NO20003511L - Lipase-inhiberende polymerer - Google Patents
Lipase-inhiberende polymererInfo
- Publication number
- NO20003511L NO20003511L NO20003511A NO20003511A NO20003511L NO 20003511 L NO20003511 L NO 20003511L NO 20003511 A NO20003511 A NO 20003511A NO 20003511 A NO20003511 A NO 20003511A NO 20003511 L NO20003511 L NO 20003511L
- Authority
- NO
- Norway
- Prior art keywords
- inhibiting polymers
- lipase inhibiting
- polymers
- patient
- methods
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 4
- 102000004882 Lipase Human genes 0.000 title abstract 2
- 108090001060 Lipase Proteins 0.000 title abstract 2
- 239000004367 Lipase Substances 0.000 title abstract 2
- 235000019421 lipase Nutrition 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
Det er beskrevet en fremgangsmåte for å behandle fedme i en pasient ved administrering til pasienten en polymer som er blitt substituert med en eller flere grupper som inhiberer lipaser, som har enzymer ansvarlig for hydrolyse av fett. Det er videre beskrevet polymerer anvendt i metodene beskrevet heri samt nye mellom-produkter og fremgangsmåter for fremstilling av polymerene.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US537998A | 1998-01-09 | 1998-01-09 | |
| US09/166,510 US6267952B1 (en) | 1998-01-09 | 1998-10-05 | Lipase inhibiting polymers |
| PCT/US1999/000195 WO1999034786A2 (en) | 1998-01-09 | 1999-01-06 | Lipase inhibiting polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003511D0 NO20003511D0 (no) | 2000-07-07 |
| NO20003511L true NO20003511L (no) | 2000-09-07 |
Family
ID=26674279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003511A NO20003511L (no) | 1998-01-09 | 2000-07-07 | Lipase-inhiberende polymerer |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US6267952B1 (no) |
| EP (1) | EP1043982B1 (no) |
| JP (1) | JP2002500182A (no) |
| KR (1) | KR100620634B1 (no) |
| CN (2) | CN1636574A (no) |
| AT (1) | ATE308979T1 (no) |
| AU (1) | AU747016B2 (no) |
| BR (1) | BR9907233A (no) |
| CA (1) | CA2318416A1 (no) |
| DE (1) | DE69928219T2 (no) |
| DK (1) | DK1043982T3 (no) |
| ES (1) | ES2253872T3 (no) |
| HK (1) | HK1079706A1 (no) |
| HU (1) | HUP0101128A3 (no) |
| IL (1) | IL137098A (no) |
| NO (1) | NO20003511L (no) |
| NZ (1) | NZ505296A (no) |
| PL (1) | PL193453B1 (no) |
| RU (1) | RU2207861C2 (no) |
| WO (1) | WO1999034786A2 (no) |
Families Citing this family (82)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| EP1212097B1 (en) * | 1999-09-10 | 2005-11-16 | The Procter & Gamble Company | Enzyme inhibitors |
| PE20010588A1 (es) * | 1999-09-10 | 2001-06-23 | Procter & Gamble | Conjugados polimericos inhibidores de enzimas proteoliticas y lipoliticas |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| AR025609A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones lipidas solidas |
| EP1132389A1 (en) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | New aza-indolyl derivatives for the treatment of obesity |
| ES2269441T3 (es) * | 2000-06-27 | 2007-04-01 | F. Hoffmann-La Roche Ag | Metodo para la preparacion de una composicion. |
| ATE293477T1 (de) | 2000-07-28 | 2005-05-15 | Hoffmann La Roche | Neue verwendung von lipase-inhibitoren |
| KR100572785B1 (ko) | 2000-07-28 | 2006-04-19 | 에프. 호프만-라 로슈 아게 | 신규한 약학 조성물 |
| CA2417607C (en) | 2000-08-09 | 2008-01-29 | Christine Feinle | Lipase inhibitors for the treatment of dyspepsia |
| US6900226B2 (en) | 2000-09-06 | 2005-05-31 | Hoffman-La Roche Inc. | Neuropeptide Y antagonists |
