NO20060108L - Look-through mutagenesis - Google Patents
Look-through mutagenesisInfo
- Publication number
- NO20060108L NO20060108L NO20060108A NO20060108A NO20060108L NO 20060108 L NO20060108 L NO 20060108L NO 20060108 A NO20060108 A NO 20060108A NO 20060108 A NO20060108 A NO 20060108A NO 20060108 L NO20060108 L NO 20060108L
- Authority
- NO
- Norway
- Prior art keywords
- polypeptide
- libraries
- mutagenesis
- amino acids
- function
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Gram-positive bacteria
- C07K16/1282—Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48328203P | 2003-06-27 | 2003-06-27 | |
| PCT/US2004/020306 WO2005003345A2 (en) | 2003-06-27 | 2004-06-25 | Look-through mutagenesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20060108L true NO20060108L (no) | 2006-03-24 |
Family
ID=33563915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060108A NO20060108L (no) | 2003-06-27 | 2006-01-06 | Look-through mutagenesis |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20050136428A1 (pt) |
| EP (1) | EP1660655B1 (pt) |
| JP (2) | JP4791960B2 (pt) |
| KR (1) | KR20060034650A (pt) |
| CN (1) | CN1836041A (pt) |
| AU (1) | AU2004254352A1 (pt) |
| BR (1) | BRPI0412007A (pt) |
| CA (1) | CA2542192C (pt) |
| ES (1) | ES2609102T3 (pt) |
| IL (1) | IL172736A0 (pt) |
| NO (1) | NO20060108L (pt) |
| RU (1) | RU2005140664A (pt) |
| WO (1) | WO2005003345A2 (pt) |
| ZA (1) | ZA200510460B (pt) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329725B1 (en) | 2003-10-29 | 2008-02-12 | Nastech Pharmaceutical Company Inc. | Phage displayed Trp cage ligands |
| JP5143551B2 (ja) | 2004-07-06 | 2013-02-13 | バイオレン，インク． | ユニバーサル抗体のライブラリー |
| ATE528396T1 (de) | 2004-07-06 | 2011-10-15 | Bioren Inc | Look-through-mutagenese zur entwicklung veränderter polypeptide mit verbesserten eigenschaften |
| WO2006014477A1 (en) * | 2004-07-06 | 2006-02-09 | Bioren, Inc. | HIGH AFFINITY ANTI-TNF-α ANTIBODIES AND METHOD |
| US20080207467A1 (en) * | 2005-03-03 | 2008-08-28 | Xencor, Inc. | Methods for the design of libraries of protein variants |
| US20060234303A1 (en) * | 2005-03-03 | 2006-10-19 | Xencor, Inc. | Methods for the design of libraries of protein variants |
| EP1877441A2 (en) * | 2005-04-26 | 2008-01-16 | Bioren, Inc. | Method of producing human igg antibodies with enhanced effector functions |
| RU2008110060A (ru) * | 2005-08-15 | 2009-09-27 | Арана Терапьютикс Лимитед (Au) | Сконструированные антитела с каркасными участками приматов нового света |
| US8716195B2 (en) * | 2005-11-14 | 2014-05-06 | Bioren, Inc. | Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening |
| WO2007086994A1 (en) * | 2005-11-15 | 2007-08-02 | Balyasnikova Irina V | Single chain fragment of monoclonal antibody 9b9 and uses thereof |
| US7981414B2 (en) | 2005-12-20 | 2011-07-19 | Cephalon Australia Pty Ltd | Anti-inflammatory dAb |
| EP1987064A4 (en) | 2006-02-01 | 2010-04-07 | Arana Therapeutics Ltd | DOMAIN ANTIBODY CONSTRUCT |
| US7704953B2 (en) * | 2006-02-17 | 2010-04-27 | Mdrna, Inc. | Phage displayed cell binding peptides |
| WO2007112054A2 (en) * | 2006-03-23 | 2007-10-04 | Sea Lane Biotechnologies, Llc | Facilitation of translocation of molecules through the gastrointestinal tract |
| WO2007134327A2 (en) | 2006-05-15 | 2007-11-22 | Sea Lane Biotechnologies, Llc. | Neutralizing antibodies to influenza viruses |
