DK1483284T3 - Selektive dipeptidinhibitorer af kallikrein - Google Patents

Selektive dipeptidinhibitorer af kallikrein

Info

Publication number: DK1483284T3
Authority: DK; Denmark
Prior art keywords: kallikrein; dipeptide inhibitors; selective dipeptide; selective; inhibitors
Prior art date: 2002-03-08

Application number

DK03706759T

Other languages

English (en)

Inventor

David Michael Evans

Original Assignee

Ferring Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-08

Filing date

2003-03-04

Publication date

2006-10-16

2003-03-04 Application filed by Ferring Bv filed Critical Ferring Bv

2006-10-16 Application granted granted Critical

2006-10-16 Publication of DK1483284T3 publication Critical patent/DK1483284T3/da

Links

108010016626 Dipeptides Proteins 0.000 title 1
102000001399 Kallikrein Human genes 0.000 title 1
108060005987 Kallikrein Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK03706759T 2002-03-08 2003-03-04 Selektive dipeptidinhibitorer af kallikrein DK1483284T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0205527.5A GB0205527D0 (en)	2002-03-08	2002-03-08	Inhibitors

Publications (1)

Publication Number	Publication Date
DK1483284T3 true DK1483284T3 (da)	2006-10-16

Family

ID=9932619

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK03706759T DK1483284T3 (da)	2002-03-08	2003-03-04	Selektive dipeptidinhibitorer af kallikrein

Country Status (26)

Country	Link
US (1)	US7649000B2 (da)
EP (1)	EP1483284B1 (da)
JP (1)	JP4330450B2 (da)
KR (1)	KR100974633B1 (da)
CN (1)	CN1274713C (da)
AR (1)	AR039868A1 (da)
AT (1)	ATE333463T1 (da)
AU (1)	AU2003208471B2 (da)
CA (1)	CA2478099C (da)
DE (1)	DE60306904T2 (da)
DK (1)	DK1483284T3 (da)
EG (1)	EG25482A (da)
ES (1)	ES2264523T3 (da)
GB (1)	GB0205527D0 (da)
IL (2)	IL163710A0 (da)
MX (1)	MXPA04008523A (da)
MY (1)	MY130830A (da)
NO (1)	NO332678B1 (da)
NZ (1)	NZ534891A (da)
PL (1)	PL209670B1 (da)
PT (1)	PT1483284E (da)
RU (1)	RU2301225C2 (da)
TW (1)	TWI283685B (da)
UY (1)	UY27699A1 (da)
WO (1)	WO2003076458A2 (da)
ZA (1)	ZA200406856B (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005095327A1 (ja)	2004-03-31	2005-10-13	Ajinomoto Co., Inc.	アニリン誘導体
WO2009026334A2 (en) *	2007-08-21	2009-02-26	Genzyme Corporation	Treatment with kallikrein inhibitors
GB0918924D0 (en) *	2009-10-28	2009-12-16	Vantia Ltd	Azaindole derivatives
US9290485B2 (en)	2010-08-04	2016-03-22	Novartis Ag	N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB2494851A (en)	2011-07-07	2013-03-27	Kalvista Pharmaceuticals Ltd	Plasma kallikrein inhibitors
WO2013111107A1 (en)	2012-01-27	2013-08-01	Novartis Ag	Aminopyridine derivatives as plasma kallikrein inhibitors
WO2013111108A1 (en)	2012-01-27	2013-08-01	Novartis Ag	5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
GB201212081D0 (en)	2012-07-06	2012-08-22	Kalvista Pharmaceuticals Ltd	New polymorph
GB201300304D0 (en)	2013-01-08	2013-02-20	Kalvista Pharmaceuticals Ltd	Benzylamine derivatives
IL239682B (en)	2013-01-08	2018-10-31	Kalvista Pharmaceuticals Ltd	History of benzylamine and 2-(aminomethyl)pyridine
GB2510407A (en)	2013-02-04	2014-08-06	Kalvista Pharmaceuticals Ltd	Aqueous suspensions of kallikrein inhibitors for parenteral administration
BR112015028879B1 (pt)	2013-05-23	2022-12-20	Kalvista Pharmaceuticals Limited	Compostos derivados heterocíclicos, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos
GB2517908A (en) *	2013-08-14	2015-03-11	Kalvista Pharmaceuticals Ltd	Bicyclic inhibitors
CA2920815C (en)	2013-08-14	2021-09-21	Kalvista Pharmaceuticals Limited	Inhibitors of plasma kallikrein
TWI636047B (zh)	2013-08-14	2018-09-21	英商卡爾維斯塔製藥有限公司	雜環衍生物
US10294274B2 (en) *	2013-10-28	2019-05-21	Bicyclerd Limited	Polypeptide ligands specific for plasma kallikrein
US9499532B2 (en)	2014-02-07	2016-11-22	eXIthera Pharmaceuticals Inc.	Therapeutic compounds and compositions
GB201421085D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
GB201421083D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	Enzyme inhibitors
GB201421088D0 (en)	2014-11-27	2015-01-14	Kalvista Pharmaceuticals Ltd	New enzyme inhibitors
WO2017207983A1 (en)	2016-05-31	2017-12-07	Kalvista Pharmaceuticals Limited	Pyrazole derivatives as plasma kallikrein inhibitors
GB201609607D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en)	2016-06-01	2016-07-13	Kalvista Pharmaceuticals Ltd	Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
JP7078722B2 (ja)	2017-11-29	2022-05-31	カルビスタ・ファーマシューティカルズ・リミテッド	血漿カリクレイン阻害剤を含む剤形
GB201719881D0 (en)	2017-11-29	2018-01-10	Kalvista Pharmaceuticals Ltd	Solid forms of plasma kallikrein inhibitor and salts thereof
AU2019369518A1 (en)	2018-10-30	2021-04-22	Exithera Pharmaceuticals, Inc.	Therapeutic compounds and compositions
GB201910116D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of hereditary angioedema
GB201910125D0 (en)	2019-07-15	2019-08-28	Kalvista Pharmaceuticals Ltd	Treatments of angioedema
WO2021028645A1 (en)	2019-08-09	2021-02-18	Kalvista Pharmaceuticals Limited	Plasma kallikrein inhibitors
GB201918994D0 (en)	2019-12-20	2020-02-05	Kalvista Pharmaceuticals Ltd	Treatments of diabetic macular edema and impaired visual acuity
GB2591730A (en)	2019-12-09	2021-08-11	Kalvista Pharmaceuticals Ltd	New polymorphs
WO2021198534A1 (en)	2020-04-04	2021-10-07	Oxurion NV	Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
WO2022079446A1 (en)	2020-10-15	2022-04-21	Kalvista Pharmaceuticals Limited	Treatments of angioedema
EP4232031A1 (en)	2020-10-23	2023-08-30	Kalvista Pharmaceuticals Limited	Treatments of angioedema
US20240122909A1 (en)	2021-02-09	2024-04-18	Kalvista Pharmaceuticals Limited	Treatments of hereditary angioedema
WO2023002219A1 (en)	2021-07-23	2023-01-26	Kalvista Pharmaceuticals Limited	Treatments of hereditary angioedema
WO2023144030A1 (en)	2022-01-31	2023-08-03	Oxurion NV	Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en)	2022-02-04	2023-08-10	Oxurion NV	Biomarker for plasma kallikrein inhibitor therapy response
CA3255900A1 (en)	2022-04-27	2023-11-02	Kalvista Pharmaceuticals Limited	FORMULATIONS OF A PLASMA KALLICEREIN INHIBITOR
EP4673437A1 (en)	2023-02-27	2026-01-07	Kalvista Pharmaceuticals Limited	New solid form of a plasma kallikrein inhibitor
WO2025153806A1 (en)	2024-01-15	2025-07-24	Kalvista Pharmaceuticals Limited	Methods for determining amidolytic activity
WO2025172692A1 (en)	2024-02-13	2025-08-21	Kalvista Pharmaceuticals Limited	Oral sebetralstat for the treatment of an attack of hereditary angioedema
WO2025172693A1 (en)	2024-02-13	2025-08-21	Kalvista Pharmaceuticals Limited	Oral sebetralstat for the treatment of an attack of hereditary angioedema

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9019558D0 (en) *	1990-09-07	1990-10-24	Szelke Michael	Enzyme inhibitors
AU2882792A (en) *	1991-10-23	1993-05-21	Procter & Gamble Company, The	Tripeptide derivative anti-inflammatory agents
SE9301911D0 (sv) *	1993-06-03	1993-06-03	Ab Astra	New peptide derivatives
GB9318637D0 (en) *	1993-09-08	1993-10-27	Ferring Res Ltd	Enzyme inhibitors

2002
- 2002-03-08 GB GBGB0205527.5A patent/GB0205527D0/en not_active Ceased
2003
- 2003-02-26 TW TW092104061A patent/TWI283685B/zh not_active IP Right Cessation
- 2003-03-03 EG EG2003030209A patent/EG25482A/xx active
- 2003-03-04 PL PL372977A patent/PL209670B1/pl unknown
- 2003-03-04 MX MXPA04008523A patent/MXPA04008523A/es active IP Right Grant
- 2003-03-04 WO PCT/GB2003/000908 patent/WO2003076458A2/en not_active Ceased
- 2003-03-04 AU AU2003208471A patent/AU2003208471B2/en not_active Ceased
- 2003-03-04 CN CNB038054019A patent/CN1274713C/zh not_active Expired - Fee Related
- 2003-03-04 RU RU2004126610/04A patent/RU2301225C2/ru not_active IP Right Cessation
- 2003-03-04 ES ES03706759T patent/ES2264523T3/es not_active Expired - Lifetime
- 2003-03-04 PT PT03706759T patent/PT1483284E/pt unknown
- 2003-03-04 NZ NZ534891A patent/NZ534891A/xx not_active IP Right Cessation
- 2003-03-04 US US10/506,535 patent/US7649000B2/en not_active Expired - Lifetime
- 2003-03-04 DE DE60306904T patent/DE60306904T2/de not_active Expired - Lifetime
- 2003-03-04 DK DK03706759T patent/DK1483284T3/da active
- 2003-03-04 JP JP2003574673A patent/JP4330450B2/ja not_active Expired - Fee Related
- 2003-03-04 CA CA2478099A patent/CA2478099C/en not_active Expired - Lifetime
- 2003-03-04 KR KR1020047013816A patent/KR100974633B1/ko not_active Expired - Fee Related
- 2003-03-04 AT AT03706759T patent/ATE333463T1/de active
- 2003-03-04 IL IL16371003A patent/IL163710A0/xx unknown
- 2003-03-04 EP EP03706759A patent/EP1483284B1/en not_active Expired - Lifetime
- 2003-03-06 AR ARP030100772A patent/AR039868A1/es active IP Right Grant
- 2003-03-06 UY UY27699A patent/UY27699A1/es not_active Application Discontinuation
- 2003-03-07 MY MYPI20030803A patent/MY130830A/en unknown
2004
- 2004-08-24 IL IL163710A patent/IL163710A/en active IP Right Grant
- 2004-08-27 ZA ZA200406856A patent/ZA200406856B/en unknown
- 2004-09-03 NO NO20043695A patent/NO332678B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1483284B1 (en)	2006-07-19
JP2005533750A (ja)	2005-11-10
IL163710A0 (en)	2005-12-18
GB0205527D0 (en)	2002-04-24
EG25482A (en)	2012-01-15
IL163710A (en)	2010-12-30
AU2003208471A1 (en)	2003-09-22
DE60306904T2 (de)	2007-02-08
AR039868A1 (es)	2005-03-09
TW200403255A (en)	2004-03-01
JP4330450B2 (ja)	2009-09-16
PL209670B1 (pl)	2011-10-31
WO2003076458A2 (en)	2003-09-18
NO20043695L (no)	2004-10-07
NZ534891A (en)	2006-03-31
CN1639186A (zh)	2005-07-13
ZA200406856B (en)	2005-11-30
US7649000B2 (en)	2010-01-19
CA2478099C (en)	2011-10-04
TWI283685B (en)	2007-07-11
US20060052313A1 (en)	2006-03-09
NO332678B1 (no)	2012-12-03
UY27699A1 (es)	2003-10-31
KR20040089705A (ko)	2004-10-21
HK1072265A1 (en)	2005-08-19
AU2003208471B2 (en)	2006-09-28
EP1483284A2 (en)	2004-12-08
MY130830A (en)	2007-07-31
ATE333463T1 (de)	2006-08-15
RU2301225C2 (ru)	2007-06-20
MXPA04008523A (es)	2004-12-06
RU2004126610A (ru)	2005-05-27
DE60306904D1 (de)	2006-08-31
KR100974633B1 (ko)	2010-08-06
WO2003076458A3 (en)	2003-11-06
ES2264523T3 (es)	2007-01-01
CN1274713C (zh)	2006-09-13
PL372977A1 (en)	2005-08-08
PT1483284E (pt)	2006-11-30
CA2478099A1 (en)	2003-09-18

Publication	Publication Date	Title
NO20043695L (no)	2004-10-07	Selektive dipeptidinhibitorer av kallikrein
DK1501508T3 (da)	2007-05-21	Inhibitorer af histondeatylase
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
NO20043645L (no)	2004-08-31	Sykloalkylinhibitorer av kaliumkanal-funksjon
DK1542977T3 (da)	2007-03-19	2,5-dioxoimidazolidin-4-ylacetamider og analoger som inhibitorer af metalloproteinase MMP12
DK1699455T3 (da)	2013-08-05	Heterocykliske aspartylproteasehæmmere
DK1505963T3 (da)	2011-08-08	Hepatitis C-inhibitorer
EP1667982A4 (en)	2008-08-13	Isoquinolinone CALIUMKANALINHIBITOREN
DK1575416T3 (da)	2014-01-13	Fremgangsmåder til diagnosticering af præeklampsi
DK1562902T3 (da)	2006-08-14	2-pyridonderivater som inhibitorer af neutrofilelastase
DE60320933D1 (de)	2008-06-26	Rho-kinase inhibitoren
NO20034044L (no)	2003-11-10	Metallproteinase-inhibitorer
NO20044258L (no)	2004-10-28	Cystein proteaseinhibitor
DE602004018837D1 (de)	2009-02-12	Ptidase-iv-inhibitoren
EP1667978A4 (en)	2007-08-29	Isoquinolinone POTASSIUM CHANNEL INHIBITORS
DK1458447T3 (da)	2010-01-18	Kombination af cytokrom-p450-beroende proteasinhibitorer
DK1686113T3 (da)	2012-02-20	Inhibitorer af aspartylprotease
DE602005019971D1 (de)	2010-04-29	Inhibitoren von cysteinprotease
EP1474093A4 (en)	2005-02-16	Granzyme B INHIBITORS
DK1567529T4 (da)	2021-05-10	Pseudopolymorfe former af en hiv-proteaseinhibitor
EP1660436A4 (en)	2006-11-22	cathepsin inhibitors
NO20034032L (no)	2003-11-10	Metallproteinase-inhibitorer
EP1817276A4 (en)	2009-12-09	CATHEPSINCYSTEINPROTEASEHEMMER
ATE402700T1 (de)	2008-08-15	Glycinamid-derivate als raf-kinase-hemmer
DK1536796T3 (da)	2008-06-09	N-arylpiperidinsubstituerede biphenylcarboxamider som inhibitorer af apolipoprotein B-sektion