NO20051225L - 1,2,4- oksadiazoler som modulatorer av metabotropisk glutamat-reseptor-5 - Google Patents
1,2,4- oksadiazoler som modulatorer av metabotropisk glutamat-reseptor-5Info
- Publication number
- NO20051225L NO20051225L NO20051225A NO20051225A NO20051225L NO 20051225 L NO20051225 L NO 20051225L NO 20051225 A NO20051225 A NO 20051225A NO 20051225 A NO20051225 A NO 20051225A NO 20051225 L NO20051225 L NO 20051225L
- Authority
- NO
- Norway
- Prior art keywords
- oxadiazoles
- modulators
- glutamate receptor
- metabotropic glutamate
- compounds
- Prior art date
Links
- 150000005071 1,2,4-oxadiazoles Chemical class 0.000 title 1
- 108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 title 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40204002P | 2002-08-09 | 2002-08-09 | |
| PCT/US2003/024846 WO2004014881A2 (en) | 2002-08-09 | 2003-08-08 | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20051225L true NO20051225L (no) | 2005-05-09 |
Family
ID=31715777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20051225A NO20051225L (no) | 2002-08-09 | 2005-03-09 | 1,2,4- oksadiazoler som modulatorer av metabotropisk glutamat-reseptor-5 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20040152699A1 (pl) |
| EP (1) | EP1529045A2 (pl) |
| JP (2) | JP4637578B2 (pl) |
| KR (1) | KR20050033070A (pl) |
| CN (2) | CN1894241A (pl) |
| AR (1) | AR040847A1 (pl) |
| AU (1) | AU2003259068B2 (pl) |
| BR (1) | BR0313265A (pl) |
| CA (1) | CA2494987C (pl) |
| IL (1) | IL166510A0 (pl) |
| IS (1) | IS7733A (pl) |
| MX (1) | MXPA05001594A (pl) |
| NO (1) | NO20051225L (pl) |
| NZ (1) | NZ538225A (pl) |
| PL (1) | PL375256A1 (pl) |
| RU (1) | RU2352568C9 (pl) |
| TW (1) | TWI341314B (pl) |
| UA (1) | UA87653C2 (pl) |
| WO (1) | WO2004014881A2 (pl) |
| ZA (1) | ZA200500886B (pl) |
Families Citing this family (86)
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|---|---|---|---|---|
| NZ538225A (en) * | 2002-08-09 | 2008-05-30 | Astrazeneca Ab | "1,2,4"Oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| EP1644363B1 (en) | 2003-05-30 | 2012-02-22 | Gemin X Pharmaceuticals Canada Inc. | Triheterocyclic compounds, compositions, and methods for treating cancer |
| WO2005077345A1 (en) * | 2004-02-03 | 2005-08-25 | Astrazeneca Ab | Compounds for the treatment of gastro-esophageal reflux disease |
| CN101018779A (zh) * | 2004-02-18 | 2007-08-15 | 阿斯利康(瑞典)有限公司 | 三唑化合物及其作为代谢型谷氨酸受体拮抗剂的应用 |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| AU2005214380A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders |
| EP1745040B9 (en) * | 2004-02-23 | 2010-06-02 | Glaxo Group Limited | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine d3 receptors |
| AU2005230867A1 (en) * | 2004-03-26 | 2005-10-20 | Amphora Discovery Corporation | Certain triazole-based compounds, compositions, and uses thereof |
| WO2006030805A1 (ja) | 2004-09-16 | 2006-03-23 | Astellas Pharma Inc. | トリアゾール誘導体またはその塩 |
| JP4557685B2 (ja) | 2004-11-15 | 2010-10-06 | 独立行政法人理化学研究所 | 蛍光蛋白質 |
| JP2008521908A (ja) * | 2004-12-01 | 2008-06-26 | カリプシス・インコーポレーテッド | 誘導型一酸化窒素シンターゼ阻害剤 |
| ES2346685T3 (es) * | 2005-01-14 | 2010-10-19 | F. Hoffmann-La Roche Ag | Deribados de tiazol-4-carboxamida como antagonistas de mglur5. |
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| GB0510142D0 (en) * | 2005-05-18 | 2005-06-22 | Addex Pharmaceuticals Sa | Novel compounds A1 |
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| TW200804345A (en) | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
| UY29796A1 (es) | 2005-09-29 | 2007-04-30 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de trastornos neurológicos, psiquiátricos o del dolor |
| BRPI0620526A2 (pt) * | 2005-11-28 | 2011-11-16 | Kalypsys Inc | sal de acetato e método para alcançar um efeito em um paciente |
| TW200811157A (en) | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
| CA2663113A1 (en) | 2006-09-11 | 2008-03-20 | Novartis Ag | Nicotinic acid derivatives as modulators of metabotropic glutanate receptors |
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| EP1958631A1 (en) * | 2007-02-14 | 2008-08-20 | AEterna Zentaris GmbH | Novel triazole derivatives as ligands of G-protein coupled receptors |
| EP2181110A2 (en) | 2007-07-13 | 2010-05-05 | ADDEX Pharma S.A. | Novel heteroaromatic derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors |
| EP2786993B1 (en) | 2007-08-13 | 2017-11-15 | Monsanto Technology LLC | Compositions and methods for controlling nematodes |
| WO2009051705A1 (en) * | 2007-10-18 | 2009-04-23 | Merck & Co., Inc. | Substituted 1,2,4-oxadiazoles and analogs thereof as cb2 receptor modulators, useful in the treatment of pain, respiratory and non-respiratory diseases |
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| JP5502077B2 (ja) | 2008-06-05 | 2014-05-28 | グラクソ グループ リミテッド | 新規な化合物 |
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| AU2009265760B2 (en) | 2008-06-30 | 2013-07-18 | Novartis Ag | Combinations comprising mGluR modulators for the treatment of parkinson's disease |
| LT2298747T (lt) | 2008-07-03 | 2017-02-10 | Astellas Pharma Inc. | Triazolo darinys arba jo druska |
| DE102009041242A1 (de) | 2009-09-11 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung |
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2003
- 2003-08-08 NZ NZ538225A patent/NZ538225A/en not_active IP Right Cessation
- 2003-08-08 PL PL03375256A patent/PL375256A1/pl unknown
- 2003-08-08 CN CNA038238454A patent/CN1894241A/zh active Pending
- 2003-08-08 BR BR0313265-0A patent/BR0313265A/pt not_active Application Discontinuation
- 2003-08-08 US US10/637,012 patent/US20040152699A1/en not_active Abandoned
- 2003-08-08 KR KR1020057002101A patent/KR20050033070A/ko not_active Ceased
- 2003-08-08 JP JP2004527872A patent/JP4637578B2/ja not_active Expired - Fee Related
- 2003-08-08 MX MXPA05001594A patent/MXPA05001594A/es active IP Right Grant
- 2003-08-08 EP EP03785036A patent/EP1529045A2/en not_active Withdrawn
- 2003-08-08 TW TW092121880A patent/TWI341314B/zh not_active IP Right Cessation
- 2003-08-08 WO PCT/US2003/024846 patent/WO2004014881A2/en not_active Ceased
- 2003-08-08 RU RU2005106844/04A patent/RU2352568C9/ru not_active IP Right Cessation
- 2003-08-08 AR AR20030102891A patent/AR040847A1/es unknown
- 2003-08-08 AU AU2003259068A patent/AU2003259068B2/en not_active Ceased
- 2003-08-08 CA CA2494987A patent/CA2494987C/en not_active Expired - Fee Related
- 2003-08-08 UA UAA200501100A patent/UA87653C2/ru unknown
- 2003-08-08 CN CN200910208474A patent/CN101723941A/zh active Pending
- 2003-08-08 IL IL16651003A patent/IL166510A0/xx unknown
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2005
- 2005-01-31 ZA ZA200500886A patent/ZA200500886B/en unknown
- 2005-03-09 NO NO20051225A patent/NO20051225L/no unknown
- 2005-03-09 IS IS7733A patent/IS7733A/is unknown
- 2005-11-14 US US11/274,611 patent/US7456200B2/en not_active Expired - Fee Related
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2010
- 2010-06-14 JP JP2010135508A patent/JP2010248214A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2494987A1 (en) | 2004-02-19 |
| AU2003259068B2 (en) | 2009-07-02 |
| US7456200B2 (en) | 2008-11-25 |
| US20040152699A1 (en) | 2004-08-05 |
| WO2004014881B1 (en) | 2004-07-15 |
| CN1894241A (zh) | 2007-01-10 |
| WO2004014881A3 (en) | 2004-05-27 |
| JP2006503009A (ja) | 2006-01-26 |
| CA2494987C (en) | 2012-04-17 |
| IS7733A (is) | 2005-03-09 |
| TWI341314B (en) | 2011-05-01 |
| JP2010248214A (ja) | 2010-11-04 |
| CN101723941A (zh) | 2010-06-09 |
| KR20050033070A (ko) | 2005-04-08 |
| NZ538225A (en) | 2008-05-30 |
| WO2004014881A2 (en) | 2004-02-19 |
| AR040847A1 (es) | 2005-04-20 |
| JP4637578B2 (ja) | 2011-02-23 |
| UA87653C2 (en) | 2009-08-10 |
| AU2003259068A1 (en) | 2004-02-25 |
| IL166510A0 (en) | 2006-01-15 |
| RU2005106844A (ru) | 2005-08-27 |
| MXPA05001594A (es) | 2005-09-20 |
| EP1529045A2 (en) | 2005-05-11 |
| PL375256A1 (pl) | 2005-11-28 |
| RU2352568C2 (ru) | 2009-04-20 |
| TW200413361A (en) | 2004-08-01 |
| BR0313265A (pt) | 2005-07-05 |
| ZA200500886B (en) | 2006-07-26 |
| US20060122397A1 (en) | 2006-06-08 |
| RU2352568C9 (ru) | 2009-06-27 |
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