NO20062884L - AKT-proteinkinaseinhibitorer - Google Patents

AKT-proteinkinaseinhibitorer

Info

Publication number
NO20062884L
NO20062884L NO20062884A NO20062884A NO20062884L NO 20062884 L NO20062884 L NO 20062884L NO 20062884 A NO20062884 A NO 20062884A NO 20062884 A NO20062884 A NO 20062884A NO 20062884 L NO20062884 L NO 20062884L
Authority
NO
Norway
Prior art keywords
protein kinase
kinase inhibitors
akt protein
compounds
diastereomers
Prior art date
Application number
NO20062884A
Other languages
English (en)
Inventor
Dengming Xiao
Mark Munson
Guy Vigers
John Anthony Josey
Peter Stengel
Ian S Mitchell
Keith L Spencer
Yongxin Han
Nicholas Kallan
James Blake
Anthony Piscopio
Scott Miller
Riu Xu
Chang Rao
Bin Wang
April L Bernacki
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of NO20062884L publication Critical patent/NO20062884L/no

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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser, inkludert utledede enantiomerer, diastereomerer, solvater og farmasøytisk akseptable salter derav, som omfatter Formelen: A-L-CR der CR er en syklisk kjernegruppe, L er en linkergruppe og A er som definert her. Også tilveiebrakt er fremgangsmåter for å benytte forbindelsene ifølge denne oppfinnelsen som AKT-proteinkinaseinhibitorer og til behandlingen av hyperproliferative sykdommer slik som kreft.
NO20062884A 2003-11-21 2006-06-20 AKT-proteinkinaseinhibitorer NO20062884L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52400303P 2003-11-21 2003-11-21
PCT/US2004/039094 WO2005051304A2 (en) 2003-11-21 2004-11-19 Akt protein kinase inhibitors

Publications (1)

Publication Number Publication Date
NO20062884L true NO20062884L (no) 2006-08-18

Family

ID=34632854

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20062884A NO20062884L (no) 2003-11-21 2006-06-20 AKT-proteinkinaseinhibitorer

Country Status (15)

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US (3) US20050130954A1 (no)
EP (1) EP1684694A2 (no)
JP (1) JP2007512364A (no)
KR (2) KR20110137838A (no)
CN (2) CN1882347A (no)
AU (1) AU2004293026B2 (no)
BR (1) BRPI0416852A (no)
CA (1) CA2546754A1 (no)
IL (2) IL175221A (no)
NO (1) NO20062884L (no)
NZ (2) NZ590160A (no)
PH (1) PH12012501891A1 (no)
RU (1) RU2006121990A (no)
WO (1) WO2005051304A2 (no)
ZA (1) ZA200604069B (no)

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SI1664041T1 (sl) 2003-09-22 2008-12-31 Euro Celtique Sa Fenil-karboksamidne spojine, uporabne za tretiranje bolečine
US7402652B2 (en) * 2004-09-14 2008-07-22 Miller Landon C G Baclofen conjugate and a pharmaceutical composition for treatment of neuronal disorders
MY179032A (en) * 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
KR101278522B1 (ko) 2004-12-02 2013-06-25 다이이찌 산쿄 가부시키가이샤 7원환 화합물 및 그 제조법 및 의약 용도
AU2005322085B2 (en) * 2004-12-28 2012-07-19 Exelixis, Inc. [1H-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70S6K, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
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EP1702916A1 (en) * 2005-03-18 2006-09-20 Santhera Pharmaceuticals (Schweiz) GmbH DPP-IV inhibitors
JP2008545660A (ja) * 2005-05-20 2008-12-18 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼ阻害剤として有用なピロロピリジン化合物
US8071768B2 (en) 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
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US20140148436A1 (en) 2014-05-29
WO2005051304A2 (en) 2005-06-09
JP2007512364A (ja) 2007-05-17
NZ590160A (en) 2012-07-27
KR101223914B1 (ko) 2013-01-18
KR20070026332A (ko) 2007-03-08
ZA200604069B (en) 2009-04-29
PH12012501891A1 (en) 2013-09-02
IL175221A (en) 2015-05-31
KR20110137838A (ko) 2011-12-23

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