|
US6908744B1
(en)
*
|
2000-03-14 |
2005-06-21 |
Regeneron Pharmaceuticals, Inc. |
Methods of stimulating cartilage formation
|
|
AU8337701A
(en)
*
|
2000-08-14 |
2002-02-25 |
Us Health |
Enhanced homologous recombination mediated by lambda recombination proteins
|
|
US20050144655A1
(en)
|
2000-10-31 |
2005-06-30 |
Economides Aris N. |
Methods of modifying eukaryotic cells
|
|
US6596541B2
(en)
|
2000-10-31 |
2003-07-22 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
US6586251B2
(en)
*
|
2000-10-31 |
2003-07-01 |
Regeneron Pharmaceuticals, Inc. |
Methods of modifying eukaryotic cells
|
|
GB0110029D0
(en)
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
SG141296A1
(en)
|
2002-05-17 |
2008-04-28 |
Sinai School Medicine |
Mesoderm and definitive endoderm cell populations
|
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
EP2314629B2
(en)
|
2002-07-18 |
2022-11-16 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
|
AU2003278790A1
(en)
*
|
2002-09-09 |
2004-03-29 |
California Institute Of Technology |
Methods and compositions for the generation of humanized mice
|
|
WO2004067725A2
(en)
*
|
2003-01-30 |
2004-08-12 |
Regeneron Pharmaceuticals, Inc. |
Methods of identifying modulators of nmur2-mediated activity
|
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
|
WO2004106375A1
(en)
|
2003-05-30 |
2004-12-09 |
Merus Biopharmaceuticals B.V. I.O. |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
|
WO2006044962A1
(en)
|
2004-10-19 |
2006-04-27 |
Regeneron Pharmaceuticals, Inc. |
Method for generating an animal homozygous for a genetic modification
|
|
US20060117396A1
(en)
*
|
2004-11-30 |
2006-06-01 |
Murphy Andrew J |
Assay methods for identifying modulators of OPSDL3 and transgenic knockouts
|
|
SG196697A1
(en)
|
2007-03-22 |
2014-02-13 |
Biogen Idec Inc |
Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof
|
|
CA2688834C
(en)
|
2007-06-01 |
2020-01-07 |
Ronald Buelow |
Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies
|
|
AU2008335178A1
(en)
*
|
2007-12-10 |
2009-06-18 |
Ablexis Llc |
Methods for sequential replacement of targeted region by homologous recombination
|
|
JP2011518555A
(ja)
*
|
2008-04-14 |
2011-06-30 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
標的組込みのための線形ドナーコンストラクト
|
|
US20090328240A1
(en)
*
|
2008-06-24 |
2009-12-31 |
Sing George L |
Genetically modified mice as predictors of immune response
|
|
DE102008002715A1
(de)
*
|
2008-06-27 |
2009-12-31 |
Evonik Röhm Gmbh |
2-Hydroxyisobuttersäure produzierende rekombinante Zelle
|
|
WO2010039900A2
(en)
|
2008-09-30 |
2010-04-08 |
Aliva Biopharmaceuticals, Inc. |
Non-human mammals for the production of chimeric antibodies
|
|
CN102638971B
(zh)
|
2009-07-08 |
2015-10-07 |
科马布有限公司 |
动物模型及治疗分子
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US8541646B2
(en)
|
2009-10-06 |
2013-09-24 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified mice and engraftment
|
|
PT2494047T
(pt)
|
2009-10-29 |
2017-02-08 |
Regeneron Pharma |
Alelos multifuncionais
|
|
DK2509409T3
(en)
|
2009-12-10 |
2016-11-14 |
Regeneron Pharma |
MICE, WHICH PRODUCES HEAVY CHAIN ANTIBODIES
|
|
NO2516457T3
(no)
|
2009-12-21 |
2018-08-11 |
|
|
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US20120021409A1
(en)
|
2010-02-08 |
2012-01-26 |
Regeneron Pharmaceuticals, Inc. |
Common Light Chain Mouse
|
|
HRP20151188T4
(hr)
|
2010-02-08 |
2021-10-01 |
Regeneron Pharmaceuticals, Inc. |
Miš sa zajedničkim lakim lancem
|
|
PL3251503T3
(pl)
|
2010-03-31 |
2024-07-08 |
Ablexis, Llc |
Modyfikacja myszy metodami inżynierii genetycznej w celu wytworzenia przeciwciał chimerycznych
|
|
WO2011159847A2
(en)
|
2010-06-15 |
2011-12-22 |
The Regents Of The University Of California |
Receptor tyrosine kinase-like orphan receptor 1 (ror1) single chain fv antibody fragment conjugates and methods of use thereof
|
|
SI2480675T1
(sl)
|
2010-06-22 |
2016-08-31 |
Regeneron Pharmaceuticals, Inc. |
Miši, ki izražajo lahko verigo s spremenljivo regijo humanega lambda in konstantno mišjo regijo
|
|
US10793829B2
(en)
|
2010-07-26 |
2020-10-06 |
Trianni, Inc. |
Transgenic mammals and methods of use thereof
|
|
US10662256B2
(en)
|
2010-07-26 |
2020-05-26 |
Trianni, Inc. |
Transgenic mammals and methods of use thereof
|
|
RU2580017C2
(ru)
|
2010-07-26 |
2016-04-10 |
Трианни, Инк. |
Трансгенные животные и способы применения
|
|
KR102306967B1
(ko)
|
2010-08-02 |
2021-10-01 |
리제너론 파아마슈티컬스, 인크. |
Vl 도메인을 포함하는 결합 단백질을 생성하는 마우스
|
|
WO2012063048A1
(en)
|
2010-11-08 |
2012-05-18 |
Kymab Limited |
Cells & vertebrates for enhanced somatic hypermutation and class switch recombination
|
|
CA2858350A1
(en)
|
2011-01-14 |
2013-07-19 |
The Regents Of The University Of California |
Therapeutic antibodies against ror-1 protein and methods for use of same
|
|
PT4233537T
(pt)
|
2011-02-15 |
2025-09-08 |
Regeneron Pharma |
Ratinhos humanizados para m-csf e utilizações dos mesmos
|
|
US10920242B2
(en)
|
2011-02-25 |
2021-02-16 |
Recombinetics, Inc. |
Non-meiotic allele introgression
|
|
LT2738259T
(lt)
|
2011-02-25 |
2020-03-10 |
Regeneron Pharmaceuticals, Inc. |
Adam6 pelės
|
|
DK2527842T3
(da)
|
2011-05-12 |
2013-09-08 |
Regeneron Pharma |
Neuropeptidfrisætningsanalyse til natriumkanaler
|
|
PT3865581T
(pt)
|
2011-08-05 |
2024-10-04 |
Regeneron Pharma |
Murganhos da cadeia leve universal humanizada
|
|
AU2012311286B2
(en)
|
2011-09-19 |
2018-07-26 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
EP3741862A1
(en)
|
2011-09-19 |
2020-11-25 |
Kymab Limited |
Animals, repertoires & methods for the production of human antibodies
|
|
WO2013045916A1
(en)
|
2011-09-26 |
2013-04-04 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
KR20140082824A
(ko)
|
2011-10-17 |
2014-07-02 |
리제너론 파아마슈티컬스, 인크. |
제한된 면역글로불린 중쇄 마우스
|
|
ES2741649T3
(es)
|
2011-10-28 |
2020-02-11 |
Regeneron Pharma |
Ratones con complejo mayor de histocompatibilidad modificado genéticamente
|
|
HUE053444T2
(hu)
|
2011-10-28 |
2021-06-28 |
Regeneron Pharma |
Genetikailag módosított T-sejt receptoros egerek
|
|
US9043996B2
(en)
|
2011-10-28 |
2015-06-02 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex animals
|
|
GB2496375A
(en)
|
2011-10-28 |
2013-05-15 |
Kymab Ltd |
A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
|
|
RS63220B1
(sr)
|
2011-10-28 |
2022-06-30 |
Regeneron Pharma |
Genetski modifikovani miševi sa ekspresijom himernih molekula klase ii glavnog kompleksa histokompatibilnosti (mhc)
|
|
US9591835B2
(en)
|
2011-10-28 |
2017-03-14 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex animals
|
|
CA2853470A1
(en)
|
2011-10-31 |
2013-05-10 |
Merck Sharp & Dohme Corp. |
Nano-suspension process
|
|
GB201122047D0
(en)
|
2011-12-21 |
2012-02-01 |
Kymab Ltd |
Transgenic animals
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
PT3527070T
(pt)
|
2011-12-20 |
2025-12-19 |
Regeneron Pharma |
Murganhos de cadeia leve humanizada
|
|
NZ810648A
(en)
|
2012-02-01 |
2025-11-28 |
Regeneron Pharma |
Humanized rodents that express heavy chains containing vl domains
|
|
MX353278B
(es)
|
2012-03-06 |
2018-01-05 |
Regeneron Pharma |
Raton con cadena ligera comun.
|
|
HK1200271A1
(en)
|
2012-03-16 |
2015-08-07 |
瑞泽恩制药公司 |
Mice that produce antigen-binding proteins with ph-dependent binding characteristics
|
|
US20140013456A1
(en)
|
2012-03-16 |
2014-01-09 |
Regeneron Pharmaceuticals, Inc. |
Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same
|
|
KR102213535B1
(ko)
|
2012-03-16 |
2021-02-08 |
리제너론 파마슈티칼스 인코포레이티드 |
pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물
|
|
DK2825036T3
(en)
|
2012-03-16 |
2018-07-16 |
Regeneron Pharma |
Histidine engineered light chain antibodies and genetically modified rodents to generate them
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
EP2831245A1
(en)
|
2012-03-28 |
2015-02-04 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class - switched, fully human, antibodies
|
|
GB2502127A
(en)
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
RU2645475C2
(ru)
|
2012-04-25 |
2018-02-21 |
Регенерон Фармасьютикалз, Инк. |
Опосредованное нуклеазой нацеливание с большими нацеливающими векторами
|
|
EP3912464A1
(en)
|
2012-06-12 |
2021-11-24 |
Regeneron Pharmaceuticals, Inc. |
Humanized non-human animals with restricted immunoglobulin heavy chain loci
|
|
AR091482A1
(es)
*
|
2012-06-21 |
2015-02-04 |
Recombinetics Inc |
Celulas modificadas geneticamente y metodos par su obtencion
|
|
SG10201912773TA
(en)
|
2012-08-23 |
2020-02-27 |
Agensys Inc |
Antibody drug conjugates (adc) that bind to 158p1d7 proteins
|
|
CA2881966C
(en)
|
2012-08-24 |
2020-10-06 |
The Regents Of The University Of California |
Antibodies and vaccines for use in treating ror1 cancers and inhibiting metastasis
|
|
UA118090C2
(uk)
*
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
|
IN2015DN02032A
(no)
|
2012-09-07 |
2015-08-14 |
Univ Yale |
|
|
ES2884598T3
(es)
|
2012-11-05 |
2021-12-10 |
Regeneron Pharma |
Animales no humanos modificados genéticamente y métodos de uso de los mismos
|
|
CA2900832A1
(en)
|
2013-02-20 |
2014-08-28 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing humanized t-cell co-receptors
|
|
US20140235933A1
(en)
|
2013-02-20 |
2014-08-21 |
Regeneron Pharmaceuticals, Inc. |
Genetic modification of rats
|
|
MY185881A
(en)
|
2013-02-20 |
2021-06-14 |
Regeneron Pharma |
Non-human animals with modified immunoglobulin heavy chain sequences
|
|
US20150342163A1
(en)
|
2013-02-22 |
2015-12-03 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified major histocompatibility complex mice
|
|
CA2900824A1
(en)
|
2013-02-22 |
2014-08-28 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing humanized major histocompatibility complex
|
|
AU2014249150B2
(en)
|
2013-03-11 |
2020-04-02 |
Regeneron Pharmaceuticals, Inc. |
Transgenic mice expressing chimeric major histocompatibility complex (MHC) class I molecules
|
|
CA3249218A1
(en)
|
2013-03-11 |
2026-03-02 |
Regeneron Pharmaceuticals, Inc. |
Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
|
|
JP2016519568A
(ja)
|
2013-03-13 |
2016-07-07 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
共通軽鎖のマウス
|
|
EP4218409B1
(en)
|
2013-03-13 |
2025-02-12 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
DK2986729T3
(en)
|
2013-04-16 |
2018-10-29 |
Regeneron Pharma |
TARGETED MODIFICATION OF ROOT THROUGH
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
HK1225621A1
(zh)
|
2013-08-01 |
2017-09-15 |
Agensys, Inc. |
结合cd37蛋白的抗体药物偶联物(adc)
|
|
EP3178928B1
(en)
|
2013-08-07 |
2020-06-10 |
Regeneron Pharmaceuticals, Inc. |
Pint knockout mouse exhibiting a premature aging-associated phenotype
|
|
JP6621750B2
(ja)
|
2013-09-18 |
2019-12-18 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
ヒスチジン操作軽鎖抗体およびそれを生成するための遺伝子改変非ヒト動物
|
|
MX368931B
(es)
|
2013-09-23 |
2019-10-22 |
Regeneron Pharma |
Animales no humanos que tienen un gen de proteina reguladora de señal humanizado.
|
|
CA2925723A1
(en)
|
2013-10-01 |
2015-04-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
BR112016011004A2
(pt)
|
2013-11-19 |
2017-12-05 |
Regeneron Pharma |
animal roedor geneticamente modificado, célula tronco embrionária de roedor, embrião de roedor, e, métodos para fabricar um animal roedor e para enxertar células humanas em um camundongo
|
|
US20150143558A1
(en)
|
2013-11-19 |
2015-05-21 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized b-cell activating factor gene
|
|
PT3080279T
(pt)
|
2013-12-11 |
2018-12-17 |
Regeneron Pharma |
Métodos e composições para a modificação direcionada de um genoma
|
|
WO2015088643A1
(en)
*
|
2013-12-11 |
2015-06-18 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for the targeted modification of a genome
|
|
US11160879B2
(en)
|
2014-01-15 |
2021-11-02 |
Masamichi Yamamoto |
Transgenic animal for visualization of ATP and use thereof
|
|
TWI681969B
(zh)
*
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
CN106164092A
(zh)
|
2014-03-21 |
2016-11-23 |
瑞泽恩制药公司 |
表现不同结合特征的vl抗原结合蛋白
|
|
CN106255410B
(zh)
|
2014-03-21 |
2020-01-10 |
瑞泽恩制药公司 |
产生单结构域结合蛋白的非人动物
|
|
PT3482629T
(pt)
|
2014-05-19 |
2021-02-18 |
Univ Yale |
Animais não humanos geneticamente modificados que expressam epo humana
|
|
AU2015266841C1
(en)
|
2014-05-30 |
2018-06-07 |
Regeneron Pharmaceuticals, Inc. |
Humanized dipeptidyl peptidase IV (DPP4) animals
|
|
RU2704283C9
(ru)
|
2014-06-06 |
2020-02-07 |
Регенерон Фармасьютикалз, Инк. |
Способы и композиции для модификации целевого локуса
|
|
EP3683238A1
(en)
*
|
2014-06-19 |
2020-07-22 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized programmed cell death 1 gene
|
|
RS60366B1
(sr)
|
2014-06-23 |
2020-07-31 |
Regeneron Pharma |
Sastavljanje dnk posredovano nukleazom
|
|
PT3161128T
(pt)
|
2014-06-26 |
2018-11-21 |
Regeneron Pharma |
Métodos e composições para modificações genéticas alvejadas e métodos de utilização
|
|
KR20170083534A
(ko)
|
2014-09-19 |
2017-07-18 |
리제너론 파마슈티칼스 인코포레이티드 |
키메라 항원 수용체
|
|
SG11201702309RA
(en)
|
2014-10-15 |
2017-04-27 |
Regeneron Pharma |
Methods and compositions for generating or maintaining pluripotent cells
|
|
CA2968440A1
(en)
|
2014-11-21 |
2016-05-26 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
KR102659123B1
(ko)
|
2014-11-24 |
2024-04-22 |
리제너론 파마슈티칼스 인코포레이티드 |
인간화 cd3 복합체를 발현하는 비인간 동물
|
|
FI3850946T3
(fi)
|
2014-12-05 |
2023-12-28 |
Regeneron Pharma |
Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni
|
|
EP3808775B1
(en)
|
2014-12-09 |
2024-04-17 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized cluster of differentiation 274 gene
|
|
BR112017013104A2
(en)
*
|
2014-12-19 |
2018-05-15 |
Regeneron Pharmaceuticals, Inc. |
methods for modifying a target genomic locus in a cell, for enhancing homologous recombination at a target genomic locus in a cell, and for producing an f0 generation from a nonhuman animal.
|
|
WO2016145099A1
(en)
|
2015-03-09 |
2016-09-15 |
Agensys, Inc. |
Antibody drug conjugates (adc) that bind to flt3 proteins
|
|
AU2016233250C1
(en)
|
2015-03-16 |
2022-08-18 |
Regeneron Pharmaceuticals, Inc. |
Non-human animal exhibiting diminished upper and lower motor neuron function and sensory perception
|
|
US11111314B2
(en)
|
2015-03-19 |
2021-09-07 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals that select for light chain variable regions that bind antigen
|
|
RU2732628C2
(ru)
|
2015-04-06 |
2020-09-21 |
Регенерон Фармасьютикалз, Инк. |
Опосредованные гуманизированными т-клетками иммунные ответы у не относящихся к человеку животных
|
|
PT3282835T
(pt)
|
2015-04-13 |
2023-07-25 |
Univ Yale |
Ratinhos knockin de sirpa-il15 humanizadas e métodos de utilização dos mesmos
|
|
JP6857138B2
(ja)
|
2015-05-18 |
2021-04-14 |
アジェンシス,インコーポレイテッド |
Axlタンパク質に結合する抗体
|
|
US10395759B2
(en)
|
2015-05-18 |
2019-08-27 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for copy number variant detection
|
|
US10787517B2
(en)
|
2015-05-18 |
2020-09-29 |
Agensys, Inc. |
Antibodies that bind to AXL proteins
|
|
EP3689139B1
(en)
*
|
2015-05-29 |
2025-01-01 |
Regeneron Pharmaceuticals, Inc. |
Rodent cells having a disruption in a c9orf72 locus
|
|
US10412939B2
(en)
|
2015-09-02 |
2019-09-17 |
Regeneron Pharmaceuticals, Inc. |
Rodent model of prostate cancer
|
|
TW202417497A
(zh)
|
2015-10-12 |
2024-05-01 |
美商再生元醫藥公司 |
活化瘦素受體的抗原結合蛋白
|
|
KR102454546B1
(ko)
|
2015-11-20 |
2022-10-14 |
리제너론 파마슈티칼스 인코포레이티드 |
인간화 림프구 활성화 유전자 3을 갖는 비인간 동물
|
|
BR112018010639A2
(pt)
*
|
2015-11-24 |
2019-01-22 |
Glaxosmithkline Ip Dev Ltd |
método de transfecção transitória para produção retroviral.
|
|
EP3380604B1
(en)
*
|
2015-11-24 |
2022-12-28 |
GlaxoSmithKline Intellectual Property Development Limited |
Stable cell lines for retroviral production
|
|
WO2017095939A1
(en)
|
2015-12-03 |
2017-06-08 |
Trianni, Inc. |
Enhanced immunoglobulin diversity
|
|
IL302725A
(en)
|
2016-01-13 |
2023-07-01 |
Regeneron Pharma |
Rodents having an engineered heavy chain diversity region
|
|
US20170218398A1
(en)
*
|
2016-01-30 |
2017-08-03 |
Markus Alexander Brown |
Method to selectively target cancerous cells for genetic manipulation
|
|
AU2017213633B2
(en)
|
2016-02-04 |
2023-08-03 |
Trianni, Inc. |
Enhanced production of immunoglobulins
|
|
EP3411392B1
(en)
*
|
2016-02-04 |
2021-12-29 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having an engineered angptl8 gene
|
|
EP3414691A1
(en)
|
2016-02-12 |
2018-12-19 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for detection of abnormal karyotypes
|
|
SG11201806427WA
(en)
|
2016-02-16 |
2018-08-30 |
Regeneron Pharma |
Non-human animals having a mutant kynureninase gene
|
|
EP3895529B1
(en)
|
2016-02-29 |
2026-04-29 |
Regeneron Pharmaceuticals, Inc. |
Rodents having a humanized tmprss gene
|
|
SG11201808261RA
(en)
|
2016-03-29 |
2018-10-30 |
Regeneron Pharma |
Genetic variant-phenotype analysis system and methods of use
|
|
US20170332610A1
(en)
|
2016-05-20 |
2017-11-23 |
Regeneron Pharmaceuticals, Inc. |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
KR102483193B1
(ko)
|
2016-06-03 |
2023-01-04 |
리제너론 파마슈티칼스 인코포레이티드 |
외인성 말단 데옥시뉴클레오타이드 전달효소를 발현하는 비인간 동물
|
|
EP3474854A4
(en)
|
2016-06-27 |
2020-02-19 |
The Regents of The University of California |
CANCER TREATMENT COMBINATIONS
|
|
EP3476865B1
(en)
|
2016-06-28 |
2023-09-13 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Method for constructing pd-1 gene-modified humanized animal model and use thereof
|
|
KR20190041476A
(ko)
|
2016-07-29 |
2019-04-22 |
리제너론 파마슈티칼스 인코포레이티드 |
C-절단된 피브릴린-1의 발현을 유도하는 돌연변이를 포함하는 마우스
|
|
EP3518667B1
(en)
|
2016-09-30 |
2024-10-30 |
Regeneron Pharmaceuticals, Inc. |
Rodents having a hexanucleotide repeat expansion in a c9orf72 locus
|
|
PT4082334T
(pt)
|
2016-11-04 |
2025-05-21 |
Regeneron Pharma |
Animais não humanos possuindo um lócus da cadeia leve lambda de immunoglobulina geneticamente modificada
|
|
US12016313B2
(en)
|
2017-01-19 |
2024-06-25 |
Omniab Operations, Inc. |
Human antibodies from transgenic rodents with multiple heavy chain immunoglobulin loci
|
|
CN110461146A
(zh)
|
2017-02-27 |
2019-11-15 |
再生元制药公司 |
视网膜劈裂的非人类动物模型
|
|
CA3068072A1
(en)
|
2017-07-31 |
2019-02-07 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for assessing crispr/cas-mediated disruption or excision and crispr/cas-induced recombination with an exogenous donor nucleic acid in vivo
|
|
CN110891420B
(zh)
|
2017-07-31 |
2022-06-03 |
瑞泽恩制药公司 |
Cas转基因小鼠胚胎干细胞和小鼠及其应用
|
|
PT3687287T
(pt)
|
2017-09-29 |
2023-11-03 |
Regeneron Pharma |
Roedores que expressam complexo c1q humanizado
|
|
JP7139419B2
(ja)
|
2017-09-29 |
2022-09-20 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
ヒト化ttr遺伝子座を含む非ヒト動物および使用方法
|
|
WO2019072241A1
(en)
|
2017-10-13 |
2019-04-18 |
Beijing Biocytogen Co., Ltd |
NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
|
|
CN109666701B
(zh)
*
|
2017-10-13 |
2021-08-24 |
百奥赛图(北京)医药科技股份有限公司 |
一种pd-1基因修饰人源化动物模型的构建方法及其应用
|
|
IL274740B2
(en)
|
2017-11-30 |
2024-06-01 |
Regeneron Pharma |
Non-human animals comprising a humanized trkb locus
|
|
TW202438676A
(zh)
|
2017-12-05 |
2024-10-01 |
美商再生元醫藥公司 |
具有經改造免疫球蛋白λ輕鏈的非人類動物及其用途
|
|
KR20240038811A
(ko)
|
2018-03-19 |
2024-03-25 |
리제너론 파마슈티칼스 인코포레이티드 |
CRISPR/Cas 시스템을 사용한 동물에서의 전사 조절
|
|
WO2019190990A1
(en)
|
2018-03-26 |
2019-10-03 |
Regeneron Pharmaceuticals, Inc. |
Humanized rodents for testing therapeutic agents
|
|
LT3773713T
(lt)
|
2018-04-06 |
2025-08-25 |
Regeneron Pharmaceuticals, Inc. |
Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija
|
|
KR20210022616A
(ko)
|
2018-06-01 |
2021-03-03 |
리제너론 파마슈티칼스 인코포레이티드 |
희소 벡터 기반 매트릭스 변환 방법 및 시스템
|
|
IL318469A
(en)
|
2018-06-14 |
2025-03-01 |
Regeneron Pharma |
Non-human animals capable of reorganizing transgenic DH-DH, and their uses
|
|
IL315703A
(en)
|
2018-07-16 |
2024-11-01 |
Regeneron Pharma |
Non-human animal models of DITRA disease and their uses
|
|
CN109504708A
(zh)
*
|
2018-12-03 |
2019-03-22 |
江苏集萃药康生物科技有限公司 |
一种筛选标记自我删除的基因打靶载体及方法
|
|
US11690362B2
(en)
|
2018-12-20 |
2023-07-04 |
Regeneran Pharmaceuticals, Inc. |
Nuclease-mediated repeat expansion
|
|
WO2020152607A1
(en)
|
2019-01-22 |
2020-07-30 |
St. Jude Children's Research Hospital |
Modulation of lc3-associated endocytosis pathway and genetically modified non-human animals as a model of neuroinflammation and neurodegeneration
|
|
CA3125380A1
(en)
*
|
2019-02-18 |
2020-08-27 |
Biocytogen Pharmaceuticals (Beijing) Co., Ltd. |
Genetically modified non-human animals with humanized immunoglobulin locus
|
|
SG11202107589PA
(en)
|
2019-02-22 |
2021-08-30 |
Regeneron Pharma |
Rodents having genetically modified sodium channels and methods of use thereof
|
|
ES2966625T3
(es)
|
2019-04-04 |
2024-04-23 |
Regeneron Pharma |
Roedores que comprenden un locus del factor de coagulación 12 humanizado
|
|
AU2020253531C1
(en)
|
2019-04-04 |
2022-06-16 |
Regeneron Pharmaceuticals, Inc. |
Methods for scarless introduction of targeted modifications into targeting vectors
|
|
AU2020258384B2
(en)
|
2019-04-15 |
2026-05-14 |
Qwixel Therapeutics Llc |
Fusion protein composition(s) comprising targeted masked type I interferons (IFNA and IFNB) and an antibody against tumor antigen, for use in the treatment of cancer
|
|
US11891618B2
(en)
|
2019-06-04 |
2024-02-06 |
Regeneron Pharmaceuticals, Inc. |
Mouse comprising a humanized TTR locus with a beta-slip mutation and methods of use
|
|
SG11202111258TA
(en)
|
2019-06-05 |
2021-11-29 |
Regeneron Pharma |
Non-human animals having a limited lambda light chain repertoire expressed from the kappa locus and uses thereof
|
|
CA3137764A1
(en)
|
2019-06-07 |
2020-12-10 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized albumin locus
|
|
JP7706380B2
(ja)
|
2019-06-27 |
2025-07-11 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Tdp-43タンパク症のモデル化
|
|
BR112021026410A2
(pt)
|
2019-07-01 |
2022-02-08 |
Tonix Pharma Ltd |
Anticorpos anti-cd154 e usos dos mesmos
|
|
KR20220079590A
(ko)
|
2019-10-04 |
2022-06-13 |
티에이이 라이프 사이언시스 |
Fc 돌연변이 및 부위-특이적인 접합 성질을 포함하는 항체 조성물
|
|
WO2021108363A1
(en)
|
2019-11-25 |
2021-06-03 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas-mediated upregulation of humanized ttr allele
|
|
CN115175559A
(zh)
|
2020-01-28 |
2022-10-11 |
瑞泽恩制药公司 |
包含人源化pnpla3基因座的非人动物及其使用方法
|
|
WO2021158883A1
(en)
|
2020-02-07 |
2021-08-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized klkb1 locus and methods of use
|
|
EP4125348A1
(en)
|
2020-03-23 |
2023-02-08 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising a humanized ttr locus comprising a v30m mutation and methods of use
|
|
CA3167557A1
(en)
|
2020-04-21 |
2021-10-28 |
Davor Frleta |
Non-human animals having a humanized cxcl13 gene
|
|
KR20230018439A
(ko)
|
2020-06-02 |
2023-02-07 |
바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 |
공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물
|
|
RU2751237C1
(ru)
*
|
2020-06-10 |
2021-07-12 |
Регенерон Фармасьютикалс, Инк. |
Способы и композиции для направленной модификации генома
|
|
WO2021261620A1
(ko)
|
2020-06-25 |
2021-12-30 |
주식회사 휴맵 |
이형접합성 형질전환 동물
|
|
KR20230066386A
(ko)
|
2020-09-11 |
2023-05-15 |
리제너론 파마슈티칼스 인코포레이티드 |
항원 특이적 항체의 확인 및 제조
|
|
IL301493B2
(en)
|
2020-10-01 |
2025-02-01 |
Regeneron Pharma |
Rodent animals expressing human CR1
|
|
US12012441B2
(en)
|
2020-10-26 |
2024-06-18 |
Neptune Biosciences Llc |
Engineered human IL-21 cytokines and methods for using the same
|
|
AU2021400584A1
(en)
|
2020-12-16 |
2023-06-29 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing humanized fc alpha receptors
|
|
CA3171455A1
(en)
|
2020-12-21 |
2022-06-30 |
Yajun Tang |
Non-human animals having a humanized tslp gene, a humanized tslp receptor gene, and/or a humanized il7ra gene
|
|
US20240317849A1
(en)
|
2020-12-23 |
2024-09-26 |
Regeneron Pharmaceuticals, Inc. |
Nucleic acids encoding anchor modified antibodies and uses thereof
|
|
JP2024503625A
(ja)
|
2021-01-06 |
2024-01-26 |
トニックス ファーマ リミテッド |
改変された抗cd154抗体により免疫寛容を誘導する方法
|
|
US12376573B2
(en)
|
2021-03-31 |
2025-08-05 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified mice comprising humanized cellular immune system components with improved diversity of TCRB repertoire
|
|
US20240199725A1
(en)
|
2021-04-16 |
2024-06-20 |
Korea University Research And Business Foundation |
Human antibody targeting covid-19 virus
|
|
US20250325634A1
(en)
|
2021-06-18 |
2025-10-23 |
Nammi Therapeutics, Inc. |
Fusion Protein Composition(s) Comprising Masked Type I Interferons (IFNa and IFNb) For Use in the Treatment of Cancer and Methods Thereof
|
|
JP2024540086A
(ja)
|
2021-10-28 |
2024-10-31 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
C5をノックアウトするためのcrispr/cas関連方法及び組成物
|
|
US12582104B2
(en)
|
2021-12-08 |
2026-03-24 |
Regeneron Pharmaceuticals, Inc. |
Mutant myocilin disease model and uses thereof
|
|
EP4451863A1
(en)
|
2021-12-20 |
2024-10-30 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals comprising humanized ace2 and tmprss loci
|
|
EP4475671A1
(en)
|
2022-02-07 |
2024-12-18 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for defining optimal treatment timeframes in lysosomal disease
|
|
CA3242729A1
(en)
|
2022-02-11 |
2023-08-17 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for screening 4r tau targeting agents
|
|
US20250295096A1
(en)
|
2022-04-26 |
2025-09-25 |
Regeneron Pharmaceuticals, Inc. |
A rodent model of fibrodysplasia ossificans progressiva
|
|
US20250344681A1
(en)
|
2022-05-31 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Animal model of tdp-43 proteinopathy
|
|
WO2023235725A2
(en)
|
2022-05-31 |
2023-12-07 |
Regeneron Pharmaceuticals, Inc. |
Crispr-based therapeutics for c9orf72 repeat expansion disease
|
|
US20230417899A1
(en)
|
2022-06-27 |
2023-12-28 |
Oshkosh Corporation |
Position tracking for a lift device
|
|
AU2023310163A1
(en)
|
2022-07-19 |
2025-01-16 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified animal model and its use to model the human immune system
|
|
US20240099279A1
(en)
|
2022-09-22 |
2024-03-28 |
Regeneron Pharmaceuticals, Inc. |
Genetically modified mice expressing components of human cellular immune system
|
|
EP4593590A1
(en)
|
2022-09-29 |
2025-08-06 |
Regeneron Pharmaceuticals, Inc. |
Correction of hepatosteatosis in humanized liver animals through restoration of il6/il6r/gp130 signaling in human hepatocytes
|
|
WO2024163650A1
(en)
|
2023-02-01 |
2024-08-08 |
Regeneron Pharmaceuticals, Inc. |
Animals comprising a modified klhdc7b locus
|
|
KR20260026054A
(ko)
|
2023-06-13 |
2026-02-25 |
애드센트릭스 테라퓨틱스 잉크. |
넥틴-4 단백질에 결합하는 항체 및 항체 약물 접합체 (adc)와 관련된 방법 및 조성물
|
|
IL325100A
(en)
|
2023-06-16 |
2026-02-01 |
Regeneron Pharma |
Vectors, genetically modified cells and genetically modified non-human animals containing them
|
|
WO2025122669A1
(en)
|
2023-12-05 |
2025-06-12 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having a humanized complement factor b gene
|
|
WO2025171307A1
(en)
|
2024-02-08 |
2025-08-14 |
Regeneron Pharmaceuticals, Inc. |
Vectors, genetically modified cells, and genetically modified non-human animals comprising the same
|
|
WO2025212991A1
(en)
|
2024-04-05 |
2025-10-09 |
Regeneron Pharmaceuticals, Inc. |
Rodent models of disease
|
|
WO2025235388A1
(en)
|
2024-05-06 |
2025-11-13 |
Regeneron Pharmaceuticals, Inc. |
Transgene genomic identification by nuclease-mediated long read sequencing
|
|
WO2025250495A1
(en)
|
2024-05-28 |
2025-12-04 |
Regeneron Pharmaceuticals, Inc. |
Acceleration of human hepatocyte engraftment in humanized liver animals by supplementing paracrine ligands or agonists that activate human liver regeneration signals
|
|
WO2025264533A1
(en)
|
2024-06-17 |
2025-12-26 |
Adcentrx Therapeutics Inc. |
Methods and compositions related to antibody drug conjugates (adcs) that bind steap-1 proteins
|
|
WO2026030428A2
(en)
|
2024-08-01 |
2026-02-05 |
Regeneron Pharmaceuticals, Inc. |
Prostate-specific antigen peptides and uses thereof
|
|
US20260123608A1
(en)
|
2024-08-06 |
2026-05-07 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof
|
|
WO2026039661A1
(en)
|
2024-08-15 |
2026-02-19 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals with humanized fc epsilon receptors that lack functional alpha-1, 3-galactosyltransferase (ggta1)
|
|
WO2026096502A1
(en)
|
2024-10-28 |
2026-05-07 |
Tae Life Sciences Llc |
Methods of performing boron neutron capture therapy (bnct) in combination with immune checkpoint inhibitors
|
|
WO2026096736A1
(en)
|
2024-10-31 |
2026-05-07 |
Regeneron Pharmaceuticals, Inc. |
Rodents expressing humanized polymeric immunoglobulin receptor
|