NO20053677L - Fremgangsmate for fremstilling av albumin - Google Patents
Fremgangsmate for fremstilling av albuminInfo
- Publication number
- NO20053677L NO20053677L NO20053677A NO20053677A NO20053677L NO 20053677 L NO20053677 L NO 20053677L NO 20053677 A NO20053677 A NO 20053677A NO 20053677 A NO20053677 A NO 20053677A NO 20053677 L NO20053677 L NO 20053677L
- Authority
- NO
- Norway
- Prior art keywords
- stabilizer
- optionally
- albumin
- albumin solution
- groups
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 6
- 108010088751 Albumins Proteins 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000011159 matrix material Substances 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Det beskrives et terapeutisk anvendelig virusinaktivert albumin og en fremgangsmåte for fremstilling av terapeutisk anvendelig virusinaktiverte albuminer som kjennetegnes ved kombinasjonen av følgende trinn: (a) underkastelse av en første vandig albuminløsning en behandling for virusinaktivering etter SD-metoden gjennom kontakt med SD-reagenser ved en temperatur under 45°C, (b) fjerning av SD-reagensene ved oljeekstraksjon og påfølgende hydrofob interaksjonskromatografi, i det minste i det vesentlige, hvorunder det under kromatograferingen benyttes en hydrofob matriks, særlig en matriks som eventuelt hydrofobe grupper kan være bundet til, under den forutsetning at disse gruppene er alifatiske grupper med C>24, og hvor det oppnås en andre albuminløsning, som (c) eventuelt tilsettes én eller flere stabilisatorer innen gruppen sukker, aminosyrer og sukkeralkoholer, under forutsetning av at det som stabilisator ikke benyttes noen indol-stabilisator og ingen C6-C10-fettsyre, hvoretter (d) den andre, eventuelt stabilisator-tilsatte, albuminiøsning, sluttbehandles og sterilfiltreres og eventuelt påfylles den endelige beholder.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT2182003 | 2003-02-13 | ||
| PCT/EP2004/001397 WO2004071524A1 (de) | 2003-02-13 | 2004-02-13 | Albuminlösung und verfahren zu ihrer herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053677D0 NO20053677D0 (no) | 2005-07-29 |
| NO20053677L true NO20053677L (no) | 2005-10-31 |
Family
ID=32854882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20053677A NO20053677L (no) | 2003-02-13 | 2005-07-29 | Fremgangsmate for fremstilling av albumin |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1592439B1 (no) |
| JP (1) | JP2006517938A (no) |
| KR (1) | KR20050103292A (no) |
| CN (1) | CN100384471C (no) |
| AT (1) | ATE362376T1 (no) |
| AU (1) | AU2004212324B2 (no) |
| BR (1) | BRPI0407458A (no) |
| CA (1) | CA2514163A1 (no) |
| CY (1) | CY1106793T1 (no) |
| DE (1) | DE502004003834D1 (no) |
| DK (1) | DK1592439T3 (no) |
| ES (1) | ES2285427T3 (no) |
| IL (1) | IL169828A0 (no) |
| MX (1) | MXPA05008276A (no) |
| NO (1) | NO20053677L (no) |
| PL (1) | PL376644A1 (no) |
| PT (1) | PT1592439E (no) |
| RS (1) | RS50891B (no) |
| RU (1) | RU2305556C2 (no) |
| UA (1) | UA80469C2 (no) |
| WO (1) | WO2004071524A1 (no) |
| ZA (1) | ZA200506452B (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005023155A1 (de) * | 2005-05-13 | 2006-11-16 | Albutec Gmbh | Albuminlösung |
| KR20080078010A (ko) * | 2005-12-22 | 2008-08-26 | 체에스엘 베링 게엠베하 | 옥타노에이트-감소된 사람 알부민 |
| ES2332846B1 (es) | 2007-10-26 | 2010-07-08 | Grifols, S.A. | Utilizacion de albumina humana terapeutica para la preparacion de un medicamento para el tratamiento de pacientes afectados por desordenes cognitivos. |
| ES2294976B1 (es) * | 2007-11-12 | 2008-12-16 | Grifols, S.A. | "procedimiento de obtencion de albumina humana de alta eficacia para su uso en terapia de detoxificacion". |
| EP2382993A1 (en) | 2010-04-19 | 2011-11-02 | KTB Tumorforschungsgesellschaft mbH | Combination of drugs with protein-binding prodrugs |
