NO20043695L - Selektive dipeptidinhibitorer av kallikrein - Google Patents

Selektive dipeptidinhibitorer av kallikrein

Info

Publication number: NO20043695L
Authority: NO; Norway
Prior art keywords: kallikrein; dipeptide inhibitors; selective dipeptide; selective; inhibitors
Prior art date: 2002-03-08

Application number

NO20043695A

Other languages

English (en)

Other versions

NO332678B1 (no

Inventor

David Michael Evans

Original Assignee

Kalvista Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2004-09-03

Publication date

2004-10-07

2004-09-03 Application filed by Kalvista Pharmaceuticals Ltd filed Critical Kalvista Pharmaceuticals Ltd

2004-10-07 Publication of NO20043695L publication Critical patent/NO20043695L/no

2012-12-03 Publication of NO332678B1 publication Critical patent/NO332678B1/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20043695A 2002-03-08 2004-09-03 Selektive dipeptidinhibitorer av kallikrein NO332678B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0205527.5A GB0205527D0 (en)	2002-03-08	2002-03-08	Inhibitors
PCT/GB2003/000908 WO2003076458A2 (en)	2002-03-08	2003-03-04	Selective dipeptide inhibitors of kallikrein

Publications (2)

Publication Number	Publication Date
NO20043695L true NO20043695L (no)	2004-10-07
NO332678B1 NO332678B1 (no)	2012-12-03

Family

ID=9932619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20043695A NO332678B1 (no)	2002-03-08	2004-09-03	Selektive dipeptidinhibitorer av kallikrein

Country Status (26)

Country	Link
US (1)	US7649000B2 (no)
EP (1)	EP1483284B1 (no)
JP (1)	JP4330450B2 (no)
KR (1)	KR100974633B1 (no)
CN (1)	CN1274713C (no)
AR (1)	AR039868A1 (no)
AT (1)	ATE333463T1 (no)
AU (1)	AU2003208471B2 (no)
CA (1)	CA2478099C (no)
DE (1)	DE60306904T2 (no)
DK (1)	DK1483284T3 (no)
EG (1)	EG25482A (no)
ES (1)	ES2264523T3 (no)
GB (1)	GB0205527D0 (no)
IL (2)	IL163710A0 (no)
MX (1)	MXPA04008523A (no)
MY (1)	MY130830A (no)
NO (1)	NO332678B1 (no)
NZ (1)	NZ534891A (no)
PL (1)	PL209670B1 (no)
PT (1)	PT1483284E (no)
RU (1)	RU2301225C2 (no)
TW (1)	TWI283685B (no)
UY (1)	UY27699A1 (no)
WO (1)	WO2003076458A2 (no)
ZA (1)	ZA200406856B (no)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4775259B2 (ja)	2004-03-31	2011-09-21	味の素株式会社	アニリン誘導体
WO2009026334A2 (en) *	2007-08-21	2009-02-26	Genzyme Corporation	Treatment with kallikrein inhibitors
GB0918924D0 (en) *	2009-10-28	2009-12-16	Vantia Ltd	Azaindole derivatives
US9290485B2 (en)	2010-08-04	2016-03-22	Novartis Ag	N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB2494851A (en) *	2011-07-07	2013-03-27	Kalvista Pharmaceuticals Ltd	Plasma kallikrein inhibitors
US20140378474A1 (en)	2012-01-27	2014-12-25	Novartis Ag	5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
US20140350034A1 (en)	2012-01-27	2014-11-27	Novartis Ag	Aminopyridine derivatives as plasma kallikrein inhibitors
GB201212081D0 (en)	2012-07-06	2012-08-22	Kalvista Pharmaceuticals Ltd	New polymorph
GB201300304D0 (en)	2013-01-08	2013-02-20	Kalvista Pharmaceuticals Ltd	Benzylamine derivatives
IL239682B (en)	2013-01-08	2018-10-31	Kalvista Pharmaceuticals Ltd	History of benzylamine and 2-(aminomethyl)pyridine
GB2510407A (en)	2013-02-04	2014-08-06	Kalvista Pharmaceuticals Ltd	Aqueous suspensions of kallikrein inhibitors for parenteral administration
RU2712621C2 (ru)	2013-05-23	2020-01-30	Калвиста Фармасьютикалз Лимитед	Азотсодержащие гетероциклические производные, полезные в качестве ингибитора калликреина плазмы
HUE14755117T2 (hu)	2013-08-14	2018-12-28	Kalvista Pharmaceuticals Ltd	Plazma-kallikrein inhibitorok
TWI636047B (zh)	2013-08-14	2018-09-21	英商卡爾維斯塔製藥有限公司	雜環衍生物
GB2517908A (en) *	2013-08-14	2015-03-11	Kalvista Pharmaceuticals Ltd	Bicyclic inhibitors
WO2015063465A2 (en) *	2013-10-28	2015-05-07	Bicycle Therapeutics Limited	Novel polypeptides
US9499532B2 (en)	2014-02-07	2016-11-22	eXIthera Pharmaceuticals Inc.	Therapeutic compounds and compositions
GB201421088D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
GB201421085D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
GB201421083D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	Enzyme inhibitors
ME03794B (me)	2016-05-31	2021-04-20	Kalvista Pharmaceuticals Ltd	Derivati pirazola kao inhibitori kalikreina plazme
GB201609607D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
PL3716952T3 (pl)	2017-11-29	2022-05-02	Kalvista Pharmaceuticals Limited	Postacie dawkowania zawierające inhibitor kalikreiny osoczowej
GB201719881D0 (en)	2017-11-29	2018-01-10	Kalvista Pharmaceuticals Ltd	Solid forms of plasma kallikrein inhibitor and salts thereof
CA3117549A1 (en)	2018-10-30	2020-05-07	eXIthera Pharmaceuticals Inc.	Therapeutic compounds and compositions
GB201910125D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of angioedema
GB201910116D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of hereditary angioedema
WO2021028645A1 (en)	2019-08-09	2021-02-18	Kalvista Pharmaceuticals Limited	Plasma kallikrein inhibitors
GB2591730A (en)	2019-12-09	2021-08-11	Kalvista Pharmaceuticals Ltd	New polymorphs
GB201918994D0 (en)	2019-12-20	2020-02-05	Kalvista Pharmaceuticals Ltd	Treatments of diabetic macular edema and impaired visual acuity
WO2021198534A1 (en)	2020-04-04	2021-10-07	Oxurion NV	Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
TW202228686A (zh)	2020-10-15	2022-08-01	英商卡爾維斯塔製藥有限公司	血管性水腫之治療
WO2022084693A1 (en)	2020-10-23	2022-04-28	Kalvista Pharmaceuticals Limited	Treatments of angioedema
JP2024505596A (ja)	2021-02-09	2024-02-06	カルビスタ・ファーマシューティカルズ・リミテッド	遺伝性血管性浮腫の治療
WO2023002219A1 (en)	2021-07-23	2023-01-26	Kalvista Pharmaceuticals Limited	Treatments of hereditary angioedema
WO2023144030A1 (en)	2022-01-31	2023-08-03	Oxurion NV	Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en)	2022-02-04	2023-08-10	Oxurion NV	Biomarker for plasma kallikrein inhibitor therapy response
US20250281397A1 (en)	2022-04-27	2025-09-11	Kalvista Pharmaceuticals Limited	Formulations of a plasma kallikrein inhibitor
EP4673437A1 (en)	2023-02-27	2026-01-07	Kalvista Pharmaceuticals Limited	New solid form of a plasma kallikrein inhibitor
WO2025153806A1 (en)	2024-01-15	2025-07-24	Kalvista Pharmaceuticals Limited	Methods for determining amidolytic activity
WO2025172693A1 (en)	2024-02-13	2025-08-21	Kalvista Pharmaceuticals Limited	Oral sebetralstat for the treatment of an attack of hereditary angioedema
WO2025172692A1 (en)	2024-02-13	2025-08-21	Kalvista Pharmaceuticals Limited	Oral sebetralstat for the treatment of an attack of hereditary angioedema

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9019558D0 (en) *	1990-09-07	1990-10-24	Szelke Michael	Enzyme inhibitors
AU2882792A (en) *	1991-10-23	1993-05-21	Procter & Gamble Company, The	Tripeptide derivative anti-inflammatory agents
SE9301911D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptide derivatives
GB9318637D0 (en) *	1993-09-08	1993-10-27	Ferring Res Ltd	Enzyme inhibitors

2002
- 2002-03-08 GB GBGB0205527.5A patent/GB0205527D0/en not_active Ceased
2003
- 2003-02-26 TW TW092104061A patent/TWI283685B/zh not_active IP Right Cessation
- 2003-03-03 EG EG2003030209A patent/EG25482A/xx active
- 2003-03-04 IL IL16371003A patent/IL163710A0/xx unknown
- 2003-03-04 NZ NZ534891A patent/NZ534891A/xx not_active IP Right Cessation
- 2003-03-04 EP EP03706759A patent/EP1483284B1/en not_active Expired - Lifetime
- 2003-03-04 RU RU2004126610/04A patent/RU2301225C2/ru not_active IP Right Cessation
- 2003-03-04 MX MXPA04008523A patent/MXPA04008523A/es active IP Right Grant
- 2003-03-04 PL PL372977A patent/PL209670B1/pl unknown
- 2003-03-04 ES ES03706759T patent/ES2264523T3/es not_active Expired - Lifetime
- 2003-03-04 DE DE60306904T patent/DE60306904T2/de not_active Expired - Lifetime
- 2003-03-04 PT PT03706759T patent/PT1483284E/pt unknown
- 2003-03-04 KR KR1020047013816A patent/KR100974633B1/ko not_active Expired - Fee Related
- 2003-03-04 AU AU2003208471A patent/AU2003208471B2/en not_active Ceased
- 2003-03-04 CN CNB038054019A patent/CN1274713C/zh not_active Expired - Fee Related
- 2003-03-04 US US10/506,535 patent/US7649000B2/en not_active Expired - Lifetime
- 2003-03-04 DK DK03706759T patent/DK1483284T3/da active
- 2003-03-04 AT AT03706759T patent/ATE333463T1/de active
- 2003-03-04 JP JP2003574673A patent/JP4330450B2/ja not_active Expired - Fee Related
- 2003-03-04 CA CA2478099A patent/CA2478099C/en not_active Expired - Lifetime
- 2003-03-04 WO PCT/GB2003/000908 patent/WO2003076458A2/en not_active Ceased
- 2003-03-06 UY UY27699A patent/UY27699A1/es not_active Application Discontinuation
- 2003-03-06 AR ARP030100772A patent/AR039868A1/es active IP Right Grant
- 2003-03-07 MY MYPI20030803A patent/MY130830A/en unknown
2004
- 2004-08-24 IL IL163710A patent/IL163710A/en active IP Right Grant
- 2004-08-27 ZA ZA200406856A patent/ZA200406856B/en unknown
- 2004-09-03 NO NO20043695A patent/NO332678B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1483284E (pt)	2006-11-30
IL163710A (en)	2010-12-30
MY130830A (en)	2007-07-31
PL372977A1 (en)	2005-08-08
KR20040089705A (ko)	2004-10-21
CN1639186A (zh)	2005-07-13
US7649000B2 (en)	2010-01-19
JP2005533750A (ja)	2005-11-10
GB0205527D0 (en)	2002-04-24
CN1274713C (zh)	2006-09-13
UY27699A1 (es)	2003-10-31
MXPA04008523A (es)	2004-12-06
DE60306904D1 (de)	2006-08-31
TWI283685B (en)	2007-07-11
JP4330450B2 (ja)	2009-09-16
AU2003208471A1 (en)	2003-09-22
NO332678B1 (no)	2012-12-03
WO2003076458A3 (en)	2003-11-06
NZ534891A (en)	2006-03-31
RU2301225C2 (ru)	2007-06-20
CA2478099C (en)	2011-10-04
ZA200406856B (en)	2005-11-30
EP1483284B1 (en)	2006-07-19
CA2478099A1 (en)	2003-09-18
PL209670B1 (pl)	2011-10-31
DE60306904T2 (de)	2007-02-08
EG25482A (en)	2012-01-15
ES2264523T3 (es)	2007-01-01
ATE333463T1 (de)	2006-08-15
TW200403255A (en)	2004-03-01
US20060052313A1 (en)	2006-03-09
WO2003076458A2 (en)	2003-09-18
KR100974633B1 (ko)	2010-08-06
AR039868A1 (es)	2005-03-09
IL163710A0 (en)	2005-12-18
HK1072265A1 (en)	2005-08-19
EP1483284A2 (en)	2004-12-08
RU2004126610A (ru)	2005-05-27
DK1483284T3 (da)	2006-10-16
AU2003208471B2 (en)	2006-09-28

Legal Events

Date	Code	Title	Description
2014-11-03	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
DK1483284T3 (da)	2006-10-16	Selektive dipeptidinhibitorer af kallikrein
NO20043645L (no)	2004-08-31	Sykloalkylinhibitorer av kaliumkanal-funksjon
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
DK1699455T3 (da)	2013-08-05	Heterocykliske aspartylproteasehæmmere
IS7792A (is)	2005-04-11	Hýdantóínafleiður og notkun þeirra sem TACE hemla
LU93072I2 (fr)	2016-07-12	Inhibiteur de la protéinase alpha-1 humaine
DE60319430D1 (de)	2008-04-10	R- und fgfr-inhibitoren
DE60320933D1 (de)	2008-06-26	Rho-kinase inhibitoren
IS7717A (is)	2005-02-28	Pýrídasínónafleiður sem PDF4-hemlar
SE0701538L (sv)	2007-06-26	Azaspiroalkanderivat som hämmare av metalloproteaser
EP1549316A4 (en)	2008-04-09	HAMMER OF TFGbeta
EP1474093A4 (en)	2005-02-16	Granzyme B INHIBITORS
DK1501508T3 (da)	2007-05-21	Inhibitorer af histondeatylase
EP1467951A4 (en)	2006-09-06	ACTIVE ACOUSTIC PIPING
NO20034308L (no)	2003-11-26	Nye tyrokinase-inhibitorer
NO20026283L (no)	2003-02-28	Inhibitorer av kobberholdige aminosydaser
DE602004018837D1 (de)	2009-02-12	Ptidase-iv-inhibitoren
NO20016034L (no)	2002-01-18	Inhibitorer av aspartylprotease
EP1660436A4 (en)	2006-11-22	cathepsin inhibitors
NO20052348D0 (no)	2005-05-12	Behandling av hemoragisk sjokk
NO20050118D0 (no)	2005-01-10	Substituerte fenylsulfonamidinhibitorer av beta-amyolid produksjon
NO20044916L (no)	2004-12-16	Preparater av sulfinylacetamid
DK1458447T3 (da)	2010-01-18	Kombination af cytokrom-p450-beroende proteasinhibitorer
IL165475A0 (en)	2006-01-15	Nitrooxyderivatives of eyclooxygenase-2 inhibitors
NO20050563L (no)	2005-01-31	N-aryl-piperidinsubstituerte bifenylkarboksamider som inhibitorer av apolipoprotein B-sekresjon