NO20055754L - Kolkisosidanaloger - Google Patents

Kolkisosidanaloger

Info

Publication number: NO20055754L
Authority: NO; Norway
Prior art keywords: colchicine; kolkisosidanaloger; formula; demethylthio; demethyl
Prior art date: 2003-06-06

Application number

NO20055754A

Other languages

English (en)

Other versions

NO330964B1 (no

Inventor

Gabriele Fontana

Ezio Bombardelli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2005-12-05

Publication date

2005-12-05

2005-12-05 Application filed by Indena Spa filed Critical Indena Spa

2005-12-05 Publication of NO20055754L publication Critical patent/NO20055754L/no

2011-08-29 Publication of NO330964B1 publication Critical patent/NO330964B1/no

Links

IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
229960002708 antigout preparations Drugs 0.000 abstract 1
229940045695 antineooplastic colchicine derivative Drugs 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000003205 muscle Anatomy 0.000 abstract 1
JRRUSQGIRBEMRN-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical group O=C1C(OC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 JRRUSQGIRBEMRN-HNNXBMFYSA-N 0.000 abstract 1
PKYOHQGXPPVIGD-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound O=C1C(SC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 PKYOHQGXPPVIGD-HNNXBMFYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002040 relaxant effect Effects 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Physical Education & Sports Medicine (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20055754A 2003-06-06 2005-12-05 Kolkisosidanaloger NO330964B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT001144A ITMI20031144A1 (it)	2003-06-06	2003-06-06	Analoghi del colchicoside.
PCT/EP2004/005645 WO2004111068A1 (en)	2003-06-06	2004-05-26	Colchicoside analogues

Publications (2)

Publication Number	Publication Date
NO20055754L true NO20055754L (no)	2005-12-05
NO330964B1 NO330964B1 (no)	2011-08-29

Family

ID=30131160

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20055754A NO330964B1 (no)	2003-06-06	2005-12-05	Kolkisosidanaloger

Country Status (23)

Country	Link
US (1)	US7683163B2 (no)
EP (1)	EP1631574B1 (no)
JP (1)	JP4718449B2 (no)
KR (1)	KR101121374B1 (no)
CN (1)	CN100348605C (no)
AT (1)	ATE425174T1 (no)
AU (1)	AU2004247346B2 (no)
BR (1)	BRPI0411068B8 (no)
CA (1)	CA2528223C (no)
CY (1)	CY1109019T1 (no)
DE (1)	DE602004019914D1 (no)
DK (1)	DK1631574T3 (no)
ES (1)	ES2321838T3 (no)
IL (1)	IL172358A (no)
IT (1)	ITMI20031144A1 (no)
MX (1)	MXPA05013161A (no)
NO (1)	NO330964B1 (no)
NZ (1)	NZ543943A (no)
PL (1)	PL1631574T3 (no)
PT (1)	PT1631574E (no)
RU (1)	RU2343157C2 (no)
SI (1)	SI1631574T1 (no)
WO (1)	WO2004111068A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20051418A1 (it) *	2005-07-22	2007-01-23	Indena Spa	Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
US8232254B2 (en)	2006-10-06	2012-07-31	Wisconsin Alumni Research Foundation	Colchicine neoglycosides and methods for their synthesis and use
PT2128170E (pt) *	2008-05-28	2011-02-23	Indena Spa	Processo para a glicosidação de colchicina e tiocolchicina
US8722205B2 (en)	2009-03-23	2014-05-13	Universal Display Corporation	Heteroleptic iridium complex
US8497290B2 (en) *	2009-05-27	2013-07-30	Takeda Pharmaceuticals U.S.A., Inc.	Thiocolchicine derivatives, method of making and methods of use thereof
US20150164831A1 (en) *	2012-03-30	2015-06-18	Takeda Pharmaceuticals U.S.A., Inc.	Colchicine formulations; methods of making; and methods of use thereof
US12324799B2 (en)	2018-06-29	2025-06-10	Alberta Health Services	Methods and uses of colchicine derivatives
IT202000014362A1 (it) *	2020-06-16	2021-12-16	Indena Spa	Processo semisintetico per la preparazione di colchicina

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB773729A (en) *	1955-06-10	1957-05-01	Roussel Uclaf	New derivatives of n-deacetylalkylthiocolchiceines and process for their production
CH341831A (fr)	1955-06-10	1959-10-31	Uclaf Societe Anonyme	Procédé de préparation de produits de condensation de saccharides sur l'azote des N-désacétyl-alcoylthiocolchicéines
JPS5619357B2 (no) *	1972-05-02	1981-05-07
JP2894366B2 (ja) *	1990-12-25	1999-05-24	有限会社尾源研究所	デアセチルコルヒチンの製造方法
AU634921B2 (en) *	1990-12-25	1993-03-04	Ohgen Research Laboratories Ltd.	Deacetylcolchicine derivatives
IT1270124B (it) *	1994-10-05	1997-04-28	Indena Spa	Derivati della colchicina e loro impiego terapeutico
IT1276996B1 (it) *	1995-06-27	1997-11-04	Indena Spa	Derivati della colchicina, loro uso e formulazioni che li contengono
IT1282584B1 (it) *	1996-02-08	1998-03-31	Indena Spa	Processo di glicosidazione di derivati colchicinici e prodotti ottenuti
IT1285777B1 (it) *	1996-10-07	1998-06-18	Indena Spa	Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
CN1208003A (zh) *	1997-08-08	1999-02-17	韩财元	摆翼式直升飞机
FR2779147B1 (fr) *	1998-05-27	2000-06-30	Synthelabo	Derive de thiocolchicoside sa preparation et son application en therapeutique

2003
- 2003-06-06 IT IT001144A patent/ITMI20031144A1/it unknown
2004
- 2004-05-26 KR KR1020057023042A patent/KR101121374B1/ko not_active Expired - Fee Related
- 2004-05-26 SI SI200431102T patent/SI1631574T1/sl unknown
- 2004-05-26 DK DK04739355T patent/DK1631574T3/da active
- 2004-05-26 ES ES04739355T patent/ES2321838T3/es not_active Expired - Lifetime
- 2004-05-26 NZ NZ543943A patent/NZ543943A/en unknown
- 2004-05-26 JP JP2006508205A patent/JP4718449B2/ja not_active Expired - Fee Related
- 2004-05-26 DE DE602004019914T patent/DE602004019914D1/de not_active Expired - Lifetime
- 2004-05-26 CA CA2528223A patent/CA2528223C/en not_active Expired - Lifetime
- 2004-05-26 MX MXPA05013161A patent/MXPA05013161A/es active IP Right Grant
- 2004-05-26 PL PL04739355T patent/PL1631574T3/pl unknown
- 2004-05-26 US US10/559,462 patent/US7683163B2/en not_active Expired - Lifetime
- 2004-05-26 AU AU2004247346A patent/AU2004247346B2/en not_active Ceased
- 2004-05-26 CN CNB2004800156654A patent/CN100348605C/zh not_active Expired - Lifetime
- 2004-05-26 EP EP04739355A patent/EP1631574B1/en not_active Expired - Lifetime
- 2004-05-26 WO PCT/EP2004/005645 patent/WO2004111068A1/en not_active Ceased
- 2004-05-26 RU RU2005137870/04A patent/RU2343157C2/ru active
- 2004-05-26 AT AT04739355T patent/ATE425174T1/de active
- 2004-05-26 PT PT04739355T patent/PT1631574E/pt unknown
- 2004-05-26 BR BRPI0411068A patent/BRPI0411068B8/pt not_active IP Right Cessation
2005
- 2005-12-05 NO NO20055754A patent/NO330964B1/no not_active IP Right Cessation
- 2005-12-05 IL IL172358A patent/IL172358A/en active IP Right Grant
2009
- 2009-05-05 CY CY20091100483T patent/CY1109019T1/el unknown