| US7473691B2 (en) * | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| US6660731B2 (en) * | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| AU2001290912A1 (en) | 2000-09-15 | 2002-03-26 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2002044152A1 (en) | 2000-10-16 | 2002-06-06 | F. Hoffmann-La Roche Ag | Indoline derivatives and their use as 5-ht2 receptor ligands |
| GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
| BR0116493A (pt) * | 2000-12-21 | 2003-09-30 | Vertex Pharma | Compostos de pirazol úteis como inibidores de proteìna cinase |
| BR0116605A (pt) | 2000-12-27 | 2003-09-30 | Hoffmann La Roche | Composto, processo para a preparação de um composto, composição farmacêutica que compreende o mesmo, sua utilização e processo para o tratamento e profilaxia de distúrbios do sistema nervoso central, distúrbios cardiovasculares, distúrbios gastrintestinais e apnéia do sono |
| GB0106177D0 (en) | 2001-03-13 | 2001-05-02 | Hoffmann La Roche | Piperazine derivatives |
| AU2002338896B2 (en) | 2001-05-21 | 2006-04-27 | F.Hoffman-La Roche Ag | Quinoline derivatives as ligands for the neuropeptide Y receptor |
| US20030027786A1 (en) | 2001-06-06 | 2003-02-06 | Karsten Maeder | Lipase inhibiting composition |
| US6787558B2 (en) | 2001-09-28 | 2004-09-07 | Hoffmann-La Roche Inc. | Quinoline derivatives |
| GB0202015D0 (en) | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| PL372295A1 (en) | 2002-02-04 | 2005-07-11 | F.Hoffmann-La Roche Ag | Quinoline derivatives as npy antagonists |
| KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Gsk-3의 억제제로서 유용한 헤테로아릴 화합물 |
| WO2003070907A2 (en) * | 2002-02-19 | 2003-08-28 | The Procter & Gamble Company | Novel fungal lipase |
| BR0308108A (pt) | 2002-02-28 | 2004-12-07 | Hoffmann La Roche | Compostos; processo para a preparação de composto; composição farmacêutica que compreende o mesmo, utilização dos compostos e método de tratamento e profilaxia de enfermidades e de obesidade |
| US20040009981A1 (en) * | 2002-03-15 | 2004-01-15 | David Bebbington | Compositions useful as inhibitors of protein kinases |
| AU2003223930A1 (en) * | 2002-06-14 | 2003-12-31 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| CA2489251A1 (en) | 2002-07-05 | 2004-01-15 | F. Hoffmann-La Roche Ag | Quinazoline derivatives |
| MXPA05001367A (es) | 2002-08-02 | 2005-04-28 | Vertex Pharma | Composiciones de pirazol utiles como inhibidores de gsk-3. |
| AU2003253364B2 (en) | 2002-08-07 | 2007-06-07 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| AU2003291567A1 (en) * | 2002-11-19 | 2004-06-15 | Genzyme Corporation | Polymeric boronic acid derivatives as lipase inhibitors |
| WO2004072029A2 (en) * | 2003-02-06 | 2004-08-26 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridazines useful as inhibitors of protein kinases |
| GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
| CN100393718C (zh) | 2003-08-12 | 2008-06-11 | 霍夫曼-拉罗奇有限公司 | 作为npy拮抗剂的噻唑衍生物 |
| CA2533463A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | 2-amino-5-benzoylthiazole npy antagonists |
| US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
| US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| JP4691041B2 (ja) | 2003-11-20 | 2011-06-01 | チルドレンズ ホスピタル メディカル センター | Gtpアーゼ阻害剤および使用方法 |
| CN1902193B (zh) * | 2003-12-04 | 2011-07-13 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的喹喔啉 |
| US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
| US7462394B2 (en) * | 2004-05-06 | 2008-12-09 | Ppg Industries Ohio, Inc. | Method of stabilizing metal pigments against gassing |
| CN101974125B (zh) * | 2004-07-30 | 2013-09-18 | 巴斯夫欧洲公司 | 聚合物硼酸衍生物及其在造纸中的用途 |
