PL377492A1 - Atropoizomery pochodnych 3-podstawionego-4-arylochinolin-2-onu - Google Patents
Atropoizomery pochodnych 3-podstawionego-4-arylochinolin-2-onuInfo
- Publication number
- PL377492A1 PL377492A1 PL377492A PL37749203A PL377492A1 PL 377492 A1 PL377492 A1 PL 377492A1 PL 377492 A PL377492 A PL 377492A PL 37749203 A PL37749203 A PL 37749203A PL 377492 A1 PL377492 A1 PL 377492A1
- Authority
- PL
- Poland
- Prior art keywords
- sup
- atropisomers
- arylquinolin
- derivatives
- substituted
- Prior art date
Links
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43616002P | 2002-12-23 | 2002-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL377492A1 true PL377492A1 (pl) | 2006-02-06 |
Family
ID=32682352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL377492A PL377492A1 (pl) | 2002-12-23 | 2003-12-18 | Atropoizomery pochodnych 3-podstawionego-4-arylochinolin-2-onu |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6939968B2 (pl) |
| EP (1) | EP1575589B1 (pl) |
| JP (1) | JP2006512378A (pl) |
| KR (1) | KR20050102081A (pl) |
| CN (1) | CN1750821A (pl) |
| AT (1) | ATE472328T1 (pl) |
| AU (1) | AU2003300425A1 (pl) |
| BR (1) | BR0317679A (pl) |
| CZ (1) | CZ2005407A3 (pl) |
| DE (1) | DE60333226D1 (pl) |
| IL (1) | IL169294A (pl) |
| MX (1) | MXPA05006814A (pl) |
| NO (1) | NO20053078L (pl) |
| NZ (1) | NZ541237A (pl) |
| PL (1) | PL377492A1 (pl) |
| RU (1) | RU2352563C2 (pl) |
| TR (1) | TR200502440T2 (pl) |
| WO (1) | WO2004058260A1 (pl) |
| ZA (1) | ZA200505077B (pl) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2133330T3 (pl) * | 2007-04-09 | 2014-06-30 | Daiichi Sankyo Co Ltd | Atropoizomer pochodnej pirolu |
| US8680116B2 (en) | 2009-07-22 | 2014-03-25 | Merck Sharp & Dohme Corp. | Quinolinone PDE2 inhibitors |
| HUE041725T2 (hu) * | 2013-04-10 | 2019-05-28 | Daiichi Sankyo Co Ltd | (S)-1-(2-hidroxietil)-4-metil-N-[4-(metilszulfonil)fenil]-5-[2-(trifluormetil)fenil]-1H-pirrol-3-karboxamid kristálya |
| IL291867A (en) * | 2019-10-07 | 2022-06-01 | De Shaw Res Llc | Heterocyclic aryl compounds as Shaker kv1.3 potassium channel blockers |
| CN114828963A (zh) * | 2019-10-07 | 2022-07-29 | D·E·萧尔研究有限责任公司 | 作为Kv1.3钾SHAKER通道阻滞剂的芳基杂二环化合物 |
| PY2125608A (es) * | 2020-04-01 | 2021-12-28 | Fmc Corp | Atropisómeros de derivados de piridazinona como herbicidas |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU1774624C (ru) * | 1990-11-11 | 1995-02-09 | Украинская фармацевтическая академия | Диэтиламиноэтиламида 1-пропил-2-оксо-4-гидроксихинолин-3-карбоновой кислоты гидрохлорид, проявляющий анестезирующую, противоаритмическую, антиоксидантную, антимикробную и фунгицидную активность |
| TW504504B (en) | 1996-11-26 | 2002-10-01 | Bristol Myers Squibb Co | 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators |
| CN1248248A (zh) * | 1997-02-28 | 2000-03-22 | 辉瑞产品公司 | 3－芳基－4(3h)－喹唑啉酮化合物的阻转异构体及其作为ampa－受体拮抗剂的应用 |
| JP2002531549A (ja) * | 1998-12-04 | 2002-09-24 | ブリストル−マイヤーズ スクイブ カンパニー | カリウムチャネル・モジュレーターとしての３−置換−４−アリールキノリン−２−オン誘導体 |
| TW562799B (en) * | 1999-12-01 | 2003-11-21 | Bristol Myers Squibb Co | Preparation of 3-substituted-4-arylquinolin-2-one derivatives |
| AU2002246677B2 (en) * | 2000-12-20 | 2006-11-16 | Merck Sharp & Dohme Corp. | (Halo-Benzo Carbonyl)Heterocyclo Fused Phenyl p38 Kinase Inhibiting Agents |
-
2003
- 2003-12-17 US US10/739,449 patent/US6939968B2/en not_active Expired - Fee Related
- 2003-12-18 JP JP2004562595A patent/JP2006512378A/ja active Pending
- 2003-12-18 KR KR1020057011916A patent/KR20050102081A/ko not_active Ceased
- 2003-12-18 BR BR0317679-7A patent/BR0317679A/pt not_active IP Right Cessation
- 2003-12-18 MX MXPA05006814A patent/MXPA05006814A/es active IP Right Grant
- 2003-12-18 TR TR2005/02440T patent/TR200502440T2/xx unknown
- 2003-12-18 WO PCT/US2003/041548 patent/WO2004058260A1/en not_active Ceased
- 2003-12-18 CN CNA2003801098331A patent/CN1750821A/zh active Pending
- 2003-12-18 AU AU2003300425A patent/AU2003300425A1/en not_active Abandoned
- 2003-12-18 AT AT03814399T patent/ATE472328T1/de not_active IP Right Cessation
- 2003-12-18 CZ CZ2005407A patent/CZ2005407A3/cs unknown
- 2003-12-18 RU RU2005123046/04A patent/RU2352563C2/ru not_active IP Right Cessation
- 2003-12-18 PL PL377492A patent/PL377492A1/pl not_active Application Discontinuation
- 2003-12-18 DE DE60333226T patent/DE60333226D1/de not_active Expired - Lifetime
- 2003-12-18 EP EP03814399A patent/EP1575589B1/en not_active Expired - Lifetime
- 2003-12-18 NZ NZ541237A patent/NZ541237A/en unknown
-
2005
- 2005-06-20 IL IL169294A patent/IL169294A/en not_active IP Right Cessation
- 2005-06-22 ZA ZA200505077A patent/ZA200505077B/en unknown
- 2005-06-23 NO NO20053078A patent/NO20053078L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050102081A (ko) | 2005-10-25 |
| JP2006512378A (ja) | 2006-04-13 |
| EP1575589B1 (en) | 2010-06-30 |
| CN1750821A (zh) | 2006-03-22 |
| EP1575589A1 (en) | 2005-09-21 |
| ZA200505077B (en) | 2006-09-27 |
| AU2003300425A1 (en) | 2004-07-22 |
| IL169294A (en) | 2010-11-30 |
| RU2352563C2 (ru) | 2009-04-20 |
| US20040147749A1 (en) | 2004-07-29 |
| CZ2005407A3 (cs) | 2005-10-12 |
| US6939968B2 (en) | 2005-09-06 |
| WO2004058260A1 (en) | 2004-07-15 |
| TR200502440T2 (tr) | 2005-10-21 |
| NZ541237A (en) | 2008-09-26 |
| NO20053078L (no) | 2005-08-29 |
| EP1575589A4 (en) | 2008-05-21 |
| DE60333226D1 (de) | 2010-08-12 |
| MXPA05006814A (es) | 2005-09-08 |
| BR0317679A (pt) | 2005-11-29 |
| ATE472328T1 (de) | 2010-07-15 |
| RU2005123046A (ru) | 2006-01-20 |
| NO20053078D0 (no) | 2005-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |