NO20053726L - Forbindelser med prolyloligopeptidase-hemmende aktivitet - Google Patents

Forbindelser med prolyloligopeptidase-hemmende aktivitet

Info

Publication number
NO20053726L
NO20053726L NO20053726A NO20053726A NO20053726L NO 20053726 L NO20053726 L NO 20053726L NO 20053726 A NO20053726 A NO 20053726A NO 20053726 A NO20053726 A NO 20053726A NO 20053726 L NO20053726 L NO 20053726L
Authority
NO
Norway
Prior art keywords
compounds
prolyl oligopeptidase
inhibitory activity
formula
treatment
Prior art date
Application number
NO20053726A
Other languages
English (en)
Norwegian (no)
Other versions
NO20053726D0 (no
Inventor
Tomi Jarvinen
Jouko Vepsalainen
Johannes A M Christiaans
Elina Jahro
Pekka Mannisto
Taija Saarinen
Jukka Ghynter
Erik Wallen
Markus Forsberg
Antti Poso
Jarkko Venalainen
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of NO20053726D0 publication Critical patent/NO20053726D0/no
Publication of NO20053726L publication Critical patent/NO20053726L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
NO20053726A 2003-01-03 2005-08-03 Forbindelser med prolyloligopeptidase-hemmende aktivitet NO20053726L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20030014A FI20030014A0 (fi) 2003-01-03 2003-01-03 Prolyylioligopeptidaasia inhiboivaa aktiivisuutta omaavia yhdisteitä
PCT/FI2004/000001 WO2004060862A2 (en) 2003-01-03 2004-01-02 Compounds having prolyl oligopeptidase inhibitory activity

Publications (2)

Publication Number Publication Date
NO20053726D0 NO20053726D0 (no) 2005-08-03
NO20053726L true NO20053726L (no) 2005-09-28

Family

ID=8565256

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053726A NO20053726L (no) 2003-01-03 2005-08-03 Forbindelser med prolyloligopeptidase-hemmende aktivitet

Country Status (18)

Country Link
US (1) US20060229254A1 (is)
EP (1) EP1581489A2 (is)
JP (1) JP2006516557A (is)
KR (1) KR20060027789A (is)
CN (1) CN1747930A (is)
AU (1) AU2004203788A1 (is)
BR (1) BRPI0406618A (is)
CA (1) CA2511856A1 (is)
EA (1) EA010022B1 (is)
FI (1) FI20030014A0 (is)
HR (1) HRP20050693A2 (is)
IS (1) IS7963A (is)
MX (1) MXPA05007262A (is)
NO (1) NO20053726L (is)
PL (1) PL378329A1 (is)
RS (1) RS20050514A (is)
WO (1) WO2004060862A2 (is)
ZA (1) ZA200505183B (is)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102812003B (zh) 2009-12-18 2015-01-21 欧洲筛选有限公司 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法
EP2730571A1 (en) 2012-11-12 2014-05-14 Universitat De Barcelona 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives
CN105916500A (zh) * 2013-11-27 2016-08-31 欧洲筛选有限公司 用于治疗炎性疾病的化合物、药物组合物和方法
KR101913506B1 (ko) * 2017-07-18 2018-10-30 경상대학교산학협력단 프롤릴 올리고펩티다아제 억제제를 유효성분으로 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물
KR20230035604A (ko) 2020-07-07 2023-03-14 어큐어 테라퓨틱스, 에스.엘. 1-[1-(4-벤질옥시-3,5-디플루오로-벤조일)-4-플루오로-피롤리딘-2-카보닐]-피롤리딘-2-카보니트릴

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483991A (en) * 1983-01-17 1984-11-20 American Home Products Corporation Hypotensive agents
CA1309805C (en) * 1985-04-16 1992-11-03 Naoki Higuchi Dipeptide derivative and synthesis and use thereof
JPH0696563B2 (ja) * 1986-02-04 1994-11-30 サントリー株式会社 アシルアミノ酸誘導体、その製法並びに用途
CA1320734C (en) * 1986-02-04 1993-07-27 Suntory Limited Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same
FI925500A7 (fi) * 1990-06-04 1992-12-03 Pfizer Aromaattisia pyrrolidiini- ja tiatsolidiiniamideja
AU643300B2 (en) * 1990-06-07 1993-11-11 Zeria Pharmaceutical Co., Ltd. Novel arylalkanoylamine derivative and drug containing the same
DK0915088T3 (da) * 1997-10-31 2003-01-27 Hoffmann La Roche D-prolinderivater

Also Published As

Publication number Publication date
CN1747930A (zh) 2006-03-15
KR20060027789A (ko) 2006-03-28
FI20030014A0 (fi) 2003-01-03
WO2004060862A3 (en) 2004-11-25
MXPA05007262A (es) 2005-09-08
BRPI0406618A (pt) 2005-12-06
AU2004203788A1 (en) 2004-07-22
EP1581489A2 (en) 2005-10-05
HRP20050693A2 (en) 2005-10-31
WO2004060862A2 (en) 2004-07-22
EA200501083A1 (ru) 2006-02-24
CA2511856A1 (en) 2004-07-22
NO20053726D0 (no) 2005-08-03
IS7963A (is) 2005-07-28
EA010022B1 (ru) 2008-06-30
JP2006516557A (ja) 2006-07-06
RS20050514A (sr) 2007-12-31
PL378329A1 (pl) 2006-03-20
ZA200505183B (en) 2006-04-26
US20060229254A1 (en) 2006-10-12

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application