NO20063058L - Fremgangsmate for fremstilling av (3-okso-2,3-dihydro-1H-isoindol-1-yl)acetylguanidinderivater - Google Patents

Fremgangsmate for fremstilling av (3-okso-2,3-dihydro-1H-isoindol-1-yl)acetylguanidinderivater

Info

Publication number
NO20063058L
NO20063058L NO20063058A NO20063058A NO20063058L NO 20063058 L NO20063058 L NO 20063058L NO 20063058 A NO20063058 A NO 20063058A NO 20063058 A NO20063058 A NO 20063058A NO 20063058 L NO20063058 L NO 20063058L
Authority
NO
Norway
Prior art keywords
dihydro
isoindol
oxo
preparation
derivatives
Prior art date
Application number
NO20063058A
Other languages
English (en)
Inventor
Gerrit Schubert
Heinz-Werner Kleemann
Jorg Rieke-Zapp
Johannes Keil
Reda Hanna
Bao-Guo Huang
Xiao-Dong Wu
Yves Gouraud
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of NO20063058L publication Critical patent/NO20063058L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Det er beskrevet fremgangsmåter for fremstilling av (3 -okso-2,3 -dihydro- IH-isoindol-1 -yl)- acetylguanidinderivater med formel (I) over 3 -hydroksy-2,3 -dihydro- IH-isoindol-1 -onderivater eller 3 -(2-karbamoyl-fenyl)akrylsyreesterderivater som meUomstadier, en fremgangsmåte for racematspaltning, samt mellomprodukter av fremgangsmåten.
NO20063058A 2003-12-02 2006-06-30 Fremgangsmate for fremstilling av (3-okso-2,3-dihydro-1H-isoindol-1-yl)acetylguanidinderivater NO20063058L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10356717A DE10356717A1 (de) 2003-12-02 2003-12-02 Verfahren zur Herstellung von (3-Oxo-2,3-dihydro-1H-isoindol-1-yl)-acetylguanidin-Derivaten
PCT/EP2004/013153 WO2005054195A1 (de) 2003-12-02 2004-11-19 VERFAHREN ZUR HERSTELLUNG VON (3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-Yl)-ACETYLGUANIDIN-DERIVATEN

Publications (1)

Publication Number Publication Date
NO20063058L true NO20063058L (no) 2006-06-30

Family

ID=34638338

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063058A NO20063058L (no) 2003-12-02 2006-06-30 Fremgangsmate for fremstilling av (3-okso-2,3-dihydro-1H-isoindol-1-yl)acetylguanidinderivater

Country Status (37)

Country Link
EP (1) EP1692105B1 (no)
JP (1) JP4809774B2 (no)
KR (1) KR101202604B1 (no)
CN (1) CN100526297C (no)
AR (1) AR046733A1 (no)
AT (1) ATE395334T1 (no)
AU (1) AU2004295056B2 (no)
BR (1) BRPI0417147A (no)
CA (1) CA2548020C (no)
CR (1) CR8376A (no)
CY (1) CY1108187T1 (no)
DE (2) DE10356717A1 (no)
DK (1) DK1692105T3 (no)
EC (1) ECSP066597A (no)
EG (1) EG25498A (no)
ES (1) ES2304634T3 (no)
HR (1) HRP20080253T3 (no)
IL (1) IL175834A (no)
JO (1) JO2498B1 (no)
MA (1) MA28220A1 (no)
MY (1) MY136467A (no)
NO (1) NO20063058L (no)
NZ (1) NZ547625A (no)
OA (1) OA13293A (no)
PA (1) PA8618701A1 (no)
PE (1) PE20051037A1 (no)
PL (1) PL1692105T3 (no)
PT (1) PT1692105E (no)
RS (1) RS50571B (no)
RU (1) RU2397159C2 (no)
SI (1) SI1692105T1 (no)
TN (1) TNSN06167A1 (no)
TW (1) TWI334348B (no)
UA (1) UA83883C2 (no)
UY (1) UY28648A1 (no)
WO (1) WO2005054195A1 (no)
ZA (1) ZA200603338B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
ES2385185T3 (es) * 2008-04-16 2012-07-19 Kissei Pharmaceutical Co., Ltd. Hemifumarato de un derivado de pirazol
RU2518740C1 (ru) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ДИГИДРОХЛОРИД 2-(3,4-МЕТИЛЕНДИОКСИФЕНИЛ)-9-МОРФОЛИНОЭТИЛИМИДАЗО[1,2-a]БЕНЗИМИДАЗОЛА
CN107778238B (zh) * 2016-08-29 2022-07-22 中山大学 一种3，4-二氢异喹啉-1-酮的合成新方法
CN107286074B (zh) * 2017-08-16 2019-08-20 厦门华厦学院 3-羟基异吲哚-1-酮衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU581324B2 (en) * 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
DE19737224A1 (de) * 1997-08-27 1999-03-18 Hoechst Marion Roussel De Gmbh Pharmazeutisches Kombinationspräparat aus einem Inhibitor des Natrium-Wasserstoff-Austauschers und einem Arzneimittel zur Behandlung von Herz-Kreislauferkrankungen
DE19832429A1 (de) * 1998-07-18 2000-01-20 Hoechst Marion Roussel De Gmbh Imidazolderivate mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
RU2186057C1 (ru) * 2001-03-22 2002-07-27 Аляутдин Ренад Николаевич 4-нитро-3-трифторметил-перфторнонаноиланилид (флустат), способ его получения и фармацевтическая композиция на его основе
EP1767525A1 (en) * 2001-04-09 2007-03-28 Novartis Vaccines and Diagnostics, Inc. Guanidino compounds as melanocortin-4 receptor (MC4-R) agonists
FR2840302B1 (fr) * 2002-06-03 2004-07-16 Aventis Pharma Sa Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
KR101202604B1 (ko) 2012-11-19
ZA200603338B (en) 2007-06-27
EP1692105A1 (de) 2006-08-23
AU2004295056B2 (en) 2011-04-14
ECSP066597A (es) 2006-10-25
DK1692105T3 (da) 2008-08-25
TWI334348B (en) 2010-12-11
WO2005054195A1 (de) 2005-06-16
AR046733A1 (es) 2005-12-21
PT1692105E (pt) 2008-07-04
KR20060111558A (ko) 2006-10-27
JP2007516243A (ja) 2007-06-21
IL175834A (en) 2010-12-30
CA2548020A1 (en) 2005-06-16
OA13293A (en) 2007-01-31
JO2498B1 (en) 2009-10-05
TW200526207A (en) 2005-08-16
PL1692105T3 (pl) 2008-09-30
NZ547625A (en) 2010-01-29
PE20051037A1 (es) 2005-12-29
AU2004295056A1 (en) 2005-06-16
CY1108187T1 (el) 2014-02-12
CN100526297C (zh) 2009-08-12
DE10356717A1 (de) 2005-07-07
RU2397159C2 (ru) 2010-08-20
BRPI0417147A (pt) 2007-03-06
IL175834A0 (en) 2006-10-05
SI1692105T1 (sl) 2008-08-31
TNSN06167A1 (en) 2007-11-15
EG25498A (en) 2012-01-22
DE502004007177D1 (de) 2008-06-26
CA2548020C (en) 2013-01-08
ES2304634T3 (es) 2008-10-16
ATE395334T1 (de) 2008-05-15
UY28648A1 (es) 2005-06-30
JP4809774B2 (ja) 2011-11-09
UA83883C2 (en) 2008-08-26
MY136467A (en) 2008-10-31
CR8376A (es) 2007-12-04
HRP20080253T3 (en) 2008-09-30
EP1692105B1 (de) 2008-05-14
HK1097525A1 (zh) 2007-06-29
CN1886374A (zh) 2006-12-27
RS50571B (sr) 2010-05-07
MA28220A1 (fr) 2006-10-02
PA8618701A1 (es) 2006-07-03
RU2006123410A (ru) 2008-01-10

