NO20053078L - Atropisomerer av 3-substituerte-4-arylkinolin-2-on-derivater. - Google Patents

Atropisomerer av 3-substituerte-4-arylkinolin-2-on-derivater.

Info

Publication number
NO20053078L
NO20053078L NO20053078A NO20053078A NO20053078L NO 20053078 L NO20053078 L NO 20053078L NO 20053078 A NO20053078 A NO 20053078A NO 20053078 A NO20053078 A NO 20053078A NO 20053078 L NO20053078 L NO 20053078L
Authority
NO
Norway
Prior art keywords
sup
atropisomers
arylquinolin
derivatives
substituted
Prior art date
Application number
NO20053078A
Other languages
English (en)
Other versions
NO20053078D0 (no
Inventor
Valentin Kala Gribkoff
Vivekananda M Vrudhula
Bireshwar Dasgupta
Christopher G Boissard
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20053078D0 publication Critical patent/NO20053078D0/no
Publication of NO20053078L publication Critical patent/NO20053078L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Quinoline Compounds (AREA)

Abstract

Atropisomerer av 3-substituerte 4-arylkinolin-2-on-derivatier som har den generelle formel hvor R, R1, R2, R3, R4 og R5 er som definert her, eller et ikke-toksisk, farmasøytisk akseptabelt salt, solvat eller prodrug derav. Atropisomerene kan modulere høykonduktans kalsium-aktiverte K+-kanaler og er anvendelige ved behandling av lidelser som er responsive overfor åpning av kaliumkanalene. I tillegg kan atropisomerene være stabile, dvs. interkonverteres ikke, i perioder på opptil én måned eller lenger.
NO20053078A 2002-12-23 2005-06-23 Atropisomerer av 3-substituerte-4-arylkinolin-2-on-derivater. NO20053078L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43616002P 2002-12-23 2002-12-23
PCT/US2003/041548 WO2004058260A1 (en) 2002-12-23 2003-12-18 Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives

Publications (2)

Publication Number Publication Date
NO20053078D0 NO20053078D0 (no) 2005-06-23
NO20053078L true NO20053078L (no) 2005-08-29

Family

ID=32682352

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053078A NO20053078L (no) 2002-12-23 2005-06-23 Atropisomerer av 3-substituerte-4-arylkinolin-2-on-derivater.

Country Status (19)

Country Link
US (1) US6939968B2 (no)
EP (1) EP1575589B1 (no)
JP (1) JP2006512378A (no)
KR (1) KR20050102081A (no)
CN (1) CN1750821A (no)
AT (1) ATE472328T1 (no)
AU (1) AU2003300425A1 (no)
BR (1) BR0317679A (no)
CZ (1) CZ2005407A3 (no)
DE (1) DE60333226D1 (no)
IL (1) IL169294A (no)
MX (1) MXPA05006814A (no)
NO (1) NO20053078L (no)
NZ (1) NZ541237A (no)
PL (1) PL377492A1 (no)
RU (1) RU2352563C2 (no)
TR (1) TR200502440T2 (no)
WO (1) WO2004058260A1 (no)
ZA (1) ZA200505077B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101679243B (zh) * 2007-04-09 2012-09-26 第一三共株式会社 吡咯衍生物的阻转异构体
US8680116B2 (en) 2009-07-22 2014-03-25 Merck Sharp & Dohme Corp. Quinolinone PDE2 inhibitors
CA2958625C (en) 2013-04-10 2019-05-28 Daiichi Sankyo Company, Limited Crystal of pyrrole derivative and method for producing the same
CN114728177B (zh) * 2019-10-07 2025-06-24 D·E·萧尔研究有限责任公司 作为Kv1.3钾Shaker通道阻滞剂的芳基杂二环化合物
BR112022006292A2 (pt) * 2019-10-07 2022-06-28 De Shaw Res Llc Compostos heterobicílicos de arila como bloqueadores de canais de agitador de potássio kv1.3
UY39137A (es) * 2020-04-01 2021-10-29 Fmc Corp Atropisómeros de derivados de piridazinona como herbicidas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1774624C (ru) * 1990-11-11 1995-02-09 Украинская фармацевтическая академия Диэтиламиноэтиламида 1-пропил-2-оксо-4-гидроксихинолин-3-карбоновой кислоты гидрохлорид, проявляющий анестезирующую, противоаритмическую, антиоксидантную, антимикробную и фунгицидную активность
TW504504B (en) 1996-11-26 2002-10-01 Bristol Myers Squibb Co 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators
SK113299A3 (en) * 1997-02-28 2001-05-10 Pfizer Prod Inc Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists
EP1133474B1 (en) * 1998-12-04 2007-02-21 Bristol-Myers Squibb Company 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators
TW562799B (en) * 1999-12-01 2003-11-21 Bristol Myers Squibb Co Preparation of 3-substituted-4-arylquinolin-2-one derivatives
EP1345603A4 (en) * 2000-12-20 2004-09-08 Merck & Co Inc (HALO-BENZO-CARBONYL) HETEROCYCLO-CONDENSED PHENYL-P38-KINASE INHIBITING AGENTS

Also Published As

Publication number Publication date
JP2006512378A (ja) 2006-04-13
BR0317679A (pt) 2005-11-29
ATE472328T1 (de) 2010-07-15
WO2004058260A1 (en) 2004-07-15
TR200502440T2 (tr) 2005-10-21
US20040147749A1 (en) 2004-07-29
RU2352563C2 (ru) 2009-04-20
CN1750821A (zh) 2006-03-22
EP1575589A1 (en) 2005-09-21
NO20053078D0 (no) 2005-06-23
US6939968B2 (en) 2005-09-06
DE60333226D1 (de) 2010-08-12
EP1575589B1 (en) 2010-06-30
MXPA05006814A (es) 2005-09-08
IL169294A (en) 2010-11-30
RU2005123046A (ru) 2006-01-20
KR20050102081A (ko) 2005-10-25
ZA200505077B (en) 2006-09-27
NZ541237A (en) 2008-09-26
EP1575589A4 (en) 2008-05-21
CZ2005407A3 (cs) 2005-10-12
AU2003300425A1 (en) 2004-07-22
PL377492A1 (pl) 2006-02-06

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