/de not_active Expired - Lifetime
- 1998-11-30 PL PL98341659A patent/PL195712B1/pl unknown
- 1998-11-30 KR KR10-2000-7006262A patent/KR100532898B1/ko not_active Expired - Fee Related
- 1998-11-30 IL IL136283A patent/IL136283A/en not_active IP Right Cessation
- 1998-11-30 CZ CZ20002159A patent/CZ296366B6/cs not_active IP Right Cessation
- 1998-11-30 ES ES98965703T patent/ES2190136T5/es not_active Expired - Lifetime
- 1998-11-30 SI SI9830374T patent/SI1047704T2/sl unknown
- 1998-11-30 HU HU0100169A patent/HU226997B1/hu not_active IP Right Cessation
- 1998-11-30 SK SK887-2000A patent/SK283475B6/sk not_active IP Right Cessation
- 1998-11-30 AU AU21550/99A patent/AU739574B2/en not_active Ceased
- 1998-11-30 DK DK98965703T patent/DK1047704T4/da active
- 1998-11-30 WO PCT/EP1998/007651 patent/WO1999029710A2/de not_active Ceased
- 1998-11-30 KR KR1020057012396A patent/KR20050085937A/ko not_active Ceased
- 1998-11-30 CA CA002313486A patent/CA2313486A1/en not_active Abandoned
- 1998-11-30 AT AT98965703T patent/ATE231880T1/de active
- 1998-11-30 DE DE29825173U patent/DE29825173U1/de not_active Expired - Lifetime
- 1998-11-30 DE DE59807096T patent/DE59807096D1/de not_active Expired - Lifetime
- 1998-12-10 ZA ZA9811338A patent/ZA9811338B/xx unknown
- 1998-12-10 TW TW087120530A patent/TW424093B/zh not_active IP Right Cessation
- 1998-12-10 US US09/208,587 patent/US6046322A/en not_active Expired - Lifetime
1999
- 1999-12-23 US US09/471,040 patent/US7547776B1/en not_active Expired - Fee Related
2000
- 2000-06-09 NO NO20002962A patent/NO315324B1/no not_active IP Right Cessation
2005
- 2005-07-14 AT AT0048105U patent/AT8617U1/de not_active IP Right Cessation
2008
- 2008-10-27 JP JP2008276079A patent/JP2009040797A/ja active Pending

Also Published As

Publication number	Publication date
AU2155099A (en)	1999-06-28
KR20050085937A (ko)	2005-08-29
CZ20002159A3 (cs)	2000-09-13
SK8872000A3 (en)	2001-03-12
HUP0100169A3 (en)	2002-04-29
CA2313486A1 (en)	1999-06-17
SI1047704T2 (sl)	2008-02-29
ATE231880T1 (de)	2003-02-15
JP4261051B2 (ja)	2009-04-30
EP1047704B1 (de)	2003-01-29
IL136283A0 (en)	2001-05-20
NO315324B1 (no)	2003-08-18
ES2190136T3 (es)	2003-07-16
JP2009040797A (ja)	2009-02-26
HU226997B1 (en)	2010-04-28
EP1047704B2 (de)	2007-11-07
DK1047704T3 (da)	2003-06-23
KR100532898B1 (ko)	2005-12-05
SK283475B6 (sk)	2003-08-05
AT8617U1 (de)	2006-10-15
DE59807096D1 (de)	2003-03-06
US6046322A (en)	2000-04-04
EP1047704A2 (de)	2000-11-02
DK1047704T4 (da)	2008-03-25
HUP0100169A1 (hu)	2001-11-28
PL341659A1 (en)	2001-04-23
NO20002962D0 (no)	2000-06-09
KR20010032919A (ko)	2001-04-25
WO1999029710A3 (de)	1999-09-10
US7547776B1 (en)	2009-06-16
TW424093B (en)	2001-03-01
ES2190136T5 (es)	2008-03-01
DE29825173U1 (de)	2005-12-22
ZA9811338B (en)	1999-06-10
PL195712B1 (pl)	2007-10-31
CZ296366B6 (cs)	2006-02-15
AU739574B2 (en)	2001-10-18
SI1047704T1 (en)	2004-02-29
WO1999029710A2 (de)	1999-06-17
JP2001525418A (ja)	2001-12-11
IL136283A (en)	2006-10-31
HK1033831A1 (en)	2001-09-28