Similar Documents

Publication Publication Date Title
NO20060544L (no) Enzymatiske prosesser for produksjon av 4-substituerte 3-hydroksysmorsyrederivater og naerliggende cyano, hydroksy substituerte karboksylsyre estere
DE69912581D1 (de) Biarylessigsäure-derivate und ihre verwendung als cox-2 inhibitoren
NO20071577L (no) Bifenyloksyiddiksyrederivater for behandling av luftveissykdommer
EA200000358A1 (ru) Способ получения диарилпиридинов, полезных в качестве ингибиторов cox-2
NO20041379L (no) Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater
PT923554E (pt) N-benzilpiperidina e derivados tetrahidropiridina
CA2665931C (en) Hydrobenzamide derivatives as inhibitors of hsp90
EA200600621A1 (ru) Производные тетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
WO2004080922A3 (en) Substituted vitamin d analogues and their therapeutic uses
UA87822C2 (ru) Производные нафтилена как ингибиторы цитохрома p450
NO20040388L (no) Fremgangsmåte for fremstilling av beraprost og salter derav, samt forbindelser som er mellomprodukter i fremgangsmåten
ATE373001T1 (de) Verfahren zur herstellung von oh-geschützten (4- (2,6-diamino-9h-purin-9-yl)-1,3-dioxolan-2- yl)methanol-derivaten
EE04642B1 (et) (1H)benso[c]kinolisiin-3-ooni derivaatide sünteesi meetod
NO20050612L (no) Pyrrolidinderivater som oksytocinantagonister
CY1108187T1 (el) Μεθοδος για την παρασκευη παραγωγων της (3-οξο 2,3-διυδρο-1η-ισοϊνδολ-1-υλο)-ακετυλογουανιδινης
DE602005011267D1 (de) Benzofuran- und benzothiophenderivate, die sich für die behandlung von herzkreislauferkrankungen eignen
NO994049L (no) Metode for aa fremstille farmasöytiske forbindelser
NO20033880D0 (no) Fremgangsmåte for fremstilling av optiske aktive propoksyanilinderivater
EA200500028A1 (ru) Новые соединения 3-(4-оксо-4h-хромен-2-ил)-(1h)-хинолин-4-она, способ их получения и фармацевтические композиции, которые их содержат
WO2004096828A3 (fr) Nouveau procede et intermediaires de preparation de composes 19-nor-steroïdes
NO20022690D0 (no) Nye strukturelle analoger av Vitamin D
NO20020561L (no) Fremgangsmåte for fremstilling av syrer via alfa-klorepoksi- estere
TW200604140A (en) N- (4- oxo-butanoic acid) -l-amino acid-ester derivatives and methods of preparation thereof
ATE260271T1 (de) Ammonium-3,5,6-trihydroxyhexansäure-derivate und methoden zu ihrer herstellung
NO20064410L (no) Fremgangsmate for fremstilling av tryptaseinhibitorer