| RU2007119315A (ru) * | 2004-10-25 | 2008-11-27 | Зольвай Фармасьютиклз Гмбх (De) | Фармацевтические композиции, содержащие антагонисты каннабиноидного рецептора св1 и открыватели калиевых каналов, предназначенные для лечения сахарного диабета типа i, ожирения и связанных с ними состояний |
| CA2609634C (en) | 2005-05-03 | 2011-02-01 | F. Hoffmann-La Roche Ag | Tetracyclic azapyrazinoindolines as 5-ht2 ligands |
| WO2007016539A2 (en) | 2005-07-29 | 2007-02-08 | Children's Hospital Medical Center | Gtpase inhibitors and methods of use and crystal structure of rac-1 gtpase |
| DE602006006712D1 (de) | 2005-08-18 | 2009-06-18 | Hoffmann La Roche | Thiazolylpiperidin-derivate nützlich als h3 rezeptor modulatoren |
| US7737151B2 (en) * | 2005-08-18 | 2010-06-15 | Vertex Pharmaceuticals Incorporated | Pyrazine kinase inhibitors |
| AR056499A1 (es) * | 2005-09-06 | 2007-10-10 | Serapis Farmaceuticals Ltd | Compuestos |
| JP5249770B2 (ja) * | 2005-11-03 | 2013-07-31 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼインヒビターとして有用なアミノピリジン |
| ATE507222T1 (de) | 2005-11-30 | 2011-05-15 | Hoffmann La Roche | 1,1-dioxo-thiomorpholinyl-indolyl-methanon- derivate zur verwendung als h3-modulatoren |
| DE602006020482D1 (de) | 2005-11-30 | 2011-04-14 | Hoffmann La Roche | 1,5-substituierte indol-2-yl amidderivative |
| CA2630270A1 (en) | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 5-substituted indole-2-carboxamide derivatives |
| ES2333672T3 (es) | 2005-12-09 | 2010-02-25 | F. Hoffmann-La Roche Ag | Derivados de amida triciclica para tratamiento de obesidad. |
| CN101326187A (zh) | 2005-12-15 | 2008-12-17 | 霍夫曼-拉罗奇有限公司 | 吡咯并[2,3-c]吡啶衍生物 |
| BRPI0619985A2 (pt) | 2005-12-16 | 2011-10-25 | Hoffmann La Roche | compostos, processo para a sua manufatura, composições farmacêuticas, métodos para o tratamento e/ou prevenção de enfermidades que estão associadas com a modulação de receptores de h3, de obesidade e de diabetes do tipo ii em um ser humano ou animal e usos dos compostos |
| US7432255B2 (en) | 2006-05-16 | 2008-10-07 | Hoffmann-La Roche Inc. | 1H-indol-5-yl-piperazin-1-yl-methanone derivatives |
| EP2032554A1 (en) | 2006-05-30 | 2009-03-11 | F. Hoffmann-Roche AG | Piperidinyl pyrimidine derivatives |
| US7514433B2 (en) | 2006-08-03 | 2009-04-07 | Hoffmann-La Roche Inc. | 1H-indole-6-yl-piperazin-1-yl-methanone derivatives |
| CA2668429A1 (en) * | 2006-11-02 | 2008-05-15 | Vertex Pharmaceuticals Incorporated | Aminopyridines and aminopyrimidines useful as inhibitors of protein kinases |
| US20080146559A1 (en) | 2006-12-08 | 2008-06-19 | Li Chen | 4,5,6,7-Tetrahydro-Thieno [2,3-C] Pyridine Derivatives |
| NZ577768A (en) * | 2006-12-19 | 2012-01-12 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases |
| NZ579483A (en) | 2007-03-09 | 2012-07-27 | Vertex Pharma | Aminopyridines useful as inhibitors of protein kinases |
| JP5393489B2 (ja) * | 2007-03-09 | 2014-01-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | 蛋白キナーゼの阻害剤として有用なアミノピリミジン |
| CN101663295B (zh) * | 2007-03-09 | 2014-11-05 | 沃泰克斯药物股份有限公司 | 可用作蛋白激酶抑制剂的氨基嘧啶类化合物 |
| MX2009011059A (es) | 2007-04-13 | 2009-11-26 | Vertex Pharma | Aminopirimidinas utiles como inhibidores de cinasas. |
| CA2688584A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| AU2008247594A1 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| WO2008137619A2 (en) * | 2007-05-02 | 2008-11-13 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
| AU2008257044A1 (en) * | 2007-05-24 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Thiazoles and pyrazoles useful as kinase inhibitors |
