NO20053555L - Polymerkonjugater av cytokiner, chemokiner, vekstfaktorer, polypeptidhormoner og antagonister derav med preservert reseptorbindingsaktivitet. - Google Patents

Polymerkonjugater av cytokiner, chemokiner, vekstfaktorer, polypeptidhormoner og antagonister derav med preservert reseptorbindingsaktivitet.

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Publication number
NO20053555L
NO20053555L NO20053555A NO20053555A NO20053555L NO 20053555 L NO20053555 L NO 20053555L NO 20053555 A NO20053555 A NO 20053555A NO 20053555 A NO20053555 A NO 20053555A NO 20053555 L NO20053555 L NO 20053555L
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NO
Norway
Prior art keywords
conjugates
chemokines
cytokines
growth factors
receptor binding
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Application number
NO20053555A
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English (en)
Other versions
NO20053555D0 (no
Inventor
Merry R Sherman
Mark G P Saifer
David L Williams
Shyam S Bhaskaran
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Mountain View Pharmaceuticals
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Publication date
Application filed by Mountain View Pharmaceuticals filed Critical Mountain View Pharmaceuticals
Publication of NO20053555D0 publication Critical patent/NO20053555D0/no
Publication of NO20053555L publication Critical patent/NO20053555L/no

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/46—Polyesters chemically modified by esterification
    • C08G63/48—Polyesters chemically modified by esterification by unsaturated higher fatty oils or their acids; by resin acids

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Abstract

Det tilveiebringes fremgangsmåter for syntese av polymerkonjugater av cytokiner, kjemokiner, vekstfaktorer, polypeptidhormoner og reseptorbindende antagonister derav, hvilke konjugater bibeholder uventet høy reseptorbindende aktivitet. Fremstilling av polymerkonjugater ifølge oppfinnelsens fremgangsmåter reduserer eller unngår sterisk inhibering av reseptor-ligand interaksjoner som vanligvis oppstår ved festing av polymerer på reseptorbindende områder av cytokiner, kjemokiner, vekstfaktorer og polypeptidhorinoner, så vel som til agnostiske eller antagnostiske analoger derav. Oppfinnelsen tilveiebringer videre konjugater og preparater som fremstilles ved slike metoder. Konjugatene ifølge oppfinnelsen bibeholder et høyere nivå av reseptorbindende aktivitet enn de som er fremstilt ved tradisjonell polymerkoblings og som ikke tar sikte på å unngå reseptorbindingsdomener av cytokiner, kjemokiner, vekstfaktorer og polypeptidhormoner. Konjugatene ifølge oppfinnelsen viser også en halveringstid in vivo og in vitro sammenlignet med ikke-konjugerte cytokiner, kjemokiner, vekstfaktorer og polypeptidhormoner. Oppfinnelsen tilveiebringer også sett omfattende slike konjugater og/eller preparater samt metoder for å benytte slike konjugater og preparater i et antall diagnostiske, profylaktiske, terapeutiske og bioprosesserende anvendelser.
NO20053555A 2002-12-26 2005-07-20 Polymerkonjugater av cytokiner, chemokiner, vekstfaktorer, polypeptidhormoner og antagonister derav med preservert reseptorbindingsaktivitet. NO20053555L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43602002P 2002-12-26 2002-12-26
US47991403P 2003-06-20 2003-06-20
PCT/US2003/041162 WO2004060300A2 (en) 2002-12-26 2003-12-23 Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity

Publications (2)

Publication Number Publication Date
NO20053555D0 NO20053555D0 (no) 2005-07-20
NO20053555L true NO20053555L (no) 2005-09-23

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NO20053555A NO20053555L (no) 2002-12-26 2005-07-20 Polymerkonjugater av cytokiner, chemokiner, vekstfaktorer, polypeptidhormoner og antagonister derav med preservert reseptorbindingsaktivitet.

Country Status (19)

Country Link
US (2) US20040136952A1 (no)
EP (1) EP1628618A4 (no)
JP (2) JP2006519170A (no)
KR (1) KR101162908B1 (no)
AU (1) AU2003303636B2 (no)
BR (1) BR0317752A (no)
CA (1) CA2511815A1 (no)
CR (1) CR7895A (no)
EA (1) EA013535B1 (no)
EC (1) ECSP055931A (no)
GE (1) GEP20084487B (no)
IS (1) IS7931A (no)
MX (1) MXPA05006945A (no)
NO (1) NO20053555L (no)
NZ (1) NZ541122A (no)
PL (2) PL380269A1 (no)
RS (1) RS20050501A (no)
TW (1) TWI364295B (no)
WO (1) WO2004060300A2 (no)

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