NO20052478L - Vitamin D-analoger, sammensetninger omfattende analogene og deres anvendelse. - Google Patents

Vitamin D-analoger, sammensetninger omfattende analogene og deres anvendelse.

Info

Publication number: NO20052478L
Authority: NO; Norway
Prior art keywords: bond; hydrogen; ethylene; proviso; represent
Prior art date: 2002-10-23

Application number

NO20052478A

Other languages

English (en)

Norwegian (no)

Other versions

NO20052478D0 (no

Inventor

Martin John Calverley

Ernst Torndal Binderup

Kai Holst Hansen

Claus Aage Svensgaard Bretting

Original Assignee

Leo Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-23

Filing date

2005-05-23

Publication date

2005-05-23

2005-05-23 Application filed by Leo Pharma As filed Critical Leo Pharma As

2005-05-23 Publication of NO20052478D0 publication Critical patent/NO20052478D0/no

2005-05-23 Publication of NO20052478L publication Critical patent/NO20052478L/no

Links

QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 title abstract 3
229930003316 Vitamin D Natural products 0.000 title 1
239000000203 mixture Substances 0.000 title 1
235000019166 vitamin D Nutrition 0.000 title 1
239000011710 vitamin D Substances 0.000 title 1
150000003710 vitamin D derivatives Chemical class 0.000 title 1
229940046008 vitamin d Drugs 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
239000005977 Ethylene Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 abstract 2
235000005282 vitamin D3 Nutrition 0.000 abstract 2
239000011647 vitamin D3 Substances 0.000 abstract 2
229940021056 vitamin d3 Drugs 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000005677 ethinylene group Chemical group [*:2]C#C[*:1] 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Virology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Psychiatry (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
AIDS & HIV (AREA)
Emergency Medicine (AREA)

NO20052478A 2002-10-23 2005-05-23 Vitamin D-analoger, sammensetninger omfattende analogene og deres anvendelse. NO20052478L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DKPA200201608		2002-10-23
US42078302P	2002-10-24	2002-10-24
PCT/DK2003/000718 WO2004037781A1 (en)	2002-10-23	2003-10-23	Vitamin d analogues, compositions comprising said analogues and their use

Publications (2)

Publication Number	Publication Date
NO20052478D0 NO20052478D0 (no)	2005-05-23
NO20052478L true NO20052478L (no)	2005-05-23

Family

ID=32178574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20052478A NO20052478L (no)	2002-10-23	2005-05-23	Vitamin D-analoger, sammensetninger omfattende analogene og deres anvendelse.

Country Status (12)

Country	Link
EP (1)	EP1556345B1 (pl)
JP (1)	JP4512490B2 (pl)
KR (1)	KR20050055784A (pl)
AU (1)	AU2003273781B2 (pl)
BR (1)	BR0315553A (pl)
CA (1)	CA2500640A1 (pl)
IS (1)	IS7835A (pl)
MX (1)	MXPA05003499A (pl)
NO (1)	NO20052478L (pl)
PL (1)	PL376148A1 (pl)
RU (1)	RU2320644C2 (pl)
WO (1)	WO2004037781A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2233209B1 (es)	2003-11-28	2006-04-01	Laboratorios Viñas S.A.	Compuestos monohalogenovinilderivados de vitamina d.
UA94568C2 (ru) *	2004-04-02	2011-05-25	Лео Фарма А/С	Способ получения промежуточных соединений, которые применяют для синтеза аналогов витамина d
EP1844010B1 (en) *	2006-03-17	2013-02-13	Leo Pharma A/S	Isomerisation of pharmaceutical intermediates
CN106265695B (zh) *	2009-08-14	2021-05-07	博格有限责任公司	用于治疗脱发的维生素d3及其类似物
US9775903B2 (en) *	2010-01-13	2017-10-03	Johns Hopkins University	1-deoxy analogs of 1,25-dihydroxyvitamin D3 compounds
ES2386219B1 (es) *	2010-12-28	2013-06-24	Laboratorios Viñas S.A.	Procedimiento para isomerizar c-22 iodovinilderivados por fotoisomerización.
CN103508999B (zh) *	2013-10-12	2015-05-13	浙江海正药业股份有限公司	马沙骨化醇的合成中间体及其制备方法和用途
CN104693087A (zh) *	2013-12-10	2015-06-10	南京理工大学	24,28-烯-1α-羟基维生素D类衍生物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8915770D0 (en) *	1989-07-10	1989-08-31	Leo Pharm Prod Ltd	Chemical compounds
GB9017890D0 (en) *	1990-08-15	1990-09-26	Leo Pharm Prod Ltd	Chemical compounds i
GB9314400D0 (en) *	1993-07-12	1993-08-25	Leo Pharm Prod Ltd	Produktionsaktieselskab) chemical compounds
CN1090180C (zh) *	1997-06-25	2002-09-04	帝人株式会社	维生素d3衍生物及其用于炎性呼吸道疾病的治疗剂
US5972917A (en) *	1998-05-29	1999-10-26	Bone Care Int Inc	1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof
EP1321141A4 (en) *	2000-08-30	2004-02-18	Teijin Ltd	INHIBITORS OF PARATHORMONE PRODUCTION CONTAINING VITAMIN D3 DERIVATIVES
MXPA04002640A (es) *	2001-09-21	2004-06-07	Hoffmann La Roche	Esteres de analogos de 3-desoxi-vitamina d3.

2003
- 2003-10-23 PL PL03376148A patent/PL376148A1/pl not_active Application Discontinuation
- 2003-10-23 WO PCT/DK2003/000718 patent/WO2004037781A1/en not_active Ceased
- 2003-10-23 KR KR1020057007054A patent/KR20050055784A/ko not_active Abandoned
- 2003-10-23 RU RU2005115482/04A patent/RU2320644C2/ru not_active IP Right Cessation
- 2003-10-23 AU AU2003273781A patent/AU2003273781B2/en not_active Ceased
- 2003-10-23 JP JP2004545731A patent/JP4512490B2/ja not_active Expired - Fee Related
- 2003-10-23 CA CA002500640A patent/CA2500640A1/en not_active Abandoned
- 2003-10-23 MX MXPA05003499A patent/MXPA05003499A/es active IP Right Grant
- 2003-10-23 EP EP03757738A patent/EP1556345B1/en not_active Expired - Lifetime
- 2003-10-23 BR BR0315553-6A patent/BR0315553A/pt not_active IP Right Cessation
2005
- 2005-05-03 IS IS7835A patent/IS7835A/is unknown
- 2005-05-23 NO NO20052478A patent/NO20052478L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL376148A1 (pl)	2005-12-27
NO20052478D0 (no)	2005-05-23
RU2320644C2 (ru)	2008-03-27
IS7835A (is)	2005-05-03
EP1556345A1 (en)	2005-07-27
AU2003273781B2 (en)	2010-04-29
MXPA05003499A (es)	2005-06-17
JP2006503880A (ja)	2006-02-02
KR20050055784A (ko)	2005-06-13
EP1556345B1 (en)	2010-12-15
JP4512490B2 (ja)	2010-07-28
CA2500640A1 (en)	2004-05-06
BR0315553A (pt)	2005-08-23
RU2005115482A (ru)	2005-11-10
AU2003273781A1 (en)	2004-05-13
WO2004037781A1 (en)	2004-05-06

Legal Events

Date	Code	Title	Description
2012-01-02	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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NO20052478L (no)	2005-05-23	Vitamin D-analoger, sammensetninger omfattende analogene og deres anvendelse.
ATE135348T1 (de)	1996-03-15	Pyrimidin-4-carboxamidderivate, ihre herstellung und ihre verwendung in der therapie
MX2023009045A (es)	2023-08-10	Derivados novedosos de pirimidin-2-il sulfonamida.
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BG104933A (en)	2001-10-31	Water soluble azoles and broad-spectrum antifungals
NO20080025L (no)	2008-04-16	Pyrazolderivater som CB1 modulatorer
MX2025001765A (es)	2025-05-02	Derivados deuterados de pirimidin-2-il sulfonamida
NO20062491L (no)	2006-09-06	Benzoksazinderivter og deres anvendelse
AU1274495A (en)	1995-07-17	Unsaturate amino compounds for use as anticancer and antiprotozoic agent
WO2004098507A3 (en)	2005-01-20	1,3 aclyated 24-keto-vitamin d3 compounds and methods of use thereof
ATE439128T1 (de)	2009-08-15	Indol-3-carboxamide, deren herstellung und therapeutische verwendung
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WO2004028455A3 (en)	2005-04-21	Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
DK0655057T3 (da)	1998-04-14	Cyanoguanidiner som kaliumkanalblokkere