Also Published As

Publication number	Publication date
BRPI0411068B8 (pt)	2021-05-25
IL172358A0 (en)	2009-02-11
BRPI0411068B1 (pt)	2017-12-26
KR20060057536A (ko)	2006-05-26
CN1802383A (zh)	2006-07-12
PT1631574E (pt)	2009-05-05
EP1631574B1 (en)	2009-03-11
ES2321838T3 (es)	2009-06-12
CA2528223A1 (en)	2004-12-23
AU2004247346A1 (en)	2004-12-23
ITMI20031144A1 (it)	2004-12-07
ATE425174T1 (de)	2009-03-15
BRPI0411068A (pt)	2006-08-01
US7683163B2 (en)	2010-03-23
SI1631574T1 (sl)	2009-06-30
MXPA05013161A (es)	2006-03-17
KR101121374B1 (ko)	2012-03-09
CY1109019T1 (el)	2014-07-02
NO330964B1 (no)	2011-08-29
RU2005137870A (ru)	2006-06-10
IL172358A (en)	2012-01-31
EP1631574A1 (en)	2006-03-08
AU2004247346B2 (en)	2008-12-18
CA2528223C (en)	2011-11-22
PL1631574T3 (pl)	2009-07-31
NZ543943A (en)	2008-09-26
WO2004111068A1 (en)	2004-12-23
ITMI20031144A0 (it)	2003-06-06
RU2343157C2 (ru)	2009-01-10
HK1090062A1 (zh)	2006-12-15
DE602004019914D1 (de)	2009-04-23
JP2006527173A (ja)	2006-11-30
US20070129315A1 (en)	2007-06-07
JP4718449B2 (ja)	2011-07-06
CN100348605C (zh)	2007-11-14
DK1631574T3 (da)	2009-05-25

Legal Events

Date	Code	Title	Description
2023-12-27	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO20070224L (no)	2007-04-02	2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
BRPI0409109A (pt)	2006-03-28	novos compostos
BR0211473A (pt)	2004-10-26	Novos compostos
ATE381535T1 (de)	2008-01-15	Phenethanolaminderivate
SE0301009D0 (sv)	2003-04-07	Novel compounds
EA200300776A1 (ru)	2004-06-24	Производные фенэтаноламина для лечения респираторных заболеваний
HRP20040317A2 (en)	2006-06-30	1,8-naphthyridine derivatives as antidiabetics
BR0211472A (pt)	2004-11-09	Novos compostos
UA84048C2 (ru)	2008-09-10	Производные сульфонамида для лечения заболеваний, способ их получения (варианты), фармацевтическая композиция на их основе
ATE307810T1 (de)	2005-11-15	Imidazol-2-carbonsäureamid derivate als raf- kinase-inhibitoren
GEP20084452B (en)	2008-08-10	Sulfonamide derivatives for the treatment of diseases
SE0403171D0 (sv)	2004-12-23	New compounds
CY1109366T1 (el)	2014-07-02	Υποκατεστημενες ενωσεις 1,4,8-τριαζασπειρο[4.5]δεκαν-2-ονης
SE0100569D0 (sv)	2001-02-20	New compounds
SE9903894D0 (sv)	1999-10-28	Novel compounds
CY1109019T1 (el)	2014-07-02	Αναλογα κολχικοζιδης
SE0101322D0 (sv)	2001-04-12	Novel compounds
SE0303480D0 (sv)	2003-12-19	Benzofuranes
NO20092413L (no)	2009-07-20	Pyrazolanaloger
SE0403118D0 (sv)	2004-12-21	New compounds 2
NO20055749L (no)	2005-12-14	Sulfamat benzotiofenderivater som steroid sulfatase inhibitorer
HUP0401895A2 (hu)	2004-12-28	Paroxetin N-formil származékai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
SE0403117D0 (sv)	2004-12-21	New compounds 1
DK1406865T3 (da)	2006-05-08	Ravsyrederivater
UY27475A1 (es)	2003-06-30	Amidas de ácido piperazinciclohexanocarboxílico sustituidas y su utilización