| WO2007136840A2 (en) * | 2006-05-20 | 2007-11-29 | Codon Devices, Inc. | Nucleic acid library design and assembly |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| CN101548034B (zh) * | 2006-10-02 | 2013-11-13 | 航道生物技术有限责任公司 | 多样性合成肽和多肽文库的设计和构建 |
| EP2078077A2 (en) * | 2006-10-04 | 2009-07-15 | Codon Devices, Inc | Nucleic acid libraries and their design and assembly |
| BRPI0812446A2 (pt) * | 2007-06-06 | 2014-10-14 | Danisco Us Inc Genecor Division | Métodos para aperfeiçoamento de propriedades de proteína múltiplas |
| WO2009009045A2 (en) * | 2007-07-10 | 2009-01-15 | The Scripps Research Institute | Escape libraries of target polypeptides |
| US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
| US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
| EP2222846B1 (en) * | 2007-08-10 | 2017-05-03 | Protelix, Inc. | Universal fibronectin type iii binding-domain libraries |
| CN101970490A (zh) | 2007-11-27 | 2011-02-09 | 埃博灵克斯股份有限公司 | 针对异二聚体细胞因子和/或其受体的氨基酸序列以及包括所述氨基酸序列的多肽 |
| WO2009121004A2 (en) | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
| EP2131243B1 (en) * | 2008-06-02 | 2015-07-01 | ASML Netherlands B.V. | Lithographic apparatus and method for calibrating a stage position |
| WO2010115995A2 (en) | 2009-04-10 | 2010-10-14 | Ablynx Nv | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders |
| AU2010233658B2 (en) | 2009-04-10 | 2013-11-28 | Ablynx Nv | Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders |
| EP2438087B1 (en) | 2009-06-05 | 2017-05-10 | Ablynx N.V. | Trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections |
| KR20210013294A (ko) | 2009-07-17 | 2021-02-03 | 바이오아트라, 엘엘씨 | 생산 숙주에서 항체/단백질 성능과 발현을 동시에 통합 선택하고 진화시키는 방법 |
| GB0914691D0 (en) * | 2009-08-21 | 2009-09-30 | Lonza Biologics Plc | Immunoglobulin variants |
| EP3434769B1 (en) | 2009-10-30 | 2020-11-25 | Novartis AG | Universal fibronectin type iii bottom-side binding domain libraries |
| WO2011064382A1 (en) | 2009-11-30 | 2011-06-03 | Ablynx N.V. | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| CA2805862A1 (en) | 2010-07-30 | 2012-02-02 | Novartis Ag | Fibronectin cradle molecules and libraries thereof |
| US9753040B2 (en) | 2010-12-01 | 2017-09-05 | Mitsubishi Tanabe Pharma Corporation | Polynucleotide construct capable of displaying fab in a cell-free translation system, and method for manufacturing and screening fab using same |
| US10138302B2 (en) | 2011-09-23 | 2018-11-27 | Ablynx N.V. | Methods for treating rheumatoid arthritis by administering interleukin-6 receptor antibodies |
| EP2820043B1 (en) | 2012-03-02 | 2020-01-15 | Ablynx N.V. | Biparatopic pseudomonas aeruginosa pcrv binding single variable domain antibodies |
| US9777055B2 (en) | 2012-04-20 | 2017-10-03 | Thomas Jefferson University | Engineered antibody for inhibition of fibrosis |
| TR201910420T4 (tr) * | 2012-05-25 | 2019-08-21 | Chr Hansen As | Geliştirilmiş süt pıhtılaştırma niteliklerine sahip kimozin varyantları. |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
| KR101600902B1 (ko) | 2012-12-11 | 2016-03-10 | 주식회사 셀레믹스 | 코돈 조합화 및 변이유발을 이용한 유전자 라이브러리의 합성 방법 |
| US20140314741A1 (en) * | 2013-04-18 | 2014-10-23 | Developmen Center For Biotechnology | Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases |
| CA2924520C (en) * | 2013-11-01 | 2023-09-26 | Ibc Pharmaceuticals, Inc. | Bispecific antibodies that neutralize both tnf-alpha and il-6: novel therapeutic agent for autoimmune disease |
| CN104805507B (zh) * | 2014-01-29 | 2019-01-22 | 杭州康万达医药科技有限公司 | 噬菌体展示文库及其应用和制备方法 |
| US10982204B2 (en) | 2014-02-26 | 2021-04-20 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| CA2963712A1 (en) | 2014-10-21 | 2016-04-28 | Ablynx Nv | Treatment of il-6r related diseases |
| EP3310914B1 (en) | 2015-06-22 | 2022-04-06 | Chr. Hansen A/S | Variants of chymosin with improved properties |
| CA2995755A1 (en) | 2015-08-31 | 2017-03-09 | Chr. Hansen A/S | Variants of chymosin with improved properties |
| US11484592B2 (en) * | 2016-01-08 | 2022-11-01 | Momotaro-Gene Inc. | Combination therapy using REIC/Dkk-3 gene and a checkpoint inhibitor |
| WO2017198829A1 (en) | 2016-05-19 | 2017-11-23 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| US10954505B2 (en) | 2016-05-19 | 2021-03-23 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| CN109843922B (zh) | 2016-09-02 | 2023-10-03 | 莱蒂恩技术公司 | 用DuoCAR治疗癌症的组合物和方法 |
| KR102847676B1 (ko) | 2017-12-15 | 2025-08-21 | 알레타 바이오쎄라퓨틱스, 인크. | Cd19 변이체 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0527809B1 (en) * | 1990-04-05 | 1995-08-16 | CREA, Roberto | Walk-through mutagenesis |
| WO1995023813A1 (en) * | 1994-03-04 | 1995-09-08 | Merck & Co., Inc. | In vitro antibody affinity maturation using alanine scanning mutagenesis |
| WO2001044463A1 (en) * | 1999-12-15 | 2001-06-21 | Genentech, Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
-
2004
- 2004-06-25 ES ES04756045.3T patent/ES2609102T3/es not_active Expired - Lifetime
- 2004-06-25 WO PCT/US2004/020306 patent/WO2005003345A2/en not_active Ceased
- 2004-06-25 CA CA2542192A patent/CA2542192C/en not_active Expired - Lifetime
- 2004-06-25 EP EP04756045.3A patent/EP1660655B1/en not_active Expired - Lifetime
- 2004-06-25 US US10/877,467 patent/US20050136428A1/en not_active Abandoned
- 2004-06-25 CN CNA2004800229706A patent/CN1836041A/zh active Pending
- 2004-06-25 KR KR1020057025136A patent/KR20060034650A/ko not_active Withdrawn
- 2004-06-25 RU RU2005140664/13A patent/RU2005140664A/ru not_active Application Discontinuation
- 2004-06-25 JP JP2006517625A patent/JP4791960B2/ja not_active Expired - Lifetime
- 2004-06-25 BR BRPI0412007-8A patent/BRPI0412007A/pt not_active IP Right Cessation
- 2004-06-25 AU AU2004254352A patent/AU2004254352A1/en not_active Abandoned
-
2005
- 2005-12-21 IL IL172736A patent/IL172736A0/en unknown
- 2005-12-22 ZA ZA200510460A patent/ZA200510460B/xx unknown
-
2006
- 2006-01-06 NO NO20060108A patent/NO20060108L/no not_active Application Discontinuation
-
2011
- 2011-03-22 JP JP2011062697A patent/JP5358604B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1660655A2 (en) | 2006-05-31 |
| CA2542192A1 (en) | 2005-01-13 |
| JP2011182794A (ja) | 2011-09-22 |
| RU2005140664A (ru) | 2007-08-27 |
| CN1836041A (zh) | 2006-09-20 |
| KR20060034650A (ko) | 2006-04-24 |
| EP1660655B1 (en) | 2016-11-02 |
| ES2609102T3 (es) | 2017-04-18 |
| BRPI0412007A (pt) | 2006-08-15 |
| JP4791960B2 (ja) | 2011-10-12 |
| ZA200510460B (en) | 2006-11-29 |
| JP2007524390A (ja) | 2007-08-30 |
| CA2542192C (en) | 2013-05-28 |
| AU2004254352A1 (en) | 2005-01-13 |
| IL172736A0 (en) | 2006-04-10 |
| WO2005003345A3 (en) | 2005-03-24 |
| US20050136428A1 (en) | 2005-06-23 |
| JP5358604B2 (ja) | 2013-12-04 |
| WO2005003345A2 (en) | 2005-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |