ATE234308T1 - 3'-epi k-252a derivate - Google Patents

3'-epi k-252a derivate

Info

Publication number: ATE234308T1
Authority: AT; Austria
Prior art keywords: epi; derivatives; compounds; survival; enhancement
Prior art date: 1997-12-31

Application number

AT98964309T

Other languages

English (en)

Inventor

Robert L Hudkins

Diane E Gingrich

Original Assignee

Cephalon Inc

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-12-31

Filing date

1998-12-30

Publication date

2003-03-15

1998-12-30 Application filed by Cephalon Inc, Kyowa Hakko Kogyo Kk filed Critical Cephalon Inc

2003-03-15 Application granted granted Critical

2003-03-15 Publication of ATE234308T1 publication Critical patent/ATE234308T1/de

Links

KOZFSFOOLUUIGY-IYYJOCMQSA-N k-252a, nocardiopsis sp. Chemical compound C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@@H]1C[C@](C(=O)OC)(O)[C@@]4(C)O1 KOZFSFOOLUUIGY-IYYJOCMQSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
102000004022 Protein-Tyrosine Kinases Human genes 0.000 abstract 1
108090000412 Protein-Tyrosine Kinases Proteins 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
210000002932 cholinergic neuron Anatomy 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1
230000001228 trophic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

AT98964309T 1997-12-31 1998-12-30 3'-epi k-252a derivate ATE234308T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7026397P	1997-12-31	1997-12-31
PCT/US1998/027644 WO1999033836A1 (en)	1997-12-31	1998-12-30	3'-epimeric k-252a derivatives

Publications (1)

Publication Number	Publication Date
ATE234308T1 true ATE234308T1 (de)	2003-03-15

Family

ID=22094212

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98964309T ATE234308T1 (de)	1997-12-31	1998-12-30	3'-epi k-252a derivate

Country Status (15)

Country	Link
US (2)	US6093713A (de)
EP (1)	EP1044203B1 (de)
JP (1)	JP4405667B2 (de)
KR (1)	KR20010033737A (de)
CN (1)	CN1285836A (de)
AT (1)	ATE234308T1 (de)
AU (1)	AU1947499A (de)
BR (1)	BR9814543A (de)
CA (1)	CA2315953C (de)
DE (1)	DE69812177T2 (de)
DK (1)	DK1044203T3 (de)
ES (1)	ES2194385T3 (de)
NO (1)	NO20003397L (de)
PT (1)	PT1044203E (de)
WO (1)	WO1999033836A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2431187A1 (en) *	2000-12-08	2002-06-13	Ortho-Mcneil Pharmaceutical, Inc.	Macroheterocylic compounds useful as kinase inhibitors
US7018999B2 (en)	2001-05-16	2006-03-28	Cephalon, Inc.	Methods for the treatment and prevention of pain
DE60212836T2 (de) *	2001-05-16	2007-01-25	Gpc Biotech Ag	Pyridylpyrimidin-derivate als wirksame verbindungen gegen prionen-krankheiten
DE10161940A1 (de) *	2001-12-17	2003-07-03	Nad Ag	N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren
US6723844B1 (en) *	2003-02-27	2004-04-20	Abbott Laboratories	Preparation of K-252a
DE102004025726B4 (de) *	2004-05-26	2006-07-06	Roder, Hanno, Dr.	Verwendung eines spezifischen K252a-Derivats zur Verhinderung oder Behandlung der Alzheimerschen Krankheit
US20060058250A1 (en) *	2004-09-10	2006-03-16	Cephalon, Inc.	Methods of treating proliferative skin diseases using carbazole derivatives
US20080021013A1 (en) *	2006-07-21	2008-01-24	Cephalon, Inc.	JAK inhibitors for treatment of myeloproliferative disorders
WO2008076394A1 (en) *	2006-12-14	2008-06-26	Tautatis, Inc.	Compositions and methods for the treatment of cancer

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62155284A (ja) *	1985-12-27	1987-07-10	Kyowa Hakko Kogyo Co Ltd	生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja)	1987-01-22	1996-03-13	協和醗酵工業株式会社	生理活性物質ｋ−２５２の誘導体
EP0303697B1 (de) *	1987-03-09	1997-10-01	Kyowa Hakko Kogyo Co., Ltd.	Derivate des physiologisch aktiven mittels k-252
US5461146A (en) *	1992-07-24	1995-10-24	Cephalon, Inc.	Selected protein kinase inhibitors for the treatment of neurological disorders
US5621100A (en) *	1992-07-24	1997-04-15	Cephalon, Inc.	K-252a derivatives for treatment of neurological disorders
EP0839814A3 (de)	1993-05-28	1998-09-16	Cephalon, Inc.	Indolocarbazolderivate und ihre Verwendung zur Behandlung von Störungen der Vorsteherdrüse
US5468872A (en) *	1993-09-16	1995-11-21	Cephalon, Inc.	K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
ES2157331T3 (es) *	1994-07-04	2001-08-16	Kyowa Hakko Kogyo Kk	Procedimiento de produccion de un derivado de indolocarbazol.
WO1997005140A1 (en)	1995-07-31	1997-02-13	Novartis Ag	Trindene compounds
WO1997007081A2 (en)	1995-08-11	1997-02-27	Yale University	Glycosylated indolocarbazole synthesis

1998
- 1998-12-30 EP EP98964309A patent/EP1044203B1/de not_active Expired - Lifetime
- 1998-12-30 DK DK98964309T patent/DK1044203T3/da active
- 1998-12-30 US US09/223,518 patent/US6093713A/en not_active Expired - Lifetime
- 1998-12-30 DE DE69812177T patent/DE69812177T2/de not_active Expired - Lifetime
- 1998-12-30 KR KR1020007007260A patent/KR20010033737A/ko not_active Withdrawn
- 1998-12-30 BR BR9814543-6A patent/BR9814543A/pt not_active Application Discontinuation
- 1998-12-30 JP JP2000526515A patent/JP4405667B2/ja not_active Expired - Fee Related
- 1998-12-30 PT PT98964309T patent/PT1044203E/pt unknown
- 1998-12-30 WO PCT/US1998/027644 patent/WO1999033836A1/en not_active Ceased
- 1998-12-30 ES ES98964309T patent/ES2194385T3/es not_active Expired - Lifetime
- 1998-12-30 AU AU19474/99A patent/AU1947499A/en not_active Abandoned
- 1998-12-30 CA CA2315953A patent/CA2315953C/en not_active Expired - Fee Related
- 1998-12-30 AT AT98964309T patent/ATE234308T1/de not_active IP Right Cessation
- 1998-12-30 CN CN98812812A patent/CN1285836A/zh active Pending
2000
- 2000-02-15 US US09/503,812 patent/US6451786B1/en not_active Expired - Fee Related
- 2000-06-29 NO NO20003397A patent/NO20003397L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU1947499A (en)	1999-07-19
DK1044203T3 (da)	2003-07-14
NO20003397D0 (no)	2000-06-29
WO1999033836A1 (en)	1999-07-08
CA2315953C (en)	2010-11-09
PT1044203E (pt)	2003-07-31
ES2194385T3 (es)	2003-11-16
JP2001527079A (ja)	2001-12-25
EP1044203A1 (de)	2000-10-18
DE69812177D1 (de)	2003-04-17
NO20003397L (no)	2000-08-31
CN1285836A (zh)	2001-02-28
KR20010033737A (ko)	2001-04-25
DE69812177T2 (de)	2004-01-15
BR9814543A (pt)	2000-10-10
JP4405667B2 (ja)	2010-01-27
CA2315953A1 (en)	1999-07-08
EP1044203B1 (de)	2003-03-12
US6093713A (en)	2000-07-25
WO1999033836A9 (en)	2000-09-14
US6451786B1 (en)	2002-09-17

Legal Events

Date

Code

Title

Description

2003-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1044203

Country of ref document: EP

2010-09-15

REN

Ceased due to non-payment of the annual fee

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