NO20050355L - IL-7 drug substance, il-7 comprising composition, preparation and uses thereof - Google Patents

IL-7 drug substance, il-7 comprising composition, preparation and uses thereof

Info

Publication number
NO20050355L
NO20050355L NO20050355A NO20050355A NO20050355L NO 20050355 L NO20050355 L NO 20050355L NO 20050355 A NO20050355 A NO 20050355A NO 20050355 A NO20050355 A NO 20050355A NO 20050355 L NO20050355 L NO 20050355L
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NO
Norway
Prior art keywords
drug
drug substance
product
preparation
well
Prior art date
Application number
NO20050355A
Other languages
English (en)
Other versions
NO332305B1 (no
Inventor
Michel Christian Morre
Brigitte Assouline
Pierre Cortez
Anne Gregoire
Original Assignee
Cytheris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytheris filed Critical Cytheris
Publication of NO20050355L publication Critical patent/NO20050355L/no
Publication of NO332305B1 publication Critical patent/NO332305B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5418—IL-7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Den foreliggende oppfinnelse vedrører generelt områdene immunologi og molekylær biologi. Ifølge oppfinnelsen beskrives nærmere bestemt interieukin-7-legemiddelsubstanser, korresponderende, spesifikke immunreaktive antistoffer samt preparater som inneholder samme, samt fremstilling og anvendelser derav. Ifølge oppfinnelsen beskrives også fremgangsmåter til å karakterisere forurensningsprofilen i en r-hiL-7-legemiddelsubstans anvendt for terapeutiske formål, samt optimaliserte nukleotidsekvenser som koder for pattedyr-IL-7, rekombinante ekspresjonsvektorer samt fremgangsmåter til fremstilling og rensing av polypeptidene. Oppfinnelsen er basert på den uventede iakttakelse at langtidsaktiviteten til rekombinant IL-7 for det meste uttrykkes av en spesifikk conformer og at andre conformere, potensielle produktrelaterte substanser, produktrelaterte forurensninger og prosessrelaterte forurensninger, som normalt ville være inkludert i legemiddelsubstansen og/eller legemiddelproduktet bør, selv om de er bioaktive minimaliseres strengt pga. at de er i stand til å utløse en immunreaksjon mot det ønskede IL-7-molekyl.
NO20050355A 2002-08-08 2005-01-25 IL-7 -legemiddelsubstans, preparat, samt fremstilling og anvendelse derav NO332305B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02291996A EP1391513A1 (en) 2002-08-08 2002-08-08 IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof
US47588103P 2003-06-05 2003-06-05
PCT/EP2003/008701 WO2004018681A2 (en) 2002-08-08 2003-08-06 Il-7 drug substance, il- 7 comprising composition, preparation and uses thereof

Publications (2)

Publication Number Publication Date
NO20050355L true NO20050355L (no) 2005-05-06
NO332305B1 NO332305B1 (no) 2012-08-20

Family

ID=30775891

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050355A NO332305B1 (no) 2002-08-08 2005-01-25 IL-7 -legemiddelsubstans, preparat, samt fremstilling og anvendelse derav

Country Status (17)

Country Link
US (1) US7585947B2 (no)
EP (2) EP1391513A1 (no)
JP (3) JP2005534339A (no)
AT (1) ATE482273T1 (no)
AU (1) AU2003250216B2 (no)
CA (1) CA2494974C (no)
CY (1) CY1110994T1 (no)
DE (1) DE60334301D1 (no)
DK (1) DK1527179T3 (no)
ES (1) ES2353006T3 (no)
IL (1) IL166543A (no)
NO (1) NO332305B1 (no)
PL (1) PL213710B1 (no)
PT (1) PT1527179E (no)
SI (1) SI1527179T1 (no)
WO (1) WO2004018681A2 (no)
ZA (1) ZA200501914B (no)

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EP1746161A1 (en) * 2005-07-20 2007-01-24 Cytheris Glycosylated IL-7, preparation and uses
CA2619989C (en) * 2005-08-23 2014-06-17 National Research Council Of Canada Regulation of heterologous recombinant protein expression in methylotrophic and methanotrophic bacteria
ES2686593T3 (es) 2006-05-31 2018-10-18 The Regents Of The University Of California Expresión de CD127 que correlaciona inversamente con FoxP3 y la función supresora de Treg CD4+
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Also Published As

Publication number Publication date
WO2004018681A2 (en) 2004-03-04
CA2494974C (en) 2014-07-29
WO2004018681A3 (en) 2004-04-01
ES2353006T3 (es) 2011-02-24
EP1527179B1 (en) 2010-09-22
US7585947B2 (en) 2009-09-08
ZA200501914B (en) 2005-11-30
EP1527179A2 (en) 2005-05-04
AU2003250216B2 (en) 2010-08-05
JP5980467B2 (ja) 2016-08-31
AU2003250216A1 (en) 2004-03-11
PL213710B1 (pl) 2013-04-30
JP2010115203A (ja) 2010-05-27
EP1391513A1 (en) 2004-02-25
NO332305B1 (no) 2012-08-20
PT1527179E (pt) 2010-12-07
CA2494974A1 (en) 2004-03-04
US20050249701A1 (en) 2005-11-10
JP2005534339A (ja) 2005-11-17
DK1527179T3 (da) 2011-01-03
DE60334301D1 (de) 2010-11-04
SI1527179T1 (sl) 2011-04-29
IL166543A (en) 2012-02-29
ATE482273T1 (de) 2010-10-15
HK1075465A1 (en) 2005-12-16
JP2014147396A (ja) 2014-08-21
CY1110994T1 (el) 2015-06-11
PL373606A1 (en) 2005-09-05
IL166543A0 (en) 2006-01-15

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