NO20054645L - S-[2[(1-Iminoetyl)amino]etyl]-2-metyl-L-cystein maleat hydroklorid krystallinsk salt - Google Patents
S-[2[(1-Iminoetyl)amino]etyl]-2-metyl-L-cystein maleat hydroklorid krystallinsk saltInfo
- Publication number
- NO20054645L NO20054645L NO20054645A NO20054645A NO20054645L NO 20054645 L NO20054645 L NO 20054645L NO 20054645 A NO20054645 A NO 20054645A NO 20054645 A NO20054645 A NO 20054645A NO 20054645 L NO20054645 L NO 20054645L
- Authority
- NO
- Norway
- Prior art keywords
- iminoethyl
- ethyl
- amino
- methyl
- maleate hydrochloride
- Prior art date
Links
- QCVDKYGQDGDZJA-KZDSSNOQSA-N (2r)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]-2-methylpropanoic acid;(z)-but-2-enedioic acid Chemical compound OC(=O)\C=C/C(O)=O.CC(N)=NCCSC[C@](C)(N)C(O)=O QCVDKYGQDGDZJA-KZDSSNOQSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- NWBJAUFHPXRBKI-QMMMGPOBSA-N (2r)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]-2-methylpropanoic acid Chemical compound CC(=N)NCCSC[C@](C)(N)C(O)=O NWBJAUFHPXRBKI-QMMMGPOBSA-N 0.000 abstract 1
- KQPWGISKSWKNKA-MGKKNRTKSA-N (2r)-2-amino-3-[2-(1-aminoethylideneamino)ethylsulfanyl]-2-methylpropanoic acid;(z)-but-2-enedioic acid;hydrochloride Chemical compound Cl.OC(=O)\C=C/C(O)=O.CC(N)=NCCSC[C@](C)(N)C(O)=O KQPWGISKSWKNKA-MGKKNRTKSA-N 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
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- C07—ORGANIC CHEMISTRY
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- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/26—Separation; Purification; Stabilisation; Use of additives
- C07C319/28—Separation; Purification
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
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Abstract
Det beskrives et nytt blandet salt av S-[2-[(l-iminoetyl)amino]etyl]-2-metyl-L-cystein. Det nye blandede salt, S-[2-[(l-iminoetyl)amino]-etyl]-2-metyl-Lcysteinmaleathydroklorid, kan fremstilles i form av krystaller som kan være anordnet som generelt ordnet pakkede agglomerater som spesielt er brukbare for fremstilling av farmasøytiske preparater. Videre beskrives farmasøytiske preparater så vel som metoder for å fremstille krystallinsk S-[2-[(1-iminoetyl)amino]etyl]-2-metyl-L-cysteinmaleathydroklorid og fremgangsmater for å behandle tilstander som karakteriseres ved en overekspresjon av nitrogenoksid fra den induserbare isoform av nitrogenoksidsyntase ved bruk av S-[2-[(1-iminoetyl)amino]etyl]-2-metyl-L-cysteinmaleathydroklorid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45349603P | 2003-03-11 | 2003-03-11 | |
| PCT/IB2004/000678 WO2004080956A1 (en) | 2003-03-11 | 2004-03-04 | S-[2-[(1-iminoethyl)amino]ethyl]-2-methyl-l-cysteine maleate hydrochloride crystalline salt |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20054645D0 NO20054645D0 (no) | 2005-10-10 |
| NO20054645L true NO20054645L (no) | 2005-11-25 |
Family
ID=32990778
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20054645A NO20054645L (no) | 2003-03-11 | 2005-10-10 | S-[2[(1-Iminoetyl)amino]etyl]-2-metyl-L-cystein maleat hydroklorid krystallinsk salt |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US20050038120A1 (no) |
| EP (1) | EP1603872B1 (no) |
| JP (1) | JP4794433B2 (no) |
| KR (2) | KR20090048521A (no) |
| CN (1) | CN100460387C (no) |
| AR (1) | AR043521A1 (no) |
| AT (1) | ATE509909T1 (no) |
| AU (1) | AU2004220266B2 (no) |
| BR (1) | BRPI0408226A (no) |
| CA (1) | CA2518745C (no) |
| CL (1) | CL2004000472A1 (no) |
| CO (1) | CO5611122A2 (no) |
| CY (1) | CY1112461T1 (no) |
| DK (1) | DK1603872T3 (no) |
| ES (1) | ES2363001T3 (no) |
| GT (1) | GT200400040A (no) |
| IL (1) | IL170554A (no) |
| MX (1) | MXPA05008674A (no) |
| NL (1) | NL1025691C2 (no) |
| NO (1) | NO20054645L (no) |
| NZ (1) | NZ574218A (no) |
| PA (1) | PA8597701A1 (no) |
| PE (1) | PE20050309A1 (no) |
| PL (1) | PL1603872T3 (no) |
| PT (1) | PT1603872E (no) |
| RU (1) | RU2357953C2 (no) |
| SG (1) | SG155782A1 (no) |
| SI (1) | SI1603872T1 (no) |
| TW (1) | TWI352076B (no) |
| UY (1) | UY28229A1 (no) |
| WO (1) | WO2004080956A1 (no) |
| ZA (1) | ZA200506459B (no) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6094101A (en) * | 1999-03-17 | 2000-07-25 | Tropian, Inc. | Direct digital frequency synthesis enabling spur elimination |
| PT1793187E (pt) * | 2004-09-21 | 2012-03-05 | Joan Vives Iglesias | Processo e máquina destinados à sinterização e/ou secagem de materiais em pó utilizando uma radiação infravermelha |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9103572D0 (sv) * | 1991-11-29 | 1991-11-29 | Astra Ab | Organic salts of n,n'-diacetyl cystine |
| DE69529101T2 (de) * | 1994-06-15 | 2003-11-13 | Wellcome Found | Zwischenprodukte verwendbar in der Herstellung von Enzym-Inhibitoren |
| MY117948A (en) * | 1997-01-13 | 2004-08-30 | Glaxo Group Ltd | Nitride oxide synthase inhibitors. |
| GEP20094625B (en) * | 2000-03-24 | 2009-03-10 | Pharmacia Corp | Amidino compound and salts thereof useful as nitric oxide synthase inhibitors |
| AR031609A1 (es) * | 2000-09-15 | 2003-09-24 | Pharmacia Corp | Derivados de acido 2-amino-2-alquil-3 heptenoico y heptinoico utiles como inhibidores de oxido nitrico sintetasa |
| AR031608A1 (es) * | 2000-09-15 | 2003-09-24 | Pharmacia Corp | Derivados de los acidos 2-amino-2-alquil-3-hexenoico y -hexinoico utiles como inhibidores de oxido nitrico sintetasa |
-
2004
- 2004-03-04 AT AT04717188T patent/ATE509909T1/de active
- 2004-03-04 EP EP04717188A patent/EP1603872B1/en not_active Expired - Lifetime
- 2004-03-04 AU AU2004220266A patent/AU2004220266B2/en not_active Ceased
- 2004-03-04 CA CA2518745A patent/CA2518745C/en not_active Expired - Fee Related
- 2004-03-04 SG SG200802031-5A patent/SG155782A1/en unknown
- 2004-03-04 NZ NZ574218A patent/NZ574218A/en not_active IP Right Cessation
- 2004-03-04 BR BRPI0408226-5A patent/BRPI0408226A/pt not_active IP Right Cessation
- 2004-03-04 SI SI200431696T patent/SI1603872T1/sl unknown
- 2004-03-04 MX MXPA05008674A patent/MXPA05008674A/es active IP Right Grant
- 2004-03-04 PL PL04717188T patent/PL1603872T3/pl unknown
- 2004-03-04 WO PCT/IB2004/000678 patent/WO2004080956A1/en not_active Ceased
- 2004-03-04 KR KR1020097008258A patent/KR20090048521A/ko not_active Ceased
- 2004-03-04 ES ES04717188T patent/ES2363001T3/es not_active Expired - Lifetime
- 2004-03-04 JP JP2006506318A patent/JP4794433B2/ja not_active Expired - Fee Related
- 2004-03-04 PT PT04717188T patent/PT1603872E/pt unknown
- 2004-03-04 CN CNB200480012896XA patent/CN100460387C/zh not_active Expired - Fee Related
- 2004-03-04 DK DK04717188.9T patent/DK1603872T3/da active
- 2004-03-04 RU RU2005125833/04A patent/RU2357953C2/ru not_active IP Right Cessation
- 2004-03-04 KR KR1020057016858A patent/KR100927911B1/ko not_active Expired - Fee Related
- 2004-03-09 AR ARP040100751A patent/AR043521A1/es not_active Application Discontinuation
- 2004-03-09 CL CL200400472A patent/CL2004000472A1/es unknown
- 2004-03-09 PE PE2004000257A patent/PE20050309A1/es not_active Application Discontinuation
- 2004-03-10 GT GT200400040A patent/GT200400040A/es unknown
- 2004-03-10 TW TW093106315A patent/TWI352076B/zh not_active IP Right Cessation
- 2004-03-10 US US10/797,462 patent/US20050038120A1/en not_active Abandoned
- 2004-03-10 PA PA20048597701A patent/PA8597701A1/es unknown
- 2004-03-11 UY UY28229A patent/UY28229A1/es not_active Application Discontinuation
- 2004-03-11 NL NL1025691A patent/NL1025691C2/nl not_active IP Right Cessation
-
2005
- 2005-08-11 ZA ZA200506459A patent/ZA200506459B/en unknown
- 2005-08-29 IL IL170554A patent/IL170554A/en not_active IP Right Cessation
- 2005-09-09 CO CO05091013A patent/CO5611122A2/es not_active Application Discontinuation
- 2005-10-10 NO NO20054645A patent/NO20054645L/no not_active Application Discontinuation
-
2008
- 2008-12-05 US US12/315,744 patent/US7767850B2/en not_active Expired - Fee Related
-
2011
- 2011-06-06 CY CY20111100540T patent/CY1112461T1/el unknown
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