ATE425174T1 - Colchicosidanaloge - Google Patents

Colchicosidanaloge

Info

Publication number: ATE425174T1
Authority: AT; Austria
Prior art keywords: colchicoside; analogues; colchicine; formula; demethylthio
Prior art date: 2003-06-06

Application number

AT04739355T

Other languages

English (en)

Inventor

Ezio Bombardelli

Gabriele Fontana

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2004-05-26

Publication date

2009-03-15

2004-05-26 Application filed by Indena Spa filed Critical Indena Spa

2009-03-15 Application granted granted Critical

2009-03-15 Publication of ATE425174T1 publication Critical patent/ATE425174T1/de

Links

UXAFRQPVHYZDED-ZZEDUEFDSA-N Colchicoside Chemical class C1([C@@H](NC(C)=O)CCC2=C3)=CC(=O)C(OC)=CC=C1C2=C(OC)C(OC)=C3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UXAFRQPVHYZDED-ZZEDUEFDSA-N 0.000 title 1
IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
229960002708 antigout preparations Drugs 0.000 abstract 1
229940045695 antineooplastic colchicine derivative Drugs 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000003205 muscle Anatomy 0.000 abstract 1
JRRUSQGIRBEMRN-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2,10-trimethoxy-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical group O=C1C(OC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 JRRUSQGIRBEMRN-HNNXBMFYSA-N 0.000 abstract 1
PKYOHQGXPPVIGD-HNNXBMFYSA-N n-[(7s)-3-hydroxy-1,2-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound O=C1C(SC)=CC=C2C3=C(OC)C(OC)=C(O)C=C3CC[C@H](NC(C)=O)C2=C1 PKYOHQGXPPVIGD-HNNXBMFYSA-N 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002040 relaxant effect Effects 0.000 abstract 1
229910052717 sulfur Chemical group 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/248—Colchicine radicals, e.g. colchicosides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Neurology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)

AT04739355T 2003-06-06 2004-05-26 Colchicosidanaloge ATE425174T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT001144A ITMI20031144A1 (it)	2003-06-06	2003-06-06	Analoghi del colchicoside.

Publications (1)

Publication Number	Publication Date
ATE425174T1 true ATE425174T1 (de)	2009-03-15

Family

ID=30131160

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04739355T ATE425174T1 (de)	2003-06-06	2004-05-26	Colchicosidanaloge

Country Status (23)

Country	Link
US (1)	US7683163B2 (de)
EP (1)	EP1631574B1 (de)
JP (1)	JP4718449B2 (de)
KR (1)	KR101121374B1 (de)
CN (1)	CN100348605C (de)
AT (1)	ATE425174T1 (de)
AU (1)	AU2004247346B2 (de)
BR (1)	BRPI0411068B8 (de)
CA (1)	CA2528223C (de)
CY (1)	CY1109019T1 (de)
DE (1)	DE602004019914D1 (de)
DK (1)	DK1631574T3 (de)
ES (1)	ES2321838T3 (de)
IL (1)	IL172358A (de)
IT (1)	ITMI20031144A1 (de)
MX (1)	MXPA05013161A (de)
NO (1)	NO330964B1 (de)
NZ (1)	NZ543943A (de)
PL (1)	PL1631574T3 (de)
PT (1)	PT1631574E (de)
RU (1)	RU2343157C2 (de)
SI (1)	SI1631574T1 (de)
WO (1)	WO2004111068A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20051418A1 (it) *	2005-07-22	2007-01-23	Indena Spa	Analoghi del tiocolchicoside ad attivita'miorilassante e antiinfiammatoria
WO2008067039A2 (en) *	2006-10-06	2008-06-05	Wisconsin Alumni Research Foundation	Colchicine neoglycosides and methods for their synthesis and use
SI2128170T1 (sl) *	2008-05-28	2011-04-29	Indena Spa	Postopek za glikozidacijo kolhicina in tiokolhicina
US8722205B2 (en)	2009-03-23	2014-05-13	Universal Display Corporation	Heteroleptic iridium complex
WO2010138670A2 (en) *	2009-05-27	2010-12-02	Mutual Pharmaceutical Company, Inc.	Thiocolchicine derivatives, method of making and methods of use thereof
EP2830606A4 (de) *	2012-03-30	2015-08-12	Takeda Pharmaceuticals Usa Inc	Colchizinformulierungen, verfahren zur herstellung und verfahren zur verwendung davon
AU2019295499B2 (en)	2018-06-29	2025-02-13	Alberta Health Services	Methods and uses of colchicine derivatives
IT202000014362A1 (it) *	2020-06-16	2021-12-16	Indena Spa	Processo semisintetico per la preparazione di colchicina