| WO2009013195A1 (en) | 2007-07-25 | 2009-01-29 | F. Hoffmann-La Roche Ag | Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators |
| WO2009018415A1 (en) * | 2007-07-31 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1h-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
| US8185398B2 (en) * | 2007-12-31 | 2012-05-22 | Intel-Ge Care Innovations Llc | Reading device with shortcut read function |
| AU2009288200A1 (en) * | 2008-09-03 | 2010-03-11 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical formulations comprising the same |
| CA2792733C (en) * | 2010-03-13 | 2015-06-02 | Eastpond Laboratories Limited | Fat-binding compositions comprising .alpha.- or .beta.-cyclodextrin |
| CN102199172A (zh) * | 2010-03-24 | 2011-09-28 | 金凯美(大连)医药科技有限公司 | 一种1-取代亚磷酰二氯的制备方法 |
| US9980942B2 (en) | 2012-05-02 | 2018-05-29 | Children's Hospital Medical Center | Rejuvenation of precursor cells |
| US10028503B2 (en) | 2014-06-18 | 2018-07-24 | Children's Hospital Medical Center | Platelet storage methods and compositions for same |
| CN114450027A (zh) | 2019-08-16 | 2022-05-06 | 儿童医院医疗中心 | 用cdc42特异性抑制剂治疗受试者的方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7017227A (no) | 1969-12-27 | 1971-06-29 | ||
| US3923972A (en) | 1971-10-12 | 1975-12-02 | Monsanto Co | Method of lowering blood cholesterol level |
| US4211765A (en) * | 1971-10-12 | 1980-07-08 | Monsanto Company | Method for controlling obesity |
| IT1052819B (it) | 1975-12-12 | 1981-07-20 | Fargal Pharmasint Lab Biochim | Preparato inibitore dell assorbimento dei lipidi a base di dietilamminoetildestrano |
| US4265879A (en) | 1977-09-13 | 1981-05-05 | Monsanto Company | Method for controlling blood triglycerides |
| US4218443A (en) | 1979-01-15 | 1980-08-19 | Hoffmann-La Roche Inc. | Polyether ionophores as antiobesity and hypotriglyceridemic agents |
| US4302450A (en) | 1979-01-15 | 1981-11-24 | Hoffmann-La Roche Inc. | Polyether ionophores as antiobesity and hypotriglyceridemic agents |
| CA1213397A (en) | 1980-10-20 | 1986-10-28 | Judith L. Page | Weight control with alkyl styrene polymers |
| US4432968A (en) | 1980-10-20 | 1984-02-21 | The Dow Chemical Company | Weight control with fat imbibing polymers |
| US5597810A (en) | 1984-12-27 | 1997-01-28 | Hoffman; Allan S. | Method for reducing absorption of undesired lipids in the gastrointestinal tract |
| US5200183A (en) | 1987-11-19 | 1993-04-06 | Oklahoma Medical Research Foundation | Recombinant bile salt activated lipases |
| US5089163A (en) | 1989-01-30 | 1992-02-18 | Lever Brothers Company, Division Of Conopco, Inc. | Enzymatic liquid detergent composition |
| US4959179A (en) | 1989-01-30 | 1990-09-25 | Lever Brothers Company | Stabilized enzymes liquid detergent composition containing lipase and protease |
| US5484777A (en) | 1989-04-20 | 1996-01-16 | Lange, Iii; Louis G. | Pancreatic cholesterol esterase inhibitor |
| US5063210A (en) | 1989-04-20 | 1991-11-05 | Lange Iii Louis G | Use of sulfated polysaccharides to decrease cholesterol and fatty acid absorption |
| US5674482A (en) | 1989-08-14 | 1997-10-07 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Polymers with alkyl- or heteroalkyl -aryl backbone and pharmaceutical compositions incorporating same |
| DE69029269T2 (de) | 1989-08-29 | 1997-05-28 | The Regents Of The University Of California, Berkeley, Calif. | Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze |
| US5308766A (en) | 1989-08-29 | 1994-05-03 | The Regents Of The University Of California | Hydrolytic enzyme inhibitors/inactivators and methods for using same |
| US5376640A (en) * | 1989-12-25 | 1994-12-27 | Nisshin Flour Milling Co., Ltd. | Lipolytic enzyme inhibitors |
