NO20005668L - Forbindelser med veksthormonfrigjörende egenskaper - Google Patents

Forbindelser med veksthormonfrigjörende egenskaper

Info

Publication number
NO20005668L
NO20005668L NO20005668A NO20005668A NO20005668L NO 20005668 L NO20005668 L NO 20005668L NO 20005668 A NO20005668 A NO 20005668A NO 20005668 A NO20005668 A NO 20005668A NO 20005668 L NO20005668 L NO 20005668L
Authority
NO
Norway
Prior art keywords
compounds
growth hormone
hormone releasing
releasing properties
disubstituted
Prior art date
Application number
NO20005668A
Other languages
English (en)
Other versions
NO20005668D0 (no
NO318080B1 (no
Inventor
Thomas Kruse Hansen
Michael Ankersen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of NO20005668D0 publication Critical patent/NO20005668D0/no
Publication of NO20005668L publication Critical patent/NO20005668L/no
Publication of NO318080B1 publication Critical patent/NO318080B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
NO20005668A 1998-05-11 2000-11-10 4,4- og 3,3-disubstiterte piperidin-forbindelser med veksthormonfrigjorende egenskaper,farmasoytiske preparater som omfatter forbindelsene, samt anvendelse av forbindelsene eller preparatene til fremstilling av medikamenter NO318080B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK63698 1998-05-11
DKPA199800875 1998-07-01
PCT/DK1999/000260 WO1999058501A1 (en) 1998-05-11 1999-05-10 Compounds with growth hormone releasing properties

Publications (3)

Publication Number Publication Date
NO20005668D0 NO20005668D0 (no) 2000-11-10
NO20005668L true NO20005668L (no) 2001-01-10
NO318080B1 NO318080B1 (no) 2005-01-31

Family

ID=26064372

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20005668A NO318080B1 (no) 1998-05-11 2000-11-10 4,4- og 3,3-disubstiterte piperidin-forbindelser med veksthormonfrigjorende egenskaper,farmasoytiske preparater som omfatter forbindelsene, samt anvendelse av forbindelsene eller preparatene til fremstilling av medikamenter

Country Status (23)