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB773729A (en) *	1955-06-10	1957-05-01	Roussel Uclaf	New derivatives of n-deacetylalkylthiocolchiceines and process for their production
CH341831A (fr) *	1955-06-10	1959-10-31	Uclaf Societe Anonyme	Procédé de préparation de produits de condensation de saccharides sur l'azote des N-désacétyl-alcoylthiocolchicéines
JPS5619357B2 (de) *	1972-05-02	1981-05-07
JP2894366B2 (ja) *	1990-12-25	1999-05-24	有限会社尾源研究所	デアセチルコルヒチンの製造方法
AU634921B2 (en) *	1990-12-25	1993-03-04	Ohgen Research Laboratories Ltd.	Deacetylcolchicine derivatives
IT1270124B (it) *	1994-10-05	1997-04-28	Indena Spa	Derivati della colchicina e loro impiego terapeutico
IT1276996B1 (it) *	1995-06-27	1997-11-04	Indena Spa	Derivati della colchicina, loro uso e formulazioni che li contengono
IT1282584B1 (it) *	1996-02-08	1998-03-31	Indena Spa	Processo di glicosidazione di derivati colchicinici e prodotti ottenuti
IT1285777B1 (it) *	1996-10-07	1998-06-18	Indena Spa	Processo di biotrasformazione di composti colchicinoidi nei corrispondenti 3-glicosilderivati
CN1208003A (zh) *	1997-08-08	1999-02-17	韩财元	摆翼式直升飞机
FR2779147B1 (fr) *	1998-05-27	2000-06-30	Synthelabo	Derive de thiocolchicoside sa preparation et son application en therapeutique

2003
- 2003-06-06 IT IT001144A patent/ITMI20031144A1/it unknown
2004
- 2004-05-26 MX MXPA05013161A patent/MXPA05013161A/es active IP Right Grant
- 2004-05-26 ES ES04739355T patent/ES2321838T3/es not_active Expired - Lifetime
- 2004-05-26 RU RU2005137870/04A patent/RU2343157C2/ru active
- 2004-05-26 SI SI200431102T patent/SI1631574T1/sl unknown
- 2004-05-26 NZ NZ543943A patent/NZ543943A/en unknown
- 2004-05-26 DE DE602004019914T patent/DE602004019914D1/de not_active Expired - Lifetime
- 2004-05-26 BR BRPI0411068A patent/BRPI0411068B8/pt not_active IP Right Cessation
- 2004-05-26 CA CA2528223A patent/CA2528223C/en not_active Expired - Lifetime
- 2004-05-26 EP EP04739355A patent/EP1631574B1/de not_active Expired - Lifetime
- 2004-05-26 PL PL04739355T patent/PL1631574T3/pl unknown
- 2004-05-26 JP JP2006508205A patent/JP4718449B2/ja not_active Expired - Fee Related
- 2004-05-26 WO PCT/EP2004/005645 patent/WO2004111068A1/en not_active Ceased
- 2004-05-26 AT AT04739355T patent/ATE425174T1/de active
- 2004-05-26 CN CNB2004800156654A patent/CN100348605C/zh not_active Expired - Lifetime
- 2004-05-26 AU AU2004247346A patent/AU2004247346B2/en not_active Ceased
- 2004-05-26 DK DK04739355T patent/DK1631574T3/da active
- 2004-05-26 KR KR1020057023042A patent/KR101121374B1/ko not_active Expired - Fee Related
- 2004-05-26 PT PT04739355T patent/PT1631574E/pt unknown
- 2004-05-26 US US10/559,462 patent/US7683163B2/en not_active Expired - Lifetime
2005
- 2005-12-05 NO NO20055754A patent/NO330964B1/no not_active IP Right Cessation
- 2005-12-05 IL IL172358A patent/IL172358A/en active IP Right Grant
2009
- 2009-05-05 CY CY20091100483T patent/CY1109019T1/el unknown

Also Published As

Publication number	Publication date
CY1109019T1 (el)	2014-07-02
DE602004019914D1 (de)	2009-04-23
MXPA05013161A (es)	2006-03-17
US20070129315A1 (en)	2007-06-07
IL172358A0 (en)	2009-02-11
ITMI20031144A0 (it)	2003-06-06
PT1631574E (pt)	2009-05-05
ES2321838T3 (es)	2009-06-12
IL172358A (en)	2012-01-31
SI1631574T1 (sl)	2009-06-30
NO20055754L (no)	2005-12-05
KR101121374B1 (ko)	2012-03-09
BRPI0411068B8 (pt)	2021-05-25
NO330964B1 (no)	2011-08-29
EP1631574A1 (de)	2006-03-08
JP4718449B2 (ja)	2011-07-06
JP2006527173A (ja)	2006-11-30
HK1090062A1 (zh)	2006-12-15
RU2005137870A (ru)	2006-06-10
US7683163B2 (en)	2010-03-23
NZ543943A (en)	2008-09-26
DK1631574T3 (da)	2009-05-25
ITMI20031144A1 (it)	2004-12-07
BRPI0411068B1 (pt)	2017-12-26
AU2004247346B2 (en)	2008-12-18
BRPI0411068A (pt)	2006-08-01
AU2004247346A1 (en)	2004-12-23
WO2004111068A1 (en)	2004-12-23
RU2343157C2 (ru)	2009-01-10
PL1631574T3 (pl)	2009-07-31
CN1802383A (zh)	2006-07-12
CA2528223C (en)	2011-11-22
KR20060057536A (ko)	2006-05-26
EP1631574B1 (de)	2009-03-11
CA2528223A1 (en)	2004-12-23
CN100348605C (zh)	2007-11-14

Legal Events

Date

Code

Title

Description

2009-11-15

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