NO20006507L - Propenyl kefalosporinderivater - Google Patents
Propenyl kefalosporinderivaterInfo
- Publication number
- NO20006507L NO20006507L NO20006507A NO20006507A NO20006507L NO 20006507 L NO20006507 L NO 20006507L NO 20006507 A NO20006507 A NO 20006507A NO 20006507 A NO20006507 A NO 20006507A NO 20006507 L NO20006507 L NO 20006507L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- carbon
- sulfur
- nitrogen
- exceeding
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- -1 Propenyl cephalosporin Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 102100034741 Cyclin-dependent kinase 20 Human genes 0.000 abstract 1
- 101500014379 Lymnaea stagnalis Ovulation hormone Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/40—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Fremlagt er kefalosporinderivater med den generelle forme- len R-S-CH^ CDCH hvori R er en organisk residu med en molekylvekt som ikke overstiger 400 bundet til det tilgrensende svovelatomet via karbon og består av karbon, hydrogen, og valgfritt oksygen, svovel, nitrogen og/eller halogenatomer; R1 er hydrogen, lavere alkyl eller fenyl; og A er et sekundært, tertiært eller kvaternært nitrogen atom bundet direkte til propenylgruppen og er substituert med en organisk residu med en molekylvekt som ikke overstiger 400 og består av karbon, hydrogen, og valgfritt oksygen, svovel, nitrogen og/eller halogenatomer, i tillegg til lett hydrolyserbare estere derav, farmasøytisk akseptable salter av forbindel- sene og hydrater av forbindelsene med formel I og av deres estere og salter. Også fremlagt er en prosess for deres fremstilling, mellomprodukter anvendbare deri. Medikamen- ter inneholdende sluttproduktene og anvendelse av sist- nevnte for behandling og profylakse av infeksjonssykdommer eller for fremstillingen av medikamentene.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98111415 | 1998-06-22 | ||
| EP99108149 | 1999-04-26 | ||
| PCT/EP1999/004034 WO1999067255A1 (en) | 1998-06-22 | 1999-06-11 | Propenyl cephalosporin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20006507L true NO20006507L (no) | 2000-12-20 |
| NO20006507D0 NO20006507D0 (no) | 2000-12-20 |
Family
ID=26149364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20006507A NO20006507D0 (no) | 1998-06-22 | 2000-12-20 | Propenyl kefalosporinderivater |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6583133B1 (no) |
| EP (1) | EP1090013A1 (no) |
| JP (1) | JP4033630B2 (no) |
| KR (1) | KR100414336B1 (no) |
| CN (1) | CN1173979C (no) |
| AU (1) | AU761450B2 (no) |
| BR (1) | BR9911445A (no) |
| CA (1) | CA2335288A1 (no) |
| HU (1) | HUP0102350A2 (no) |
| ID (1) | ID28433A (no) |
| IL (1) | IL140010A0 (no) |
| MA (1) | MA26657A1 (no) |
| NO (1) | NO20006507D0 (no) |
| PL (1) | PL345266A1 (no) |
| TR (1) | TR200003807T2 (no) |
| WO (1) | WO1999067255A1 (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020085176A (ko) * | 2001-05-07 | 2002-11-16 | 주식회사 엘지생명과학 | 신규 세팔로스포린계 항생제 및 이의 제조 방법 |
| KR20020085180A (ko) * | 2001-05-07 | 2002-11-16 | 주식회사 엘지생명과학 | 신규 세팔로스포린계 항생제 및 이의 제조 방법 |
| ITRM20020014A1 (it) * | 2002-01-15 | 2003-07-15 | Sigma Tau Ind Farmaceuti | Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del |
| KR100693298B1 (ko) * | 2003-06-27 | 2007-03-13 | 영진약품공업주식회사 | 신규한 세팔로스포린계 화합물 및 약제학적으로 허용되는염과 그의 제조 방법 |
| JP3928086B2 (ja) * | 2005-03-29 | 2007-06-13 | 塩野義製薬株式会社 | ３−プロペニルセフェム誘導体 |
| UA121298C2 (uk) | 2013-03-15 | 2020-05-12 | Мерк Шарп І Доум Корп. | Антибіотична композиція на основі цефтолозану і тазобактаму |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3983113A (en) * | 1975-08-15 | 1976-09-28 | Syntex (U.S.A.) Inc. | Cephalosporin type antibacterials |
| US4486586A (en) | 1983-02-10 | 1984-12-04 | Bristol-Myers Company | Cephalosporin derivatives |
| US4751295A (en) | 1984-04-09 | 1988-06-14 | Bristol-Myers Company | Cephalosporin derivatives |
| CA1276929C (en) | 1984-04-09 | 1990-11-27 | Masahisa Oka | Cephalosporin antibacterial agents |
| FR2622585B1 (fr) | 1987-11-03 | 1991-04-19 | Roussel Uclaf | Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus |
| DE68928174T2 (de) * | 1988-03-16 | 1997-12-18 | Eisai Co., Ltd., Tokio/Tokyo | Verfahren zur Herstellung von Cephemderivaten |
| EP0503453B1 (en) | 1991-03-08 | 2001-05-09 | Biochemie Gesellschaft M.B.H. | New process for the production of cephalosporines and novel intermediates in this process |
| AT396108B (de) * | 1991-08-21 | 1993-06-25 | Biochemie Gmbh | Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten |
| US5523400A (en) * | 1993-04-16 | 1996-06-04 | Hoffmann-La Roche Inc. | Cephalosporin antibiotics |
| CA2143519A1 (en) * | 1994-03-11 | 1995-09-12 | F. Hoffmann-La Roche Ag | Beta-lactams |
| US5804577A (en) * | 1995-09-12 | 1998-09-08 | Hoffmann-La Roche Inc. | Cephalosporin derivatives |
| DE69737382T2 (de) | 1996-11-06 | 2007-10-31 | Basilea Pharmaceutica Ag | Vinylpyrrolidinon-Cephalosporin-Derivate |
| US6150350A (en) * | 1997-09-15 | 2000-11-21 | Hoffman-La Roche Inc. | Antimicrobial compositions |
-
1999
- 1999-06-11 AU AU46081/99A patent/AU761450B2/en not_active Ceased
- 1999-06-11 HU HU0102350A patent/HUP0102350A2/hu unknown
- 1999-06-11 JP JP2000555907A patent/JP4033630B2/ja not_active Expired - Fee Related
- 1999-06-11 CN CNB998077682A patent/CN1173979C/zh not_active Expired - Fee Related
- 1999-06-11 EP EP99929182A patent/EP1090013A1/en not_active Withdrawn
- 1999-06-11 ID IDW20010140A patent/ID28433A/id unknown
- 1999-06-11 PL PL99345266A patent/PL345266A1/xx unknown
- 1999-06-11 WO PCT/EP1999/004034 patent/WO1999067255A1/en not_active Ceased
- 1999-06-11 KR KR10-2000-7014573A patent/KR100414336B1/ko not_active Expired - Fee Related
- 1999-06-11 BR BR9911445-3A patent/BR9911445A/pt not_active IP Right Cessation
- 1999-06-11 IL IL14001099A patent/IL140010A0/xx unknown
- 1999-06-11 CA CA002335288A patent/CA2335288A1/en not_active Abandoned
- 1999-06-11 TR TR2000/03807T patent/TR200003807T2/xx unknown
- 1999-06-21 MA MA25640A patent/MA26657A1/fr unknown
- 1999-06-22 US US09/337,908 patent/US6583133B1/en not_active Expired - Fee Related
-
2000
- 2000-12-20 NO NO20006507A patent/NO20006507D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6583133B1 (en) | 2003-06-24 |
| CN1173979C (zh) | 2004-11-03 |
| WO1999067255A1 (en) | 1999-12-29 |
| TR200003807T2 (tr) | 2001-06-21 |
| ID28433A (id) | 2001-05-24 |
| AU761450B2 (en) | 2003-06-05 |
| CN1306536A (zh) | 2001-08-01 |
| IL140010A0 (en) | 2002-02-10 |
| JP4033630B2 (ja) | 2008-01-16 |
| BR9911445A (pt) | 2001-03-20 |
| NO20006507D0 (no) | 2000-12-20 |
| AU4608199A (en) | 2000-01-10 |
| JP2002518505A (ja) | 2002-06-25 |
| PL345266A1 (en) | 2001-12-03 |
| CA2335288A1 (en) | 1999-12-29 |
| MA26657A1 (fr) | 2004-12-20 |
| KR20010053092A (ko) | 2001-06-25 |
| KR100414336B1 (ko) | 2004-01-07 |
| HUP0102350A2 (hu) | 2001-11-28 |
| EP1090013A1 (en) | 2001-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |