NO20032101L - Apolipoproteinanaloger - Google Patents

Apolipoproteinanaloger

Info

Publication number
NO20032101L
NO20032101L NO20032101A NO20032101A NO20032101L NO 20032101 L NO20032101 L NO 20032101L NO 20032101 A NO20032101 A NO 20032101A NO 20032101 A NO20032101 A NO 20032101A NO 20032101 L NO20032101 L NO 20032101L
Authority
NO
Norway
Prior art keywords
apolipoprotein
construct
apo
constructs
nucleic acid
Prior art date
Application number
NO20032101A
Other languages
English (en)
Other versions
NO331274B1 (no
NO20032101D0 (no
Inventor
Jonas Graversen
Soeren Moestrup
Original Assignee
Proteopharma Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proteopharma Aps filed Critical Proteopharma Aps
Publication of NO20032101D0 publication Critical patent/NO20032101D0/no
Publication of NO20032101L publication Critical patent/NO20032101L/no
Publication of NO331274B1 publication Critical patent/NO331274B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Oppfinnelsen angår et apolipoproteinkonstrukt, et apolipoproteinkonstrukt for anvendelse som et medikament, et ny nukleinsyresekvens som koder for apolipoproteinkonstruktet, en vektor som omfatter nukleinsyresekvensen, en fremgangsmåte for å fremstille apolipoproteinkonstruktet og anvendelse av apolipoproteinkonstruktet for fremstilling av et farmasøytisk preparat. De presenterte data dokumenterer at konstruktene ifølge oppfinnelsen er i stand til å binde lipider, er i stand til å binde kubilin som er en sterk Apo Al-reseptor, sterkere enn naturlig Apo A-I og at konstruktets plasmahalveringstid er i det minste tre ganger bedre sammenlignet med det naturlige Apo A-I. Til sammen dokumenterer disse dataene at konstruktene ifølge oppfinnelsen er sterke kandidater for behandling av kardiovaskulære sykdommer.
NO20032101A 2000-11-10 2003-05-09 Apolipoproteinanaloger NO331274B1 (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200001682 2000-11-10
DKPA200100057 2001-01-15
US26402201P 2001-01-26 2001-01-26
PCT/DK2001/000739 WO2002038609A2 (en) 2000-11-10 2001-11-09 Apolipoprotein conjugates

Publications (3)

Publication Number Publication Date
NO20032101D0 NO20032101D0 (no) 2003-05-09
NO20032101L true NO20032101L (no) 2003-07-08
NO331274B1 NO331274B1 (no) 2011-11-14

Family

ID=27222453

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032101A NO331274B1 (no) 2000-11-10 2003-05-09 Apolipoproteinanaloger

Country Status (10)

Country Link
US (4) US6897039B2 (no)
EP (2) EP2343317A1 (no)
JP (2) JP4344136B2 (no)
CN (1) CN1268641C (no)
AU (2) AU1384302A (no)
BR (1) BR0115257A (no)
CA (1) CA2428114C (no)
CY (1) CY1111118T1 (no)
NO (1) NO331274B1 (no)
WO (1) WO2002038609A2 (no)

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US20090136467A1 (en) 2009-05-28
CN1268641C (zh) 2006-08-09
CA2428114A1 (en) 2002-05-16
AU2002213843B2 (en) 2008-02-07
JP2009118849A (ja) 2009-06-04
WO2002038609A3 (en) 2002-09-26
EP1335938A2 (en) 2003-08-20
NO20032101D0 (no) 2003-05-09
BR0115257A (pt) 2003-08-12
CY1111118T1 (el) 2015-06-11
US20050096277A1 (en) 2005-05-05
JP2004522424A (ja) 2004-07-29
CN1486327A (zh) 2004-03-31
US20020156007A1 (en) 2002-10-24
US20050142639A1 (en) 2005-06-30
US6897039B2 (en) 2005-05-24
AU1384302A (en) 2002-05-21
AU2002213843A2 (en) 2002-05-21
JP4344136B2 (ja) 2009-10-14
EP1335938B1 (en) 2010-09-22
CA2428114C (en) 2013-07-23
EP2343317A1 (en) 2011-07-13
WO2002038609A2 (en) 2002-05-16

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