Country Link
EP (1) EP1077941B1 (no)
JP (2) JP4142253B2 (no)
KR (1) KR100593601B1 (no)
CN (1) CN1142911C (no)
AT (1) ATE439346T1 (no)
AU (1) AU757217B2 (no)
BR (1) BR9910329A (no)
CA (1) CA2329881C (no)
CY (1) CY1109626T1 (no)
CZ (1) CZ301276B6 (no)
DE (1) DE69941255D1 (no)
DK (1) DK1077941T3 (no)
ES (1) ES2331102T3 (no)
HU (1) HUP0102071A3 (no)
IL (2) IL139090A0 (no)
NO (1) NO318080B1 (no)
PL (1) PL194560B1 (no)
PT (1) PT1077941E (no)
RU (1) RU2243215C2 (no)
SI (1) SI1077941T1 (no)
TW (1) TWI222969B (no)
UA (1) UA72210C2 (no)
WO (1) WO1999058501A1 (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7711000A (en) 1999-09-29 2001-04-30 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
UA73530C2 (uk) 1999-11-10 2005-08-15 Ново Нордіск А/С Сполука з властивостями вивільнювати гормон росту
US20010020012A1 (en) * 2000-02-01 2001-09-06 Andersen Maibritt Bansholm Use of compounds for the regulation of food intake
US6656953B2 (en) 2000-12-06 2003-12-02 Sepracor Inc. 4,4-Disubstituted piperidines, and methods of use thereof
JP2004532838A (ja) 2001-03-02 2004-10-28 ブリストル−マイヤーズ スクイブ カンパニー メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物
DE10113604A1 (de) * 2001-03-20 2002-10-24 Ibfb Gmbh Privates Inst Fuer B Verfahren zur Spaltung des humanen Wachstumshormons GH
JP2004529918A (ja) 2001-04-09 2004-09-30 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド インテグリンに由来する疾患の治療のためのキナゾリンおよびキナゾリン類似化合物
US6911447B2 (en) * 2001-04-25 2005-06-28 The Procter & Gamble Company Melanocortin receptor ligands
FR2827518B1 (fr) * 2001-07-17 2005-07-08 Sod Conseils Rech Applic Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a traiter la sarcopenie
AU2002331064B2 (en) 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7026335B2 (en) 2002-04-30 2006-04-11 The Procter & Gamble Co. Melanocortin receptor ligands
EP1407779A1 (en) 2002-10-10 2004-04-14 Gastrotech A/S Use of ghrelin for treating low body weight and body fat in gastrectomized individuals
TW200504033A (en) 2002-10-23 2005-02-01 Procter & Gamble Melanocortin receptor ligands
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CA2565324A1 (en) * 2004-03-30 2005-10-20 Sapphire Therapeutics, Inc. Method of reducing c-reactive protein using growth hormone secretagogues
US7825138B2 (en) * 2004-06-29 2010-11-02 Helsinn Therapeutics (U.S.), Inc. Crystal forms of (3R)-1-(2-methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid 1,2,2-trimethylhydrazide
WO2006020930A2 (en) * 2004-08-12 2006-02-23 Sapphire Therapeutics, Inc. Method of stimulating the motility of the gastrointestinal system using growth hormone secretagogues
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
CN101595107A (zh) * 2006-06-30 2009-12-02 先灵公司 能提高p53活性的有取代哌啶及其用途
EP2644618B1 (en) 2007-02-09 2016-08-17 Ocera Therapeutics, Inc. tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators
WO2012131090A1 (en) 2011-03-31 2012-10-04 Galderma Research & Development Method for treatment of xeroderma pigmentosum
CN114805305B (zh) * 2022-04-20 2024-04-26 成都诺和晟泰生物科技有限公司 一种化合物及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013069A1 (en) * 1993-11-09 1995-05-18 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US5492916A (en) * 1993-12-23 1996-02-20 Merck & Co., Inc. Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5721250A (en) * 1993-12-23 1998-02-24 Merck & Co. Inc. Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
US5559128A (en) * 1995-04-18 1996-09-24 Merck & Co., Inc. 3-substituted piperidines promote release of growth hormone
WO1996035713A1 (en) * 1995-05-08 1996-11-14 Pfizer, Inc. Dipeptides which promote release of growth hormone
DE69533991T2 (de) * 1995-05-29 2006-04-13 Pfizer Inc. Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
GB2308064A (en) * 1995-10-31 1997-06-18 Merck & Co Inc Treatment of congestive heart failure with a growth hormone secretagogue
AU2722297A (en) * 1996-04-03 1997-10-22 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
EP0923539B1 (en) * 1996-07-22 2002-06-05 Novo Nordisk A/S Compounds with growth hormone releasing properties
AU4342097A (en) * 1996-09-13 1998-04-02 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
WO1998016527A1 (en) * 1996-10-15 1998-04-23 Fujisawa Pharmaceutical Co., Ltd. Benzoxepine derivatives which promote release of growth hormone

Also Published As

Publication number Publication date
CA2329881A1 (en) 1999-11-18
JP4938708B2 (ja) 2012-05-23
HUP0102071A3 (en) 2002-06-28
HUP0102071A2 (hu) 2002-03-28
TWI222969B (en) 2004-11-01
CN1142911C (zh) 2004-03-24
CA2329881C (en) 2010-03-16
DE69941255D1 (de) 2009-09-24
AU3701099A (en) 1999-11-29
IL139090A (en) 2007-03-08
RU2243215C2 (ru) 2004-12-27
PL344042A1 (en) 2001-09-24
BR9910329A (pt) 2001-01-30
CN1300281A (zh) 2001-06-20
CZ301276B6 (cs) 2009-12-30
WO1999058501A1 (en) 1999-11-18
CY1109626T1 (el) 2014-08-13
PL194560B1 (pl) 2007-06-29
EP1077941B1 (en) 2009-08-12
UA72210C2 (uk) 2005-02-15
AU757217B2 (en) 2003-02-06
KR100593601B1 (ko) 2006-06-28
CZ20004129A3 (en) 2001-06-13
JP2008156372A (ja) 2008-07-10
DK1077941T3 (da) 2009-12-07
JP4142253B2 (ja) 2008-09-03
ES2331102T3 (es) 2009-12-21
SI1077941T1 (sl) 2010-01-29
IL139090A0 (en) 2001-11-25
ATE439346T1 (de) 2009-08-15
JP2004500312A (ja) 2004-01-08
KR20010043422A (ko) 2001-05-25
EP1077941A1 (en) 2001-02-28
NO20005668D0 (no) 2000-11-10
NO318080B1 (no) 2005-01-31
PT1077941E (pt) 2010-07-01

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: HELSINN HEALTHCARE SA, CH

MK1K Patent expired