NO20031694L - Crystalline monohydrate, process for its preparation and use thereof for the manufacture of a drug - Google Patents

Crystalline monohydrate, process for its preparation and use thereof for the manufacture of a drug

Info

Publication number: NO20031694L
Authority: NO; Norway
Prior art keywords: drug; manufacture; preparation; crystalline monohydrate; monohydrate
Prior art date: 2000-10-12

Application number

NO20031694A

Other languages

Norwegian (no)

Other versions

NO20031694D0 (en

NO328465B1 (en

Inventor

Rolf Banholzer

Manfred Graulich

Christian Kulinna

Andreas Mathes

Helmut Meissner

Peter Sieger

Peter Specht

Michael Trunk

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-12

Filing date

2003-04-11

Publication date

2003-04-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20031694(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-11 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2003-04-11 Publication of NO20031694D0 publication Critical patent/NO20031694D0/en

2003-04-11 Publication of NO20031694L publication Critical patent/NO20031694L/en

2010-02-22 Publication of NO328465B1 publication Critical patent/NO328465B1/en

Links

239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
150000004682 monohydrates Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20031694A 2000-10-12 2003-04-11 Crystalline monohydrate, process for the preparation thereof and use thereof for the preparation of a medicament NO328465B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10050621		2000-10-12
PCT/EP2001/011225 WO2002030928A1 (en)	2000-10-12	2001-09-28	Crystalline monohydrate, method for producing the same and the use thereof in the production of a medicament

Publications (3)

Publication Number	Publication Date
NO20031694D0 NO20031694D0 (en)	2003-04-11
NO20031694L true NO20031694L (en)	2003-04-11
NO328465B1 NO328465B1 (en)	2010-02-22

Family

ID=7659568

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20031694A NO328465B1 (en)	2000-10-12	2003-04-11	Crystalline monohydrate, process for the preparation thereof and use thereof for the preparation of a medicament

Country Status (46)

Country	Link
EP (2)	EP1468998A1 (en)
JP (1)	JP3764422B2 (en)
KR (1)	KR100823860B1 (en)
CN (2)	CN100519558C (en)
AP (1)	AP1572A (en)
AR (2)	AR034389A1 (en)
AT (1)	ATE276253T1 (en)
AU (2)	AU1499602A (en)
BG (1)	BG66161B1 (en)
BR (1)	BR0114584A (en)
CA (1)	CA2425539C (en)
CR (1)	CR6938A (en)
CZ (1)	CZ301841B6 (en)
DE (1)	DE50103666D1 (en)
DK (1)	DK1326862T3 (en)
DZ (1)	DZ3478A1 (en)
EA (1)	EA004381B1 (en)
EC (1)	ECSP034540A (en)
EE (1)	EE04567B1 (en)
EG (1)	EG24142A (en)
ES (1)	ES2228965T3 (en)
GE (1)	GEP20063905B (en)
HR (1)	HRP20030276B1 (en)
HU (1)	HU226830B1 (en)
IL (2)	IL155335A0 (en)
IS (1)	IS2339B (en)
MA (1)	MA25842A1 (en)
ME (2)	ME00243B (en)
MX (1)	MXPA03003221A (en)
MY (1)	MY126931A (en)
NO (1)	NO328465B1 (en)
NZ (1)	NZ525733A (en)
OA (1)	OA12403A (en)
PE (1)	PE20020422A1 (en)
PL (1)	PL207870B1 (en)
PT (1)	PT1326862E (en)
RS (1)	RS50218B (en)
SA (1)	SA01220412B1 (en)
SI (1)	SI1326862T1 (en)
SK (1)	SK287009B6 (en)
TR (1)	TR200402579T4 (en)
TW (1)	TW589313B (en)
UA (1)	UA74215C2 (en)
UY (2)	UY26962A1 (en)
WO (1)	WO2002030928A1 (en)
ZA (1)	ZA200302500B (en)

Families Citing this family (74)

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PL208137B1 (en) *	2001-06-22	2011-03-31	Boehringer Ingelheim Pharma	Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6608055B2 (en)	2001-06-22	2003-08-19	Boehringer Ingelheim Pharma Kg	Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
DE10212264A1 (en)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Crystalline micronisate, process for its preparation and its use for the manufacture of a medicament
US7244415B2 (en)	2002-03-28	2007-07-17	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations of an anhydrate
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US7311894B2 (en)	2002-03-28	2007-12-25	Boehringer Ingelheim Pharma Gmbh & Co. Kg	HFA suspension formulations containing an anticholinergic
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
DE10317461A1 (en)	2003-04-16	2004-10-28	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt
UY28590A1 (en) *	2003-11-03	2005-06-30	Boehringer Ingelheim Int	PROCEDURE FOR THE PREPARATION OF NEW SALTS OF TIOTROPIO, NEW SALTS OF TIOTROPIO AS SUCH, AS WELL AS THE MEDICINAL FORMULATIONS CONTAINING THEM.
EP2083007B1 (en) *	2003-11-03	2013-04-24	Boehringer Ingelheim International Gmbh	Tiotropium salts, method for creating same and medicinal formulations containing same
CN100509809C (en) *	2003-11-03	2009-07-08	贝林格尔·英格海姆国际有限公司	Novel crystalline anhydride with anticholinergic effect
US7968717B2 (en)	2003-11-03	2011-06-28	Boehringer Ingelhein International Gmbh	Crystalline anhydrate with anticholinergic efficacy
WO2005102349A1 (en)	2004-04-22	2005-11-03	Boehringer Ingelheim International Gmbh	Pharmaceutical combinations containing benzoxazine for treating respiratory diseases
DE102004016179A1 (en) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Compounds for the treatment of proliferative processes
DE102004024454A1 (en)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Novel enantiomerically pure beta agonists, process for their preparation and their use as pharmaceuticals
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE602004020337D1 (en)	2004-08-11	2009-05-14	Boehringer Ingelheim Pharma	Anticholinergic drugs for the treatment of urinary tract disorders
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (en)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modification of surfaces of lactose as adjuvant for use with powder inhalants
EP1827541B1 (en) *	2004-10-21	2013-05-29	Boehringer Ingelheim International GmbH	Blister for inhalers
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CN101163706A (en)	2005-04-21	2008-04-16	贝林格尔·英格海姆国际有限公司	Dihydrothienopyrimidines for the treatment of inflammatory diseases
NZ563448A (en)	2005-04-28	2011-01-28	Boehringer Ingelheim Int	Benzofuranone derivatives for treating inflammatory diseases
JP5227790B2 (en)	2005-05-02	2013-07-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	New crystalline tiotropium bromide
EP1879888A2 (en) *	2005-05-02	2008-01-23	Boehringer Ingelheim International GmbH	Crystalline forms of tiotropium bromide
RU2418796C2 (en) *	2005-06-15	2011-05-20	Берингер Ингельхайм Интернациональ Гмбх	Method of producing novel tiotropium salts
DE102005030733A1 (en)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	New drug combinations for the treatment of respiratory diseases containing long-acting beta-2 agonists and at least one other active ingredient
KR20080039974A (en) *	2005-08-06	2008-05-07	베링거 인겔하임 인터내셔날 게엠베하	Use of tiotropium salt in the treatment of severe persistent asthma
KR101360803B1 (en)	2005-08-15	2014-02-11	베링거 인겔하임 인터내셔날 게엠베하	Method for producing betamimetics
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US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
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EP1847543A1 (en)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidines for the treatment of inflammatory diseases
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US20090324510A1 (en)	2006-08-07	2009-12-31	Boehringer Ingelheim International Gmbh	Drug combinations for the treatment of respiratory tract diseases
PE20080610A1 (en)	2006-08-22	2008-07-15	Boehringer Ingelheim Int	NEW ENANTHOMERICALLY PURE BETA-AGONISTS, PROCEDURES FOR THEIR PREPARATION AND USE AS MEDICINES
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EP1925295A1 (en)	2006-11-22	2008-05-28	Boehringer Ingelheim Pharma GmbH & Co. KG	Stable powder formulation containing a new antichinolinergic agent
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CN104069112A (en)	2007-10-19	2014-10-01	贝林格尔.英格海姆国际有限公司	Substituted piperidino-dihydrothienopyrimidines
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WO2011073154A1 (en)	2009-12-17	2011-06-23	Boehringer Ingelheim International Gmbh	New ccr2 receptor antagonists and uses thereof
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CN102822172A (en)	2010-01-29	2012-12-12	贝林格尔.英格海姆国际有限公司	Substituted naphthyridines and their use as syk kinase inhibitors
US8877745B2 (en)	2010-05-12	2014-11-04	Boehringer Ingelheim International Gmbh	CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
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US8841313B2 (en)	2010-05-17	2014-09-23	Boehringer Ingelheim International Gmbh	CCR2 antagonists and uses thereof
US9018212B2 (en)	2010-05-25	2015-04-28	Boehringer Ingelheim International Gmbh	Pyridazine carboxamides as CCR2 receptor antagonists
EP2576538B1 (en)	2010-06-01	2015-10-28	Boehringer Ingelheim International GmbH	New CCR2 antagonists
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2001
- 2001-09-28 DE DE50103666T patent/DE50103666D1/en not_active Expired - Lifetime
- 2001-09-28 RS YU27303A patent/RS50218B/en unknown
- 2001-09-28 EP EP04016877A patent/EP1468998A1/en not_active Withdrawn
- 2001-09-28 WO PCT/EP2001/011225 patent/WO2002030928A1/en not_active Ceased
- 2001-09-28 MX MXPA03003221A patent/MXPA03003221A/en active IP Right Grant
- 2001-09-28 PL PL366041A patent/PL207870B1/en unknown
- 2001-09-28 SK SK436-2003A patent/SK287009B6/en not_active IP Right Cessation
- 2001-09-28 CZ CZ20031025A patent/CZ301841B6/en not_active IP Right Cessation
- 2001-09-28 AU AU1499602A patent/AU1499602A/en active Pending
- 2001-09-28 ME MEP-2008-400A patent/ME00243B/en unknown
- 2001-09-28 KR KR1020037005083A patent/KR100823860B1/en not_active Expired - Lifetime
- 2001-09-28 EA EA200300457A patent/EA004381B1/en not_active IP Right Cessation
- 2001-09-28 ES ES01983510T patent/ES2228965T3/en not_active Expired - Lifetime
- 2001-09-28 PT PT01983510T patent/PT1326862E/en unknown
- 2001-09-28 TR TR2004/02579T patent/TR200402579T4/en unknown
- 2001-09-28 SI SI200130219T patent/SI1326862T1/en unknown
- 2001-09-28 UA UA2003054185A patent/UA74215C2/en unknown
- 2001-09-28 NZ NZ525733A patent/NZ525733A/en not_active IP Right Cessation
- 2001-09-28 EP EP01983510A patent/EP1326862B1/en not_active Expired - Lifetime
- 2001-09-28 AT AT01983510T patent/ATE276253T1/en active
- 2001-09-28 JP JP2002534314A patent/JP3764422B2/en not_active Expired - Lifetime
- 2001-09-28 HR HR20030276A patent/HRP20030276B1/en not_active IP Right Cessation
- 2001-09-28 AP APAP/P/2003/002775A patent/AP1572A/en active
- 2001-09-28 GE GE5214A patent/GEP20063905B/en unknown
- 2001-09-28 DK DK01983510T patent/DK1326862T3/en active
- 2001-09-28 DZ DZ013478A patent/DZ3478A1/en active
- 2001-09-28 IL IL15533501A patent/IL155335A0/en active IP Right Grant
- 2001-09-28 BR BR0114584-3A patent/BR0114584A/en not_active Application Discontinuation
- 2001-09-28 CN CNB2005100977370A patent/CN100519558C/en not_active Ceased
- 2001-09-28 OA OA1200300107A patent/OA12403A/en unknown
- 2001-09-28 HU HU0301022A patent/HU226830B1/en unknown
- 2001-09-28 CA CA002425539A patent/CA2425539C/en not_active Expired - Lifetime
- 2001-09-28 EE EEP200300171A patent/EE04567B1/en unknown
- 2001-09-28 AU AU2002214996A patent/AU2002214996B2/en not_active Expired
- 2001-09-28 ME MEP-400/08A patent/MEP40008A/en unknown
- 2001-09-28 CN CNB018171435A patent/CN1221549C/en not_active Ceased
- 2001-10-02 SA SA01220412A patent/SA01220412B1/en unknown
- 2001-10-09 TW TW090124963A patent/TW589313B/en active
- 2001-10-09 EG EG20011058A patent/EG24142A/en active
- 2001-10-10 MY MYPI20014705A patent/MY126931A/en unknown
- 2001-10-10 PE PE2001001000A patent/PE20020422A1/en active IP Right Grant
- 2001-10-10 UY UY26962A patent/UY26962A1/en not_active Application Discontinuation
- 2001-10-12 AR ARP010104782A patent/AR034389A1/en active IP Right Grant
2003
- 2003-03-26 CR CR6938A patent/CR6938A/en unknown
- 2003-03-28 BG BG107687A patent/BG66161B1/en unknown
- 2003-03-31 ZA ZA200302500A patent/ZA200302500B/en unknown
- 2003-04-07 EC EC2003004540A patent/ECSP034540A/en unknown
- 2003-04-08 MA MA27102A patent/MA25842A1/en unknown
- 2003-04-09 IS IS6772A patent/IS2339B/en unknown
- 2003-04-10 IL IL155335A patent/IL155335A/en unknown
- 2003-04-11 NO NO20031694A patent/NO328465B1/en not_active IP Right Cessation
2008
- 2008-09-19 AR ARP080104109A patent/AR068527A2/en unknown
2013
- 2013-07-11 UY UY34901A patent/UY34901A/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
EE200300171A (en)	2003-06-16
IS2339B (en)	2008-02-15
CZ301841B6 (en)	2010-07-07
KR100823860B1 (en)	2008-04-21
ES2228965T3 (en)	2005-04-16
IL155335A0 (en)	2003-11-23
KR20030042008A (en)	2003-05-27
UA74215C2 (en)	2005-11-15
NO20031694D0 (en)	2003-04-11
MXPA03003221A (en)	2004-12-03
PT1326862E (en)	2004-11-30
YU27303A (en)	2006-05-25
CR6938A (en)	2004-10-28
NZ525733A (en)	2005-01-28
PL207870B1 (en)	2011-02-28
EA004381B1 (en)	2004-04-29
GEP20063905B (en)	2006-08-25
HRP20030276B1 (en)	2006-02-28
EE04567B1 (en)	2005-12-15
DK1326862T3 (en)	2004-11-22
DE50103666D1 (en)	2004-10-21
BG66161B1 (en)	2011-09-30
EG24142A (en)	2008-08-06
SK4362003A3 (en)	2003-08-05
AP1572A (en)	2006-02-13
ATE276253T1 (en)	2004-10-15
HK1060567A1 (en)	2004-08-13
EP1326862A1 (en)	2003-07-16
JP3764422B2 (en)	2006-04-05
MEP40008A (en)	2011-02-10
IL155335A (en)	2009-02-11
HRP20030276A2 (en)	2005-02-28
JP2004526668A (en)	2004-09-02
SK287009B6 (en)	2009-09-07
SA01220412B1 (en)	2006-11-05
EP1468998A1 (en)	2004-10-20
HK1086557A1 (en)	2006-09-22
IS6772A (en)	2003-04-09
AP2003002775A0 (en)	2003-03-31
PE20020422A1 (en)	2002-06-28
HUP0301022A2 (en)	2003-10-28
CN1733761A (en)	2006-02-15
MY126931A (en)	2006-10-31
ECSP034540A (en)	2003-07-25
NO328465B1 (en)	2010-02-22
OA12403A (en)	2006-04-18
DZ3478A1 (en)	2002-04-18
EP1326862B1 (en)	2004-09-15
RS50218B (en)	2009-07-15
CN100519558C (en)	2009-07-29
ZA200302500B (en)	2004-04-22
CA2425539A1 (en)	2003-04-11
CN1221549C (en)	2005-10-05
CN1469877A (en)	2004-01-21
SI1326862T1 (en)	2005-02-28
PL366041A1 (en)	2005-01-24
CA2425539C (en)	2007-04-03
MA25842A1 (en)	2003-07-01
BG107687A (en)	2003-09-30
AR034389A1 (en)	2004-02-25
BR0114584A (en)	2003-08-26
AU2002214996B2 (en)	2007-03-15
UY34901A (en)	2015-02-27
AR068527A2 (en)	2009-11-18
TW589313B (en)	2004-06-01
ME00243B (en)	2011-05-10
WO2002030928A1 (en)	2002-04-18
AU1499602A (en)	2002-04-22
HU226830B1 (en)	2009-11-30
UY26962A1 (en)	2002-06-20
HUP0301022A3 (en)	2005-12-28
EA200300457A1 (en)	2003-10-30
TR200402579T4 (en)	2004-12-21

Legal Events

Date	Code	Title	Description
2021-10-11	MK1K	Patent expired

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