Legal Events

Date	Code	Title	Description
2014-06-23	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
EP0780370A3 (de)	1997-08-27	Verfahren zur Herstellung von D,L-Methionin oder dessen Salzen
NO20002962D0 (no)	2000-06-09	FremgangsmÕte for fremstilling av fludarabinfosfatlium-, - natrium-, -kalium-, -kalsium- og -magnesiumsalter, fremgangsmÕte for rensing av fludarabinfosfat, og fludarabinfosfat som er minst 99,5% rent
IL70882A0 (en)	1984-05-31	Certain benzazocinone and benzazoninone derivatives
ATE334993T1 (de)	2006-08-15	Hydratformen des natriumsalzes von alendronat, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die diese enthalten
IL141328A0 (en)	2002-03-10	Pantoprazole magnesium dihydrat
FI972150A7 (fi)	1997-05-20	Menetelmä kalsiumkarbonaatin puhdistamiseksi
IT8748394A0 (it)	1987-09-16	E la prevenzione della osteoporosi composizione di fluoro e calcio a e simili affezioni ossee lento rilascio, per il trattamento
BR9407743A (pt)	1997-02-12	Composiçao oral de peróxido de cálcio-bicarbonato
NO986086D0 (no)	1998-12-23	FremgangsmÕte for fremstilling av 17-estere av 9<alfa>,21-dihalo-pregnan-11
AU1945495A (en)	1995-10-03	Acid addition salts of 2,3,4,5-tetrahydro-1h-3-benzazepine compounds
FI945596A7 (fi)	1995-01-25	Kvartäärisiä typpipitoisia fosfonaattiyhdisteitä epänormaalin kalsium- ja fosfaattiyhdisteitä epänormaalin kalsium- ja fosfaattiaineenvaihdunnan sekä hammaskiven ja hammastäplän hoitamiseksi
NO964350L (no)	1998-04-14	Fremgangsmåte for fremstilling av magnesiumkloridgranuler
FI945322L (fi)	1995-05-16	Menetelmä 2',3'-didehydro-2',3'-dideoksinukleosidien laajamittaista valmistusta varten
ITMI940419A0 (it)	1994-03-08	Procedimento per il trattamento di rifiuti solidi urbani, nonche' impianto per la sua realizzazione
NL1000834C2 (nl)	1996-06-17	Werkwijze voor de bereiding van watervrij natriumcarbonaat.
NO20006393L (no)	2001-02-15	Enantiomerisk rene substituerte oksa-aza forbindelser, salter av de samme og fremgangsmåter for deres fremstilling
FR2708203B1 (fr)	1995-09-22	Procédé d'inhibition de la perception des odeurs.
AUPO646097A0 (en)	1997-05-22	Production of potassium and calcium salts from saline wastewaters
FR2740968B1 (fr)	1998-01-30	Ligament artificiel, notamment pour la cheville
PL346536A1 (en)	2002-02-11	Process for the preparation of calcium hydroxyalkane sulphonates
FI973836A0 (fi)	1997-09-29	Enfasig gipsbaeddsprocess foer produktion av kaliumsalter
FI951566A0 (fi)	1995-04-03	Menetelmä natriumkarbonaatin käsittelemiseksi
HUP9700988A3 (en)	1999-08-30	Backing industrial product, short of sodium, with calcium, potassium magnesium and/or selene
ZA968383B (en)	1997-08-01	Composition for treatment of osteoporosis.
NO981135D0 (no)	1998-03-13	Syreaddisjonssalter av 2,3,4,5-tetrahydro-1H-3-benzazepinforbindelser