NO20061419L - Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser - Google Patents

Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser

Info

Publication number
NO20061419L
NO20061419L NO20061419A NO20061419A NO20061419L NO 20061419 L NO20061419 L NO 20061419L NO 20061419 A NO20061419 A NO 20061419A NO 20061419 A NO20061419 A NO 20061419A NO 20061419 L NO20061419 L NO 20061419L
Authority
NO
Norway
Prior art keywords
lower alkyl
hydrogen
trifluoromethyl
halogen
group
Prior art date
Application number
NO20061419A
Other languages
English (en)
Norwegian (no)
Inventor
Henri Stalder
Emmanuel Pinard
Simona Maria Ceccarelli
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20061419L publication Critical patent/NO20061419L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20061419A 2003-10-23 2006-03-28 Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser NO20061419L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03024415 2003-10-23
PCT/EP2004/011552 WO2005040166A1 (fr) 2003-10-23 2004-10-14 Derives de triaza-spiropiperidine a utiliser comme inhibiteurs de glyt-1 dans le traitement de troubles neurologiques et neuropsychiatriques

Publications (1)

Publication Number Publication Date
NO20061419L true NO20061419L (no) 2006-07-14

Family

ID=34486099

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061419A NO20061419L (no) 2003-10-23 2006-03-28 Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser

Country Status (19)

Country Link
US (1) US7189850B2 (fr)
EP (1) EP1678177B1 (fr)
JP (1) JP4490434B2 (fr)
KR (1) KR100798161B1 (fr)
CN (1) CN100467468C (fr)
AR (1) AR046186A1 (fr)
AU (1) AU2004283843B2 (fr)
BR (1) BRPI0415833A (fr)
CA (1) CA2543308C (fr)
CO (1) CO5690643A2 (fr)
DE (1) DE602004010419T2 (fr)
ES (1) ES2297502T3 (fr)
IL (1) IL174734A (fr)
MX (1) MXPA06004305A (fr)
NO (1) NO20061419L (fr)
RU (1) RU2006117368A (fr)
TW (1) TW200526662A (fr)
WO (1) WO2005040166A1 (fr)
ZA (1) ZA200603221B (fr)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5266042B2 (ja) * 2005-04-11 2013-08-21 エール ユニヴァーシティ 統合失調症前駆症の治療方法
DE102005038141A1 (de) * 2005-08-12 2007-02-15 Grünenthal GmbH Substituierte 8-(3-Aminopropyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-on-Derivate
MX2008011216A (es) 2006-03-08 2008-09-11 Hoffmann La Roche 1,5-dihidro-imidazol-2-onas 4-amino-1,5-substituidas.
JP2009530247A (ja) * 2006-03-16 2009-08-27 グラクソ グループ リミテッド N−フェニル−2−オキソ−1,4−ジアザスピロ[4.5]デカ−3−エン−1−イルアセトアミド誘導体およびグリシン輸送体阻害剤としてのそれらの使用
GB0607398D0 (en) * 2006-04-12 2006-05-24 Glaxo Group Ltd Compounds
CN101472924A (zh) * 2006-06-20 2009-07-01 惠氏公司 Kv1.5钾通道抑制剂
US20100113545A1 (en) * 2007-02-01 2010-05-06 Steven Coulton Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
WO2008092874A1 (fr) * 2007-02-01 2008-08-07 Glaxo Group Limited Inhibiteurs du transporteur de glyt1 et leurs utilisations pour le traitement de troubles neurologiques et neuropsychiatriques
US20100105713A1 (en) * 2007-02-01 2010-04-29 Glaxo Group Limited GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders
EP2121624A1 (fr) * 2007-02-01 2009-11-25 Glaxo Group Limited Inhibiteurs du transporteur de glyt1 et leurs utilisations pour le traitement de troubles neurologiques et neuropsychiatriques
GB0701985D0 (en) * 2007-02-01 2007-03-14 Glaxo Group Ltd Compounds
GB0701955D0 (en) * 2007-02-01 2007-03-14 Glaxo Group Ltd Compounds
WO2008092877A2 (fr) * 2007-02-01 2008-08-07 Glaxo Group Limited Inhibiteurs du transporteur glyt1 et leurs utilisations dans le traitement de troubles neurologiques et neuropsychiatriques
AU2008259841B2 (en) 2007-05-31 2015-02-05 Sunovion Pharmaceuticals Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
CA2691704A1 (fr) 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines et leur utilisation comme antidepresseurs
MX2009014235A (es) 2007-08-22 2010-04-27 Abbott Gmbh & Co Kg 4-bencilaminoquinolonas, composiciones farmaceuticas que las contiene y su uso.
WO2009034062A1 (fr) * 2007-09-11 2009-03-19 Glaxo Group Limited Composés qui inhibent le transporteur de glycine et ses utilisations en médecine
US20090077077A1 (en) * 2007-09-18 2009-03-19 Gerhard Geldenbott Optimal selection of MSAG address for valid civic/postal address
US7981904B2 (en) * 2008-03-20 2011-07-19 Takeda Pharmaceutical Company Limited Acetyl CoA carboxylase inhibitors
EP2527328A1 (fr) 2008-04-01 2012-11-28 Abbott GmbH & Co. KG Tétrahydroisoquinoléines, compositions pharmaceutiques les contenant et leur utilisation en thérapie
SG173116A1 (en) * 2009-01-27 2011-08-29 Hoffmann La Roche Aroylamino - and heteroaroylamino-substituted piperidines as glyt-1 inhibitors
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8691830B2 (en) 2010-10-25 2014-04-08 G1 Therapeutics, Inc. CDK inhibitors
MX338327B (es) 2010-10-25 2016-04-12 G1 Therapeutics Inc Inhibidores de cdk.
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
CN104011028A (zh) 2011-11-18 2014-08-27 艾伯维德国有限责任两合公司 N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2868966C (fr) 2012-03-29 2021-01-26 Francis Xavier Tavares Lactames inhibiteurs de kinases
JP2015157764A (ja) * 2012-06-14 2015-09-03 大正製薬株式会社 グリシントランスポーター阻害物質
ME03557B (fr) 2013-03-15 2020-07-20 G1 Therapeutics Inc Protection transitoire de cellules normales pendant une chimiothérapie
CA2906157C (fr) 2013-03-15 2022-05-17 G1 Therapeutics, Inc. Agents antineoplasiques et antiproliferatifs hautement actifs
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
SG11201602935PA (en) 2013-10-17 2016-05-30 Abbvie Deutschland Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015055770A1 (fr) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Dérivés d'aminochromane, d'aminothiochromane et d'amino-1,2,3,4-tétrahydroquinoléine, compositions pharmaceutiques contenant ceux-ci et leur utilisation thérapeutique
CN106061969B (zh) 2014-01-06 2019-10-29 阿尔戈么迪克斯有限公司 Trpa1调节剂
WO2015161288A1 (fr) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Lactames tricycliques utilisés en tant qu'agents anti-néoplasiques et anti-prolifératifs
EP3134406A1 (fr) 2014-04-24 2017-03-01 Dart Neuroscience (Cayman) Ltd Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c]pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c]pyridine utilisés comme inhibiteurs de glyt1
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016040848A1 (fr) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Traitement de tumeurs rb-négatives en utilisant des inhibiteurs de la topoisomérase en association avec des inhibiteurs des kinases cycline-dépendantes 4/6
EP3191098A4 (fr) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinaisons et régimes posologiques pour traiter des tumeurs rb-positives
EP3215500A1 (fr) 2014-11-05 2017-09-13 Dart NeuroScience (Cayman) Ltd. Composés azétidinyles substitués utilisés comme inhibiteurs de glyt1
CN108713019B (zh) 2016-03-17 2021-06-15 豪夫迈·罗氏有限公司 具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
WO2018005863A1 (fr) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Composés à base de pyrimidine pour le traitement du cancer
MX2019008158A (es) 2017-01-06 2019-12-09 G1 Therapeutics Inc Terapia de combinacion para el tratamiento del cancer.
WO2019006393A1 (fr) 2017-06-29 2019-01-03 G1 Therapeutics, Inc. Formes morphiques de git38 et leurs procédés de fabrication
AU2019325685B2 (en) 2018-08-24 2025-07-24 Pharmacosmos Holding A/S Improved synthesis of 1,4-diazaspiro(5.5)undecan-3-one
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0921125T1 (en) * 1997-12-05 2002-04-30 F. Hoffmann-La Roche Ag 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
ATE212635T1 (de) * 1997-12-05 2002-02-15 1,3,8-triazaspiro(4,5)decan-4-on-derivate
SI1594840T1 (sl) * 2003-02-17 2006-12-31 Hoffmann La Roche Derivati piperidin-benzensulfonamida

Also Published As

Publication number Publication date
CA2543308C (fr) 2012-03-06
ZA200603221B (en) 2009-04-29
MXPA06004305A (es) 2006-06-05
CO5690643A2 (es) 2006-10-31
BRPI0415833A (pt) 2007-01-02
US20050107373A1 (en) 2005-05-19
IL174734A (en) 2010-05-31
IL174734A0 (en) 2006-08-20
EP1678177A1 (fr) 2006-07-12
ES2297502T3 (es) 2008-05-01
AU2004283843B2 (en) 2010-04-22
US7189850B2 (en) 2007-03-13
AU2004283843A1 (en) 2005-05-06
AR046186A1 (es) 2005-11-30
CA2543308A1 (fr) 2005-05-06
CN1871238A (zh) 2006-11-29
DE602004010419T2 (de) 2008-10-09
JP2007509097A (ja) 2007-04-12
DE602004010419D1 (de) 2008-01-10
KR100798161B1 (ko) 2008-01-28
WO2005040166A1 (fr) 2005-05-06
KR20060076317A (ko) 2006-07-04
EP1678177B1 (fr) 2007-11-28
CN100467468C (zh) 2009-03-11
JP4490434B2 (ja) 2010-06-23
TW200526662A (en) 2005-08-16
RU2006117368A (ru) 2007-12-10

Similar Documents

Publication Publication Date Title
NO20061419L (no) Triaza-spiropiperidinderivater for anvendelse som Glyt-1-inhibitorer i behandling av nevrologiske og nevropsykiatriske lidelser
NO20060975L (no) 1-Benzoyl-piperazinderivater som glycin gjenopptaksinhibitorer for behandling av psykoser
TW200505907A (en) Piperidine-benzenesulfonamide derivatives
NO20073667L (no) [4-(heteroaryl) piperazin-1-yl]-(2,5-substituert-fenyl)metanonderivater som glycintransportor 1(GLYT-1)- inhibitorer for behandling av neurologiske og neuropsykiatriske lidelser
AU611997B2 (en) 3,4 amino quinolines and 4 amino 3 nitroquinolines
DK2297120T3 (en) Aminodihydrothiazine derivatives as bace inhibitors for the treatment of Alzheimer's disease
SE0202134D0 (sv) Therapeutic agents
NO20072833L (no) Bi- og tricykliske substituterte fenylmetanoner som glycinetransportor I-(Glyt-1)-inhibitorer for behandling av Alzheimers sykdom
HUP0301671A2 (hu) 4-Fenil-piridin-származékok, mint neurokinin-1-receptor antagonisták, eljárás az előállításukra és alkalmazásuk
NO20015686D0 (no) Nye forbindelser, deres anvendelse og fremstilling
NZ532494A (en) Dibenzylamine compound and medicinal use thereof
PE20071009A1 (es) Compuestos derivados de fenoxipiperidinas como antagonistas de histamina h3
JP2002504484A (ja) 新規化合物
NO20081056L (no) Nye, heterosykliske NF-kB-inhibitorer
DE69835877D1 (de) Trizyklische verbindungen
JP2011510972A5 (fr)
CA2488761A1 (fr) Amides 2-benzofuryle ou benzothiophenyle-quinuclidinyle en tant qu'inhibiteurs du recepteur nicotinique de l'acetylcholine
HU203233B (en) Process for producing aryl piperazinyl alkoxy derivatives of cyclic imides and pharmaceutical compositions comprising such compounds
RU2008148165A (ru) Замещенные производные фенилметанона
AU2004215523B2 (en) Method for Preparing Acid Addition Salts of Polyacidic Basic Compounds
WO2007054444A3 (fr) Derives du 3-aryl-isoxazole-4-carbonyl-benzofurane
NZ243340A (en) 2-aminopyrimidine-4-carboxamide derivatives, pharmaceutical compositions
US4677104A (en) Antipsychotic fused-ring pyridinylpiperazine derivatives
Alagarsamy et al. Synthesis of 4-butyl-1-substituted-4H-[1, 2, 4] triazolo [4, 3-a] quinazolin-5-ones as new class of H1-antihistaminic agents
NO20070972L (no) Benzyloksyderivater som MAOB-inhibitorer

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application