| US5260310A (en) | 1990-02-26 | 1993-11-09 | Hoffmann-La Roche Inc. | Oxetanone compounds and pharmaceutical compositions containing them |
| DK244090D0 (da) | 1990-10-09 | 1990-10-09 | Novo Nordisk As | Kemiske forbindelser |
| US5137716A (en) | 1990-11-15 | 1992-08-11 | Weisenfeld Michael S | Method of reducing weight in mammals |
| ATE183924T1 (de) | 1992-01-14 | 1999-09-15 | Hisamitsu Pharmaceutical Co | Cholesterinspiegelsenkendes mittel |
| CA2063499C (en) | 1992-03-19 | 1996-06-18 | Leon Edward St. Pierre | Ingestible polymeric phosphonium salts for the lowering of blood cholesterol |
| JP2667351B2 (ja) | 1992-03-24 | 1997-10-27 | 麒麟麦酒株式会社 | 食餌脂質消化吸収阻害剤および飲食品 |
| ATE130193T1 (de) | 1992-03-28 | 1995-12-15 | Hoechst Ag | Arzneimittel aus polyhydroxymethylenderivaten, verfahren zu deren herstellung und verwendung. |
| RU2066185C1 (ru) * | 1993-01-11 | 1996-09-10 | Институт пищевых веществ РАН | Гиполипидемический энтеросорбент |
| US5618530A (en) | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
| US5607669A (en) | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
| US5624963A (en) | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5703188A (en) | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
| US5569452A (en) | 1993-08-31 | 1996-10-29 | Tsrl, Inc. | Pharmaceutical formulation having enhanced bile acid binding affinity |
| US5414068A (en) | 1994-01-24 | 1995-05-09 | Rohm And Haas Company | Crosslinked anion exchange particles and method for producing the particles |
| TW474813B (en) | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
| US5474993A (en) | 1994-06-14 | 1995-12-12 | Sterling Winthrop, Inc. | Lactam inhibitors of cholesterol esterase |
| JPH0859458A (ja) | 1994-08-25 | 1996-03-05 | Zeria Pharmaceut Co Ltd | インダン誘導体を含有する高脂血症治療剤 |
| JP3532999B2 (ja) | 1995-03-24 | 2004-05-31 | 株式会社ロッテ | 新規なタンニン類およびこれを有効成分とするリパーゼ阻害剤 |
| US5993675A (en) * | 1997-12-31 | 1999-11-30 | Hagerthy; Albert P. | Fuel-water separator for marine and diesel engines |
| US6299868B1 (en) * | 1999-07-14 | 2001-10-09 | Geltex Pharmaceuticals, Inc. | Fat-binding polymers |
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| PL193452B1 (pl) * | 1998-01-09 | 2007-02-28 | Genzyme Corp | Kompozycja farmaceutyczna albo zestaw do leczenia otyłości i/lub zmniejszania wchłaniania tłuszczu u ssaka oraz zastosowania |
| US5942500A (en) * | 1998-04-27 | 1999-08-24 | Perry; Stephen C. | Dietary composition to reduce dietary fats |
-
1998
- 1998-10-05 US US09/166,510 patent/US6267952B1/en not_active Expired - Fee Related
-
1999
- 1999-01-06 BR BR9907233-5A patent/BR9907233A/pt not_active Application Discontinuation
- 1999-01-06 CN CNA2004100879814A patent/CN1636574A/zh active Pending
- 1999-01-06 KR KR1020007007607A patent/KR100620634B1/ko not_active Expired - Fee Related
- 1999-01-06 JP JP2000527237A patent/JP2002500182A/ja active Pending
- 1999-01-06 DK DK99901332T patent/DK1043982T3/da active
- 1999-01-06 IL IL137098A patent/IL137098A/en active IP Right Grant
- 1999-01-06 CA CA002318416A patent/CA2318416A1/en not_active Abandoned
- 1999-01-06 HU HU0101128A patent/HUP0101128A3/hu unknown
- 1999-01-06 CN CN99802023A patent/CN1287489A/zh active Pending
- 1999-01-06 DE DE69928219T patent/DE69928219T2/de not_active Expired - Fee Related
- 1999-01-06 ES ES99901332T patent/ES2253872T3/es not_active Expired - Lifetime
- 1999-01-06 AU AU21056/99A patent/AU747016B2/en not_active Ceased
- 1999-01-06 NZ NZ505296A patent/NZ505296A/xx unknown
- 1999-01-06 AT AT99901332T patent/ATE308979T1/de not_active IP Right Cessation
