NO20031694L - Crystalline monohydrate, process for its preparation and use thereof for the manufacture of a drug - Google Patents

Crystalline monohydrate, process for its preparation and use thereof for the manufacture of a drug

Info

Publication number: NO20031694L
Authority: NO; Norway
Prior art keywords: drug; manufacture; preparation; crystalline monohydrate; monohydrate
Prior art date: 2000-10-12

Application number

NO20031694A

Other languages

Norwegian (no)

Other versions

NO328465B1 (en

NO20031694D0 (en

Inventor

Rolf Banholzer

Manfred Graulich

Christian Kulinna

Andreas Mathes

Helmut Meissner

Peter Sieger

Peter Specht

Michael Trunk

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2003-04-11

Publication date

2003-04-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20031694(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-11 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2003-04-11 Publication of NO20031694L publication Critical patent/NO20031694L/en

2003-04-11 Publication of NO20031694D0 publication Critical patent/NO20031694D0/en

2010-02-22 Publication of NO328465B1 publication Critical patent/NO328465B1/en

Links

239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
150000004682 monohydrates Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20031694A 2000-10-12 2003-04-11 Crystalline monohydrate, process for the preparation thereof and use thereof for the preparation of a medicament NO328465B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (en)	2000-10-12	2001-09-28	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Publications (3)

Publication Number	Publication Date
NO20031694L true NO20031694L (en)	2003-04-11
NO20031694D0 NO20031694D0 (en)	2003-04-11
NO328465B1 NO328465B1 (en)	2010-02-22

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031694A NO328465B1 (en)	2000-10-12	2003-04-11	Crystalline monohydrate, process for the preparation thereof and use thereof for the preparation of a medicament

Country Status (46)

Country	Link
EP (2)	EP1326862B1 (en)
JP (1)	JP3764422B2 (en)
KR (1)	KR100823860B1 (en)
CN (2)	CN100519558C (en)
AP (1)	AP1572A (en)
AR (2)	AR034389A1 (en)
AT (1)	ATE276253T1 (en)
AU (2)	AU1499602A (en)
BG (1)	BG66161B1 (en)
BR (1)	BR0114584A (en)
CA (1)	CA2425539C (en)
CR (1)	CR6938A (en)
CZ (1)	CZ301841B6 (en)
DE (1)	DE50103666D1 (en)
DK (1)	DK1326862T3 (en)
DZ (1)	DZ3478A1 (en)
EA (1)	EA004381B1 (en)
EC (1)	ECSP034540A (en)
EE (1)	EE04567B1 (en)
EG (1)	EG24142A (en)
ES (1)	ES2228965T3 (en)
GE (1)	GEP20063905B (en)
HR (1)	HRP20030276B1 (en)
HU (1)	HU226830B1 (en)
IL (2)	IL155335A0 (en)
IS (1)	IS2339B (en)
MA (1)	MA25842A1 (en)
ME (2)	MEP40008A (en)
MX (1)	MXPA03003221A (en)
MY (1)	MY126931A (en)
NO (1)	NO328465B1 (en)
NZ (1)	NZ525733A (en)
OA (1)	OA12403A (en)
PE (1)	PE20020422A1 (en)
PL (1)	PL207870B1 (en)
PT (1)	PT1326862E (en)
RS (1)	RS50218B (en)
SA (1)	SA01220412B1 (en)
SI (1)	SI1326862T1 (en)
SK (1)	SK287009B6 (en)
TR (1)	TR200402579T4 (en)
TW (1)	TW589313B (en)
UA (1)	UA74215C2 (en)
UY (2)	UY26962A1 (en)
WO (1)	WO2002030928A1 (en)
ZA (1)	ZA200302500B (en)

Families Citing this family (74)

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US6608055B2 (en)	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
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DE10212264A1 (en)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
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DE10214263A1 (en) *	2002-03-28	2003-10-16	Boehringer Ingelheim Pharma	HFA suspension formulations containing an anticholinergic
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (en)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt
MXPA06004697A (en)	2003-11-03	2006-07-05	Boehringer Ingelheim Int	Method for producing tiotropium salts, tiotropium salts and pharmaceutical formulations, containing the same.
AU2004285685B2 (en) *	2003-11-03	2011-03-24	Boehringer Ingelheim International Gmbh	Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
ES2338563T3 (en) *	2003-11-03	2010-05-10	Boehringer Ingelheim International Gmbh	NEW CRYSTAL ANHYDRATE WITH ANTICOLINERGIC EFFECT.
US7968717B2 (en)	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
DE102004016179A1 (en) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Compounds for the treatment of proliferative processes
AU2005235419B2 (en)	2004-04-22	2010-11-04	Boehringer Ingelheim International Gmbh	Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
DE102004024454A1 (en)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
ES2322148T3 (en)	2004-08-11	2009-06-17	BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG	MEDICINES CONTAINING ANTI-POLINERGIC FOR TREATMENT IN URINARY ROADS.
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modification of surfaces of lactose as adjuvant for use with powder inhalants
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WO2006094924A2 (en) *	2005-03-09	2006-09-14	Boehringer Ingelheim International Gmbh	New pharmaceutical compositions based on anticholinergics and pde 5-inhibitors
NZ563448A (en)	2005-04-28	2011-01-28	Boehringer Ingelheim Int	Benzofuranone derivatives for treating inflammatory diseases
BRPI0609295A2 (en)	2005-05-02	2010-03-23	Boehringer Ingelheim Int	crystalline forms of tiotropium bromide, pharmaceutical composition, use and method for preparing same
JP2008540367A (en) *	2005-05-02	2008-11-20	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	New crystalline tiotropium bromide
NZ564697A (en) *	2005-06-15	2010-04-30	Boehringer Ingelheim Int	Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005030733A1 (en)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
AU2006277968A1 (en) *	2005-08-06	2007-02-15	Boehringer Ingelheim International Gmbh	Use of tiotropium salts in the treatment of severe persistant asthma
CN101208316B (en)	2005-08-15	2012-05-09	贝林格尔·英格海姆国际有限公司	Method for preparing beta-mimetics
TWI396541B (en) *	2005-10-10	2013-05-21	Boehringer Ingelheim Int	Novel combinations of medicaments for the treatment of respiratory diseases
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
DE102005059602A1 (en)	2005-12-14	2007-06-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Micronization process
RS52663B2 (en)	2005-12-19	2018-05-31	Sicor Inc	Novel crystalline form of tiotropium bromide and process for preparation thereof
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JP2009525950A (en) *	2006-01-04	2009-07-16	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Use of tiotropium salt in the treatment of moderate persistent asthma
MX2007012313A (en)	2006-04-19	2007-11-21	Boehringer Ingelheim Int	Dihydrothienopyrimidines for the treatment of inflammatory diseases.
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PE20080610A1 (en)	2006-08-22	2008-07-15	Boehringer Ingelheim Int	NEW ENANTHOMERICALLY PURE BETA-AGONISTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES
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GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
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US20130143905A1 (en)	2009-12-17	2013-06-06	Boehringer Ingelheim International Gmbh	Novel antagonists for ccr2 and uses thereof
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EP2576542B1 (en)	2010-05-25	2015-04-22	Boehringer Ingelheim International GmbH	Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
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2001
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/en not_active Ceased
- 2001-09-28 OA OA1200300107A patent/OA12403A/en unknown
- 2001-09-28 SI SI200130219T patent/SI1326862T1/en unknown
- 2001-09-28 HU HU0301022A patent/HU226830B1/en unknown
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/en not_active IP Right Cessation
- 2001-09-28 AT AT01983510T patent/ATE276253T1/en active
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active
- 2001-09-28 PL PL366041A patent/PL207870B1/en unknown
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/en not_active Expired - Lifetime
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/en unknown
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/en not_active IP Right Cessation
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/en active IP Right Grant
- 2001-09-28 EP EP01983510A patent/EP1326862B1/en not_active Expired - Lifetime
- 2001-09-28 EA EA200300457A patent/EA004381B1/en not_active IP Right Cessation
- 2001-09-28 IL IL15533501A patent/IL155335A0/en active IP Right Grant
- 2001-09-28 DK DK01983510T patent/DK1326862T3/en active
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/en not_active Ceased
- 2001-09-28 EE EEP200300171A patent/EE04567B1/en unknown
- 2001-09-28 AU AU1499602A patent/AU1499602A/en active Pending
- 2001-09-28 RS YU27303A patent/RS50218B/en unknown
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/en unknown
- 2001-09-28 DE DE50103666T patent/DE50103666D1/en not_active Expired - Lifetime
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/en not_active Application Discontinuation
- 2001-09-28 CN CNB018171435A patent/CN1221549C/en not_active Ceased
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/en unknown
- 2001-09-28 SK SK436-2003A patent/SK287009B6/en not_active IP Right Cessation
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/en active
- 2001-09-28 UA UA2003054185A patent/UA74215C2/en unknown
- 2001-09-28 ES ES01983510T patent/ES2228965T3/en not_active Expired - Lifetime
- 2001-09-28 PT PT01983510T patent/PT1326862E/en unknown
- 2001-09-28 EP EP04016877A patent/EP1468998A1/en not_active Withdrawn
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/en not_active Expired - Lifetime
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-10-02 SA SA01220412A patent/SA01220412B1/en unknown
- 2001-10-09 EG EG20011058A patent/EG24142A/en active
- 2001-10-09 TW TW090124963A patent/TW589313B/en active
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 UY UY26962A patent/UY26962A1/en not_active Application Discontinuation
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/en active IP Right Grant
- 2001-10-12 AR ARP010104782A patent/AR034389A1/en active IP Right Grant
2003
- 2003-03-26 CR CR6938A patent/CR6938A/en unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/en unknown
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/en unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/en unknown
- 2003-04-09 IS IS6772A patent/IS2339B/en unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/en not_active IP Right Cessation
2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/en unknown
2013
- 2013-07-11 UY UY34901A patent/UY34901A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
GEP20063905B (en)	2006-08-25
KR20030042008A (en)	2003-05-27
AR034389A1 (en)	2004-02-25
NZ525733A (en)	2005-01-28
IL155335A0 (en)	2003-11-23
PL207870B1 (en)	2011-02-28
IS6772A (en)	2003-04-09
EA004381B1 (en)	2004-04-29
SK4362003A3 (en)	2003-08-05
PL366041A1 (en)	2005-01-24
NO328465B1 (en)	2010-02-22
HU226830B1 (en)	2009-11-30
WO2002030928A1 (en)	2002-04-18
HUP0301022A2 (en)	2003-10-28
ATE276253T1 (en)	2004-10-15
JP3764422B2 (en)	2006-04-05
TR200402579T4 (en)	2004-12-21
CZ301841B6 (en)	2010-07-07
AU2002214996B2 (en)	2007-03-15
BG107687A (en)	2003-09-30
JP2004526668A (en)	2004-09-02
PE20020422A1 (en)	2002-06-28
IL155335A (en)	2009-02-11
NO20031694D0 (en)	2003-04-11
MEP40008A (en)	2011-02-10
CA2425539C (en)	2007-04-03
BG66161B1 (en)	2011-09-30
CN1469877A (en)	2004-01-21
HUP0301022A3 (en)	2005-12-28
MXPA03003221A (en)	2004-12-03
AU1499602A (en)	2002-04-22
MA25842A1 (en)	2003-07-01
ME00243B (en)	2011-05-10
CN1221549C (en)	2005-10-05
EE200300171A (en)	2003-06-16
DE50103666D1 (en)	2004-10-21
AR068527A2 (en)	2009-11-18
TW589313B (en)	2004-06-01
EP1326862A1 (en)	2003-07-16
CR6938A (en)	2004-10-28
UY34901A (en)	2015-02-27
BR0114584A (en)	2003-08-26
RS50218B (en)	2009-07-15
EG24142A (en)	2008-08-06
CN100519558C (en)	2009-07-29
ZA200302500B (en)	2004-04-22
MY126931A (en)	2006-10-31
SI1326862T1 (en)	2005-02-28
HRP20030276A2 (en)	2005-02-28
ES2228965T3 (en)	2005-04-16
DK1326862T3 (en)	2004-11-22
EE04567B1 (en)	2005-12-15
IS2339B (en)	2008-02-15
HK1060567A1 (en)	2004-08-13
CN1733761A (en)	2006-02-15
YU27303A (en)	2006-05-25
KR100823860B1 (en)	2008-04-21
UA74215C2 (en)	2005-11-15
EP1326862B1 (en)	2004-09-15
UY26962A1 (en)	2002-06-20
SK287009B6 (en)	2009-09-07
SA01220412B1 (en)	2006-11-05
OA12403A (en)	2006-04-18
EP1468998A1 (en)	2004-10-20
AP2003002775A0 (en)	2003-03-31
AP1572A (en)	2006-02-13
HRP20030276B1 (en)	2006-02-28
PT1326862E (en)	2004-11-30
DZ3478A1 (en)	2002-04-18
CA2425539A1 (en)	2003-04-11
ECSP034540A (en)	2003-07-25
HK1086557A1 (en)	2006-09-22
EA200300457A1 (en)	2003-10-30

Legal Events

Date	Code	Title	Description
2021-10-11	MK1K	Patent expired

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