NO20020029L - Fremgangsmåte for fremstilling av amlodipinbenzensulfonat - Google Patents

Fremgangsmåte for fremstilling av amlodipinbenzensulfonat

Info

Publication number: NO20020029L
Authority: NO; Norway
Prior art keywords: preparation; methyl; amlodipine benzenesulfonate; formula; amalodipine
Prior art date: 1999-07-05

Application number

NO20020029A

Other languages

English (en)

Other versions

NO321714B1 (no

NO20020029D0 (no

Inventor

Janos Fischer

Katalin Szoke

Laszlo Dobay

Sandor Levai

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-05

Filing date

2002-01-04

Publication date

2002-03-05

2002-01-04 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

2002-01-04 Publication of NO20020029D0 publication Critical patent/NO20020029D0/no

2002-03-05 Publication of NO20020029L publication Critical patent/NO20020029L/no

2006-06-26 Publication of NO321714B1 publication Critical patent/NO321714B1/no

Links

ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 title 1
229910052783 alkali metal Chemical group 0.000 abstract 1
150000001340 alkali metals Chemical group 0.000 abstract 1
229910052784 alkaline earth metal Chemical group 0.000 abstract 1
SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 1
SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Pyridine Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

NO20020029A 1999-07-05 2002-01-04 Fremgangsmate for fremstilling av amlodipinbenzensulfonat og farmasoytisk preparat omfattende dette, ftalamidinsyrederivat, forbindelse samt fremgangsmate for fremstilling av nye ftalamidinsyrederivater. NO321714B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/HU1999/000050 WO2001002360A1 (en)	1999-07-05	1999-07-05	Process for preparing amlodipine benzenesulphonate

Publications (3)

Publication Number	Publication Date
NO20020029D0 NO20020029D0 (no)	2002-01-04
NO20020029L true NO20020029L (no)	2002-03-05
NO321714B1 NO321714B1 (no)	2006-06-26

Family

ID=10991279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20020029A NO321714B1 (no)	1999-07-05	2002-01-04	Fremgangsmate for fremstilling av amlodipinbenzensulfonat og farmasoytisk preparat omfattende dette, ftalamidinsyrederivat, forbindelse samt fremgangsmate for fremstilling av nye ftalamidinsyrederivater.

Country Status (24)

Country	Link
US (1)	US6596874B1 (no)
EP (1)	EP1196383B1 (no)
JP (1)	JP3764386B2 (no)
KR (1)	KR100585442B1 (no)
CN (1)	CN1141297C (no)
AT (1)	ATE283841T1 (no)
AU (1)	AU777565B2 (no)
BG (1)	BG65657B1 (no)
CA (1)	CA2376540C (no)
CZ (1)	CZ300509B6 (no)
DE (1)	DE69922417T2 (no)
DK (1)	DK1196383T3 (no)
EA (1)	EA004208B1 (no)
EE (1)	EE05398B1 (no)
ES (1)	ES2234272T3 (no)
HK (1)	HK1044151B (no)
MX (1)	MXPA01013407A (no)
NO (1)	NO321714B1 (no)
NZ (1)	NZ517013A (no)
PL (1)	PL194193B1 (no)
PT (1)	PT1196383E (no)
SK (1)	SK285611B6 (no)
UA (1)	UA72768C2 (no)
WO (1)	WO2001002360A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100354806B1 (ko) *	2000-06-21	2002-10-05	한국유나이티드제약 주식회사	암로디핀 베실레이트의 신규 중간체 및 그의 제조방법
KR100452491B1 (ko) *	2001-03-29	2004-10-12	한미약품 주식회사	신규한 결정형 암로디핀 캠실레이트 염 및 그의 제조방법
ATE454890T1 (de) *	2001-07-06	2010-01-15	Lek Pharmaceuticals	Verfahren zur herstellung hochreines amlodipinbenzolsulfonat
US6680334B2 (en)	2001-08-28	2004-01-20	Pfizer Inc	Crystalline material
AR037565A1 (es) *	2001-11-21	2004-11-17	Synthon Bv	Formas de sales de amlodipina y procedimientos para prepararlas.
KR100496436B1 (ko) *	2002-07-30	2005-06-20	씨제이 주식회사	암로디핀의 유기산염
KR100462304B1 (ko) *	2002-07-30	2004-12-17	씨제이 주식회사	암로디핀의 유기산염
KR100467669B1 (ko) *	2002-08-21	2005-01-24	씨제이 주식회사	암로디핀의 유기산염
US6784297B2 (en)	2002-09-04	2004-08-31	Kopran Limited	Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
JP2008013489A (ja) *	2006-07-06	2008-01-24	Ohara Yakuhin Kogyo Kk	ベシル酸アムロジピン含有錠剤
EP1975167A1 (en)	2007-03-30	2008-10-01	Esteve Quimica, S.A.	Acetone solvate of phthaloyl amlodipine
CN101812014B (zh) *	2010-04-28	2011-08-24	王明	一种苯磺酸氨氯地平化合物及其制法
CN102993083A (zh) *	2012-12-21	2013-03-27	王学军	一种苯磺酸氨氯地平的制备方法
CN104262237A (zh) *	2014-09-28	2015-01-07	常州瑞明药业有限公司	氨氯地平自由碱的合成方法
US11452690B1 (en)	2021-01-27	2022-09-27	ECI Pharmaceuticals, LLC	Oral liquid compositions comprising amlodipine besylate and methods of using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK161312C (da) *	1982-03-11	1991-12-09	Pfizer	Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en)	1986-04-04	1986-05-08	Pfizer Ltd	Pharmaceutically acceptable salts
SI9200344B (sl) *	1992-11-26	1998-06-30	Lek,	Postopek za pripravo amlodipin benzensulfonata
HU221810B1 (hu) *	1997-08-12	2003-01-28	EGIS Gyógyszergyár Rt.	Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
DE19738943B4 (de)	1997-09-05	2008-01-03	Siemens Ag	Verfahren und Einrichtung zur Bestimmung von Eigenschaften eines Stahls

1999
- 1999-05-07 UA UA2002020897A patent/UA72768C2/uk unknown
- 1999-07-05 HK HK02105733.9A patent/HK1044151B/zh not_active IP Right Cessation
- 1999-07-05 MX MXPA01013407A patent/MXPA01013407A/es not_active IP Right Cessation
- 1999-07-05 DE DE69922417T patent/DE69922417T2/de not_active Expired - Lifetime
- 1999-07-05 DK DK99933061T patent/DK1196383T3/da active
- 1999-07-05 PT PT99933061T patent/PT1196383E/pt unknown
- 1999-07-05 US US10/019,424 patent/US6596874B1/en not_active Expired - Lifetime
- 1999-07-05 CA CA002376540A patent/CA2376540C/en not_active Expired - Lifetime
- 1999-07-05 EP EP99933061A patent/EP1196383B1/en not_active Expired - Lifetime
- 1999-07-05 NZ NZ517013A patent/NZ517013A/en not_active IP Right Cessation
- 1999-07-05 WO PCT/HU1999/000050 patent/WO2001002360A1/en not_active Ceased
- 1999-07-05 PL PL99352493A patent/PL194193B1/pl unknown
- 1999-07-05 SK SK2-2002A patent/SK285611B6/sk not_active IP Right Cessation
- 1999-07-05 CZ CZ20014690A patent/CZ300509B6/cs unknown
- 1999-07-05 JP JP2001507800A patent/JP3764386B2/ja not_active Expired - Lifetime
- 1999-07-05 CN CNB998167746A patent/CN1141297C/zh not_active Expired - Lifetime
- 1999-07-05 EA EA200200125A patent/EA004208B1/ru not_active IP Right Cessation
- 1999-07-05 EE EEP200100686A patent/EE05398B1/xx unknown
- 1999-07-05 ES ES99933061T patent/ES2234272T3/es not_active Expired - Lifetime
- 1999-07-05 KR KR1020027000052A patent/KR100585442B1/ko not_active Expired - Lifetime
- 1999-07-05 AT AT99933061T patent/ATE283841T1/de active
- 1999-07-05 AU AU49237/99A patent/AU777565B2/en not_active Expired
2001
- 2001-12-03 BG BG106164A patent/BG65657B1/bg unknown
2002
- 2002-01-04 NO NO20020029A patent/NO321714B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL352493A1 (en)	2003-08-25
CZ300509B6 (cs)	2009-06-03
CN1141297C (zh)	2004-03-10
EE200100686A (et)	2003-04-15
EP1196383A1 (en)	2002-04-17
WO2001002360A1 (en)	2001-01-11
EA004208B1 (ru)	2004-02-26
BG65657B1 (bg)	2009-05-29
JP3764386B2 (ja)	2006-04-05
CA2376540C (en)	2007-03-13
NZ517013A (en)	2003-08-29
KR20020022760A (ko)	2002-03-27
NO321714B1 (no)	2006-06-26
SK22002A3 (en)	2002-05-09
EE05398B1 (et)	2011-04-15
DE69922417D1 (de)	2005-01-05
AU4923799A (en)	2001-01-22
SK285611B6 (sk)	2007-04-05
AU777565B2 (en)	2004-10-21
UA72768C2 (en)	2005-04-15
CN1352634A (zh)	2002-06-05
KR100585442B1 (ko)	2006-06-02
MXPA01013407A (es)	2003-09-04
DE69922417T2 (de)	2005-12-01
BG106164A (en)	2002-07-31
EP1196383B1 (en)	2004-12-01
HK1044151A1 (en)	2002-10-11
CZ20014690A3 (cs)	2002-04-17
PL194193B1 (pl)	2007-05-31
US6596874B1 (en)	2003-07-22
NO20020029D0 (no)	2002-01-04
ATE283841T1 (de)	2004-12-15
CA2376540A1 (en)	2001-01-11
ES2234272T3 (es)	2005-06-16
JP2003503477A (ja)	2003-01-28
EA200200125A1 (ru)	2002-06-27
HK1044151B (zh)	2004-09-10
PT1196383E (pt)	2005-03-31
DK1196383T3 (da)	2005-02-21

Legal Events

Date	Code	Title	Description
2019-08-12	MK1K	Patent expired

Publication	Publication Date	Title
NO20020029D0 (no)	2002-01-04	Fremgangsmåte for fremstilling av amilodipinbenzensulfonat
NO941101L (no)	1994-05-30	Quinazolin-derivater
ES2195510T3 (es)	2003-12-01	Derivados de imidazopiridina y procedimiento para prepararlos.
DE60012751D1 (de)	2004-09-09	Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
NO20002589D0 (no)	2000-05-19	Bifenylamidinderivater
ES2151850A1 (es)	2001-01-01	Intermedio para la sintesis de amiodipino para su obtencion y utilizacion correspondiente.
NO20023126L (no)	2002-06-27	Fremgangsmåte for fremstilling av citalopram
NO20002490D0 (no)	2000-05-12	FremgangsmÕte for fremstilling av 1,4-dihydropyridiner og forbindelser anvendt ved denne fremgangsmÕten
YU76500A (sh)	2003-02-28	Hemijska sinzeza morfolinskih derivata
DK1404642T3 (da)	2010-05-17	Fremgangsmåde til fremstillimg af 7-amino-syn-3,5-dihydroxyheptansyrederivater, mellemprodukter derfor og fremgangsmåder til deres fremstilling
FI980530A0 (fi)	1998-03-09	Foerfarande foer framstaellning av ett N-bis-(2-(1,2-dikarboxietoxi)-etyl)adminderivat, produkter som erhaolls genom foerfarandet och anvaendning ar daerav
EA200000389A3 (ru)	2001-02-26	Новые замещенные пиридины или пиперидины, способ их получения и содержащие их фармацевтические композиции
DK1105392T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin
NO20026198D0 (no)	2002-12-23	Cykliske ketoner, deres fremstilling og deres anvendelse ved syntese av aminosyrer
DK0979822T3 (da)	2006-03-27	Fremgangsmåde til fremstilling af 2-carbamoyl-pyridiner
NO20052197L (no)	2005-05-04	Fremgangsmate for fremstilling av pyrazol
DK1581504T3 (da)	2009-06-29	Fremgangsmåde til fremstilling af subsituterede imidazolderivater og intermediater anvendt i fremgangsmåden
EP1319646A4 (en)	2005-11-30	PROCESS FOR THE PREPARATION OF 3,5-BISALKYLPHENOLENE
WO2001094315A3 (en)	2002-04-18	Process for the preparation of pesticidal compounds
DK1320527T3 (da)	2008-12-01	Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler
UA33033A (uk)	2001-02-15	Спосіб одержання безилату амлодипіну
DK1242390T3 (da)	2004-12-20	Fremgangsmåde til fremstilling af 1,3-disubstituerede 2-nitroguanidiner
BG102547A (en)	2000-04-28	Method for the synthesis of 2,2,6,6-tetramethyl-4-oxopiperidin p-toluenesulphonate
TH52886A3 (th)	2002-09-04	กรรมวิธีที่ปรับปรุงดีขึ้นสำหรับการเตรียมอนุพันธ์ของนอร์เบนโซมอร์เฟนที่ใช้ประโยชน์ทางเภสัชวิทยา