TR200003807T2 - Propenil sefalosporin türevleri - Google Patents

Propenil sefalosporin türevleri

Info

Publication number
TR200003807T2
TR200003807T2 TR2000/03807T TR200003807T TR200003807T2 TR 200003807 T2 TR200003807 T2 TR 200003807T2 TR 2000/03807 T TR2000/03807 T TR 2000/03807T TR 200003807 T TR200003807 T TR 200003807T TR 200003807 T2 TR200003807 T2 TR 200003807T2
Authority
TR
Turkey
Prior art keywords
hydrogen
sulfur
nitrogen
exceed
compounds
Prior art date
Application number
TR2000/03807T
Other languages
English (en)
Inventor
Angehrn Peter
Goetschi Erwin
Heinze-Krauss Ingrid
G.F.Richter Hans
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of TR200003807T2 publication Critical patent/TR200003807T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/40—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

R'nin, moleküler agriligi 400'ü asmayan ve karbon yoluyla komsu sülfür atomuna bagli ve karbon, hidrojen ve istege göre oksijen,sülfür, nitrojen ve/veya halojen atomlari içeren organik bir tortu; R1'nin hidrojen,alt-alkil veya fenil; ve A'nin dogrudan propenil grubuna baglanan ve moleküler agirligi 400'ü asmayan ve karbon, hidrojen, ve istege göre oksijen, sülfür, nitrojen ve/veya halojen atomlari içeren bir tortuyla ikame edilen ikincil,üçüncül veya dördüncül bir nitrojen atomu oldugu genel formül (I)'e ait sefalosporin türevlerinin yani sira bunlarin kolayca hidrolize edilebilir esterleri, bu bilesiklerin farmasötik açidan kabul gören tuzlari ve formül (I)'e ait bilesiklerin ve bunlarin ester ve tuzlarinin hidratlari sunulmustur.
TR2000/03807T 1998-06-22 1999-06-11 Propenil sefalosporin türevleri TR200003807T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98111415 1998-06-22
EP99108149 1999-04-26

Publications (1)

Publication Number Publication Date
TR200003807T2 true TR200003807T2 (tr) 2001-06-21

Family

ID=26149364

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03807T TR200003807T2 (tr) 1998-06-22 1999-06-11 Propenil sefalosporin türevleri

Country Status (16)

Country Link
US (1) US6583133B1 (tr)
EP (1) EP1090013A1 (tr)
JP (1) JP4033630B2 (tr)
KR (1) KR100414336B1 (tr)
CN (1) CN1173979C (tr)
AU (1) AU761450B2 (tr)
BR (1) BR9911445A (tr)
CA (1) CA2335288A1 (tr)
HU (1) HUP0102350A2 (tr)
ID (1) ID28433A (tr)
IL (1) IL140010A0 (tr)
MA (1) MA26657A1 (tr)
NO (1) NO20006507L (tr)
PL (1) PL345266A1 (tr)
TR (1) TR200003807T2 (tr)
WO (1) WO1999067255A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020085180A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
KR20020085176A (ko) * 2001-05-07 2002-11-16 주식회사 엘지생명과학 신규 세팔로스포린계 항생제 및 이의 제조 방법
ITRM20020014A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi a-feniltiocarbossilici e a-fenilossicarbossilici utili per il trattamento di patologie che rispondono all'attivazione del
KR100693298B1 (ko) * 2003-06-27 2007-03-13 영진약품공업주식회사 신규한 세팔로스포린계 화합물 및 약제학적으로 허용되는염과 그의 제조 방법
TW200637559A (en) * 2005-03-29 2006-11-01 Shionogi & Co 3-propenylcefem derivative
KR102329764B1 (ko) 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3983113A (en) * 1975-08-15 1976-09-28 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US4486586A (en) 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
US4751295A (en) 1984-04-09 1988-06-14 Bristol-Myers Company Cephalosporin derivatives
CA1276929C (en) 1984-04-09 1990-11-27 Masahisa Oka Cephalosporin antibacterial agents
FR2622585B1 (fr) 1987-11-03 1991-04-19 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
EP0612751A3 (en) * 1988-03-16 1994-09-21 Eisai Co Ltd Compounds for the preparation of cephem derivatives.
DK0503453T3 (da) 1991-03-08 2001-07-16 Biochemie Gmbh Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
AT396108B (de) * 1991-08-21 1993-06-25 Biochemie Gmbh Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
CA2143519A1 (en) * 1994-03-11 1995-09-12 F. Hoffmann-La Roche Ag Beta-lactams
US5804577A (en) * 1995-09-12 1998-09-08 Hoffmann-La Roche Inc. Cephalosporin derivatives
ATE354577T1 (de) 1996-11-06 2007-03-15 Basilea Pharmaceutica Ag Vinylpyrrolidinon-cephalosporin-derivate
US6150350A (en) * 1997-09-15 2000-11-21 Hoffman-La Roche Inc. Antimicrobial compositions

Also Published As

Publication number Publication date
ID28433A (id) 2001-05-24
IL140010A0 (en) 2002-02-10
US6583133B1 (en) 2003-06-24
JP4033630B2 (ja) 2008-01-16
BR9911445A (pt) 2001-03-20
NO20006507D0 (no) 2000-12-20
CA2335288A1 (en) 1999-12-29
CN1173979C (zh) 2004-11-03
WO1999067255A1 (en) 1999-12-29
PL345266A1 (en) 2001-12-03
EP1090013A1 (en) 2001-04-11
HUP0102350A2 (hu) 2001-11-28
CN1306536A (zh) 2001-08-01
NO20006507L (no) 2000-12-20
AU761450B2 (en) 2003-06-05
KR100414336B1 (ko) 2004-01-07
JP2002518505A (ja) 2002-06-25
AU4608199A (en) 2000-01-10
KR20010053092A (ko) 2001-06-25
MA26657A1 (fr) 2004-12-20

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