NO20061180L - Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander - Google Patents

Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander

Info

Publication number: NO20061180L
Authority: NO; Norway
Prior art keywords: disorders; compounds; crf; heteroberl; pyrazines
Prior art date: 2003-09-05

Application number

NO20061180A

Other languages

English (en)

Norwegian (no)

Inventor

Ping Ge

Raymond F Horvath

Bernd Kaiser

Yan Lu Zhang

Yasuchika Yamaguchi

Xuechun Zhang

Suoming Zhang

He Zhao

Stanly John

Neil Moorcroft

Greg Shutske

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-05

Filing date

2006-03-14

Publication date

2006-03-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20061180(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-03-14 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2006-03-31 Publication of NO20061180L publication Critical patent/NO20061180L/no

Links

108091005471 CRHR1 Proteins 0.000 title abstract 2
150000003230 pyrimidines Chemical class 0.000 title abstract 2
239000003446 ligand Substances 0.000 title 1
150000003216 pyrazines Chemical class 0.000 title 1
150000003222 pyridines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
208000035475 disorder Diseases 0.000 abstract 3
108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
230000004807 localization Effects 0.000 abstract 1
238000005259 measurement Methods 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20061180A 2003-09-05 2006-03-14 Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander NO20061180L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50041403P	2003-09-05	2003-09-05
PCT/US2004/028899 WO2005023806A2 (en)	2003-09-05	2004-09-03	Heteroaryl fused pyridines, pyrazines and pyrimidines as crf1 receptor ligands

Publications (1)

Publication Number	Publication Date
NO20061180L true NO20061180L (no)	2006-03-31

Family

ID=34272952

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20061180A NO20061180L (no)	2003-09-05	2006-03-14	Heteroarylkjedede pyridiner, pyraziner og pyrimidiner som CRF1-reseptorligander

Country Status (19)

Country	Link
US (2)	US20050113379A1 (pt)
EP (1)	EP1680424A2 (pt)
JP (1)	JP2007504271A (pt)
KR (1)	KR20060088534A (pt)
CN (1)	CN1878773A (pt)
AP (1)	AP2006003559A0 (pt)
AR (1)	AR045582A1 (pt)
AU (1)	AU2004270713A1 (pt)
BR (1)	BRPI0414087A (pt)
CA (1)	CA2537829A1 (pt)
CR (1)	CR8274A (pt)
EA (1)	EA200600372A1 (pt)
EC (1)	ECSP066408A (pt)
IL (1)	IL174084A0 (pt)
MA (1)	MA28086A1 (pt)
NO (1)	NO20061180L (pt)
TW (1)	TW200530232A (pt)
WO (1)	WO2005023806A2 (pt)
ZA (1)	ZA200601978B (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004274403A1 (en) *	2003-09-03	2005-03-31	Aventis Pharmaceuticals Inc.	5-aryl-Pyrazolo(4,3-d)pyrimidines, pyridines, and pyrazines and related compounds
WO2006133261A2 (en)	2005-06-06	2006-12-14	Intra-Cellular Therapies, Inc.	Organic compounds
EP1919913A2 (en)	2005-08-25	2008-05-14	F.Hoffmann-La Roche Ag	P38 map kinase inhibitors and methods for using the same
JP5147401B2 (ja)	2005-09-06	2013-02-20	塩野義製薬株式会社	Ｐｇｄ２受容体アンタゴニスト活性を有するインドールカルボン酸誘導体
US7405302B2 (en) *	2005-10-11	2008-07-29	Amira Pharmaceuticals, Inc.	5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en)	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
PT2404919E (pt)	2005-11-08	2013-10-22	Vertex Pharma	Composto heterocíclico útil como um modulador de transportadores de cassete de ligação a atp
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
WO2007069671A1 (ja)	2005-12-15	2007-06-21	Ono Pharmaceutical Co., Ltd.	二環式複素環化合物
WO2007133756A2 (en) *	2006-05-15	2007-11-22	Neurogen Corporation	Crf1 receptor ligands comprising heteroaryl fused bicycles
TWI398252B (zh)	2006-05-26	2013-06-11	諾華公司	吡咯并嘧啶化合物及其用途
WO2008070095A1 (en)	2006-12-05	2008-06-12	Intra-Cellular Therapies, Inc.	Novel uses
WO2008076446A1 (en) *	2006-12-18	2008-06-26	Coleman Peter R	Accelerated opiate dependence detoxification process
WO2008074676A1 (en) *	2006-12-19	2008-06-26	F. Hoffmann-La Roche Ag	Pyrazolo [3, 4 -d] pyrimidine p38 map kinase inhibitors
WO2008083070A1 (en) *	2006-12-29	2008-07-10	Neurogen Corporation	Crf1 receptor ligands comprising fused bicyclic heteroaryl moieties
EP2164840A2 (en)	2007-05-09	2010-03-24	Vertex Pharmaceuticals Incorporated	Modulators of cftr
ES2588238T3 (es) *	2007-12-06	2016-10-31	Intra-Cellular Therapies, Inc.	Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico
HUE049642T2 (hu)	2007-12-07	2020-09-28	Vertex Pharma	3-(6-(1-(2,2-Difluorbenzo[d][1,3]dioxol-5-il)-ciklopropánkarboxamido)-3-metilpiridin-2-il)-benzoesav szilárd formái
CA2989620C (en) *	2007-12-07	2022-05-03	Vertex Pharmaceuticals Incorporated	Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
CA2716109C (en)	2008-02-28	2016-07-19	Vertex Pharmaceuticals Incorporated	Heteroaryl derivatives as cftr modulators
AU2009284098B2 (en)	2008-08-22	2012-03-29	Astex Therapeutics Ltd.	Pyrrolopyrimidine compounds as CDK inhibitors
AU2009322903A1 (en)	2008-12-06	2010-06-10	Intra-Cellular Therapies, Inc.	Organic compounds
AU2009322899A1 (en)	2008-12-06	2010-06-10	Intra-Cellular Therapies, Inc.	Organic compounds
MX2011005934A (es)	2008-12-06	2011-12-16	Intra Cellular Therapies Inc	Compuestos organicos.
BRPI0922700A2 (pt)	2008-12-06	2015-08-11	Intracellular Therapies Inc	Compostos orgânicos
EA201170769A1 (ru) *	2008-12-06	2012-02-28	Интра-Селлулар Терапиз, Инк.	Органические соединения
PE20110922A1 (es)	2008-12-06	2012-01-22	Intra Cellular Therapies Inc	DERIVADOS DE PIRAZOLO[4,3-e]PIRIMIDIN COMO INHIBIDORES DE LA FOSFODIESTERASA 1 (PDE1)
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
US8551996B2 (en) *	2009-02-20	2013-10-08	Emory University	Compounds, compositions, methods of synthesis, and methods of treatment
EP2434895A4 (en)	2009-05-13	2013-08-07	Intra Cellular Therapies Inc	ORGANIC CONNECTIONS
AR080056A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de ciclohexil-amida como antagonistas de los receptores de crf
CN102762572A (zh)	2010-02-01	2012-10-31	诺瓦提斯公司	作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
EP2531490B1 (en)	2010-02-02	2014-10-15	Novartis AG	Cyclohexyl amide derivatives as crf receptor antagonists
UY33227A (es)	2010-02-19	2011-09-30	Novartis Ag	Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
ES2900353T3 (es)	2010-04-07	2022-03-16	Vertex Pharma	Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiriidin-2-il)benzoico y administración de las mismas
EP2575817A4 (en)	2010-05-31	2014-01-08	Intra Cellular Therapies Inc	ORGANIC CONNECTIONS
US9763948B2 (en)	2010-05-31	2017-09-19	Intra-Cellular Therapies, Inc.	PDE1 inhibitory compounds and methods
TW201206937A (en)	2010-05-31	2012-02-16	Intra Cellular Therapies Inc	Organic compounds
US9371327B2 (en)	2010-05-31	2016-06-21	Intra-Cellular Therapies, Inc.	PDE1 inhibitor compounds
RU2013120966A (ru)	2010-10-08	2014-11-20	Эббви Инк.	ФУРО[3,2-d]ПИРИМИДИНОВЫЕ СОЕДИНЕНИЯ
UY34094A (es)	2011-05-27	2013-01-03	Novartis Ag	Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
EP2717877B1 (en)	2011-06-10	2017-11-08	Intra-Cellular Therapies, Inc.	Organic compounds
NZ727015A (en)	2012-01-25	2017-12-22	Vertex Pharma	Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
JP6140738B2 (ja) *	2012-03-06	2017-05-31	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＧｍｂＨ	置換アザ二環およびその使用
WO2013164790A1 (en)	2012-05-03	2013-11-07	Novartis Ag	L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists
EP2956141A4 (en)	2013-02-17	2016-10-26	Intra Cellular Therapies Inc	NEW USES
DK2970279T3 (da)	2013-03-15	2020-11-30	Intra Cellular Therapies Inc	Organiske forbindelser
ES2717688T3 (es)	2013-03-15	2019-06-24	Intra Cellular Therapies Inc	Inhibidores de la PDE1 para uso en el tratamiento y/o prevención de lesiones de SNC, y enfermedades, trastornos o lesiones de SNP
EP4772247A2 (en)	2013-08-14	2026-07-08	Novartis AG	Combination therapy comprising ribociclib and fulvestrant for the treatment of cancer
CA2930199C (en)	2013-11-12	2022-10-25	Vertex Pharmaceuticals Incorporated	Process of preparing pharmaceutical compositions for the treatment of cftr mediated diseases
DK3102576T3 (da)	2014-02-03	2019-07-22	Vitae Pharmaceuticals Llc	Dihydropyrrolopyridininhibitorer af ror-gamma
EP2940022B1 (en) *	2014-04-30	2020-09-02	Masarykova Univerzita	Furopyridines as inhibitors of protein kinases
DK3157926T3 (da)	2014-06-20	2019-08-19	Intra Cellular Therapies Inc	Organiske forbindelser
US10131671B2 (en)	2014-08-07	2018-11-20	Intra-Cellular Therapies, Inc.	Organic compounds
US10285992B2 (en)	2014-08-07	2019-05-14	Intra-Cellular Therapies, Inc.	Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
CA2961212C (en)	2014-09-17	2024-02-06	Intra-Cellular Therapies, Inc.	Compounds and methods
SI3207043T1 (sl)	2014-10-14	2019-04-30	Vitae Pharmaceuticals, Inc.	Dihidropirolopiridinovi inhibitorji za ROR-gama
US9845308B2 (en)	2014-11-05	2017-12-19	Vitae Pharmaceuticals, Inc.	Isoindoline inhibitors of ROR-gamma
US9663515B2 (en)	2014-11-05	2017-05-30	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
HUE055423T2 (hu)	2014-11-18	2021-11-29	Vertex Pharma	Eljárás nagy áteresztõképességû tesztelõ nagy teljesítményû folyadék-kromatográfia elvégzésére
TW201625635A (zh)	2014-11-21	2016-07-16	默沙東藥廠	作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物
EP3331876B1 (en)	2015-08-05	2020-10-07	Vitae Pharmaceuticals, LLC	Modulators of ror-gamma
EP3868750A1 (en)	2015-11-20	2021-08-25	Vitae Pharmaceuticals, LLC	Modulators of ror-gamma
TWI757266B (zh)	2016-01-29	2022-03-11	美商維它藥物有限責任公司	ＲＯＲ－γ調節劑
US10682354B2 (en)	2016-03-28	2020-06-16	Intra-Cellular Therapies, Inc.	Compositions and methods
US9481674B1 (en)	2016-06-10	2016-11-01	Vitae Pharmaceuticals, Inc.	Dihydropyrrolopyridine inhibitors of ROR-gamma
EP3510029B1 (en) *	2016-09-07	2025-11-05	The Regents of The University of California	Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition
US11291666B2 (en)	2016-09-12	2022-04-05	Intra-Cellular Therapies, Inc.	Uses
CN115716826A (zh)	2017-07-24	2023-02-28	生命医药有限责任公司	RORγ的抑制剂
WO2019018975A1 (en)	2017-07-24	2019-01-31	Vitae Pharmaceuticals, Inc.	INHIBITORS OF ROR GAMMA
JP7401442B2 (ja)	2018-01-31	2023-12-19	イントラ－セルラー・セラピーズ・インコーポレイテッド	新規使用
CN110437846B (zh) *	2019-08-30	2022-02-25	陕西师范大学	含炔键的氟取代苯并噁唑液晶化合物及其制备方法
US12410175B2 (en)	2019-09-03	2025-09-09	Intra-Cellular Therapies, Inc.	Compounds
US12486274B2 (en)	2020-01-13	2025-12-02	Verge Analytics, Inc.	Substituted pyrazolo-pyrimidines and uses thereof
US12364695B2 (en)	2020-06-02	2025-07-22	Intra-Cellular Therapies, Inc.	Methods of treating inflammatory disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3398152B2 (ja) *	1993-10-12	2003-04-21	ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー	１ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
JPH10506126A (ja) *	1995-05-12	1998-06-16	ニューロゲンコーポレイション	新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス
JP3964478B2 (ja) *	1995-06-30	2007-08-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬
PL332040A1 (en) *	1996-08-28	1999-08-16	Pfizer	Substitution 6,5-heterobicyclic derivatives
US6310063B1 (en) *	1998-04-02	2001-10-30	Neurogen Corporation	Aminoalkyl substituted pyrrolo [3,2-E]pyridine and pyrollo [2,3-b]pyrimidine derivatives: modulators of CRF1 receptors
AU2001273639A1 (en) *	2000-06-26	2002-01-08	Neurogen Corporation	Aryl fused substituted 4-oxy-pyridines
DE10229777A1 (de) *	2002-07-03	2004-01-29	Bayer Ag	Indolin-Phenylsulfonamid-Derivate
AU2004233827B2 (en) *	2003-04-24	2009-05-28	Merck Sharp & Dohme Corp.	Inhibitors of Akt activity

2004
- 2004-09-03 EA EA200600372A patent/EA200600372A1/ru unknown
- 2004-09-03 CN CNA2004800327037A patent/CN1878773A/zh active Pending
- 2004-09-03 AP AP2006003559A patent/AP2006003559A0/xx unknown
- 2004-09-03 JP JP2006526210A patent/JP2007504271A/ja active Pending
- 2004-09-03 AU AU2004270713A patent/AU2004270713A1/en not_active Abandoned
- 2004-09-03 CA CA002537829A patent/CA2537829A1/en not_active Abandoned
- 2004-09-03 ZA ZA200601978A patent/ZA200601978B/en unknown
- 2004-09-03 BR BRPI0414087-7A patent/BRPI0414087A/pt not_active IP Right Cessation
- 2004-09-03 KR KR1020067004564A patent/KR20060088534A/ko not_active Withdrawn
- 2004-09-03 AR ARP040103174A patent/AR045582A1/es unknown
- 2004-09-03 WO PCT/US2004/028899 patent/WO2005023806A2/en not_active Ceased
- 2004-09-03 US US10/933,834 patent/US20050113379A1/en not_active Abandoned
- 2004-09-03 EP EP04788585A patent/EP1680424A2/en not_active Withdrawn
- 2004-09-06 TW TW093126841A patent/TW200530232A/zh unknown
2006
- 2006-03-02 IL IL174084A patent/IL174084A0/en unknown
- 2006-03-03 CR CR8274A patent/CR8274A/es unknown
- 2006-03-03 EC EC2006006408A patent/ECSP066408A/es unknown
- 2006-03-14 NO NO20061180A patent/NO20061180L/no not_active Application Discontinuation
- 2006-03-24 US US11/389,646 patent/US20060199823A1/en not_active Abandoned
- 2006-04-05 MA MA28916A patent/MA28086A1/fr unknown

Also Published As

Publication number	Publication date
MA28086A1 (fr)	2006-08-01
WO2005023806A3 (en)	2005-06-02
EP1680424A2 (en)	2006-07-19
AR045582A1 (es)	2005-11-02
ZA200601978B (en)	2007-05-30
BRPI0414087A (pt)	2006-10-31
CA2537829A1 (en)	2005-03-17
US20060199823A1 (en)	2006-09-07
JP2007504271A (ja)	2007-03-01
ECSP066408A (es)	2006-09-18
US20050113379A1 (en)	2005-05-26
CR8274A (es)	2008-06-10
WO2005023806A2 (en)	2005-03-17
CN1878773A (zh)	2006-12-13
AP2006003559A0 (en)	2006-04-30
AU2004270713A1 (en)	2005-03-17
TW200530232A (en)	2005-09-16
IL174084A0 (en)	2008-02-09
KR20060088534A (ko)	2006-08-04
EA200600372A1 (ru)	2006-08-25

Legal Events

Date	Code	Title	Description
2010-04-26	FC2A	Withdrawal, rejection or dismissal of laid open patent application

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