NO20003881L - Bibapcitid-baserte farmasøytiske sammensetninger for avbildning og behandling av thromber - Google Patents
Bibapcitid-baserte farmasøytiske sammensetninger for avbildning og behandling av thromberInfo
- Publication number
- NO20003881L NO20003881L NO20003881A NO20003881A NO20003881L NO 20003881 L NO20003881 L NO 20003881L NO 20003881 A NO20003881 A NO 20003881A NO 20003881 A NO20003881 A NO 20003881A NO 20003881 L NO20003881 L NO 20003881L
- Authority
- NO
- Norway
- Prior art keywords
- bibapcitide
- thrombi
- imaging
- treatment
- pharmaceutical compositions
- Prior art date
Links
- 229950010682 bibapcitide Drugs 0.000 title abstract 2
- NQQYGNMPSAJCFD-XZZMYFQKSA-N chembl2106413 Chemical compound C([C@@H]1NC(=O)CSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CSCCCN)NC1=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CS[C@@H]1C(N(COCN2C([C@@H](SC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)CNC(=O)CNC(=O)[C@H]3NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CSCCCN)NC(=O)[C@H](CC=4C=CC(O)=CC=4)NC(=O)CSC3)C(N)=O)CC2=O)=O)C(=O)C1)=O)C(N)=O)C1=CC=C(O)C=C1 NQQYGNMPSAJCFD-XZZMYFQKSA-N 0.000 title abstract 2
- 238000003384 imaging method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 4
- 239000002243 precursor Substances 0.000 abstract 4
- MEMKXPGBFFKUER-NDDSAYQWSA-N O=C1N[C@@H](CSCCCN)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(N)=O)CSCC(=O)N[C@@H]1CC1=CC=C(O)C=C1 Chemical compound O=C1N[C@@H](CSCCCN)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(N)=O)CSCC(=O)N[C@@H]1CC1=CC=C(O)C=C1 MEMKXPGBFFKUER-NDDSAYQWSA-N 0.000 abstract 2
- 239000012216 imaging agent Substances 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 150000007942 carboxylates Chemical group 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Oppfinnelsen tilveiebringer nye forløper-reagenser anvendt for fremstilling av avbildningsmidler avledet fra apcitid. Avbildingsmidler fremstilt ved å anvende. forløper-reagensene ifølge oppfinnelsen er nyttige for in vivo deteksjon og diagnose av thromber. Forløper-reagensene ifølge oppfinnelsen kan også anvendes i fremstilling av anti-thrombosemidler avledet fra apcitid. Nærværet av de frie karboksylatgruppene gir forløper-reagensene større oppløselighet enn bibapcitid i vandige medier.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/020,086 US6028056A (en) | 1998-02-06 | 1998-02-06 | Pharmaceutical compositions for imaging and treating thrombi |
| GB9802681A GB9802681D0 (en) | 1998-02-06 | 1998-02-06 | Pharmaceutical compoations for imaging and treating thrombi |
| PCT/US1999/002583 WO1999039747A1 (en) | 1998-02-06 | 1999-02-05 | Bipapcitide-based pharmaceutical compositions for imaging and treating thrombi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003881D0 NO20003881D0 (no) | 2000-07-28 |
| NO20003881L true NO20003881L (no) | 2000-07-28 |
Family
ID=26313082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003881A NO20003881L (no) | 1998-02-06 | 2000-07-28 | Bibapcitid-baserte farmasøytiske sammensetninger for avbildning og behandling av thromber |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6028056A (no) |
| EP (1) | EP1053027B1 (no) |
| JP (1) | JP2003532617A (no) |
| KR (1) | KR100452390B1 (no) |
| CN (1) | CN1103606C (no) |
| AR (1) | AR018546A1 (no) |
| AT (1) | ATE279214T1 (no) |
| AU (1) | AU761778B2 (no) |
| BR (1) | BR9908352A (no) |
| CA (1) | CA2319544C (no) |
| DE (1) | DE69921096T2 (no) |
| DK (1) | DK1053027T3 (no) |
| EA (1) | EA005406B1 (no) |
| ES (1) | ES2229681T3 (no) |
| HU (1) | HUP0100887A3 (no) |
| IL (1) | IL137076A (no) |
| NO (1) | NO20003881L (no) |
| NZ (1) | NZ505085A (no) |
| PE (1) | PE20000250A1 (no) |
| PL (1) | PL342253A1 (no) |
| PT (1) | PT1053027E (no) |
| SI (1) | SI1053027T1 (no) |
| SK (1) | SK284463B6 (no) |
| TW (1) | TWI246425B (no) |
| WO (1) | WO1999039747A1 (no) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6243335B2 (ja) | 2011-08-17 | 2017-12-06 | ピラマル イメージング ソシエテ アノニム | 血小板固有の糖タンパク質ＩＩｂ／ＩＩＩａに結合する化合物と血栓造影のためのその使用 |
| CA2900595A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| CN117177775A (zh) * | 2021-04-14 | 2023-12-05 | 启德医药科技（苏州）有限公司 | 连接子、缀合物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
-
1998
- 1998-02-06 US US09/020,086 patent/US6028056A/en not_active Expired - Fee Related
-
1999
- 1999-02-04 AR ARP990100462A patent/AR018546A1/es unknown
- 1999-02-05 JP JP2000530244A patent/JP2003532617A/ja not_active Withdrawn
- 1999-02-05 PE PE1999000094A patent/PE20000250A1/es not_active Application Discontinuation
- 1999-02-05 IL IL13707699A patent/IL137076A/en active IP Right Grant
- 1999-02-05 EA EA200000820A patent/EA005406B1/ru not_active IP Right Cessation
- 1999-02-05 KR KR10-2000-7008551A patent/KR100452390B1/ko not_active Expired - Fee Related
- 1999-02-05 AU AU26604/99A patent/AU761778B2/en not_active Ceased
- 1999-02-05 WO PCT/US1999/002583 patent/WO1999039747A1/en not_active Ceased
- 1999-02-05 SI SI9930708T patent/SI1053027T1/xx unknown
- 1999-02-05 PT PT99906771T patent/PT1053027E/pt unknown
- 1999-02-05 CA CA002319544A patent/CA2319544C/en not_active Expired - Fee Related
- 1999-02-05 PL PL99342253A patent/PL342253A1/xx not_active IP Right Cessation
- 1999-02-05 DE DE69921096T patent/DE69921096T2/de not_active Expired - Fee Related
- 1999-02-05 SK SK1139-2000A patent/SK284463B6/sk unknown
- 1999-02-05 ES ES99906771T patent/ES2229681T3/es not_active Expired - Lifetime
- 1999-02-05 NZ NZ505085A patent/NZ505085A/xx unknown
- 1999-02-05 AT AT99906771T patent/ATE279214T1/de not_active IP Right Cessation
- 1999-02-05 CN CN99802698A patent/CN1103606C/zh not_active Expired - Fee Related
- 1999-02-05 DK DK99906771T patent/DK1053027T3/da active
- 1999-02-05 HU HU0100887A patent/HUP0100887A3/hu unknown
- 1999-02-05 BR BR9908352-3A patent/BR9908352A/pt not_active IP Right Cessation
- 1999-02-05 EP EP99906771A patent/EP1053027B1/en not_active Expired - Lifetime
- 1999-02-06 TW TW088101826A patent/TWI246425B/zh not_active IP Right Cessation
-
2000
- 2000-07-28 NO NO20003881A patent/NO20003881L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |