ATE472328T1 - Atropisomere von 3-substituierten 4-arylchinolin- 2-one-derivaten - Google Patents

Atropisomere von 3-substituierten 4-arylchinolin- 2-one-derivaten

Info

Publication number
ATE472328T1
ATE472328T1 AT03814399T AT03814399T ATE472328T1 AT E472328 T1 ATE472328 T1 AT E472328T1 AT 03814399 T AT03814399 T AT 03814399T AT 03814399 T AT03814399 T AT 03814399T AT E472328 T1 ATE472328 T1 AT E472328T1
Authority
AT
Austria
Prior art keywords
sup
atropisomers
derivatives
substituted
arylcinoline
Prior art date
Application number
AT03814399T
Other languages
English (en)
Inventor
Vivekananda Vrudhula
Valentin Gribkoff
Bireshwar Dasgupta
Christopher Boissard
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE472328T1 publication Critical patent/ATE472328T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Quinoline Compounds (AREA)
AT03814399T 2002-12-23 2003-12-18 Atropisomere von 3-substituierten 4-arylchinolin- 2-one-derivaten ATE472328T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43616002P 2002-12-23 2002-12-23
PCT/US2003/041548 WO2004058260A1 (en) 2002-12-23 2003-12-18 Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives

Publications (1)

Publication Number Publication Date
ATE472328T1 true ATE472328T1 (de) 2010-07-15

Family

ID=32682352

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03814399T ATE472328T1 (de) 2002-12-23 2003-12-18 Atropisomere von 3-substituierten 4-arylchinolin- 2-one-derivaten

Country Status (19)

Country Link
US (1) US6939968B2 (de)
EP (1) EP1575589B1 (de)
JP (1) JP2006512378A (de)
KR (1) KR20050102081A (de)
CN (1) CN1750821A (de)
AT (1) ATE472328T1 (de)
AU (1) AU2003300425A1 (de)
BR (1) BR0317679A (de)
CZ (1) CZ2005407A3 (de)
DE (1) DE60333226D1 (de)
IL (1) IL169294A (de)
MX (1) MXPA05006814A (de)
NO (1) NO20053078L (de)
NZ (1) NZ541237A (de)
PL (1) PL377492A1 (de)
RU (1) RU2352563C2 (de)
TR (1) TR200502440T2 (de)
WO (1) WO2004058260A1 (de)
ZA (1) ZA200505077B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI444185B (zh) 2007-04-09 2014-07-11 Daiichi Sankyo Co Ltd 吡咯衍生物之阻轉異構物
WO2011011312A1 (en) 2009-07-22 2011-01-27 Merck Sharp & Dohme Corp. Quinolinone pde2 inhibitors
KR102234597B1 (ko) 2013-04-10 2021-03-31 다이이찌 산쿄 가부시키가이샤 피롤 유도체의 결정 및 그 제조 방법
IL291867A (en) * 2019-10-07 2022-06-01 De Shaw Res Llc Heterocyclic aryl compounds as Shaker kv1.3 potassium channel blockers
KR20220079878A (ko) * 2019-10-07 2022-06-14 디.이. 쇼우 리서치, 엘엘씨 Kv1.3 칼륨 셰이커 채널 차단제로서의 아릴 헤테로비시클릭 화합물
UY39137A (es) * 2020-04-01 2021-10-29 Fmc Corp Atropisómeros de derivados de piridazinona como herbicidas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1774624C (ru) * 1990-11-11 1995-02-09 Украинская фармацевтическая академия Диэтиламиноэтиламида 1-пропил-2-оксо-4-гидроксихинолин-3-карбоновой кислоты гидрохлорид, проявляющий анестезирующую, противоаритмическую, антиоксидантную, антимикробную и фунгицидную активность
TW504504B (en) 1996-11-26 2002-10-01 Bristol Myers Squibb Co 4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators
PT968194E (pt) * 1997-02-28 2004-08-31 Pfizer Prod Inc Atropisomeros de 3-aril-4(3h)-quinazolinonas e sua utilizacao como antagonistas dos receptores ampa
JP2002531549A (ja) * 1998-12-04 2002-09-24 ブリストル−マイヤーズ スクイブ カンパニー カリウムチャネル・モジュレーターとしての３−置換−４−アリールキノリン−２−オン誘導体
TW562799B (en) * 1999-12-01 2003-11-21 Bristol Myers Squibb Co Preparation of 3-substituted-4-arylquinolin-2-one derivatives
JP2004521892A (ja) * 2000-12-20 2004-07-22 メルク　エンド　カムパニー　インコーポレーテッド （ハロ−ベンゾカルボニル）複素環縮合フェニル系ｐ３８キナーゼ阻害剤

Also Published As

Publication number Publication date
BR0317679A (pt) 2005-11-29
NO20053078D0 (no) 2005-06-23
TR200502440T2 (tr) 2005-10-21
RU2352563C2 (ru) 2009-04-20
US20040147749A1 (en) 2004-07-29
EP1575589A4 (de) 2008-05-21
NO20053078L (no) 2005-08-29
WO2004058260A1 (en) 2004-07-15
CN1750821A (zh) 2006-03-22
RU2005123046A (ru) 2006-01-20
MXPA05006814A (es) 2005-09-08
NZ541237A (en) 2008-09-26
JP2006512378A (ja) 2006-04-13
ZA200505077B (en) 2006-09-27
AU2003300425A1 (en) 2004-07-22
US6939968B2 (en) 2005-09-06
DE60333226D1 (de) 2010-08-12
EP1575589A1 (de) 2005-09-21
PL377492A1 (pl) 2006-02-06
KR20050102081A (ko) 2005-10-25
EP1575589B1 (de) 2010-06-30
CZ2005407A3 (cs) 2005-10-12
IL169294A (en) 2010-11-30

Similar Documents

Publication Publication Date Title
MEP52408A (en) Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
NZ510987A (en) 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators
NO20044995L (no) Heterosykliske forbindelser
MY135841A (en) Novel benzodioxoles
ATE384058T1 (de) Thiazolderivate
MX2007003546A (es) Derivados de indozolona como inhibidores de 11-beta- hidroxiesteroide-deshidrogenasa.
GEP20084357B (en) Pyrimidine derivatives for the treatment of abnormal cell growth
JO2282B1 (en) Oxazole derivatives
MA27040A1 (fr) Nucleosides substitues en 4'
BG106013A (en) New compounds and compositions as protease inhibitors
NO20044996L (no) Furylforbindelser
NO20025590D0 (no) Fenylglycin-derivater
MXPA06000921A (es) Derivados de benzamidazoles como inhibidores de mek.
SE0402762D0 (sv) Indazole sulphonamide derivatives
DE60045508D1 (de) Dalda-analoge und ihre verwendung
MA28279A1 (fr) Derives d'indole et utilisation de ceux-ci comme inhibiteurs de kinase, notamment des inhibiteurs de ikk2
MXPA05007115A (es) Nuevos agonistas inversos del receptor cb 1.
MX2007011695A (es) Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
IL163026A (en) Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
SE0203303D0 (sv) Novel Compounds
MX2007011698A (es) Derivados de oxindol sustituido, medicamentos que contienen dichos derivados y uso de los mismos.
DE60333226D1 (de) Atropisomere von 3-substituierten 4-arylchinolin-2-one-derivaten
SE0300105D0 (sv) Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof
ATE259813T1 (de) Triazolopyrimidinderivate
SE0203300D0 (sv) Novel Compounds

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties