NO20004221D0 - FremgangsmÕte for fremstilling av simvastatin og derivater derav - Google Patents

FremgangsmÕte for fremstilling av simvastatin og derivater derav

Info

Publication number: NO20004221D0
Authority: NO; Norway
Prior art keywords: protecting group; formula; preparation; simvastatin; derivatives
Prior art date: 1998-02-26

Application number

NO20004221A

Other languages

English (en)

Other versions

NO326301B1 (no

NO20004221L (no

Inventor

Silvo Zupancic

Anton Stimac

Joze Gnidovec

Original Assignee

Krka Tovarna Zdravil Dd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

2000-08-23

Publication date

2000-08-23

2000-08-23 Application filed by Krka Tovarna Zdravil Dd filed Critical Krka Tovarna Zdravil Dd

2000-08-23 Publication of NO20004221D0 publication Critical patent/NO20004221D0/no

2000-08-23 Publication of NO20004221L publication Critical patent/NO20004221L/no

2008-11-03 Publication of NO326301B1 publication Critical patent/NO326301B1/no

Links

RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title 1
229960002855 simvastatin Drugs 0.000 title 1
125000006239 protecting group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
-1 diol lactone Chemical class 0.000 abstract 3
MCTWTZJPVLRJOU-UHFFFAOYSA-N 1-methyl-1H-imidazole Chemical compound CN1C=CN=C1 MCTWTZJPVLRJOU-UHFFFAOYSA-N 0.000 abstract 1
125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

NO20004221A 1998-02-26 2000-08-23 Fremgangsmate for fremstilling av simvastatin og derivater derav NO326301B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SI9800057A SI9800057A (sl)	1998-02-26	1998-02-26	Postopek za pripravo simvastatina in njegovih derivatov
PCT/SI1999/000006 WO1999043665A1 (en)	1998-02-26	1999-02-24	Process for the preparation of simvastatin and derivatives thereof

Publications (3)

Publication Number	Publication Date
NO20004221D0 true NO20004221D0 (no)	2000-08-23
NO20004221L NO20004221L (no)	2000-08-23
NO326301B1 NO326301B1 (no)	2008-11-03

Family

ID=20432210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20004221A NO326301B1 (no)	1998-02-26	2000-08-23	Fremgangsmate for fremstilling av simvastatin og derivater derav

Country Status (18)

Country	Link
US (1)	US6252091B1 (no)
EP (1)	EP1056737B1 (no)
AT (1)	ATE243207T1 (no)
AU (1)	AU3284699A (no)
BG (1)	BG64826B1 (no)
CZ (1)	CZ297405B6 (no)
DE (1)	DE69908909T2 (no)
EA (1)	EA002370B1 (no)
EE (1)	EE04345B1 (no)
HR (1)	HRP20000467B1 (no)
HU (1)	HU227916B1 (no)
NO (1)	NO326301B1 (no)
PL (1)	PL194713B1 (no)
RS (1)	RS49712B (no)
SI (1)	SI9800057A (no)
SK (1)	SK284137B6 (no)
UA (1)	UA56303C2 (no)
WO (1)	WO1999043665A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI20116A (sl) *	1998-12-02	2000-06-30	LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d.	Nov postopek za pripravo simvastatina in njegovih analogov
WO2000034264A1 (en) *	1998-12-10	2000-06-15	Kaneka Corporation	Process for producing simvastatin
AU2127500A (en)	1999-11-11	2001-06-06	Biocon India Limited	Process for manufacturing simvastatin and the novel intermediates
US6573385B1 (en)	1999-11-11	2003-06-03	Biocon India Limited	Process for manufacturing simvastatin and novel intermediates thereof
HUP0302963A3 (en)	2000-07-27	2004-03-01	Plus Chemicals Bv	Ighly purified simvastatin compositions
US6603022B1 (en)	2002-05-10	2003-08-05	Biocon India Limited	Process for manufacturing Simvastatin and novel intermediates thereof
SK285772B6 (sk) *	2002-11-20	2007-08-02	Zentiva, A. S.	Spôsob prípravy simvastatínu
CN102070587B (zh) *	2011-01-13	2015-10-14	广东东阳光药业有限公司	一锅法制备辛伐他汀的方法
US9499621B2 (en)	2013-04-08	2016-11-22	Cytodyn, Inc.	Felinized antibodies and methods of treating retroviral infections in felines
CN104311517B (zh) *	2014-10-17	2017-06-06	上海应用技术学院	他汀内酯脱水化合物及其用途
CN104356120B (zh) *	2014-10-17	2017-05-03	上海应用技术学院	多取代喹啉类他汀内酯脱水化合物及其用途
CN105111173B (zh) *	2015-06-26	2017-06-23	上海应用技术学院	他汀含氟衍生物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU535944B2 (en)	1979-06-15	1984-04-12	Merck & Co., Inc.	Hypocholestermic fermentation products from aspergillus
AU548996B2 (en) *	1980-02-04	1986-01-09	Merck & Co., Inc.	Tetrahydro-2h-pyran-2-one derivatives
US4444784A (en) *	1980-08-05	1984-04-24	Merck & Co., Inc.	Antihypercholesterolemic compounds
DE3480923D1 (de) *	1983-10-11	1990-02-08	Merck & Co Inc	Verfahren zur c-methylierung von 2-methylbutyraten.
US4845237A (en) *	1987-04-15	1989-07-04	Merck & Co., Inc.	Acylation process for the synthesis of HMG-CoA reductase inhibitors
US4820850A (en) *	1987-07-10	1989-04-11	Merck & Co., Inc.	Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
CA2036962C (en)	1990-02-26	1998-09-15	Ann E. Decamp	Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5223415A (en) *	1990-10-15	1993-06-29	Merck & Co., Inc.	Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
SI9500238A (en)	1995-07-27	1997-02-28	Krka Tovarna Zdravil	Procedure for the production of lovastatin

1998
- 1998-02-26 SI SI9800057A patent/SI9800057A/sl unknown
1999
- 1999-02-24 PL PL99342511A patent/PL194713B1/pl unknown
- 1999-02-24 CZ CZ20002857A patent/CZ297405B6/cs not_active IP Right Cessation
- 1999-02-24 EA EA200000881A patent/EA002370B1/ru not_active IP Right Cessation
- 1999-02-24 HU HU0100743A patent/HU227916B1/hu not_active IP Right Cessation
- 1999-02-24 SK SK1258-2000A patent/SK284137B6/sk not_active IP Right Cessation
- 1999-02-24 AU AU32846/99A patent/AU3284699A/en not_active Abandoned
- 1999-02-24 EP EP99936072A patent/EP1056737B1/en not_active Expired - Lifetime
- 1999-02-24 UA UA2000095504A patent/UA56303C2/uk unknown
- 1999-02-24 AT AT99936072T patent/ATE243207T1/de not_active IP Right Cessation
- 1999-02-24 WO PCT/SI1999/000006 patent/WO1999043665A1/en not_active Ceased
- 1999-02-24 RS YUP-466/00A patent/RS49712B/sr unknown
- 1999-02-24 DE DE69908909T patent/DE69908909T2/de not_active Expired - Lifetime
- 1999-02-24 HR HR20000467A patent/HRP20000467B1/xx not_active IP Right Cessation
- 1999-02-24 EE EEP200000479A patent/EE04345B1/xx not_active IP Right Cessation
2000
- 2000-08-23 NO NO20004221A patent/NO326301B1/no not_active IP Right Cessation
- 2000-09-05 BG BG104749A patent/BG64826B1/bg unknown
- 2000-09-22 US US09/668,101 patent/US6252091B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EE04345B1 (et)	2004-08-16
UA56303C2 (uk)	2003-05-15
WO1999043665A1 (en)	1999-09-02
BG104749A (en)	2001-04-30
HUP0100743A2 (hu)	2001-11-28
NO326301B1 (no)	2008-11-03
CZ297405B6 (cs)	2006-12-13
SK284137B6 (sk)	2004-09-08
DE69908909T2 (de)	2003-12-04
HRP20000467A2 (en)	2001-02-28
DE69908909D1 (de)	2003-07-24
US6252091B1 (en)	2001-06-26
RS49712B (sr)	2007-12-31
PL194713B1 (pl)	2007-06-29
ATE243207T1 (de)	2003-07-15
CZ20002857A3 (cs)	2000-11-15
EA200000881A1 (ru)	2001-02-26
EP1056737A1 (en)	2000-12-06
YU46600A (sh)	2003-12-31
EE200000479A (et)	2002-02-15
PL342511A1 (en)	2001-06-18
SK12582000A3 (sk)	2002-01-07
EP1056737B1 (en)	2003-06-18
AU3284699A (en)	1999-09-15
HUP0100743A3 (en)	2002-04-29
HU227916B1 (en)	2012-06-28
NO20004221L (no)	2000-08-23
EA002370B1 (ru)	2002-04-25
SI9800057A (sl)	1999-08-31
BG64826B1 (bg)	2006-05-31
HRP20000467B1 (en)	2009-02-28

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Legal Events

Date	Code	Title	Description
2014-09-22	MM1K	Lapsed by not paying the annual fees