- 1999-01-06 US US09/226,585 patent/US6352692B1/en not_active Expired - Fee Related
- 1999-01-06 EP EP99901332A patent/EP1043982B1/en not_active Expired - Lifetime
- 1999-01-06 PL PL99344022A patent/PL193453B1/pl not_active IP Right Cessation
- 1999-01-06 RU RU2000120917/14A patent/RU2207861C2/ru not_active IP Right Cessation
- 1999-01-06 WO PCT/US1999/000195 patent/WO1999034786A2/en not_active Ceased
-
2000
- 2000-07-07 NO NO20003511A patent/NO20003511L/no not_active Application Discontinuation
- 2000-11-16 US US09/714,541 patent/US6558657B1/en not_active Expired - Fee Related
- 2000-11-16 US US09/714,327 patent/US6572850B1/en not_active Expired - Fee Related
-
2003
- 2003-02-05 US US10/359,458 patent/US6875428B2/en not_active Expired - Fee Related
-
2004
- 2004-10-07 US US10/960,579 patent/US20050085535A1/en not_active Abandoned
-
2005
- 2005-12-29 HK HK05112104.3A patent/HK1079706A1/zh unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1043982T3 (da) | Lipasehammende polymerer | |
| BR9901174A (pt) | Microorganismo pertencente ao gênero klebsiella, ao gênero erwinia ou ao gênero pantoea e processo para produzir ácido l-glutâmico | |
| ATE163972T1 (de) | Verfahren zur bestimmung von mikroorganismen mittels mindestens zwei chromogene | |
| DE68925002D1 (de) | Verfahren zur Herstellung von optisch-aktiven alpha-substituierten organischen Säuren und Mikroorganismen und Enzyme, die dafür verwendet werden. | |
| ATE329047T1 (de) | Stimulierung der homologen rekombination in pflanzlichen organismen mittels rekombinations fördernder enzyme | |
| DE69634699D1 (de) | Methode zur regulation der ligninzusammensetzung in pflanzen | |
| EP0644889A4 (en) | COMPOSITIONS AND METHODS FOR MODULATION OF -g (b) -AMYLOID. | |
| ATE231918T1 (de) | Verfahren zur fermentativen herstellung von l- cystein oder l-cystein-derivaten | |
| CA2256758A1 (en) | Method of producing l-serine by fermentation | |
| WO1998002550A3 (de) | Mikrobielle erzeugung von isopren | |
| AU693827B2 (en) | Enzymatic hydrolysis method for the conversion of C-7 sugar to C-7 hydroxyl taxanes | |
| EP0117553A3 (en) | Heat-resistant lipase | |
| NO860321L (no) | Fremgangsmaate for fremstilling av bakerielt overflate-protein med fibronektin-, fibrinogen-, kollagen- og laminin-bindende egenskaper. | |
| BR9007975A (pt) | Preparacao que apresenta atividade enzimatica processo para produzir a mesma,cepas isoladas de bacillus stearo thermophilus,e processo para o tratamento de polpa de madeira | |
| KR850001279A (ko) | α-아밀라제의 제법 | |
| EP1672061A3 (en) | Nucleotide sequences encoding ACC synthase enzymes | |
| Suzuki et al. | A cold-active esterase with a substrate preference for vinyl esters from a psychrotroph, Acinetobacter sp. strain no. 6: gene cloning, purification, and characterization | |
| HUT63845A (en) | Polyhydroxycyclopentane derivatives, their production and use in therapy | |
| JPH0561910B2 (no) | ||
| DK0759981T3 (da) | Fremgangsmåde til dyrkning af bakterier, der producerer proteiner, som udtrykkes på en temperaturreguleret måde | |
| BR0005307A (pt) | Processo para a produção fermentativa de l-lisina usando bactérias coryneform | |
| ATE153067T1 (de) | Molekulare klonierung und expression von genen, die für lipolytische enzyme kodieren | |
| EP0200565A3 (en) | Method for production of peroxidase | |
| BR0317507A (pt) | Método para a produção de um aminoácido | |
| SE9201006D0 (sv) | Delignifying preparation exhibiting alpha-l-arabino -furanosidase activity, production and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |