NO20050832L - Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe - Google Patents

Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe

Info

Publication number
NO20050832L
NO20050832L NO20050832A NO20050832A NO20050832L NO 20050832 L NO20050832 L NO 20050832L NO 20050832 A NO20050832 A NO 20050832A NO 20050832 A NO20050832 A NO 20050832A NO 20050832 L NO20050832 L NO 20050832L
Authority
NO
Norway
Prior art keywords
estrogen receptor
selective estrogen
phenylsulonyl
group
receptor modulators
Prior art date
Application number
NO20050832A
Other languages
English (en)
Norwegian (no)
Inventor
Timothy Alan Shepherd
Scott Alan Frank
Jeffrey Alan Dodge
Scott Alan Jones
Owen Brendan Wallace
Robert Dean Dally
Kin Chiu Fong
Conrad Wilson Hummel
George Sal Lewis
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20050832L publication Critical patent/NO20050832L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20050832A 2002-07-22 2005-02-16 Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe NO20050832L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39786902P 2002-07-22 2002-07-22
US45023303P 2003-02-25 2003-02-25
PCT/IB2003/003349 WO2004009086A1 (en) 2002-07-22 2003-07-16 Selective estrogen receptor modulators containing a phenylsulfonyl group

Publications (1)

Publication Number Publication Date
NO20050832L true NO20050832L (no) 2005-02-16

Family

ID=30773044

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050832A NO20050832L (no) 2002-07-22 2005-02-16 Selektive estrogenreseptormodulatorer inneholdende en fenylsulonylgruppe

Country Status (24)

Country Link
US (2) US7399867B2 (de)
EP (1) EP1530470B9 (de)
JP (2) JP4656939B2 (de)
CN (1) CN1668303B (de)
AT (1) ATE433322T1 (de)
AU (1) AU2003253129B2 (de)
BR (1) BR0312675A (de)
CA (1) CA2490580C (de)
CO (1) CO5680445A2 (de)
CR (1) CR7657A (de)
DE (1) DE60327931D1 (de)
EA (1) EA008024B1 (de)
EC (1) ECSP055549A (de)
ES (1) ES2326593T3 (de)
HR (1) HRP20041233A2 (de)
IL (1) IL165745A0 (de)
MX (1) MXPA05000898A (de)
MY (1) MY141879A (de)
NO (1) NO20050832L (de)
NZ (1) NZ537138A (de)
PE (1) PE20040678A1 (de)
PL (1) PL374845A1 (de)
TW (1) TWI314860B (de)
WO (1) WO2004009086A1 (de)

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DE60327931D1 (de) * 2002-07-22 2009-07-23 Lilly Co Eli Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten
KR100693242B1 (ko) * 2003-02-25 2007-03-12 일라이 릴리 앤드 캄파니 결정성 비-용매화1-(4-(2-피페리디닐에톡시)페녹시)-2-(4-메탄술포닐페닐)-6-하이드록시나프탈렌 하이드로클로라이드
WO2004075894A1 (en) * 2003-02-25 2004-09-10 Eli Lilly And Company Crystalline non-solvated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride
CN1910167B (zh) * 2004-01-22 2011-08-10 伊莱利利公司 用于治疗血管舒缩症状的选择性雌激素受体调节剂
WO2005073206A1 (en) * 2004-01-22 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
AU2005207821B2 (en) * 2004-01-22 2011-02-10 Eli Lilly And Company Selective estrogen receptor modulators for the treatment of vasomotor symptoms
WO2005073190A1 (en) * 2004-01-29 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
CA2571309A1 (en) 2004-06-22 2006-01-05 Smithkline Beecham Corporation Chemical compounds
US20080200507A1 (en) * 2005-07-29 2008-08-21 Jeanette Tower Dunlap Crystalline Non-Solvated Methanesulfonic Acid Salt of 1-(4-(2-Piperidinylethoxy)Phenoxy)-2-(3-Hydroxyphenyl)-6-Hydroxynaphthalene
EP2342189A2 (de) * 2008-09-29 2011-07-13 Eli Lilly And Company Selektiver östrogenrezeptormodulator zur behandlung von osteoarthritis
DE102008057230A1 (de) 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
EP2406230A1 (de) 2009-03-11 2012-01-18 Pfizer Inc. Substituierte indazolamide und ihre verwendung als glucokinaseaktivatoren
KR20160088947A (ko) 2010-06-16 2016-07-26 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
JP6292744B2 (ja) * 2012-09-19 2018-03-14 富士カプセル株式会社 医薬品組成物
HUE039052T2 (hu) 2013-02-19 2018-12-28 Novartis Ag Benzotiofénszármazékok és azok készítményei szelektív ösztrogén receptor lebontóként
EP3935053B1 (de) 2019-03-08 2023-06-07 Syngenta Crop Protection AG Pestizidwirksame azole-amide derivate
EP3941915A1 (de) 2019-03-20 2022-01-26 Syngenta Crop Protection AG Pestizide azol-amid-verbindungen
BR112021018822A2 (pt) 2019-03-22 2021-11-23 Syngenta Crop Protection Ag Derivados de n-[1-(5-bromo-2-pirimidin-2-il-1,2,4-triazol-3-il)etil]-2-ciclopropil-6-(trifluorometil)piridina-4-carboxamida e compostos relacionados como inseticidas
UY38623A (es) 2019-03-29 2020-10-30 Syngenta Crop Protection Ag Compuestos de diazina-amida activos como pesticidas
MX2021012162A (es) 2019-04-05 2021-11-03 Syngenta Crop Protection Ag Compuestos de diazina-amida activos como pesticidas.
BR112022003375A2 (pt) 2019-08-23 2022-05-17 Syngenta Crop Protection Ag Compostos de pirazina-amida pesticidamente ativos
CN110526881B (zh) * 2019-08-27 2020-09-22 河南省锐达医药科技有限公司 一种萘胺类化合物及其生物学可接受的盐,其制备方法和应用
CN115244036A (zh) 2020-02-27 2022-10-25 先正达农作物保护股份公司 杀有害生物活性的二嗪-双酰胺化合物
WO2022237904A1 (zh) * 2021-05-14 2022-11-17 江苏亚虹医药科技股份有限公司 一种含萘环的化合物、含其的药物组合物及其应用
JP2024524883A (ja) 2021-06-09 2024-07-09 シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト 殺有害生物的に活性なジアジン-アミド化合物
WO2023283315A1 (en) * 2021-07-07 2023-01-12 South Dakota Board Of Regents Compositions and methods for treatment of cervical and ovarian cancer
US20260055089A1 (en) 2022-08-25 2026-02-26 Sanofi Novel substituted benzothiophene-6-carboxylic acid derivatives, processes for their preparation and therapeutic uses thereof

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US5998401A (en) * 1995-02-28 1999-12-07 Eli Lilly And Company Naphthyl compounds, intermediates, compositions, and methods
US5599822A (en) 1995-06-06 1997-02-04 Eli Lilly And Company Methods for minimizing bone loss
ATE284690T1 (de) * 1995-10-31 2005-01-15 Lilly Co Eli Antithrombotische diamine
KR19990087091A (ko) * 1996-02-22 1999-12-15 피터 지. 스트링거 벤조티오펜, 이를 함유하는 조성물 및 방법
ES2162198T3 (es) 1996-04-19 2001-12-16 American Home Prod Agentes estrogenos.
CA2214070C (en) 1996-08-29 2006-03-14 Eli Lilly And Company Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods
CA2213810C (en) 1996-08-29 2006-06-06 Lewis Dale Pennington Benzo¬b|thiophene compounds, intermediates, processes, compositions and methods
CA2213814A1 (en) 1996-08-29 1998-02-28 Henry Uhlman Bryant Naphthalene compounds, intermediates, formulations, and methods
ID19392A (id) 1996-08-29 1998-07-09 Lilly Co Eli Senyawa naftil dan bahan pertengahan serta komposisi dan metode penggunaan
CA2217810A1 (en) * 1996-10-10 1998-04-10 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods
JPH10204082A (ja) 1996-10-25 1998-08-04 Eli Lilly & Co 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ[b]チオフェン化合物
DE60327931D1 (de) * 2002-07-22 2009-07-23 Lilly Co Eli Selektive östrogenrezeptor modulatoren, die eine phenylsulfonyl-gruppe enthalten

Also Published As

Publication number Publication date
MXPA05000898A (es) 2005-05-16
EP1530470A1 (de) 2005-05-18
ATE433322T1 (de) 2009-06-15
WO2004009086A1 (en) 2004-01-29
JP4656939B2 (ja) 2011-03-23
PL374845A1 (en) 2005-11-14
ES2326593T3 (es) 2009-10-15
BR0312675A (pt) 2005-05-03
AU2003253129A1 (en) 2004-02-09
NZ537138A (en) 2007-11-30
CO5680445A2 (es) 2006-09-29
US20060183736A1 (en) 2006-08-17
CA2490580A1 (en) 2004-01-29
ECSP055549A (es) 2005-03-10
MY141879A (en) 2010-07-16
JP2005538089A (ja) 2005-12-15
TWI314860B (en) 2009-09-21
PE20040678A1 (es) 2004-10-06
EA200500248A1 (ru) 2005-06-30
CN1668303A (zh) 2005-09-14
JP5220800B2 (ja) 2013-06-26
IL165745A0 (en) 2006-01-15
CN1668303B (zh) 2010-10-27
AU2003253129B2 (en) 2008-12-11
HK1078003A1 (en) 2006-03-03
US20080214612A1 (en) 2008-09-04
JP2010195820A (ja) 2010-09-09
HRP20041233A2 (en) 2005-02-28
CA2490580C (en) 2012-12-11
CR7657A (es) 2005-07-13
US7585977B2 (en) 2009-09-08
EP1530470B9 (de) 2010-04-07
EA008024B1 (ru) 2007-02-27
DE60327931D1 (de) 2009-07-23
US7399867B2 (en) 2008-07-15
TW200414901A (en) 2004-08-16
EP1530470B1 (de) 2009-06-10

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