NO20041594L - Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner - Google Patents

Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner

Info

Publication number
NO20041594L
NO20041594L NO20041594A NO20041594A NO20041594L NO 20041594 L NO20041594 L NO 20041594L NO 20041594 A NO20041594 A NO 20041594A NO 20041594 A NO20041594 A NO 20041594A NO 20041594 L NO20041594 L NO 20041594L
Authority
NO
Norway
Prior art keywords
spirycyclic
pyrazolo
pyrazol
dihydro
inflammatory cytokines
Prior art date
Application number
NO20041594A
Other languages
English (en)
Norwegian (no)
Inventor
Adam Golebiowski
Biswanath De
Matthew John Laufersweiler
Michael Phillip Clark
Jane Far-Jine Djung
Todd Andrew Brugel
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO20041594L publication Critical patent/NO20041594L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO20041594A 2001-09-20 2004-04-19 Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner NO20041594L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32362501P 2001-09-20 2001-09-20
PCT/US2002/030133 WO2003024973A1 (en) 2001-09-20 2002-09-20 Spirocyclic-6,7-dihydro-5h-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Publications (1)

Publication Number Publication Date
NO20041594L true NO20041594L (no) 2004-06-21

Family

ID=23259997

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20041594A NO20041594L (no) 2001-09-20 2004-04-19 Spirysyklisk-6,7-dihydro-5H-pyrazolo[1,2 a]pyrazol-1-oner som styrer inflammatoriske cytokiner
NO20041605A NO20041605L (no) 2001-09-20 2004-04-20 6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20041605A NO20041605L (no) 2001-09-20 2004-04-20 6,7-dihydro-5H-pyrazolo[1,2A)pyrazol-1-oner som styrer inflammatoriske cytokiner

Country Status (32)

Country Link
US (2) US6821971B2 (ar)
EP (3) EP1427728B1 (ar)
JP (3) JP2005504082A (ar)
KR (4) KR20040035837A (ar)
CN (3) CN1257905C (ar)
AR (3) AR037502A1 (ar)
AT (3) ATE356126T1 (ar)
AU (2) AU2002327690B2 (ar)
BR (3) BR0212673A (ar)
CA (3) CA2461071A1 (ar)
CO (3) CO5560590A2 (ar)
CY (1) CY1106398T1 (ar)
CZ (3) CZ2004345A3 (ar)
DE (3) DE60202782T2 (ar)
DK (2) DK1427732T3 (ar)
EG (2) EG24363A (ar)
ES (3) ES2282459T3 (ar)
HU (3) HUP0402500A3 (ar)
IL (3) IL160682A0 (ar)
MA (3) MA27064A1 (ar)
MX (3) MXPA04002574A (ar)
MY (2) MY129329A (ar)
NO (2) NO20041594L (ar)
NZ (3) NZ531063A (ar)
PE (3) PE20030446A1 (ar)
PL (3) PL370415A1 (ar)
PT (3) PT1427728E (ar)
RU (3) RU2278864C2 (ar)
SA (1) SA03230529B1 (ar)
SK (3) SK1492004A3 (ar)
WO (3) WO2003024971A1 (ar)
ZA (3) ZA200401260B (ar)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087615B2 (en) 2001-09-20 2006-08-08 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia
US6849627B2 (en) 2001-09-20 2005-02-01 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines
US7473695B2 (en) * 2001-10-22 2009-01-06 Mitsubishi Tanabe Pharma Corporation 4-imidazolin-2-one compounds
US6677337B2 (en) * 2002-03-19 2004-01-13 The Procter & Gamble Company 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines
JP2006501263A (ja) * 2002-09-09 2006-01-12 アムジエン・インコーポレーテツド 炎症治療用のTNF−αおよびインターロイキン低下剤としての1,4,5−置換1,2−ジヒドロ−ピラゾール−3−オンおよび3−アルコキシ−1H−ピラゾール誘導体
WO2004087696A1 (de) * 2003-04-03 2004-10-14 Merck Patent Gmbh Pirazolidin-1,2-dicarbonsaüre-1-((phenyl)-amid)-2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen
GB0308466D0 (en) * 2003-04-11 2003-05-21 Novartis Ag Organic compounds
US7482356B2 (en) * 2003-11-10 2009-01-27 The Procter & Gamble Company Bicyclic pyrazolone cytokine inhibitors
AU2007238071B2 (en) * 2006-04-18 2012-06-07 Abbvie Inc. Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
PE20120325A1 (es) * 2009-05-19 2012-04-12 Dow Agrosciences Llc Aminopirimidinas sustituidas con arilo como agentes fungicidas
WO2016205284A1 (en) 2015-06-15 2016-12-22 Cummins Inc. Combustion chamber elasticity device
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
CN107033090B (zh) * 2017-05-16 2019-05-07 无锡捷化医药科技有限公司 一种1,2,3,4-四氢噌啉的制备方法
RU2721684C1 (ru) * 2019-09-06 2020-05-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" Метил 2,3,8-триоксо-4-фенилтетрагидро-6Н-пиразоло[1,2-а]пирроло[2,3-c]пиразол-9а(1Н)-карбоксилаты
US20240425524A1 (en) * 2021-10-27 2024-12-26 Merck Sharp & Dohme Llc Spirotricycle ripk1 inhibitors and methods of uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054291A (ar) * 1963-02-26
GB1124982A (en) * 1965-02-09 1968-08-21 Lepetit Spa Diazabicyclo octanes and derivatives thereof
CH529153A (fr) 1969-10-27 1972-10-15 Lepetit Spa Procédé de préparation de pyrazolo (1,2-b) phtalazine-1,5 (10H)-diones
US5358924A (en) * 1991-03-21 1994-10-25 Bayer Aktiengesellschaft 3-hydroxy-4-aryl-5-oxo-pyrozoline derivatives, compositions and use
DK0640086T3 (da) * 1992-05-15 1999-12-06 Merrell Pharma Inc Mercaptoacetylamido-pyridazo[1,2-a][1,2]diazepin-derivateranvendelige som enkephalinase- og ACE-inhibitorer
GB9303993D0 (en) * 1993-02-26 1993-04-14 Fujisawa Pharmaceutical Co New heterocyclic derivatives
CN1272324C (zh) * 1999-09-07 2006-08-30 辛根塔参与股份公司 新颖的除草剂
US6730668B2 (en) * 2001-09-20 2004-05-04 The Procter & Gamble Company 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines

Also Published As

Publication number Publication date
PE20030446A1 (es) 2003-07-21
AR037237A1 (es) 2004-11-03
DE60202782D1 (de) 2005-03-03
NZ531123A (en) 2006-08-31
DE60213108D1 (de) 2006-08-24
DE60218704D1 (de) 2007-04-19
CZ2004345A3 (cs) 2004-06-16
PT1427728E (pt) 2007-05-31
HUP0402500A2 (hu) 2005-03-29
RU2004111806A (ru) 2005-03-27
MY129069A (en) 2007-03-30
MXPA04002569A (es) 2004-05-31
CO5560589A2 (es) 2005-09-30
RU2004111805A (ru) 2005-04-10
US20030105084A1 (en) 2003-06-05
CN1555375A (zh) 2004-12-15
ZA200401402B (en) 2004-08-27
CZ2004361A3 (cs) 2004-07-14
BR0212905A (pt) 2004-10-13
SK1482004A3 (en) 2004-08-03
EP1427732B1 (en) 2006-07-12
US6566357B1 (en) 2003-05-20
PE20030474A1 (es) 2003-07-22
DK1427732T3 (da) 2006-10-30
CN1249066C (zh) 2006-04-05
ES2237691T3 (es) 2005-08-01
MXPA04002574A (es) 2004-06-18
EP1427728B1 (en) 2007-03-07
ATE287887T1 (de) 2005-02-15
US6821971B2 (en) 2004-11-23
HK1071366A1 (en) 2005-07-15
HUP0402500A3 (en) 2008-10-28
NZ531122A (en) 2005-09-30
EP1427732A1 (en) 2004-06-16
PT1427727E (pt) 2005-06-30
CY1106398T1 (el) 2011-10-12
PL370351A1 (en) 2005-05-16
AR037502A1 (es) 2004-11-17
CO5560590A2 (es) 2005-09-30
SK1502004A3 (en) 2004-09-08
RU2272040C2 (ru) 2006-03-20
CA2461073A1 (en) 2003-03-27
EG24413A (en) 2009-05-25
PL370362A1 (en) 2005-05-16
WO2003024971A1 (en) 2003-03-27
SA03230529B1 (ar) 2008-06-21
RU2278864C2 (ru) 2006-06-27
KR100656126B1 (ko) 2006-12-12
RU2299885C2 (ru) 2007-05-27
DE60213108T2 (de) 2007-02-08
ZA200401260B (en) 2004-08-30
MXPA04002570A (es) 2004-05-31
HUP0402378A2 (hu) 2005-02-28
AU2002334641B2 (en) 2007-03-29
BR0212673A (pt) 2004-08-24
IL160682A0 (en) 2004-08-31
HUP0402378A3 (en) 2008-10-28
NO20041605L (no) 2004-06-21
CO5560579A2 (es) 2005-09-30
NZ531063A (en) 2007-08-31
JP2005504083A (ja) 2005-02-10
SK1492004A3 (en) 2004-11-03
ES2282459T3 (es) 2007-10-16
RU2004111803A (ru) 2005-10-10
CA2461071A1 (en) 2003-03-27
KR20040035836A (ko) 2004-04-29
ZA200401403B (en) 2004-08-30
KR20040035835A (ko) 2004-04-29
DE60202782T2 (de) 2006-01-19
ES2268154T3 (es) 2007-03-16
DE60218704T2 (de) 2007-11-08
BR0212716A (pt) 2004-08-03
CN1250551C (zh) 2006-04-12
PE20030430A1 (es) 2003-06-24
IL160741A0 (en) 2004-08-31
JP2005504082A (ja) 2005-02-10
KR20060036125A (ko) 2006-04-27
EG24363A (en) 2009-03-04
MA27064A1 (fr) 2004-12-20
DK1427728T3 (da) 2007-07-09
WO2003024973A1 (en) 2003-03-27
CN1257905C (zh) 2006-05-31
KR20040035837A (ko) 2004-04-29
AR037145A1 (es) 2004-10-27
CN1556811A (zh) 2004-12-22
JP2005504081A (ja) 2005-02-10
PL370415A1 (en) 2005-05-30
CZ2004358A3 (cs) 2004-07-14
KR100623879B1 (ko) 2006-09-19
EP1427727A1 (en) 2004-06-16
CA2461072A1 (en) 2003-03-27
CN1555379A (zh) 2004-12-15
EP1427727B1 (en) 2005-01-26
IL160742A0 (en) 2004-08-31
WO2003024970A1 (en) 2003-03-27
MY129329A (en) 2007-03-30
ATE356126T1 (de) 2007-03-15
AU2002327690B2 (en) 2006-07-20
EP1427728A1 (en) 2004-06-16
MA27066A1 (fr) 2004-12-20
HUP0500752A2 (en) 2006-01-30
MA27065A1 (fr) 2004-12-20
HK1071565A1 (en) 2005-07-22
ATE332901T1 (de) 2006-08-15
PT1427732E (pt) 2006-12-29

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