| CN111195351A (zh) * | 2020-01-20 | 2020-05-26 | 华兰生物工程重庆有限公司 | 5%低浓度人血白蛋白的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2190436B1 (no) * | 1972-07-05 | 1975-06-20 | Merieux Inst | |
| SU1212416A1 (ru) * | 1984-04-03 | 1986-02-23 | Научно-Исследовательский Институт Гематологии И Переливания Крови Им.Проф.Р.О.Еоляна | Способ выделени альбумина из плазмы крови |
| JPH0669961B2 (ja) * | 1984-09-25 | 1994-09-07 | 株式会社ミドリ十字 | 免疫グロブリンの加熱処理方法 |
| US5094960A (en) * | 1988-10-07 | 1992-03-10 | New York Blood Center, Inc. | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
| US5250662A (en) * | 1989-10-05 | 1993-10-05 | Alpha Therapeutic Corporation | Albumin purification |
| RU2007423C1 (ru) * | 1991-06-04 | 1994-02-15 | Институт биофизики клетки РАН | Способ очистки сывороточного альбумина |
| DE19729778A1 (de) * | 1997-07-11 | 1999-01-21 | Blutspendedienst Der Drk Lande | Verfahren zur Herstellung von virusinaktivierten biologischen Flüssigkeiten |
| US5919907A (en) * | 1997-12-22 | 1999-07-06 | Shanbrom Technologies Llc | Preparation and utilization of a novel sterile albumin |
| IL136552A (en) * | 2000-06-05 | 2005-05-17 | Omrix Biopharmaceuticals Ltd | Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration |
-
2004
- 2004-02-13 CN CNB2004800038643A patent/CN100384471C/zh not_active Expired - Fee Related
- 2004-02-13 JP JP2006501841A patent/JP2006517938A/ja active Pending
- 2004-02-13 MX MXPA05008276A patent/MXPA05008276A/es active IP Right Grant
- 2004-02-13 DE DE502004003834T patent/DE502004003834D1/de not_active Expired - Lifetime
- 2004-02-13 AU AU2004212324A patent/AU2004212324B2/en not_active Ceased
- 2004-02-13 RU RU2005128507/15A patent/RU2305556C2/ru not_active IP Right Cessation
- 2004-02-13 PL PL376644A patent/PL376644A1/pl unknown
- 2004-02-13 BR BR0407458-0A patent/BRPI0407458A/pt not_active IP Right Cessation
- 2004-02-13 KR KR1020057014946A patent/KR20050103292A/ko not_active Ceased
- 2004-02-13 AT AT04710818T patent/ATE362376T1/de not_active IP Right Cessation
- 2004-02-13 ES ES04710818T patent/ES2285427T3/es not_active Expired - Lifetime
- 2004-02-13 WO PCT/EP2004/001397 patent/WO2004071524A1/de not_active Ceased
- 2004-02-13 PT PT04710818T patent/PT1592439E/pt unknown
- 2004-02-13 CA CA002514163A patent/CA2514163A1/en not_active Abandoned
- 2004-02-13 UA UAA200508678A patent/UA80469C2/uk unknown
- 2004-02-13 DK DK04710818T patent/DK1592439T3/da active
- 2004-02-13 RS YUP-2005/0624A patent/RS50891B/sr unknown
- 2004-02-13 EP EP04710818A patent/EP1592439B1/de not_active Expired - Lifetime
-
2005
- 2005-07-21 IL IL169828A patent/IL169828A0/en unknown
- 2005-07-29 NO NO20053677A patent/NO20053677L/no not_active Application Discontinuation
- 2005-08-12 ZA ZA200506452A patent/ZA200506452B/en unknown
-
2007
- 2007-08-07 CY CY20071101052T patent/CY1106793T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1592439E (pt) | 2007-06-22 |
| MXPA05008276A (es) | 2006-03-21 |
| CY1106793T1 (el) | 2012-05-23 |
| DE502004003834D1 (de) | 2007-06-28 |
| NO20053677D0 (no) | 2005-07-29 |
| IL169828A0 (en) | 2011-08-01 |
| RS50891B (sr) | 2010-08-31 |
| JP2006517938A (ja) | 2006-08-03 |
| ATE362376T1 (de) | 2007-06-15 |
| ES2285427T3 (es) | 2007-11-16 |
| BRPI0407458A (pt) | 2006-01-31 |
| AU2004212324A1 (en) | 2004-08-26 |
| CN1798573A (zh) | 2006-07-05 |
| EP1592439A1 (de) | 2005-11-09 |
| ZA200506452B (en) | 2007-01-31 |
| WO2004071524A1 (de) | 2004-08-26 |
| AU2004212324B2 (en) | 2009-05-07 |
| EP1592439B1 (de) | 2007-05-16 |
| CA2514163A1 (en) | 2004-08-26 |
| CN100384471C (zh) | 2008-04-30 |
| KR20050103292A (ko) | 2005-10-28 |
| DK1592439T3 (da) | 2007-09-10 |
| RU2305556C2 (ru) | 2007-09-10 |
| RS20050624A (sr) | 2007-06-04 |
| PL376644A1 (pl) | 2006-01-09 |
| UA80469C2 (en) | 2007-09-25 |
| RU2005128507A (ru) | 2006-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |