BR9908352A - Reagente precursor, e, composição farmacêutica - Google Patents
Reagente precursor, e, composição farmacêuticaInfo
- Publication number
- BR9908352A BR9908352A BR9908352-3A BR9908352A BR9908352A BR 9908352 A BR9908352 A BR 9908352A BR 9908352 A BR9908352 A BR 9908352A BR 9908352 A BR9908352 A BR 9908352A
- Authority
- BR
- Brazil
- Prior art keywords
- precursor
- pharmaceutical composition
- precursor reagents
- production
- precursor reagent
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 6
- 239000002243 precursor Substances 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- MEMKXPGBFFKUER-NDDSAYQWSA-N O=C1N[C@@H](CSCCCN)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(N)=O)CSCC(=O)N[C@@H]1CC1=CC=C(O)C=C1 Chemical compound O=C1N[C@@H](CSCCCN)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(N)=O)CSCC(=O)N[C@@H]1CC1=CC=C(O)C=C1 MEMKXPGBFFKUER-NDDSAYQWSA-N 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229960004676 antithrombotic agent Drugs 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 229950010682 bibapcitide Drugs 0.000 abstract 1
- 150000007942 carboxylates Chemical group 0.000 abstract 1
- NQQYGNMPSAJCFD-XZZMYFQKSA-N chembl2106413 Chemical compound C([C@@H]1NC(=O)CSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CSCCCN)NC1=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)NCC(=O)N[C@@H](CSCNC(=O)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CS[C@@H]1C(N(COCN2C([C@@H](SC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)CNC(=O)[C@H](CSCNC(C)=O)NC(=O)CNC(=O)CNC(=O)[C@H]3NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CSCCCN)NC(=O)[C@H](CC=4C=CC(O)=CC=4)NC(=O)CSC3)C(N)=O)CC2=O)=O)C(=O)C1)=O)C(N)=O)C1=CC=C(O)C=C1 NQQYGNMPSAJCFD-XZZMYFQKSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000012216 imaging agent Substances 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
''REAGENTE PRECURSOR, E, COMPOSIçãO FARMACEUTICA'' A invenção proporciona novos reagentes precursores usados na produção de agentes formadores de imagem derivados de apcitídeo. Agentes formadores de imagem preparados usando os reagentes precursores da invenção são úteis para detecção e diagnóstico in vivo de trombos. Os reagentes precursores da invenção também podem ser utilizados na produção de agentes antitrombóticos derivados de apcitídeo. A presença de três grupos carboxilato livres confere aos reagentes precursores solubilidade maior do que a bibapcitídeo em meios aquosos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/020,086 US6028056A (en) | 1998-02-06 | 1998-02-06 | Pharmaceutical compositions for imaging and treating thrombi |
| GB9802681A GB9802681D0 (en) | 1998-02-06 | 1998-02-06 | Pharmaceutical compoations for imaging and treating thrombi |
| PCT/US1999/002583 WO1999039747A1 (en) | 1998-02-06 | 1999-02-05 | Bipapcitide-based pharmaceutical compositions for imaging and treating thrombi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908352A true BR9908352A (pt) | 2000-11-28 |
Family
ID=26313082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908352-3A BR9908352A (pt) | 1998-02-06 | 1999-02-05 | Reagente precursor, e, composição farmacêutica |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US6028056A (pt) |
| EP (1) | EP1053027B1 (pt) |
| JP (1) | JP2003532617A (pt) |
| KR (1) | KR100452390B1 (pt) |
| CN (1) | CN1103606C (pt) |
| AR (1) | AR018546A1 (pt) |
| AT (1) | ATE279214T1 (pt) |
| AU (1) | AU761778B2 (pt) |
| BR (1) | BR9908352A (pt) |
| CA (1) | CA2319544C (pt) |
| DE (1) | DE69921096T2 (pt) |
| DK (1) | DK1053027T3 (pt) |
| EA (1) | EA005406B1 (pt) |
| ES (1) | ES2229681T3 (pt) |
| HU (1) | HUP0100887A3 (pt) |
| IL (1) | IL137076A (pt) |
| NO (1) | NO20003881L (pt) |
| NZ (1) | NZ505085A (pt) |
| PE (1) | PE20000250A1 (pt) |
| PL (1) | PL342253A1 (pt) |
| PT (1) | PT1053027E (pt) |
| SI (1) | SI1053027T1 (pt) |
| SK (1) | SK284463B6 (pt) |
| TW (1) | TWI246425B (pt) |
| WO (1) | WO1999039747A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6243335B2 (ja) | 2011-08-17 | 2017-12-06 | ピラマル イメージング ソシエテ アノニム | 血小板固有の糖タンパク質ＩＩｂ／ＩＩＩａに結合する化合物と血栓造影のためのその使用 |
| CA2900595A1 (en) | 2013-02-12 | 2014-08-21 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
| CN117177775A (zh) * | 2021-04-14 | 2023-12-05 | 启德医药科技（苏州）有限公司 | 连接子、缀合物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
| US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
| US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
| EP0641222B1 (en) * | 1992-05-21 | 2000-09-06 | Diatide, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
-
1998
- 1998-02-06 US US09/020,086 patent/US6028056A/en not_active Expired - Fee Related
-
1999
- 1999-02-04 AR ARP990100462A patent/AR018546A1/es unknown
- 1999-02-05 JP JP2000530244A patent/JP2003532617A/ja not_active Withdrawn
- 1999-02-05 PE PE1999000094A patent/PE20000250A1/es not_active Application Discontinuation
- 1999-02-05 IL IL13707699A patent/IL137076A/en active IP Right Grant
- 1999-02-05 EA EA200000820A patent/EA005406B1/ru not_active IP Right Cessation
- 1999-02-05 KR KR10-2000-7008551A patent/KR100452390B1/ko not_active Expired - Fee Related
- 1999-02-05 AU AU26604/99A patent/AU761778B2/en not_active Ceased
- 1999-02-05 WO PCT/US1999/002583 patent/WO1999039747A1/en not_active Ceased
- 1999-02-05 SI SI9930708T patent/SI1053027T1/xx unknown
- 1999-02-05 PT PT99906771T patent/PT1053027E/pt unknown
- 1999-02-05 CA CA002319544A patent/CA2319544C/en not_active Expired - Fee Related
- 1999-02-05 PL PL99342253A patent/PL342253A1/xx not_active IP Right Cessation
- 1999-02-05 DE DE69921096T patent/DE69921096T2/de not_active Expired - Fee Related
- 1999-02-05 SK SK1139-2000A patent/SK284463B6/sk unknown
- 1999-02-05 ES ES99906771T patent/ES2229681T3/es not_active Expired - Lifetime
- 1999-02-05 NZ NZ505085A patent/NZ505085A/xx unknown
- 1999-02-05 AT AT99906771T patent/ATE279214T1/de not_active IP Right Cessation
- 1999-02-05 CN CN99802698A patent/CN1103606C/zh not_active Expired - Fee Related
- 1999-02-05 DK DK99906771T patent/DK1053027T3/da active
- 1999-02-05 HU HU0100887A patent/HUP0100887A3/hu unknown
- 1999-02-05 BR BR9908352-3A patent/BR9908352A/pt not_active IP Right Cessation
- 1999-02-05 EP EP99906771A patent/EP1053027B1/en not_active Expired - Lifetime
- 1999-02-06 TW TW088101826A patent/TWI246425B/zh not_active IP Right Cessation
-
2000
- 2000-07-28 NO NO20003881A patent/NO20003881L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A E 10A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO1976 DE 18/11/2008. |